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  1. Buch ; Dissertation / Habilitation: Der Cannabinoid-CB 1 -Rezeptor am dopaminergen Neuron der Retina und am noradrenergen Neuron des ZNS im funktionellen Modell

    Timm, Jörg

    2000  

    Verfasserangabe vorgelegt von Jörg Timm
    Umfang 71 S. : graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Bonn, Univ., Diss., 2000
    HBZ-ID HT011210098
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch ; Online ; Dissertation / Habilitation: Analyse der Sequenzvariabilität des Hepatitis B Virus unter dem Einfluss der CD8 T-Zellantwort auf Populationsebene

    Schwarz, Tatjana [Verfasser] / Timm, Jörg [Gutachter] / Hegemann, Johannes [Gutachter]

    2023  

    Verfasserangabe Tatjana Schwarz ; Gutachter: Jörg Timm, Johannes Hegemann
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Deutsch
    Verlag Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Erscheinungsort Düsseldorf
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  3. Buch ; Online ; Dissertation / Habilitation: Analyse zytotoxischer Lymphozyten im Myelodysplastischen Syndrom (MDS) und der Akuten Myeloischen Leukämie (AML) unter Berücksichtigung des Zytomegalievirus-Status

    Moskorz, Wiebke [Verfasser] / Timm, Jörg [Gutachter] / Lang, Philipp [Gutachter]

    2023  

    Verfasserangabe Wiebke Moskorz ; Gutachter: Jörg Timm, Philipp Lang
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Deutsch
    Verlag Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Erscheinungsort Düsseldorf
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  4. Buch ; Online ; Dissertation / Habilitation: The human antibody response to tick-borne flaviviruses

    Kapoor, Tania [Verfasser] / Timm, Jörg [Gutachter] / Feldt, Thorsten [Gutachter]

    2023  

    Verfasserangabe Tania Kapoor ; Gutachter: Jörg Timm, Thorsten Feldt
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Englisch
    Verlag Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Erscheinungsort Düsseldorf
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  5. Artikel ; Online: Epidemiological measures for assessing the dynamics of the SARS-CoV-2-outbreak: Simulation study about bias by incomplete case-detection.

    Brinks, Ralph / Küchenhoff, Helmut / Timm, Jörg / Kurth, Tobias / Hoyer, Annika

    PloS one

    2022  Band 17, Heft 10, Seite(n) e0276311

    Abstract: During the SARS-CoV-2 outbreak, several epidemiological measures, such as cumulative case-counts (CCC), incidence rates, effective reproduction numbers (Reff) and doubling times, have been used to inform the general public and to justify interventions ... ...

    Abstract During the SARS-CoV-2 outbreak, several epidemiological measures, such as cumulative case-counts (CCC), incidence rates, effective reproduction numbers (Reff) and doubling times, have been used to inform the general public and to justify interventions such as lockdown. It has been very likely that not all infectious people have been identified during the course of the epidemic, which lead to incomplete case-detection. We compare CCC, incidence rates, Reff and doubling times in the presence of incomplete case-detection. For this, an infection-age-structured SIR model is used to simulate a SARS-CoV-2 outbreak followed by a lockdown in a hypothetical population. Different scenarios about temporal variations in case-detection are applied to the four measures during outbreak and lockdown. The biases resulting from incomplete case-detection on the four measures are compared in terms of relative errors. CCC is most prone to bias by incomplete case-detection in all of our settings. Reff is the least biased measure. The possibly biased CCC may lead to erroneous conclusions in cross-country comparisons. With a view to future reporting about this or other epidemics, we recommend including and placing an emphasis on Reff in those epidemiological measures used for informing the general public and policy makers.
    Mesh-Begriff(e) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; Communicable Disease Control/methods ; Disease Outbreaks ; Bias
    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0276311
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Characterization of CD34

    Nollmann, Cathrin / Moskorz, Wiebke / Wimmenauer, Christian / Jäger, Paul S / Cadeddu, Ron P / Timm, Jörg / Heinzel, Thomas / Haas, Rainer

    Cancers

    2024  Band 16, Heft 7

    Abstract: Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic cells from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) following their ... ...

