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  1. Artikel: Study of insoluble atmospheric material of the snow cover of the coastal zone of the southeastern Baltic Sea

    Topchaya, Victoria Yu / Chechko, Vladimir A.

    Regional studies in marine science. 2022 May, v. 52

    2022  

    Abstract: Four years of studies of the quantitative, material, and chemical composition of insoluble atmospheric matter in the snow cover of the coastal zone of the southeastern Baltic Sea have been summarized. The insoluble atmospheric particle concentration in ... ...

    Abstract Four years of studies of the quantitative, material, and chemical composition of insoluble atmospheric matter in the snow cover of the coastal zone of the southeastern Baltic Sea have been summarized. The insoluble atmospheric particle concentration in snow cover varied from 3.2 to 11.2 mg/l. The values of vertical fluxes are 1.3–5.9 mg/m²/day. The material composition component is characterized by the dominance of anthropogenic material (black carbon particle aggregate, fly ash and etc.) over lithogenic and biogenic material. The interannual content of heavy metals varies over a wide range, especially the content of Cd and Cu. Enrichment of atmospheric material with Cd, Pb, Ni, Cu, Zn, and Bi occurs mainly from anthropogenic sources. A characteristic feature of rare earth elements in the insoluble snow matter is the high enrichment of LREEs relative to HREEs with a negative europium anomaly indicates their natural origin.
    Schlagwörter carbon ; chemical composition ; coasts ; europium ; fly ash ; marine science ; snow ; snowpack ; Baltic Sea
    Sprache Englisch
    Erscheinungsverlauf 2022-05
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 2352-4855
    DOI 10.1016/j.rsma.2022.102399
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  2. Artikel: Investigation of Hafnium Thin Films for Design of TES Microcalorimeters.

    Safonova, Victoria Yu / Gordeeva, Anna V / Blagodatkin, Anton V / Pimanov, Dmitry A / Yablokov, Anton A / Ermolaeva, Olga L / Pankratov, Andrey L

    Materials (Basel, Switzerland)

    2023  Band 17, Heft 1

    Abstract: Hafnium is a superconductor with a transition temperature slightly above 100 mK. This makes it attractive for such applications as microcalorimeters with high energy resolution. We report the superconducting properties of Hf films of thicknesses ranging ... ...

    Abstract Hafnium is a superconductor with a transition temperature slightly above 100 mK. This makes it attractive for such applications as microcalorimeters with high energy resolution. We report the superconducting properties of Hf films of thicknesses ranging from 60 to 115 nm, deposited on Si and Al
    Sprache Englisch
    Erscheinungsdatum 2023-12-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17010222
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  3. Artikel ; Online: A standardized anesthetic/analgetic regimen compared to standard anesthetic/analgetic regimen for patients with high-risk factors undergoing open lumbar spine surgery: a prospective comparative single-center study.

    Byvaltsev, Vadim A / Goloborodko, Victoria Yu / Kalinin, Andrei A / Shepelev, Valerii V / Pestryakov, Yurii Ya / Riew, K Daniel

    Neurosurgical review

    2023  Band 46, Heft 1, Seite(n) 95

    Abstract: The objective of the study is to improve the results of patients undergoing lumbar spine surgery who are at high risk for anesthesia and/or surgical complications. Two independent groups were compared: the study group (SG, n = 40) (standardized ... ...

