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  1. Artikel ; Online: American Academy of Ophthalmology Clinical Practice Guidelines and Financial Disclosures-Where Is the Money Going?

    Tinsley, Shane Alexander / Davis, Matthew James / Abdollah, Firas

    JAMA ophthalmology

    2023  Band 141, Heft 8, Seite(n) 804

    Mesh-Begriff(e) Humans ; United States ; Disclosure ; Ophthalmology ; Conflict of Interest ; Academies and Institutes
    Sprache Englisch
    Erscheinungsdatum 2023-07-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.3107
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A Ten Year Experience of Men's Health Events in a Socioeconomically Diverse City in the United States - Lessons Learned.

    Tinsley, Shane / Mahabadi, Navid / Hamel, Lauren / Dyson, Gregory / Lutz, Michael / Hamilton, Andrea / Powell, Isaac / Heath, Elisabeth I

    Journal of community health

    2024  

    Abstract: Community-based health events provide an opportunity to increase knowledge, awareness, and screening for acute and chronic diseases among individuals living in a socioeconomically diverse community. Because there are limited reports of such events, here ... ...

    Abstract Community-based health events provide an opportunity to increase knowledge, awareness, and screening for acute and chronic diseases among individuals living in a socioeconomically diverse community. Because there are limited reports of such events, here we describe our ten-year experience of annual men's health fairs. This retrospective study of the Michigan Institute of Urology Foundation evaluated Men's Health Events held in Detroit, Michigan, from 2012 to 2021. Over 10 years, 11,129 men were screened and > 100,000 screenings were performed. The majority of the attendees were African-American men (61%), had a college degree (67%) or a high school diploma (26%), and had an annual income of <$35K (47%) or $35-60 K (30%). From 2012 to 2021, participants who saw a doctor in the past year rose from 62 to 70%; the median age of men rose from 52 to 58; their median testosterone levels increased from 353 ng/dL to 412 ng/dL, and men with concerning prostate-specific antigen values (≥ 4 ng/mL) doubled from 5% to 10%. Among participants, 59% had cholesterol levels of < 200 mg/dL, 28% of 200-240 mg/dL, and 13% of > 240 mg/dL; 7% had glucose levels of < 70 mg/dL, 68% of 70-105 mg/dL, and 25% of > 105 mg/dL

    24% had ≥ 140 mmHg systolic and 18% had ≥ 90 mmHg diastolic blood pressure. Our findings suggest that community health events are successful at attracting and screening diverse community members. Such events should emphasize screening of high-risk individuals for acute and chronic diseases and promote other health-related behaviors.
    Sprache Englisch
    Erscheinungsdatum 2024-04-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-024-01354-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Comparison of patient background between a real-world North American cohort and the Göteborg-2 trial.

    Chiarelli, Giuseppe / Davis, Matthew / Stephens, Alex / Cirulli, Giuseppe Ottone / Finati, Marco / Corsi, Nicholas J / Sood, Akshay / Tinsley, Shane / Carrieri, Giuseppe / Briganti, Alberto / Montorsi, Francesco / Lughezzani, Giovanni / Buffi, Nicolò / Rogers, Craig / Abdollah, Firas

    International journal of urology : official journal of the Japanese Urological Association

    2024  Band 31, Heft 5, Seite(n) 562–567

    Abstract: Objectives: To analyze the generalizability of the Göteborg-2 findings to a North American cohort.: Methods: We replicated the Göteborg-2 inclusion criteria in our Henry Ford Health (HFH) cohort, by identifying all patients 50-60 years old who had a ... ...

