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  1. Artikel: Assessment of Gastrointestinal Adverse Effects during the First Six Months of "Biktarvy" Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period.

    Suba, Madalina-Ianca / Abu-Awwad, Simona-Alina / Rosca, Ovidiu / Turaiche, Mirela-Mădălina / Hogea, Bogdan / Abu-Awwad, Ahmed / Nitu, Razvan / Lazureanu, Voichita Elena

    Diseases (Basel, Switzerland)

    2023  Band 12, Heft 1

    Abstract: Background: The battle against HIV has led to the development of antiretroviral therapy (ART), including BIKTARVY: Materials and methods: This retrospective cohort study, conducted over four years in Romania, examined 222 patients initiated on ... ...

    Abstract Background: The battle against HIV has led to the development of antiretroviral therapy (ART), including BIKTARVY
    Materials and methods: This retrospective cohort study, conducted over four years in Romania, examined 222 patients initiated on BIKTARVY
    Results: This study revealed significant differences in the prevalence of gastrointestinal symptoms between age groups, with older patients experiencing more symptoms. Notably, diarrhea did not exhibit a statistically significant age-related difference. Furthermore, weight loss exceeding 5 kg was more common in older patients. Of the patients who continued BIKTARVY
    Conclusion: Understanding age-related patterns and gastrointestinal side effects of BIKTARVY
    Sprache Englisch
    Erscheinungsdatum 2023-12-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12010003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Evaluating Hepatotoxicity: A Comparative Analysis of New Generation versus Historical Antiretroviral Agents.

    Abu-Awwad, Simona-Alina / Abu-Awwad, Ahmed / Suba, Madalina-Ianca / Lazureanu, Voichita Elena / Bolovan, Andrei-Daniel / Rosca, Ovidiu / Turaiche, Mirela-Mădălina / Benea, Adela-Teodora / Hogea, Bogdan

    Infectious disease reports

    2024  Band 16, Heft 3, Seite(n) 423–434

    Abstract: 1) Background: Since the advent of zidovudine in 1987, antiretroviral therapy has undergone significant evolution, marked by the introduction of 34 antiretroviral drugs and 24 fixed-dose combinations. Despite these advances, hepatotoxicity remains a ... ...

    Abstract (1) Background: Since the advent of zidovudine in 1987, antiretroviral therapy has undergone significant evolution, marked by the introduction of 34 antiretroviral drugs and 24 fixed-dose combinations. Despite these advances, hepatotoxicity remains a formidable challenge, influencing morbidity, mortality, and treatment adherence in HIV-infected patients. This study aims to compare the hepatotoxic effects of latest-generation antiretroviral medications with those of older-generation therapies, assessing their long-term impact on liver health in HIV patients. (2) Methods: This retrospective study analyzed data from 304 HIV patients treated with either latest-generation or older-generation antiretroviral drugs over four years. Patients were monitored for hepatotoxicity through liver function tests at diagnosis, six months, and one-year post-treatment initiation. (3) Results: Initial and six-month liver function tests showed no significant differences between the two groups. However, at one-year post-treatment, patients on latest-generation antiretrovirals exhibited significant improvements in ALT, AST, and ALP levels, suggesting a better safety profile regarding hepatotoxicity. Additionally, a significantly lower incidence of splenomegaly was observed in patients treated with newer medications. (4) Conclusions: The findings suggest that the latest-generation antiretroviral medications may offer a safer profile in terms of hepatotoxicity compared to older therapies, with potential benefits for long-term liver health. This study underscores the importance of continuous monitoring and further research to optimize ART strategies, ensuring improved patient outcomes and quality of life for individuals living with HIV.
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16030031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Direct-Acting Antiviral Use for Genotype 1b Hepatitis C Patients with Associated Hematological Disorders from Romania.

    Marincu, Iosif / Bratosin, Felix / Curescu, Manuela / Suciu, Oana / Turaiche, Mirela / Cerbu, Bianca / Vidican, Iulia

    Medicina (Kaunas, Lithuania)

    2021  Band 57, Heft 9

    Abstract: Background and ... ...

    Abstract Background and objectives
    Mesh-Begriff(e) Antiviral Agents/therapeutic use ; Drug Therapy, Combination ; Genotype ; Hepatitis C ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Romania ; Treatment Outcome
    Chemische Substanzen Antiviral Agents
    Sprache Englisch
    Erscheinungsdatum 2021-09-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57090986
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Listeria Monocytogenes Meningitis in an Immunocompetent Patient.

    Magiar, Oana / Vulpie, Silvana / Musuroi, Corina / Marincu, Iosif / Murariu, Alina / Turaiche, Mirela / Musuroi, Silvia Ioana / Muntean, Delia / Licker, Monica

    Infection and drug resistance

    2022  Band 15, Seite(n) 989–994

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    Sprache Englisch
    Erscheinungsdatum 2022-03-10
    Erscheinungsland New Zealand
    Dokumenttyp Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S351132
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Predictive Factors for the First Recurrence of

    Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

    Medicina (Kaunas, Lithuania)

    2020  Band 56, Heft 9

    Abstract: Background and objectives: ...

