Article: Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.
bioRxiv : the preprint server for biology
2023
Abstract: Early life microbe-immune interactions at barrier surfaces have lasting impacts on the trajectory towards health versus disease. Monocytes, macrophages and dendritic cells are primary sentinels in barrier tissues, yet the salient contributions of ... ...
Abstract | Early life microbe-immune interactions at barrier surfaces have lasting impacts on the trajectory towards health versus disease. Monocytes, macrophages and dendritic cells are primary sentinels in barrier tissues, yet the salient contributions of commensal-myeloid crosstalk during tissue development remain poorly understood. Here, we identify that commensal microbes facilitate accumulation of a population of monocytes in neonatal skin. Transient postnatal depletion of these monocytes resulted in heightened IL-17A production by skin T cells, which was particularly sustained among CD4 |
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Language | English |
Publishing date | 2023-10-02 |
Publishing country | United States |
Document type | Preprint |
DOI | 10.1101/2023.09.29.560039 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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