    Abstract Objectives: To analyze the generalizability of the Göteborg-2 findings to a North American cohort.
    Methods: We replicated the Göteborg-2 inclusion criteria in our Henry Ford Health (HFH) cohort, by identifying all patients 50-60 years old who had a PSA test from 2013 to 2018. The first PSA within the study period was considered PSA at entry, and included in the analysis. Chi-square test was used to compare categorical variables between the Göteborg-2 and HFH cohort, with a particular focus on Black men, who were also analyzed separately.
    Results: The HFH patients included in the cohort were 49 456, of which 8562 were Black. In patients within the entire HFH cohort, HFH Black cohort, Göteborg Reference cohort, and Göteborg Experimental cohort, the rate of PSA ≥3 ng/mL was, respectively, 6.8%, 10.2%, 6.8%, and 6.6%. The rate of biopsy performed was, respectively, 1.8%, 4.1%, 5.8%, and 2.5%. PCa was found in, respectively, 1.4%, 3.0%, 2.3%, and 1.5%; Gleason score 3 + 3 in, respectively, 0.5%, 0.8%, 1.2%, and 0.6%; Gleason score > 3 + 3 in, respectively, 0.9%, 2.2%, 1.1%, and 0.9%.
    Conclusions: Our cohort had a lower biopsy rate and a lower incidence of non-csPCa diagnosis than both Göteborg cohorts, while still maintaining the same incidence of csPCa. This implies that the benefits of reducing non-csPCa diagnosis, as observed in the Experimental Göteborg cohort, are not necessarily replicable in U.S. "real-world practice" patients. Also noteworthy, we had a significantly higher percentage of Black men, who showed more aggressive disease.
    Mesh-Begriff(e) Humans ; Male ; Middle Aged ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/diagnosis ; Prostate-Specific Antigen/blood ; Biopsy ; Black or African American/statistics & numerical data ; Cohort Studies ; Prostate/pathology ; North America/epidemiology ; United States/epidemiology
    Chemische Substanzen Prostate-Specific Antigen (EC 3.4.21.77)
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Comparative Study
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.15415
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Impact of lymphovascular invasion on survival in surgically treated upper tract urothelial carcinoma: a nationwide analysis.

    Cirulli, Giuseppe Ottone / Corsi, Nicholas / Rakic, Ivan / Stephens, Alex / Chiarelli, Giuseppe / Finati, Marco / Davis, Matthew / Tinsley, Shane / Sood, Akshay / Buffi, Nicolò / Lughezzani, Giovanni / Carrieri, Giuseppe / Salonia, Andrea / Briganti, Alberto / Montorsi, Francesco / Rogers, Craig / Abdollah, Firas

    BJU international

    2024  Band 133, Heft 5, Seite(n) 555–563

    Abstract: Objectives: To assess the prognostic ability of lymphovascular invasion (LVI) in upper tract urothelial carcinoma (UTUC) as a predictor of overall survival (OS) using a large North American cohort.: Patients and methods: Our cohort included 5940 ... ...

    Abstract Objectives: To assess the prognostic ability of lymphovascular invasion (LVI) in upper tract urothelial carcinoma (UTUC) as a predictor of overall survival (OS) using a large North American cohort.
    Patients and methods: Our cohort included 5940 patients with clinical M0 UTUC who underwent a radical nephroureterectomy (RNU), between 2010 and 2016, within the National Cancer Database. The main variable of interest was LVI status, and its interaction with pathological nodal (pN) status. Kaplan-Meier curves were used to depict the OS also stratifying patients on LVI status. Cox regression analysis tested the impact of LVI status on OS after accounting for the available covariates.
    Results: The median (interquartile range [IQR]) age at diagnosis was 71 (63-78) years and most patients had pathological T1 stage disease (48.6%). Nodal status was pN0, pN1 and pNx in 45.8%, 6.3% and 47.9%, respectively. Overall, 22.1% had LVI. The median (IQR) follow-up time was 32.6 (16.0-53.3) months. At the 5-year postoperative follow-up, the estimated OS rate was 28% in patients with LVI vs 66% in those without LVI (P < 0.001). When patients were stratified based on nodal status those rates were 32% vs 68% in pN0 patients (P < 0.001), 23% vs 30% in pN1 patients (P = 0.8), and 28% vs 65% in pNx patients (P < 0.001). On multivariable analysis, the presence of LVI was associated with less favourable OS (hazard ratio 1.79, 95% confidence interval 1.60-1.99; P < 0.001).
    Conclusion: Our study assessed the impact of LVI on OS in patients with UTUC in a large North American nationwide cohort. Our series, as the largest to date, indicate that LVI is associated with less favourable survival outcomes in patients with UTUC after RNU, and this variable could be used in counselling patients about their prognosis and might be a useful tool for future trials to risk-stratify patients.
    Mesh-Begriff(e) Humans ; Male ; Female ; Aged ; Middle Aged ; Carcinoma, Transitional Cell/surgery ; Carcinoma, Transitional Cell/mortality ; Carcinoma, Transitional Cell/pathology ; Neoplasm Invasiveness ; Lymphatic Metastasis ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Kidney Neoplasms/mortality ; Nephroureterectomy ; Ureteral Neoplasms/pathology ; Ureteral Neoplasms/surgery ; Ureteral Neoplasms/mortality ; Prognosis ; Survival Rate ; Lymphatic Vessels/pathology ; Retrospective Studies ; United States/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.107: Hefte anzeigen Standort:
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  5. Artikel ; Online: Adequacy of prostate cancer prevention and screening recommendations provided by an artificial intelligence-powered large language model.

