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  1. Artikel ; Online: Psychosocial resources and psychopathology among persons with neuromuscular disorders during the COVID-19 pandemic.

    Sanzo', Silvia / Tizzoni, Federica / Previtali, Stefano C / Berardinelli, Angela / Nobile, Maria / Molteni, Massimo / Manzoni, Martina / Tarabelloni, Arianna / Russo, Annamaria / Delle Fave, Antonella / D'Angelo, Maria Grazia

    BMC psychology

    2024  Band 12, Heft 1, Seite(n) 243

    Abstract: Background: The COVID-19 pandemic substantially affected the lives of persons with inherited neuromuscular disorders (INMD), causing disruption in clinical and support services. While several studies have investigated mental health, distress and ... ...

    Abstract Background: The COVID-19 pandemic substantially affected the lives of persons with inherited neuromuscular disorders (INMD), causing disruption in clinical and support services. While several studies have investigated mental health, distress and psychosocial resources in the general population during the pandemic, little is known about the experience of persons with INMD.
    Methods: This study was aimed to fill this gap by jointly investigating both psychopathological symptoms and psychosocial resources - specifically, resilience and perceived social support - among persons with INMD during the pandemic, taking into account demographic and clinical factors. Between April and December 2020, 59 participants with INMD (aged 15-59, 71.2% M) completed a questionnaire collecting demographic and clinical data, the Multidimensional Scale of Perceived Social Support, the Resilience Scale for Adults, and the Achenbach System of Empirically Based Assessment.
    Results: Overall, participants showed good levels of resilience and perceived social support. A minority of participants reported clinically relevant psychopathological symptoms, 28.81% for anxiety and depression. Most psychopathological symptoms were negatively correlated with resilience (-0.347 < r < - .420), but not significantly associated with social support. Consistent with previous studies, regression analyses highlighted that participants with Duchenne muscular dystrophy were more prone to report anxious and depressive symptoms (B = 1.748, p = .028, OR = 5.744), and participants with myotonic dystrophy, attention problems (B = 2.339, p = .006, OR = 10.376). Resilience emerged as a potential predictor of lower anxious-depressive symptoms (B=-1.264, p = .012, OR = 0.283).
    Conclusions: The findings suggest the importance to investigate psychosocial resources in addition to psychopathology among persons with INMD, and to design interventions supporting resilience as a protective factor for mental health promotion.
    Mesh-Begriff(e) Humans ; COVID-19/psychology ; COVID-19/epidemiology ; Adult ; Male ; Female ; Middle Aged ; Resilience, Psychological ; Neuromuscular Diseases/psychology ; Neuromuscular Diseases/epidemiology ; Social Support ; Adolescent ; Young Adult ; Anxiety/psychology ; Anxiety/epidemiology ; Depression/psychology ; Depression/epidemiology ; Surveys and Questionnaires ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2705921-2
    ISSN 2050-7283 ; 2050-7283
    ISSN (online) 2050-7283
    ISSN 2050-7283
    DOI 10.1186/s40359-024-01742-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Eye movement desensitization and reprocessing: The state of the art of efficacy in children and adolescent with post traumatic stress disorder.

    Manzoni, Martina / Fernandez, Isabel / Bertella, Silvana / Tizzoni, Federica / Gazzola, Erica / Molteni, Massimo / Nobile, Maria

    Journal of affective disorders

    2021  Band 282, Seite(n) 340–347

    Abstract: Background: PTSD in youth is more common and debilitating than it was previously thought. This untreated condition is highly correlated to critical mental health condition, such as depression, anxiety disruptive-behaviours, and substance use disorders. ... ...

    Abstract Background: PTSD in youth is more common and debilitating than it was previously thought. This untreated condition is highly correlated to critical mental health condition, such as depression, anxiety disruptive-behaviours, and substance use disorders. Despite the growing number of studies investigating Eye Movement Desensitization and Reprocessing (EMDR) treatment for posttraumatic stress disorder (PTSD) in childhood and adolescent, results have not been systematically revised since 2017. The aim of this work is to systematically reviewed all randomized controlled trials (RCTs) evaluating the effect of EMDR on PTSD symptoms in children and adolescent and asses whether EMDR therapy was effective to improve anxious and/or depressive symptoms.
    Methods: In a short series of articles, we will review the efficacy of EMDR on children and adolescent with PTSD and comorbid symptoms. The present brief review will focus on randomized controlled trials with an EMDR group condition compared to a control group published until January 2020.
    Results: eight studies (n = 150) met our inclusion criteria. Preliminary analyses showed that EMDR has a comparable efficacy to cognitive behavior therapy (CBT) in reducing PTSD, anxiety symptoms, depressive symptoms and was superior to waitlist/placebo condition. Moreover EMDR seems to be more effective in a shorter period of time.
    Conclusion: despite the small number of studies, the preliminary results suggest that EMDR therapy could be an effective treatment for children and adolescent with PTSD and anxious and/or depressive symptoms. Further research is needed to support these results.
    Mesh-Begriff(e) Adolescent ; Anxiety Disorders/therapy ; Child ; Cognitive Behavioral Therapy ; Eye Movement Desensitization Reprocessing ; Eye Movements ; Humans ; Randomized Controlled Trials as Topic ; Stress Disorders, Post-Traumatic/therapy ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-01-04
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review ; Systematic Review
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2020.12.088
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Patterns of Response to Methylphenidate Administration in Children with ADHD: A Personalized Medicine Approach through Clustering Analysis.

    Grazioli, Silvia / Rosi, Eleonora / Mauri, Maddalena / Crippa, Alessandro / Tizzoni, Federica / Tarabelloni, Arianna / Villa, Filippo Maria / Chiapasco, Federica / Reimers, Maria / Gatti, Erika / Bertella, Silvana / Molteni, Massimo / Nobile, Maria

    Children (Basel, Switzerland)

    2021  Band 8, Heft 11

    Abstract: Individual responses to methylphenidate (MPH) can significantly differ in children with attention-deficit/hyperactivity disorder (ADHD) in terms of the extent of clinical amelioration, optimal dosage needed, possible side effects, and short- and long- ... ...

    Abstract Individual responses to methylphenidate (MPH) can significantly differ in children with attention-deficit/hyperactivity disorder (ADHD) in terms of the extent of clinical amelioration, optimal dosage needed, possible side effects, and short- and long-term duration of the benefits. In the present repeated-measures observational study, we undertook a proof-of-concept study to determine whether clustering analysis could be useful to characterize different clusters of responses to MPH in children with ADHD. We recruited 33 children with ADHD who underwent a comprehensive clinical, cognitive, and neurophysiological assessment before and after one month of MPH treatment. Symptomatology changes were assessed by parents and clinicians. The neuropsychological measures used comprised pen-and-paper and computerized tasks. Functional near-infrared spectroscopy was used to measure cortical hemodynamic activation during an attentional task. We developed an unsupervised machine learning algorithm to characterize the possible clusters of responses to MPH in our multimodal data. A symptomatology improvement was observed for both clinical and neuropsychological measures. Our model identified distinct clusters of amelioration that were related to symptom severity and visual-attentional performances. The present findings provide preliminary evidence that clustering analysis can potentially be useful in identifying different responses to MPH in children with ADHD, highlighting the importance of a personalized medicine approach within the clinical framework.
    Sprache Englisch
    Erscheinungsdatum 2021-11-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children8111008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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