    Abstract The objective of the study is to improve the results of patients undergoing lumbar spine surgery who are at high risk for anesthesia and/or surgical complications. Two independent groups were compared: the study group (SG, n = 40) (standardized neuroanesthetic protocol with multimodal analgesia) and the control group (CG, n = 40) (intravenous anesthesia based on propofol and fentanyl). The data were collected using prospective observation of early and long-term results of lumbar fusion. After 24 months, the level of functional state and quality of life were studied. Patients in the SG did not have statistically significant changes in intraoperative hemodynamics; the best indicators of cognitive functions were noted. The effectiveness of the SG compared with the CG was confirmed by a statistically significantly lower amount of perioperative opioid drugs required (p = 0.01) and a minimal level of incisional pain (p < 0.05). An intergroup comparison of the adverse effects of anesthesia revealed a significantly lower number in the SG (n = 4) compared to the CG (n = 16) (p = 0.004). The number of postoperative surgical complications was comparable (p = 0.72). Intergroup comparison showed improved ODI, SF-36, and the Macnab scale at 24 months after surgery in the SG compared to the CG (p < 0.05). Long-term clinical results correlated with the level of incisional pain in the first three postoperative days. Our standardized neuroanesthetic protocol ensured effective treatment of postoperative incisional pain, significantly decreased the perioperative use of opioids, reduced adverse anesthesia events, and improved long-term clinical results in patients with high risk factors for anesthetic complications who undergoing open lumbar spine surgery.
    Mesh-Begriff(e) Humans ; Prospective Studies ; Quality of Life ; Spinal Fusion/methods ; Pain, Postoperative/drug therapy ; Anesthetics/therapeutic use ; Postoperative Complications/etiology ; Analgesics, Opioid/therapeutic use ; Lumbar Vertebrae/surgery ; Treatment Outcome
    Chemische Substanzen Anesthetics ; Analgesics, Opioid
    Sprache Englisch
    Erscheinungsdatum 2023-04-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02005-4
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  4. Buch ; Online: Quantitative analysis of the dynamics of maternal gradients of the early Drosophila embryo

    Samuta, Victoria Yu. / Spirov, Alexander V.

    2019  

    Abstract: The predetermination, formation and maintenance of the primary morphogenetic gradient (bicoid gradient) of the early Drosophila embryo involves many interrelated processes. Here we focus on a system-biological analysis of the processes of redistribution ... ...

    Abstract The predetermination, formation and maintenance of the primary morphogenetic gradient (bicoid gradient) of the early Drosophila embryo involves many interrelated processes. Here we focus on a system-biological analysis of the processes of redistribution of bicoid mRNA in an early embryo. The results of a quantitative analysis of experimental data, together with the results of their dynamic modeling, substantiate the role of active transport in the redistribution of bicoid mRNA.

    Comment: 19 pages, in russian
    Schlagwörter Quantitative Biology - Quantitative Methods ; Quantitative Biology - Cell Behavior
    Sprache Russisch
    Erscheinungsdatum 2019-09-01
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Retention of Human iPSC-Derived or Primary Cells Following Xenotransplantation into Rat Immune-Privileged Sites

    Thomas Später / Giselle Kaneda / Melissa Chavez / Julia Sheyn / Jacob Wechsler / Victoria Yu / Patricia Del Rio / Dave Huang / Melodie Metzger / Wafa Tawackoli / Dmitriy Sheyn

    Bioengineering, Vol 10, Iss 1049, p

    2023  Band 1049

    Abstract: In regenerative medicine, experimental animal models are commonly used to study potential effects of human cells as therapeutic candidates. Although some studies describe certain cells, such as mesenchymal stromal cells (MSC) or human primary cells, as ... ...

    Abstract In regenerative medicine, experimental animal models are commonly used to study potential effects of human cells as therapeutic candidates. Although some studies describe certain cells, such as mesenchymal stromal cells (MSC) or human primary cells, as hypoimmunogenic and therefore unable to trigger strong inflammatory host responses, other studies report antibody formation and immune rejection following xenotransplantation. Accordingly, the goal of our study was to test the cellular retention and survival of human-induced pluripotent stem cell (iPSCs)-derived MSCs (iMSCs) and primary nucleus pulposus cells (NPCs) following their xenotransplantation into immune-privileged knee joints (14 days) and intervertebral discs (IVD; 7 days) of immunocompromised Nude and immunocompetent Sprague Dawley (SD) rats. At the end of both experiments, we could demonstrate that both rat types revealed comparably low levels of systemic IL-6 and IgM inflammation markers, as assessed via ELISA. Furthermore, the number of recovered cells was with no significant difference between both rat types. Conclusively, our results show that xenogeneic injection of human iMSC and NPC into immunoprivileged knee and IVD sites did not lead to an elevated inflammatory response in immunocompetent rats when compared to immunocompromised rats. Hence, immunocompetent rats represent suitable animals for xenotransplantation studies targeting immunoprivileged sites.
    Schlagwörter xenotransplantation ; intervertebral discs ; mesenchymal stem cells ; nucleus pulposus cells ; inflammation ; cell therapy ; Technology ; T ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Guest editor's note: Special issue on biosimilarity assessment.