    Chiarelli, Giuseppe / Stephens, Alex / Finati, Marco / Cirulli, Giuseppe Ottone / Beatrici, Edoardo / Filipas, Dejan K / Arora, Sohrab / Tinsley, Shane / Bhandari, Mahendra / Carrieri, Giuseppe / Trinh, Quoc-Dien / Briganti, Alberto / Montorsi, Francesco / Lughezzani, Giovanni / Buffi, Nicolò / Rogers, Craig / Abdollah, Firas

    International urology and nephrology

    2024  

    Abstract: Purpose: We aimed to assess the appropriateness of ChatGPT in providing answers related to prostate cancer (PCa) screening, comparing GPT-3.5 and GPT-4.: Methods: A committee of five reviewers designed 30 questions related to PCa screening, ... ...

    Abstract Purpose: We aimed to assess the appropriateness of ChatGPT in providing answers related to prostate cancer (PCa) screening, comparing GPT-3.5 and GPT-4.
    Methods: A committee of five reviewers designed 30 questions related to PCa screening, categorized into three difficulty levels. The questions were formulated identically for both GPTs three times, varying the prompts. Each reviewer assigned a score for accuracy, clarity, and conciseness. The readability was assessed by the Flesch Kincaid Grade (FKG) and Flesch Reading Ease (FRE). The mean scores were extracted and compared using the Wilcoxon test. We compared the readability across the three different prompts by ANOVA.
    Results: In GPT-3.5 the mean score (SD) for accuracy, clarity, and conciseness was 1.5 (0.59), 1.7 (0.45), 1.7 (0.49), respectively for easy questions; 1.3 (0.67), 1.6 (0.69), 1.3 (0.65) for medium; 1.3 (0.62), 1.6 (0.56), 1.4 (0.56) for hard. In GPT-4 was 2.0 (0), 2.0 (0), 2.0 (0.14), respectively for easy questions; 1.7 (0.66), 1.8 (0.61), 1.7 (0.64) for medium; 2.0 (0.24), 1.8 (0.37), 1.9 (0.27) for hard. GPT-4 performed better for all three qualities and difficulty levels than GPT-3.5. The FKG mean for GPT-3.5 and GPT-4 answers were 12.8 (1.75) and 10.8 (1.72), respectively; the FRE for GPT-3.5 and GPT-4 was 37.3 (9.65) and 47.6 (9.88), respectively. The 2nd prompt has achieved better results in terms of clarity (all p < 0.05).
    Conclusions: GPT-4 displayed superior accuracy, clarity, conciseness, and readability than GPT-3.5. Though prompts influenced the quality response in both GPTs, their impact was significant only for clarity.
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-024-04009-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Race has no impact on prostate cancer-specific mortality, when comparing patients with similar risk of other-cause mortality: An analysis of a population-based cohort.

    Tinsley, Shane A / Finati, Marco / Stephens, Alex / Chiarelli, Giuseppe / Cirulli, Giuseppe Ottone / Williams, Eric / Morrison, Chase / Richard, Caleb / Hares, Keinnan / Sood, Akshay / Buffi, Nicolòs / Lughezzani, Giovanni / Bettocchi, Carlo / Salonia, Andrea / Briganti, Alberto / Montorsi, Francesco / Carrieri, Giuseppe / Rogers, Craig / Abdollah, Firas

    Cancer

    2024  

    Abstract: Background: Other-cause mortality (OCM) can serve as a surrogate for access-to-care. The authors sought to compare prostate cancer-specific mortality (PCSM) in Black versus White men matched based on their calculated OCM risk.: Methods: The ... ...

