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  1. Artikel ; Online: Optic pathway tumor in an infant with KIAA1109 variants.

    Shah, Krunal / Sanghavi, Niyati / Viswanathan, Aarthi / Kumar, Arun / Kumar, Nuthan / Kaushik, Prakruthi / Kumari, B S Aruna / Appaji, L

    Pediatric blood & cancer

    2022  Band 69, Heft 11, Seite(n) e29701

    Mesh-Begriff(e) Eye/pathology ; Genetic Predisposition to Disease ; Humans ; Infant ; Magnetic Resonance Imaging ; Neoplasms ; Optic Nerve Glioma ; Polymorphism, Single Nucleotide ; Proteins/genetics
    Chemische Substanzen KIAA1109 protein, human ; Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-04-04
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29701
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1131: Hefte anzeigen Standort:
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  2. Artikel ; Online: Screening of renal anomalies in first-degree relatives of children diagnosed with non-syndromic congenital anomalies of kidney and urinary tract.

    Viswanathan, Aarthi / Dawman, Lesa / Tiewsoh, Karalanglin / Saxena, Akshay Kumar / Dutta, Sourabh / Suri, Deepti

    Clinical and experimental nephrology

    2020  Band 25, Heft 2, Seite(n) 184–190

    Abstract: Background: Non-syndromic congenital anomalies of kidney and urinary tract (CAKUT) are usually sporadic in nature but familial clustering of cases have been observed suggesting a genetic predisposition to this condition. We aimed to determine the ... ...

    Abstract Background: Non-syndromic congenital anomalies of kidney and urinary tract (CAKUT) are usually sporadic in nature but familial clustering of cases have been observed suggesting a genetic predisposition to this condition. We aimed to determine the frequency and pattern of renal anomalies in first-degree relatives of children with non-syndromic CAKUT.
    Methods: We screened all the first-degree relatives of children with CAKUT. A total of 149 first-degree relatives, belonging to 62 families were screened with ultrasonography.
    Results: A renal anomaly was detected in 9 out of the 62 families. Two of these nine families had identical anomalies (child and a parent) indicating single-gene disorders with possible autosomal dominant inheritance, while the rest of families had a non-identical anomaly. The anomalies detected in the first-degree relatives were renal hypodysplasia (n = 2), multicystic dysplastic kidney (n = 3), pelviureteric junction obstruction (n = 2) and mild hydronephrosis (n = 2). The incidence of a sonographically detected anatomic renal anomaly in first-degree relatives of children with CAKUT was found to be 6.0%. Familial cystic kidney disease was found in two out of the 4 families with cystic kidney disease.
    Conclusion: Significant renal anomalies were identified in first-degree relatives of children with non-syndromic CAKUT and hence, attempts must be made to screen the family members of children with non-syndromic CAKUT.
    Mesh-Begriff(e) Child ; Child, Preschool ; Cross-Sectional Studies ; Family ; Female ; Genetic Predisposition to Disease ; Humans ; Infant ; Infant, Newborn ; Kidney/abnormalities ; Male ; Urinary Tract/abnormalities
    Sprache Englisch
    Erscheinungsdatum 2020-10-06
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-020-01977-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4922: Hefte anzeigen Standort:
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  3. Artikel ; Online: Wilms tumor with extensive cardiac thrombus: a multidisciplinary approach.

    Viswanathan, Aarthi / Kumar, Nuthan / Mathew, Anand Kuriyan / Narendra Babu, Munianjinappa / Subramanian, Anand P / Appaji, Lingappa

    Asian cardiovascular & thoracic annals

    2019  Band 28, Heft 2, Seite(n) 101–103

    Mesh-Begriff(e) Cardiopulmonary Bypass ; Chemotherapy, Adjuvant ; Child, Preschool ; Heart Diseases/etiology ; Heart Diseases/pathology ; Humans ; Kidney Neoplasms/complications ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Male ; Neoplastic Cells, Circulating/pathology ; Nephrectomy ; Thrombosis/etiology ; Thrombosis/pathology ; Treatment Outcome ; Wilms Tumor/complications ; Wilms Tumor/pathology ; Wilms Tumor/therapy
    Sprache Englisch
    Erscheinungsdatum 2019-10-01
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/0218492319881593
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5193: Hefte anzeigen Standort:
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  4. Artikel: Epidemiology and clinical features of retinoblastoma: A tertiary care center's experience in India.

    Padma, Maneya / Kumar, Nuthan / Nesargi, Prerana S / Aruna Kumari, B S / Appaji, L / Viswanathan, Aarthi

    South Asian journal of cancer

    2019  Band 9, Heft 1, Seite(n) 56–58

    Abstract: Introduction: Retinoblastoma (RB) is a prototype of heritable cancers. It is more common in the lower socioeconomic strata. Delayed presentation significantly reduces the overall outcome. We have analyzed the epidemiological and clinical data of ... ...

