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  1. Artikel ; Online: Trials and tribulations of young residents fighting COVID-19.

    Beyens, Michiel Marcel Jozef / Verelst, Faro R / Moorkens, Greta / Twickler, Marcel ThB

    European journal of clinical investigation

    2020  Band 50, Heft 7, Seite(n) e13336

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Infection Control ; Internal Medicine/education ; Internship and Residency ; Medical Staff, Hospital ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Terminal Care ; Visitors to Patients
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-16
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13336
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Is prolactin involved in the evolution of atherothrombotic disease?

    Reuwer, Anne Q / Hoekstra, Menno / Touraine, Philippe / Twickler, Marcel ThB / Goffin, Vincent

    Expert review of endocrinology & metabolism

    2019  Band 7, Heft 3, Seite(n) 345–361

    Abstract: Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances ... ...

    Abstract Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances within the arterial wall. Several endocrine disorders have been linked to this pathological state. Recent clinical and experimental studies have suggested that prolactin, a pleiotropic pituitary hormone, may potentially contribute to CVD, either through direct modulation of local cellular processes within atherosclerotic plaques/thrombi and/or through influencing conventional cardiovascular metabolic risk factors. However, the precise role of prolactin in the pathology of CVD remains largely unknown. Here, the authors speculate whether prolactin-lowering treatment may become a future therapeutic approach in patients with elevated prolactin levels and concomitantly presenting with coexisting vascular disease or a significantly elevated risk for premature atherothrombotic vascular disease. Awareness of these new developments may also change our clinical opinions about therapeutic strategies in patients with prolactinomas.
    Sprache Englisch
    Erscheinungsdatum 2019-02-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/eem.12.23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Trials and tribulations of young residents fighting COVID-19

    Beyens, Michiel Marcel Jozef / Verelst, Faro R / Moorkens, Greta / Twickler, Marcel ThB

    Eur J Clin Invest

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #612699
    Datenquelle COVID19

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  4. Artikel ; Online: Trials and tribulations of young residents fighting COVID‐19

    Beyens, Michiel Marcel Jozef / Verelst, Faro R. / Moorkens, Greta / Twickler, Marcel ThB

    European Journal of Clinical Investigation

    2020  Band 50, Heft 7

    Schlagwörter Clinical Biochemistry ; Biochemistry ; General Medicine ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13336
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel: Cardiovascular Endocrinology

    Twickler, Marcel Th.B

    Seminars in Vascular Medicine

    (Cardiovascular Endocrinology)

    2004  Band 4, Heft 02, Seite(n) 105–106

    Serientitel Cardiovascular Endocrinology
    Sprache Englisch
    Erscheinungsdatum 2004-01-01
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2055723-1
    ISSN 1529-3505 ; 1528-9648
    ISSN (online) 1529-3505
    ISSN 1528-9648
    DOI 10.1055/s-2004-835366
    Datenquelle Thieme Verlag

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  6. Artikel: High-Density Lipoprotein as a Key Component in the Prevention of Premature Atherosclerotic Disease in the Insulin Resistance Syndrome

    Hansel, Boris / Kontush, Anatol / Twickler, Marcel Th.B

    Seminars in Vascular Medicine

    2004  Band 4, Heft 02, Seite(n) 215–223

    Schlagwörter Metabolic syndrome ; insulin resistance ; HDL ; prevention ; atherosclerotic disease
    Sprache Englisch
    Erscheinungsdatum 2004-01-01
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2055723-1
    ISSN 1529-3505 ; 1528-9648
    ISSN (online) 1529-3505
    ISSN 1528-9648
    DOI 10.1055/s-2004-835381
    Datenquelle Thieme Verlag

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  7. Artikel: Mechanistic Insights and Clinical Relevance of the Interaction between Acute Coronary Syndromes and Lipid Metabolism

    Correia, Luis C.L / Twickler, Marcel Th.B / Sposito, Andrei C

    Seminars in Vascular Medicine

    2004  Band 4, Heft 02, Seite(n) 197–202

    Schlagwörter Acute coronary syndromes ; lipoproteins ; cholesterol ; triglycerides
    Sprache Englisch
    Erscheinungsdatum 2004-01-01
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2055723-1
    ISSN 1529-3505 ; 1528-9648
    ISSN (online) 1529-3505
    ISSN 1528-9648
    DOI 10.1055/s-2004-835378
    Datenquelle Thieme Verlag

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  8. Artikel ; Online: Prolactin levels and the risk of future coronary artery disease in apparently healthy men and women.

    Reuwer, Anne Q / Twickler, Marcel ThB / Hutten, Barbara A / Molema, Frederique W / Wareham, Nicholas J / Dallinga-Thie, Geesje M / Bogorad, Roman L / Goffin, Vincent / Smink-Bol, Mijke / Kastelein, John J P / Boekholdt, S Matthijs / Khaw, Kay-Tee

    Circulation. Cardiovascular genetics

    2009  Band 2, Heft 4, Seite(n) 389–395

    Abstract: Background: Prolactin is increasingly recognized to play a stimulatory role in the inflammatory response. Because inflammation is considered of crucial importance in the development of atherosclerosis, we aimed to evaluate whether prolactin levels are ... ...

    Abstract Background: Prolactin is increasingly recognized to play a stimulatory role in the inflammatory response. Because inflammation is considered of crucial importance in the development of atherosclerosis, we aimed to evaluate whether prolactin levels are associated with the occurrence of coronary artery disease (CAD).
    Methods and results: We performed a nested case-control study in the prospective EPIC-Norfolk cohort. Cases were apparently healthy men and women, aged 45 to 79 years, who developed fatal or nonfatal CAD (n=882). Controls remained free of CAD (n=1490). Overall, systemic prolactin levels did not differ between cases and controls, and people in the highest prolactin tertile did not have a significantly increased risk of developing future CAD (in men, odds ratio, 1.21; 95% CI, 0.92 to 1.61; in women, odds ratio, 1.12; 95% CI, 0.76 to 1.64). However, in a separate immunohistochemical study, the presence of prolactin receptors could be demonstrated in postmortem human coronary artery plaques (preliminary data).
    Conclusions: Elevated systemic prolactin levels do not predict CAD in the general population. However, prolactin receptors were found in human coronary artery plaques. This observation may indicate a role of prolactin within atherosclerotic plaques. More studies are needed to define the possible role of prolactin in atherosclerotic plaque development.
    Mesh-Begriff(e) Aged ; Atherosclerosis/pathology ; Case-Control Studies ; Cohort Studies ; Coronary Artery Disease/epidemiology ; Coronary Vessels/pathology ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Prolactin/blood ; Receptors, Prolactin/metabolism ; Risk Factors
    Chemische Substanzen Receptors, Prolactin ; Prolactin (9002-62-4)
    Sprache Englisch
    Erscheinungsdatum 2009-06-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.109.853572
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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