    Abstract Background: Other-cause mortality (OCM) can serve as a surrogate for access-to-care. The authors sought to compare prostate cancer-specific mortality (PCSM) in Black versus White men matched based on their calculated OCM risk.
    Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for Black and White men diagnosed with prostate cancer between 2004 to 2009, to collect long-term follow-up. A Cox regression was used to calculate the OCM risk using all available covariates. This calculated OCM risk was used to construct a 1:1 propensity score matched (PSM) cohort. Then, a competing-risks multivariable tested the impact of race on PCSM.
    Results: A total of 94,363 patients were identified, with 19,398 Black men and 74,965 White men. The median (IQR) follow-up was 11.3 years (9.8-12.8). In the unmatched-cohort at 10-years, PCSM and OCM were 5.5% versus 3.5% and 13.8% versus 8.4% in non-Hispanic Black (NHB) versus non-Hispanic White (NHW) patients (all p < .0001). The standardized mean difference was <0.15 for all covariates, indicating a good match. In the matched cohort at 10-years, OCM was 13.6% and 10.0% in NHB versus NHW (p < .0001), whereas the PCSM was 5.3% versus 4.7% (p < .01). On competing-risks multivariable analysis on PCSM, Black men had a hazard ratio of 1.08 (95% confidence interval, 0.98-1.20) compared to White men with a p = .13.
    Conclusions: The results of this study showed similar PCSM in Black and White patients, when matched with their calculated OCM risk. This report is the first to indicate at a population-based level that race has no impact on PCSM.
    Plain language summary: Prostate cancer is a very common cancer among men and it is associated with health disparities that disproportionately impact Black men compared to White men. There is an on-going discussion of whether disparities between these two groups stem from genetic or environmental factors. This study sought to examine if matching based on overall health status, a proxy for the impact of social determinants of health, mitigated significant differences in outcomes. When matched using risk of death from any cause other than prostate cancer, Black and White men had no significant differences in prostate cancer death.
    Sprache Englisch
    Erscheinungsdatum 2024-05-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.35386
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Assessing the impact of lymphovascular invasion on overall survival in surgically treated renal cell carcinoma patients: A nationwide cohort analysis.

    Rakic, Ivan / Rakic, Nikola / Stephens, Alex / Corsi, Nicholas / Davis, Matt / Tinsley, Shane / Butaney, Mohit / Arora, Sohrab / Sood, Akshay / Autorino, Riccardo / Rogers, Craig / Abdollah, Firas

    Urologic oncology

    2023  Band 41, Heft 10, Seite(n) 435.e1–435.e9

    Abstract: Introduction: Lymph-vascular invasion (LVI) is recognized as an adverse pathological feature in patients with renal cell carcinoma (RCC). However, its impact on overall survival (OS) is not clear and scarcely addressed in the literature. We aimed to ... ...

    Abstract Introduction: Lymph-vascular invasion (LVI) is recognized as an adverse pathological feature in patients with renal cell carcinoma (RCC). However, its impact on overall survival (OS) is not clear and scarcely addressed in the literature. We aimed to assess the prognostic ability of LVI as a predictor of OS in RCC patients using a large, North American cohort.
    Methods: We included 95,783 cM0 RCC patients, diagnosed between 2010 and 2015, who underwent partial or radical nephrectomy within the National Cancer Database. Kaplan-Meier curves and log-rank tests were used to depict and compare survival curves. Cox regression analysis tested the impact of LVI on OS, after adjusting for all available confounders.
    Results: Mean age (SD) was 59 (12), and most patients had pT1 stage (72.2%). Nodal status was pN0, pN1, and pNx, in 14.5%, 2.3%, and 83.3%, respectively. Overall, 9.0% of patients had LVI. The mean (SD) follow-up of the cohort was 39 months (24). At 5 years, OS was 65% in patients with LVI vs. 86% in patients without LVI (p<.0001). When patients were stratified based on nodal stage, these rates were 64% vs. 78% in pN0 patients, 31% vs. 41% in pN1 patients, and 69% vs. 87% in pNx patients (all P < 0.001). On multivariable analysis, and in comparison to patients without LVI, those with LVI had 1.37- (P < 0.001), 1.18- (P = 0.068), and 1.53-fold (P < 0.001) greater risk of death, when also harboring pN0, pN1, and pNx disease, respectively.
    Conclusions: Our findings are the first, to our best knowledge, to illustrate the clear detrimental impact of LVI on OS in surgically treated RCC patients. These findings might be useful in postoperative patient counseling and need to be accounted for when designing future clinical trials.
    Mesh-Begriff(e) Humans ; Carcinoma, Renal Cell/pathology ; Neoplasm Staging ; Lymphatic Metastasis ; Prognosis ; Cohort Studies ; Kidney Neoplasms/pathology ; Retrospective Studies ; Neoplasm Invasiveness/pathology
    Sprache Englisch
    Erscheinungsdatum 2023-08-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2023.07.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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