    Abstract Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic cells from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) following their successful treatment. The panel of markers included CD34, CD38, CD45RA, CD123 as representatives for a hierarchical hematopoietic stem and progenitor cell (HSPC) classification as well as programmed death ligand 1 (PD-L1). Rather than restricting the evaluation on a 2- or 3-dimensional analysis, we applied a t-distributed stochastic neighbor embedding (t-SNE) approach to obtain deeper insight and segregation between leukemic cells and normal HPSCs. For that purpose, we created a t-SNE map, which resulted in the visualization of 27 cell clusters based on their similarity concerning the composition and intensity of antigen expression. Two of these clusters were "leukemia-related" containing a great proportion of CD34
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071320
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch ; Online ; Dissertation / Habilitation: Analysis of invariant natural killer T cells in health and disease: lessons from acute hepatitis C virus infection

    Menne, Christopher [Verfasser] / Timm, Jörg [Gutachter] / Lang, Philipp [Gutachter]

    2022  

    Verfasserangabe Christopher Menne ; Gutachter: Jörg Timm, Philipp Lang
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Englisch
    Verlag Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Erscheinungsort Düsseldorf
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  8. Artikel: Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts

    Adams, Ortwin / Andrée, Marcel / Hermsen, Derik / Lübke, Nadine / Timm, Jörg / Schaal, Heiner / Müller, Lisa

    Journal of virological methods. 2022 June 14,

    2022  

    Abstract: Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labour-intensive and requires Biosafety Level 3 ... ...

    Abstract Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labour-intensive and requires Biosafety Level 3 certified laboratories. Therefore, several commercial SARS-CoV-2 surrogate virus neutralization tests (sVNTs) have been developed that aim to detect neutralizing antibodies targeting the receptor binding domain (RBD) of the viral spike glycoprotein (S). Neutralizing antibodies to the RBD block its interaction with the angiotensin-converting enzyme 2 (ACE2) receptor protein. Here, we compared a full virus neutralization test (VNT) with two SARS-CoV-2 surrogate virus neutralization tests (sVNT) and validated them in two cohorts of i) convalescent SARS-CoV-2-infected individuals and ii) COVID vaccinated individuals. The sVNTs showed highly different results both, compared to the VNT-titers and also between the two cohorts. This indicates that currently, sVNT provide a qualitative instead of a quantitative measurement of neutralizing antibodies. The findings in this work show that the cutoff levels for sVNTs might need to be readjusted for convalescent and vaccinated individuals.
    Schlagwörter Severe acute respiratory syndrome coronavirus 2 ; biosafety ; glycoproteins ; neutralization ; neutralization tests ; peptidyl-dipeptidase A ; quantitative analysis ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2022-0614
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114569
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel: Erfolg durch körpereigene "Krieger*innen". Natürliche Killerzellen im Kampf gegen eine Hepatitis-C-Virus-Infektion Die in diesem Beitrag beschriebene immunologische Grundlagenforschung möchte dazu beitragen, ein besseres Verständms der HCV-Infektion zu erlangen und die komplexen Mechanismen aufklären, die bei einigen Menschen zu einer spontanen Ausheilung einer HCV-Infektion führen beziehungsweise Individuen vor einer Infektion schützen. Ein besseres Verständnis der Rolle des angeborenen und erworbenen Immunsystems für den HCV-Infektionsverlauf könnte für die Entwicklung einer prophylaktischen Impfung helfen

    Senff, Tina / Timm, Jörg

    Unikate / Universitä Duisburg-Essen

    2020  Band 54, Heft 54, Seite(n) 38

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 2467342-0
    ISSN 1869-3881
    Datenquelle Current Contents Medizin

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  10. Artikel ; Online: Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts.

    Adams, Ortwin / Andrée, Marcel / Hermsen, Derik / Lübke, Nadine / Timm, Jörg / Schaal, Heiner / Müller, Lisa

    Journal of virological methods

    2022  Band 307, Seite(n) 114569

    Abstract: Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labor-intensive and requires Biosafety Level 3 ... ...

    Abstract Determination of neutralizing antibody titers is still considered the gold standard for infection protection. A full virus neutralization test (VNT) with replication-competent, infectious SARS-CoV-2, is labor-intensive and requires Biosafety Level 3 certified laboratories. Therefore, several commercial SARS-CoV-2 surrogate virus neutralization tests (sVNTs) have been developed that aim to detect neutralizing antibodies targeting the receptor binding domain (RBD) of the viral spike glycoprotein (S). Neutralizing antibodies to the RBD block its interaction with the angiotensin-converting enzyme 2 (ACE2) receptor protein. Here, we compared a full virus neutralization test (VNT) with two SARS-CoV-2 surrogate virus neutralization tests (sVNT) and validated them in two cohorts of i) convalescent SARS-CoV-2-infected individuals and ii) COVID vaccinated individuals. The sVNTs showed highly different results both, compared to the VNT-titers and also between the two cohorts. This indicates that currently, sVNT provide a qualitative instead of a quantitative measurement of neutralizing antibodies. The findings in this work show that the cutoff levels for sVNTs might need to be readjusted for convalescent and vaccinated individuals.
    Mesh-Begriff(e) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/diagnosis ; Humans ; Neutralization Tests ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemische Substanzen Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-06-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114569
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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