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  1. Buch ; Dissertation / Habilitation: Freie kappa-Leichtketten im Liquor

    Süße, Marie / Lucht, Michael / Tumani, Hayrettin / Otto, Markus

    ein Biomarker für entzündliche Erkrankungen des zentralen Nervensystems$d

    2022  

    Körperschaft Universität Greifswald
    Verfasserangabe vorgelegt von Marie Süße ; 1. Gutachter: Prof. Dr. Michael Lucht, 2. Gutachter: Prof. Dr. Hayrettin Tumani, 3. Gutachter: Prof. Dr. Markus Otto
    Schlagwörter Zentralnervensystem ; Entzündung ; Liquor cerebrospinalis ; Kappa-Kette ; Leichte Kette
    Schlagwörter L-Kette ; Cerebrospinalflüssigkeit ; Gehirnflüssigkeit ; Hirn-Rückenmarks-Flüssigkeit ; Rückenmarksflüssigkeit ; Cerebrospinal fluid ; CSF ; Zerebrospinalflüssigkeit ; Gehirn-Rückenmarks-Flüssigkeit ; Nervenwasser ; Hirnwasser ; Gehirnwasser ; Inflammatio ; Entzündungsreaktion ; Zentrales Nervensystem ; ZNS ; Systema nervosum centrale ; Central nervous system ; CNS
    Sprache Deutsch ; Englisch
    Umfang 1 Band (verschiedene Seitenzählungen), Diagramme
    Erscheinungsort Greifswald
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Habilitationsschrift, Universitätsmedizin der Universität Greifswald, 2023
    Anmerkung Text deutsch, Publikationen englisch ; Literaturverzeichnis: Blatt 27-30. - Literaturangaben
    HBZ-ID HT030366542
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch ; Online ; E-Book: Cerebrospinal fluid in neurologic disorders

    Deisenhammer, Florian / Teunissen, Charlotte E. / Tumani, Hayrettin

    (Handbook of clinical neurology ; volume 146)

    2018  

    Verfasserangabe volume editors Florian Deisenhammer, Charlotte E. Teunissen and Hayrettin Tumani
    Serientitel Handbook of clinical neurology ; volume 146
    Überordnung
    Schlagwörter Nervous System Diseases / cerebrospinal fluid ; Nervous system/Diseases/Diagnosis ; Cerebrospinal fluid/Examination
    Thema/Rubrik (Code) 616.8047582
    Sprache Englisch
    Umfang 1 Online-Ressource (xiv, 306 Seiten), Diagramme
    Verlag Elsevier
    Erscheinungsort Amsterdam
    Erscheinungsland Niederlande
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019667555
    ISBN 978-0-12-804324-0 ; 9780128042793 ; 0-12-804324-5 ; 0128042796
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Buch ; Dissertation / Habilitation: Progranulin als Inflammationsmarker bei Infektionserkrankungen am Beispiel Neuroborreliose

    Lux, Joachim / Vielhaber, Stefan / Tumani, Hayrettin

    2020  

    Körperschaft Otto-von-Guericke-Universität Magdeburg
    Verfasserangabe von Joachim Lux ; Gutachter: Prof. Dr. Stefan Vielhaber ; Prof. Dr. Hayrettin Tumani
    Schlagwörter Meningoencephalitis ; Borreliose ; Entzündung
    Schlagwörter Inflammatio ; Entzündungsreaktion ; Meningoenzephalitis
    Sprache Deutsch
    Umfang VI, 54 Blätter, Diagramme
    Verlag Otto-von-Guericke-Universität Magdeburg
    Erscheinungsort Magdeburg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Universität Magdeburg, 2021
    HBZ-ID HT021771580
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch: Aktuelle klinische Anwendungen des natürlichen Interferon-beta

    Tumani, Hayrettin

    18 Tabellen

    (Aktuelle Immunologie ; 14)

    2005  

    Verfasserangabe hrsg. von H. Tumani
    Serientitel Aktuelle Immunologie ; 14
    Überordnung
    Schlagwörter Interferon
    Schlagwörter HuIFN-beta ; IFN b ; Fibrinoblasten-Interferon ; CAS 74899-71-1Interferonum beta ; Interferon beta human
    Sprache Deutsch
    Umfang V, 56 S. : graph. Darst., 235 mm x 165 mm, 188 gr.
    Verlag Zuckschwerdt
    Erscheinungsort München u.a.
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT014554281
    ISBN 3-88603-853-X ; 978-3-88603-853-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Buch ; Dissertation / Habilitation: ZNS-Proteine im Liquor

    Tumani, Hayrettin

    welche Faktoren beeinflussen ihre Konzentration und was ist ihre klinische Relevanz?

    2000  

    Verfasserangabe vorgelegt von Hayrettin Tumani
    Sprache Deutsch
    Umfang 137 S. in getr. Zählung, Ill., graph. Darst., 30 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Ulm, Univ., Habil.-Schr., 2000
    Anmerkung Enth. Sonderdr. aus verschiedenen Zeitschr.
    HBZ-ID HT013334841
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  6. Artikel: Lumbalpunktion – Schritt für Schritt

    Tumani, Hayrettin / Lewerenz, Jan / Jesse, Sarah

    Intensivmedizin up2date

    2023  Band 19, Heft 01, Seite(n) 10–16

    Sprache Deutsch
    Erscheinungsdatum 2023-02-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2180698-6
    ISSN 1614-6697 ; 1614-4856
    ISSN (online) 1614-6697
    ISSN 1614-4856
    DOI 10.1055/a-1984-4050
    Datenquelle Thieme Verlag

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  7. Artikel ; Online: Diagnostic biomarkers in tear fluid: from sampling to preanalytical processing.