    Chang, Victoria Yu-Wei / Endrenyi, Laszlo

    Journal of biopharmaceutical statistics

    2016  Band 27, Heft 2, Seite(n) 195–196

    Mesh-Begriff(e) Biosimilar Pharmaceuticals ; Clinical Trials as Topic/statistics & numerical data ; Data Interpretation, Statistical ; Guidelines as Topic ; Humans ; Sample Size
    Chemische Substanzen Biosimilar Pharmaceuticals
    Sprache Englisch
    Erscheinungsdatum 2016-12-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1131763-2
    ISSN 1520-5711 ; 1054-3406
    ISSN (online) 1520-5711
    ISSN 1054-3406
    DOI 10.1080/10543406.2017.1272396
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3511: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel ; Online: Dosimetric impact from cardiac motion to heart substructures in thoracic cancer patients treated with a magnetic resonance guided radiotherapy system

    Ran Yan / Fang-I Chu / Yu Gao / Victoria Yu / Stephanie Yoon / David Elashoff / Percy Lee / Peng Hu / Yingli Yang

    Physics and Imaging in Radiation Oncology, Vol 17, Iss , Pp 8-

    2021  Band 12

    Abstract: Few studies have examined the cardiac volume and radiation dose differences among cardiac phases during radiation therapy (RT). Such information is crucial to dose reconstruction and understanding of RT related cardiac toxicity. In a cohort of nine ... ...

    Abstract Few studies have examined the cardiac volume and radiation dose differences among cardiac phases during radiation therapy (RT). Such information is crucial to dose reconstruction and understanding of RT related cardiac toxicity. In a cohort of nine patients, we studied the changes in the volume and doses of several cardiac substructures between the end-diastolic and end-systolic phases based on the clinical magnetic resonance-guided RT (MRgRT) treatment plans. Significant differences in the volume and dose between the two phases were observed. Onboard cardiac cine MRI holds promise for patient-specific cardiac sparing treatment designs.
    Schlagwörter Dosimetry analysis ; Cardiac substructures ; CINE MRI ; MRgRT ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Different genome-wide transcriptome responses of Nocardioides simplex VKM Ac-2033D to phytosterol and cortisone 21-acetate

    Shtratnikova, Victoria Yu / Sсhelkunov, Mikhail I / Fokina, Victoria V / Bragin, Eugeny Y / Shutov, Andrey A / Donova, Marina V

    BMC biotechnology. 2021 Dec., v. 21, no. 1

    2021  

    Abstract: BACKGROUND: Bacterial degradation/transformation of steroids is widely investigated to create biotechnologically relevant strains for industrial application. The strain of Nocardioides simplex VKM Ac-2033D is well known mainly for its superior 3- ... ...

    Abstract BACKGROUND: Bacterial degradation/transformation of steroids is widely investigated to create biotechnologically relevant strains for industrial application. The strain of Nocardioides simplex VKM Ac-2033D is well known mainly for its superior 3-ketosteroid Δ¹-dehydrogenase activity towards various 3-oxosteroids and other important reactions of sterol degradation. However, its biocatalytic capacities and the molecular fundamentals of its activity towards natural sterols and synthetic steroids were not fully understood. In this study, a comparative investigation of the genome-wide transcriptome profiling of the N. simplex VKM Ac-2033D grown on phytosterol, or in the presence of cortisone 21-acetate was performed with RNA-seq. RESULTS: Although the gene patterns induced by phytosterol generally resemble the gene sets involved in phytosterol degradation pathways in mycolic acid rich actinobacteria such as Mycolicibacterium, Mycobacterium and Rhodococcus species, the differences in gene organization and previously unreported genes with high expression level were revealed. Transcription of the genes related to KstR- and KstR2-regulons was mainly enhanced in response to phytosterol, and the role in steroid catabolism is predicted for some dozens of the genes in N. simplex. New transcription factors binding motifs and new candidate transcription regulators of steroid catabolism were predicted in N. simplex. Unlike phytosterol, cortisone 21-acetate does not provide induction of the genes with predicted KstR and KstR2 sites. Superior 3-ketosteroid-Δ¹-dehydrogenase activity of N. simplex VKM Ac-2033D is due to the kstDs redundancy in the genome, with the highest expression level of the gene KR76_27125 orthologous to kstD2, in response to cortisone 21-acetate. The substrate spectrum of N. simplex 3-ketosteroid-Δ¹-dehydrogenase was expanded in this study with progesterone and its 17α-hydroxylated and 11α,17α-dihydroxylated derivatives, that effectively were 1(2)-dehydrogenated in vivo by the whole cells of the N. simplex VKM Ac-2033D. CONCLUSION: The results contribute to the knowledge of biocatalytic features and diversity of steroid modification capabilities of actinobacteria, defining targets for further bioengineering manipulations with the purpose of expansion of their biotechnological applications.
    Schlagwörter Mycobacterium ; Pimelobacter simplex ; bioengineering ; biotechnology ; cells ; cortisone ; degradation ; genes ; industrial applications ; knowledge ; metabolism ; mycolic acids ; phytosterols ; progesterone ; sequence analysis ; strains ; transcription factors ; transcriptome ; transcriptomics
    Sprache Englisch
    Erscheinungsverlauf 2021-12
    Umfang p. 7.
    Erscheinungsort BioMed Central
    Dokumenttyp Artikel
    ISSN 1472-6750
    DOI 10.1186/s12896-021-00668-9
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  9. Artikel: G-Quadruplex Formed by the Promoter Region of the

