Article ; Online: Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery: a systematic review, meta-analysis and trial sequential analysis.
2023 Volume 78, Issue 9, Page(s) 1153–1161
Abstract: Tranexamic acid is an antifibrinolytic drug that is widely used during surgery, but there are concerns about its thromboembolic effects. We aimed to investigate the effect of prophylactic intravenous tranexamic acid on thromboembolic outcomes in patients ...
| Abstract | Tranexamic acid is an antifibrinolytic drug that is widely used during surgery, but there are concerns about its thromboembolic effects. We aimed to investigate the effect of prophylactic intravenous tranexamic acid on thromboembolic outcomes in patients undergoing non-cardiac surgery. The MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials were searched. Randomised controlled trials comparing intravenous tranexamic acid with placebo or no treatment in patients undergoing non-cardiac surgery were included. The primary outcome was a composite of peri-operative cardiovascular thromboembolic events, defined as any deep vein thrombosis, pulmonary embolism, myocardial ischaemia/infarction or cerebral ischaemia/infarction. A total of 191 randomised controlled trials (40,621 patients) were included in the review. The primary outcome occurred in 4.5% of patients receiving intravenous tranexamic acid compared with 4.9% of patients in the control group. Our analysis showed that there was no difference between groups for composite cardiovascular thromboembolic events (risk ratio 1.02, 95%CI 0.94-1.11, p = 0.65, I |
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| MeSH term(s) | Humans ; Tranexamic Acid/adverse effects ; Antifibrinolytic Agents/adverse effects ; Thromboembolism/prevention & control ; Blood Transfusion ; Myocardial Infarction ; Blood Loss, Surgical/prevention & control | |||||
| Chemical Substances | Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents | |||||
| Language | English | |||||
| Publishing date | 2023-06-14 | |||||
| Publishing country | England | |||||
| Document type | Systematic Review ; Meta-Analysis ; Journal Article ; Review | |||||
| ZDB-ID | 80033-8 | |||||
| ISSN | 1365-2044 ; 0003-2409 | |||||
| ISSN (online) | 1365-2044 | |||||
| ISSN | 0003-2409 | |||||
| DOI | 10.1111/anae.16058 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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