Artikel ; Online: A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT.
Health technology assessment (Winchester, England)
2022 Band 26, Heft 12, Seite(n) 1–82
Abstract: Background: Mother-to-baby transmission of group B : Objectives: We investigated if intrapartum antibiotic prophylaxis directed by a rapid intrapartum test reduces maternal and neonatal antibiotic use, compared with usual care (i.e. risk factor- ... ...
Abstract | Background: Mother-to-baby transmission of group B Objectives: We investigated if intrapartum antibiotic prophylaxis directed by a rapid intrapartum test reduces maternal and neonatal antibiotic use, compared with usual care (i.e. risk factor-directed antibiotics), among women with risk factors for vertical group B Design: An unblinded cluster randomised controlled trial with a nested test accuracy study, an economic evaluation and a microbiology substudy. Setting: UK maternity units were randomised to either a strategy of rapid test or usual care. Participants: Vaginal and rectal swabs were taken from women with risk factors for vertical group B Main outcome measures: Primary outcomes were rates of intrapartum antibiotic prophylaxis administered to prevent early-onset group B Results: Twenty-two maternity units were randomised and 20 were recruited. A total of 722 mothers (749 babies) participated in rapid test units and 906 mothers (951 babies) participated in usual-care units. There were no differences in the rates of intrapartum antibiotic prophylaxis for preventing early-onset group B Conclusions: The Group B Streptococcus 2 (GBS2) trial found no evidence that the rapid test reduces the rates of intrapartum antibiotic prophylaxis administered to prevent early-onset group B Future work: The role of routine testing for prevention of neonatal infection requires evaluation in a randomised controlled trial. Trial registration: Current Controlled Trials ISRCTN74746075. Funding: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in |
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Mesh-Begriff(e) | Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Cost-Benefit Analysis ; Female ; Humans ; Infant, Newborn ; Mothers ; Pregnancy ; Streptococcal Infections/diagnosis ; Streptococcal Infections/drug therapy ; Streptococcal Infections/prevention & control ; Streptococcus agalactiae |
Chemische Substanzen | Anti-Bacterial Agents |
Sprache | Englisch |
Erscheinungsdatum | 2022-02-23 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2006765-3 |
ISSN | 2046-4924 ; 1366-5278 |
ISSN (online) | 2046-4924 |
ISSN | 1366-5278 |
DOI | 10.3310/BICF1187 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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