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  1. Artikel: Deadly emotional argument: Sudden cardiac death in catecholaminergic polymorphic ventricular tachycardia (CPVT).

    Violano, Michele / Poller, Wolfgang / Abraham, Maria Roselle / Huemer, Martin / Scheinman, Melvin / Landmesser, Ulf / Heidecker, Bettina

    International journal of cardiology. Heart & vasculature

    2022  Band 41, Seite(n) 101062

    Sprache Englisch
    Erscheinungsdatum 2022-05-27
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2022.101062
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response.

    Brala, Debora / Thevathasan, Tharusan / Grahl, Simon / Barrow, Steve / Violano, Michele / Bergs, Hendrikje / Golpour, Ainoosh / Suwalski, Phillip / Poller, Wolfgang / Skurk, Carsten / Landmesser, Ulf / Heidecker, Bettina

    Journal of the American Heart Association

    2023  Band 12, Heft 4, Seite(n) e027619

    Abstract: Background Inflammatory cardiomyopathy is one of the most common causes of sudden cardiac death in young adults. Diagnosis of inflammatory cardiomyopathy remains challenging, and better monitoring tools are needed. We present magnetocardiography as a ... ...

    Abstract Background Inflammatory cardiomyopathy is one of the most common causes of sudden cardiac death in young adults. Diagnosis of inflammatory cardiomyopathy remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation and monitor treatment response. Methods and Results A total of 233 patients were enrolled, with a mean age of 45 (±18) years, and 105 (45%) were women. The primary analysis included 209 adult subjects, of whom 66 (32%) were diagnosed with inflammatory cardiomyopathy, 17 (8%) were diagnosed with cardiac amyloidosis, and 35 (17%) were diagnosed with other types of nonischemic cardiomyopathy; 91 (44%) did not have cardiomyopathy. The second analysis included 13 patients with inflammatory cardiomyopathy who underwent immunosuppressive therapy after baseline magnetocardiography measurement. Finally, diagnostic accuracy of magnetocardiography was tested in 3 independent cohorts (total n=23) and 1 patient, who developed vaccine-related myocarditis. First, we identified a magnetocardiography vector to differentiate between patients with cardiomyopathy versus patients without cardiomyopathy (vector of ≥0.051; sensitivity, 0.59; specificity, 0.95; positive predictive value, 93%; and negative predictive value, 64%). All patients with inflammatory cardiomyopathy, including a patient with mRNA vaccine-related myocarditis, had a magnetocardiography vector ≥0.051. Second, we evaluated the ability of the magnetocardiography vector to reflect treatment response. We observed a decrease of the pathologic magnetocardiography vector toward normal in all 13 patients who were clinically improving under immunosuppressive therapy. Magnetocardiography detected treatment response as early as day 7, whereas echocardiographic detection of treatment response occurred after 1 month. The magnetocardiography vector decreased from 0.10 at baseline to 0.07 within 7 days (
    Mesh-Begriff(e) Young Adult ; Humans ; Female ; Middle Aged ; Male ; Myocarditis/diagnosis ; Myocarditis/therapy ; Magnetocardiography/methods ; Stroke Volume ; Ventricular Function, Left ; Cardiomyopathies/diagnosis ; Cardiomyopathies/therapy
    Sprache Englisch
    Erscheinungsdatum 2023-02-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.122.027619
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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