    Pavlova, Anzhela V / Savitskaya, Victoria Yu / Dolinnaya, Nina G / Monakhova, Mayya V / Litvinova, Anastasia V / Kubareva, Elena A / Zvereva, Maria I

    Biomedicines

    2022  Band 10, Heft 8

    Abstract: G-quadruplexes (G4s) are a unique class of noncanonical DNAs that play a key role in cellular processes and neoplastic transformation. Herein, we focused on the promoter region of human TERT oncogene, whose product is responsible for the immortality of ... ...

    Abstract G-quadruplexes (G4s) are a unique class of noncanonical DNAs that play a key role in cellular processes and neoplastic transformation. Herein, we focused on the promoter region of human TERT oncogene, whose product is responsible for the immortality of cancer cells. It has been shown by chemical probing and spectroscopic methods that synthetic 96-nt DNAs modeling the wild-type G-rich strand of the hTERT promoter and its variants with G>A point substitutions corresponding to somatic driver mutations fold into three stacked parallel G4s with sites of local G4 destabilization caused by G>A substitutions in the G4 motif. These models were used to elucidate how the hTERT multiG4 affects the binding affinity and functional responses of two key proteins, MutS and MutL, involved in the initial stage of DNA mismatch repair (MMR) in Escherichiacoli and Neisseriagonorrhoeae with different MMR mechanisms. We have shown for the first time that (i) point substitutions do not affect the effective binding of these proteins to the hTERT G4 structure, and (ii) the endonuclease activity of MutL from N. gonorrhoeae is significantly suppressed by the stable G4 scaffold. It is likely that some of the genomic instability associated with G4 may be related to the blockage of human intrinsic methyl-independent MMR attempting to operate near G4 structures.
    Sprache Englisch
    Erscheinungsdatum 2022-08-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10081871
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  10. Artikel: Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators.

    Revin, Leonid S / Pimanov, Dmitry A / Chiginev, Alexander V / Blagodatkin, Anton V / Zbrozhek, Viktor O / Samartsev, Andrey V / Orlova, Anastasia N / Masterov, Dmitry V / Parafin, Alexey E / Safonova, Victoria Yu / Gordeeva, Anna V / Pankratov, Andrey L / Kuzmin, Leonid S / Sidorenko, Anatolie S / Masi, Silvia / de Bernardis, Paolo

    Beilstein journal of nanotechnology

    2024  Band 15, Seite(n) 26–36

    Abstract: We consider properties of dichroic antenna arrays on a silicon substrate with integrated cold-electron bolometers to detect radiation at frequencies of 210 and 240 GHz. This frequency range is widely used in cosmic microwave background experiments in ... ...

    Abstract We consider properties of dichroic antenna arrays on a silicon substrate with integrated cold-electron bolometers to detect radiation at frequencies of 210 and 240 GHz. This frequency range is widely used in cosmic microwave background experiments in space, balloon, and ground-based missions such as BICEP Array, LSPE, LiteBIRD, QUBIC, Simons Observatory, and AliCPT. As a direct radiation detector, we use cold-electron bolometers, which have high sensitivity and a wide operating frequency range, as well as immunity to spurious cosmic rays. Their other advantages are the compact size of the order of a few micrometers and the effect of direct electron cooling, which can improve sensitivity in typical closed-loop cycle
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.15.3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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