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  1. Artikel: Presence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Disease.

    DosSantos, Marcos Fabio / Filha, Lionete Gall Acosta / Veríssimo, Carla Pires / Sanz, Carolina Kaminski / Gazerani, Parisa

    Journal of integrative neuroscience

    2023  Band 22, Heft 3, Seite(n) 69

    Abstract: Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance ... ...

    Abstract Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance calcium-activated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca2+ to changes in the membrane K+ conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain.
    Mesh-Begriff(e) Calcium/metabolism ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; Potassium/metabolism ; Membrane Potentials/physiology ; Peripheral Nervous System/metabolism
    Chemische Substanzen Calcium (SY7Q814VUP) ; Small-Conductance Calcium-Activated Potassium Channels ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2203069
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance.

    Souza, Leonel Cardozo de Menezes E / Faletti, Anderson / Veríssimo, Carla Pires / Stelling, Mariana Paranhos / Borges, Helena Lobo

    Membranes

    2022  Band 12, Heft 2

    Abstract: Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect ... ...

    Abstract Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect of tumor progression, including chemoresistance. However, the molecular determinants of microenvironment-driven chemoresistance are mainly unknown. In this review, we propose that the
    Sprache Englisch
    Erscheinungsdatum 2022-02-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12020202
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Short-Term Functional and Morphological Changes in the Primary Cultures of Trigeminal Ganglion Cells.

    Veríssimo, Carla Pires / Acosta Filha, Lionete Gall / Moreira da Silva, Fábio Jorge / Westgarth, Harrison / Coelho Aguiar, Juliana De Mattos / Pontes, Bruno / Moura-Neto, Vivaldo / Gazerani, Parisa / DosSantos, Marcos F

    Current issues in molecular biology

    2022  Band 44, Heft 3, Seite(n) 1257–1272

    Abstract: Several studies have proved that glial cells, as well as neurons, play a role in pain pathophysiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to neuropathic pain. Likewise, some ... ...

    Abstract Several studies have proved that glial cells, as well as neurons, play a role in pain pathophysiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to neuropathic pain. Likewise, some works have suggested that peripheral glial cells, particularly satellite glial cells (SGCs), and the crosstalk between these cells and the sensory neurons located in the peripheral ganglia, play a role in the phenomenon that leads to pain. Nonetheless, the study of SGCs may be challenging, as the validity of studying those cells in vitro is still controversial. In this study, a research protocol was developed to examine the potential use of primary mixed neuronal-glia cell cultures obtained from the trigeminal ganglion cells (TGCs) of neonate mice (P10-P12). Primary cultures were established and analyzed at 4 h, 24 h, and 48 h. To this purpose, phase contrast microscopy, immunocytochemistry with antibodies against anti-βIII-tubulin and Sk3, scanning electron microscopy, and time-lapse photography were used. The results indicated the presence of morphological changes in the cultured SGCs obtained from the TGCs. The SGCs exhibited a close relationship with neurons. They presented a round shape in the first 4 h, and a more fusiform shape at 24 h and 48 h of culture. On the other hand, neurons changed from a round shape to a more ramified shape from 4 h to 48 h. Intriguingly, the expression of SK3, a marker of the SGCs, was high in all samples at 4 h, with some cells double-staining for SK3 and βIII-tubulin. The expression of SK3 decreased at 24 h and increased again at 48 h in vitro. These results confirm the high plasticity that the SGCs may acquire in vitro. In this scenario, the authors hypothesize that, at 4 h, a group of the analyzed cells remained undifferentiated and, therefore, were double-stained for SK3 and βIII-tubulin. After 24 h, these cells started to differentiate into SCGs, which was clearer at 48 h in the culture. Mixed neuronal-glial TGC cultures might be implemented as a platform to study the plasticity and crosstalk between primary sensory neurons and SGCs, as well as its implications in the development of chronic orofacial pain.
    Sprache Englisch
    Erscheinungsdatum 2022-03-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb44030084
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Laminin and Environmental Cues Act in the Inhibition of the Neuronal Differentiation of Enteric Glia

    Veríssimo, Carla Pires / Carvalho, Juliana da Silva / da Silva, Fábio Jorge Moreira / Campanati, Loraine / Moura-Neto, Vivaldo / Coelho-Aguiar, Juliana de Mattos

    Frontiers in neuroscience

    2019  Band 13, Seite(n) 914

    Abstract: The enteric glia, a neural crest-derived cell type that composes the Enteric Nervous System, is involved in controlling gut functions, including motility, gut permeability, and neuronal communication. Moreover this glial cell could to give rise to new ... ...

    Abstract The enteric glia, a neural crest-derived cell type that composes the Enteric Nervous System, is involved in controlling gut functions, including motility, gut permeability, and neuronal communication. Moreover this glial cell could to give rise to new neurons. It is believed that enteric neurons are generated up to 21 days postnatally; however, adult gut cells with glial characteristics can give rise to new enteric neurons under certain conditions. The factors that activate this capability of enteric glia to differentiate into neurons remain unknown. Here, we followed the progress of this neuronal differentiation and investigated this ability by challenging enteric glial cells with different culture conditions. We found that,
    Sprache Englisch
    Erscheinungsdatum 2019-09-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2019.00914
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The enteric glia: identity and functions.

    Coelho-Aguiar, Juliana de Mattos / Bon-Frauches, Ana Carina / Gomes, Ana Lúcia Tavares / Veríssimo, Carla Pires / Aguiar, Diego Pinheiro / Matias, Diana / Thomasi, Beatriz Bastos de Moraes / Gomes, Antoniella Souza / Brito, Gerly Anne de Castro / Moura-Neto, Vivaldo

    Glia

    2015  Band 63, Heft 6, Seite(n) 921–935

    Abstract: Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many ... ...

    Abstract Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many characteristics with astrocytes, the main glial cell type of the central nervous system (CNS), such as in their expression of the same markers and in their functions. Here we review the construction of the enteric nervous system (ENS), with a focus on enteric glia, and also the main studies that have revealed the action of enteric glia in different aspects of gastrointestinal tract homeostasis, such as in the intestinal barrier, in communications with neurons, and in their action as progenitor cells. We also discuss recent discoveries about the roles of enteric glia in different disorders that affect the ENS, such as degenerative pathologies including Parkinson's and prion diseases, and in cases of intestinal diseases and injury.
    Mesh-Begriff(e) Animals ; Cell Communication/physiology ; Enteric Nervous System/physiology ; Enteric Nervous System/physiopathology ; Humans ; Neurogenesis/physiology ; Neuroglia/physiology
    Sprache Englisch
    Erscheinungsdatum 2015-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.22795
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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