    Abstract Background and objectives:
    Mesh-Begriff(e) Aged ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/complications ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Cross Infection/complications ; Cross Infection/diagnosis ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Enterocolitis/complications ; Enterocolitis/diagnosis ; Enterocolitis/drug therapy ; Enterocolitis/microbiology ; Female ; Fever/microbiology ; Gastrointestinal Diseases/complications ; Humans ; Immunocompromised Host ; Male ; Reinfection ; Retrospective Studies ; Risk Factors ; Romania
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2020-08-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56090439
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Predictive Value of Comorbid Conditions for COVID-19 Mortality.

    Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Bostanaru, Andra-Cristina / Frent, Stefan / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

    Journal of clinical medicine

    2021  Band 10, Heft 12

    Abstract: In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 ... ...

    Abstract In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 hospital admissions were counted in the study, out of which 310 patients did not survive. A prediction model was developed based on this data by using a Bayesian approach. Following the data collection process for the development study, the second cohort of patients totaling 541 was built to validate the risk matrix previously created. The final model has an area under the curve of 0.773 and predicts the mortality risk of SARS-CoV-2 infection based on nine disease groups while considering the gender and age of the patient as distinct risk groups. To ease medical workers' assessment of patients, we created a visual risk matrix based on a probabilistic model, ranging from a score of 1 (very low mortality risk) to 5 (very high mortality risk). Each score comprises a correlation between existing comorbid conditions, the number of comorbid conditions, gender, and age group category. This clinical model can be generalized in a hospital context and can be used to identify patients at high risk for whom immediate intervention might be required.
    Sprache Englisch
    Erscheinungsdatum 2021-06-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10122652
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Foodborne Botulism in Western Romania: Ten Years' Experience at a Tertiary Infectious Disease Hospital.

    Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Suciu, Oana / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

    Healthcare (Basel, Switzerland)

    2021  Band 9, Heft 9

    Abstract: Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium : Methods: Medical records were retrospectively analyzed from ...

    Abstract Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium
    Methods: Medical records were retrospectively analyzed from 2010 to 2020 for all food botulism cases. A seroneutralization test was performed with type A, B and E anti-botulinum sera to establish the kind of toxin involved.
    Results: Overall, 18 cases of foodborne botulism were admitted to the hospital during this period and confirmed by laboratory analysis. Most of the participants in our study were men (61.1%), and 77.8% of the total lived in rural areas. All the participants showed classic symptoms of botulism, and dysphagia was present in all cases. The trivalent ABE antitoxin was administered by the hospital, and toxin type B was isolated in all patients. The main sources of the toxin were pork, ham and canned pork meat.
    Conclusions: Stronger efforts are needed to foster community awareness of foodborne botulism, particularly in home-preserved food.
    Sprache Englisch
    Erscheinungsdatum 2021-09-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare9091149
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Liver Impairment and Hematological Changes in Patients with Chronic Hepatitis C and COVID-19: A Retrospective Study after One Year of Pandemic.

    Cerbu, Bianca / Pantea, Stelian / Bratosin, Felix / Vidican, Iulia / Turaiche, Mirela / Frent, Stefan / Borsi, Ema / Marincu, Iosif

    Medicina (Kaunas, Lithuania)

    2021  Band 57, Heft 6

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Mesh-Begriff(e) COVID-19 ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-06-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57060597
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: The Efficacy of Convalescent Plasma Use in Critically Ill COVID-19 Patients.

    Tirnea, Livius / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Timircan, Madalina / Margan, Madalin-Marius / Marincu, Iosif

    Medicina (Kaunas, Lithuania)

    2021  Band 57, Heft 3

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Mesh-Begriff(e) Adult ; Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/physiopathology ; COVID-19/therapy ; Critical Illness ; Glucocorticoids/therapeutic use ; Humans ; Immunization, Passive/methods ; Interleukin-6/blood ; Leukocyte Count ; Male ; Middle Aged ; Pilot Projects ; Romania ; SARS-CoV-2 ; Treatment Outcome
    Chemische Substanzen Anti-Bacterial Agents ; Anticoagulants ; Antiviral Agents ; Glucocorticoids ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 2021-03-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57030257
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Coping Strategies and Health-Related Quality of Life in Pregnant Women with SARS-CoV-2 Infection.

    Timircan, Madalina / Bratosin, Felix / Vidican, Iulia / Suciu, Oana / Turaiche, Mirela / Bota, Adrian Vasile / Mitrescu, Sorina / Marincu, Iosif

    Medicina (Kaunas, Lithuania)

    2021  Band 57, Heft 10

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Mesh-Begriff(e) Adaptation, Psychological ; Anxiety/epidemiology ; COVID-19 ; Cross-Sectional Studies ; Depression/epidemiology ; Female ; Humans ; Pregnancy ; Pregnant Women ; Quality of Life ; SARS-CoV-2 ; Stress, Psychological/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2021-10-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57101113
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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