    Bachhuber, Franziska / Huss, André / Senel, Makbule / Tumani, Hayrettin

    Scientific reports

    2021  Band 11, Heft 1, Seite(n) 10064

    Abstract: Tear fluid is receiving growing attention as a source for novel diagnostic biomarkers. Multiple techniques are available for its collection and impact the composition of acquired samples. We sought to provide a direct comparison of two collection methods ...

    Abstract Tear fluid is receiving growing attention as a source for novel diagnostic biomarkers. Multiple techniques are available for its collection and impact the composition of acquired samples. We sought to provide a direct comparison of two collection methods with regard to implementation, acceptance, and impact on sample composition. Tear fluid was collected from fifteen healthy volunteers with capillary tubes and Schirmer strips and analyzed for total protein and IgG concentrations. Sampling parameters and perception by test persons were compared. The use of capillary tubes was more convenient for the participants while causing more effort for the collector. Tear flow rates as well as the relative and absolute amount of IgG were higher when Schirmer strips were used. Consecutive collections with Schirmer strips significantly influenced tear flow rates, IgG, and protein concentrations. A moderate correlation was observed between tear flow rates and IgG concentrations for both methods. Samples collected with both methods can be analyzed by isoelectric focusing, a potential diagnostic application in the field of neurology. The specific advantages and limitations of tear fluid sampling with either capillary tubes or Schirmer strips demonstrate the need for a thorough investigation of collection methods with regard to the application of interest.
    Mesh-Begriff(e) Adult ; Biomarkers/metabolism ; Eye Proteins/metabolism ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Reagent Strips/standards ; Specimen Handling/methods ; Tears/chemistry
    Chemische Substanzen Biomarkers ; Eye Proteins ; Reagent Strips
    Sprache Englisch
    Erscheinungsdatum 2021-05-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-89514-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Correspondence: Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies.

    Petereit, Hela-Felicitas / Tumani, Hayrettin / Zettl, Uwe K

    Therapeutic advances in neurological disorders

    2021  Band 14, Seite(n) 17562864211022581

    Sprache Englisch
    Erscheinungsdatum 2021-06-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/17562864211022581
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Serum neurofilament light chain and glial fibrillary acidic protein for predicting response to apheresis in steroid-refractory multiple sclerosis relapses.

    Vardakas, Ioannis / Dorst, Johannes / Huss, André / Mayer, Benjamin / Fangerau, Tanja / Taranu, Daniela / Tumani, Hayrettin / Senel, Makbule

    European journal of neurology

    2024  , Seite(n) e16323

    Abstract: Background and purpose: The predictive value of serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) for apheresis outcome in steroid-refractory multiple sclerosis (MS) relapse has not yet been evaluated.: Methods: ...

    Abstract Background and purpose: The predictive value of serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) for apheresis outcome in steroid-refractory multiple sclerosis (MS) relapse has not yet been evaluated.
    Methods: We used pre- and postapheresis serum samples from 38 participants of the IAPEMS trial (clinicaltrials.gov: NCT02671682), which investigated the use of immunoadsorption versus plasma exchange for the treatment of steroid-refractory MS attacks. Response to apheresis was classified based on improvement on (i) the Expanded Disability Status Scale (EDSS), (ii) the affected functional system scores (FSS) of the EDSS, or (iii) the visual acuity for patients with optic neuritis, 4 weeks postapheresis. sNFL and sGFAP were measured by single molecule arrays.
    Results: Preprocedural sGFAP levels could discriminate between responders and nonresponders, determined by FSS improvement (p = 0.017). In multivariate logistic regression analysis, younger age (odds ratio [OR] = 0.781, 95% confidence interval [CI] = 0.635-0.962, p = 0.020) and lower sGFAP levels (OR = 0.948, 95% CI = 0.903-0.995, p = 0.031) could predict response to apheresis in the overall cohort. We could observe a trend towards a favourable apheresis outcome with higher sNfL levels (OR = 1.413, 95% CI = 0.965-2.069, p = 0.076). Analysis of the sNfL-to-sGFAP ratio showed an OR of 1.924 (95% CI = 1.073-3.451, p = 0.028) for predicting apheresis response. The ratio showed a better predictive value than the individual parameters. Neither biomarker was affected by the number of steroid cycles preapheresis.
    Conclusions: Lower sGFAP levels, a higher sNfL-to-sGFAP ratio, and younger age are associated with a favourable apheresis outcome.
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16323
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.

    Erhart, Deborah Katharina / Klose, Veronika / Schäper, Tatjana / Tumani, Hayrettin / Senel, Makbule

    International journal of molecular sciences

    2023  Band 25, Heft 1

    Abstract: C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to ... ...

    Abstract C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to evaluate the value of CSF-CXCL13 as a diagnostic and treatment response marker and its role as an activity marker in a larger disease spectrum, including neuroborreliosis and other neuroinflammatory and malignant CNS-disorders. Patients who received a diagnostic lumbar puncture (LP) (
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Retrospective Studies ; Spinal Puncture ; Multiple Sclerosis ; Neurosyphilis ; Syndrome ; Chemokine CXCL13
    Chemische Substanzen CXCL13 protein, human ; Chemokine CXCL13
    Sprache Englisch
    Erscheinungsdatum 2023-12-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010425
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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