    Abstract Introduction: Retinoblastoma (RB) is a prototype of heritable cancers. It is more common in the lower socioeconomic strata. Delayed presentation significantly reduces the overall outcome. We have analyzed the epidemiological and clinical data of children who were diagnosed with RB between the years 2009 and 2014.
    Aim: RB being a disease of the poor, delayed presentation is common due to lack of awareness. We have analyzed the epidemiological profile of our patients and tried to establish the link between delayed presentation and the presence of high-risk features. High-risk features are associated with higher chance of metastasis and poor rates of vision salvage in RB.
    Methodology: Data were collected in a retrospective manner from the patient case files retrieved from the Medical Records Department, Kidwai cancer Institute. The data were analyzed using Excel and SPSS software (IBM Corp. released 2016, IBM SPSS statistics software for Mac OS, version 24, IBM Corp., Armonk, NY).
    Results: A total of 53 patients were diagnosed with RB in the years 2009-2014. There was a male predominance with 1.2:1 incidence. Bilateral RB was present in 21 cases. The mean age of children with bilateral RB was 2.1 years, against 1.5 years in unilateral cases. High-risk features such as optic nerve invasion, choroidal invasion, intracranial extension, and orbital involvement were found in 12, 6, 5, and 5 eyes, respectively. Bone marrow involvement was detected in 5% and lung metastasis in 2%. Intracranial involvement was found in 10.4% and cerebrospinal fluid positivity in 15%. Children with high-risk features had a significant delay in presentation in comparison to those without high-risk features (
    Conclusion: Incidence of metastatic disease and delayed presentation is still high in developing countries. Routine eye examination during vaccination visits can ensure early diagnosis and appropriate referral in many of these children.
    Sprache Englisch
    Erscheinungsdatum 2019-12-27
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X
    ISSN (online) 2278-4306
    ISSN 2278-330X
    DOI 10.4103/sajc.sajc_89_19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Epidemiology and clinical features of retinoblastoma

    Padma, Maneya / Kumar, Nuthan / Nesargi, Prerana S. / Kumari, B.S Aruna / Appaji, L. / Viswanathan, Aarthi

    South Asian Journal of Cancer

    2020  Band 09, Heft 01, Seite(n) 56–58

    Abstract: Introduction: Retinoblastoma (RB) is a prototype of heritable cancers. It is more common in the lower socioeconomic strata. Delayed presentation significantly reduces the overall outcome. We have analyzed the epidemiological and clinical data of ... ...

    Abstract Introduction: Retinoblastoma (RB) is a prototype of heritable cancers. It is more common in the lower socioeconomic strata. Delayed presentation significantly reduces the overall outcome. We have analyzed the epidemiological and clinical data of children who were diagnosed with RB between the years 2009 and 2014.
    Aim: RB being a disease of the poor, delayed presentation is common due to lack of awareness. We have analyzed the epidemiological profile of our patients and tried to establish the link between delayed presentation and the presence of high-risk features. High-risk features are associated with higher chance of metastasis and poor rates of vision salvage in RB.
    Methodology: Data were collected in a retrospective manner from the patient case files retrieved from the Medical Records Department, Kidwai cancer Institute. The data were analyzed using Excel and SPSS software (IBM Corp. released 2016, IBM SPSS statistics software for Mac OS, version 24, IBM Corp., Armonk, NY).
    Results: A total of 53 patients were diagnosed with RB in the years 2009–2014. There was a male predominance with 1.2:1 incidence. Bilateral RB was present in 21 cases. The mean age of children with bilateral RB was 2.1 years, against 1.5 years in unilateral cases. High-risk features such as optic nerve invasion, choroidal invasion, intracranial extension, and orbital involvement were found in 12, 6, 5, and 5 eyes, respectively. Bone marrow involvement was detected in 5% and lung metastasis in 2%. Intracranial involvement was found in 10.4% and cerebrospinal fluid positivity in 15%. Children with high-risk features had a significant delay in presentation in comparison to those without high-risk features ( P = 0.035).
    Conclusion: Incidence of metastatic disease and delayed presentation is still high in developing countries. Routine eye examination during vaccination visits can ensure early diagnosis and appropriate referral in many of these children.
    Schlagwörter Delayed presentation ; high-risk featurese ; metastasis
    Sprache Englisch
    Erscheinungsdatum 2020-01-01
    Verlag Thieme Medical and Scientific Publishers Pvt. Ltd.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X ; 2278-4306
    ISSN (online) 2278-4306
    ISSN 2278-330X ; 2278-4306
    DOI 10.4103/sajc.sajc_89_19
    Datenquelle Thieme Verlag

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  6. Artikel: Administration and Toxicity Profile of the Capizzi Interim Maintenance—Retrospective Study from a Tertiary Care Cancer Centre

    Viswanathan, Aarthi / Kumar, Arun / Kaushik, Prakruthi S. / Thumallapalli, Avinash / Ramachandra, C. / Aruna Kumari, B. S. / Appaji, Lingappa / Kumar, Nuthan

    Indian Journal of Medical and Paediatric Oncology

    2021  Band 42, Heft 05, Seite(n) 426–430

    Abstract: Introduction: The Capizzi-style methotrexate (MTX) is an integral part of acute lymphoblastic leukemia (ALL) treatment. The escalating dose of MTX originally used in the United Kingdom and Children’s Oncology Group protocols along with L-asparaginase ... ...

    Abstract Introduction: The Capizzi-style methotrexate (MTX) is an integral part of acute lymphoblastic leukemia (ALL) treatment. The escalating dose of MTX originally used in the United Kingdom and Children’s Oncology Group protocols along with L-asparaginase has been modified in the Indian Childhood Collaborative Leukemia (ICiCLe) group protocol where L-asparaginase has been omitted. The data regarding the incidence of toxicities and ease of administration on the Capizzi-style interim maintenance is not robust.
    Objectives: We have compiled our experience with administration and toxicity profile in children with intermediate-risk ALL.
    Materials and Methods: A retrospective data collection of all children diagnosed with intermediate-risk ALL as per the ICiCLe risk stratification in the year 2019 was included in the analysis. Each cycle of MTX was started after ensuring an absolute neutrophil count of >750/mm 3 and transaminases <2 upper limit of normal. As a unit protocol, pre- and post-MTX hydration was administered in all our children. No urine pH or midcycle biochemical parameter monitoring was done. Statistical analysis was done using Microsoft Excel and SPSS version 24 IBM Corp. in Armonk, New York, United States.
    Results: Forty-six children were included in the study. The median age of children in our study was 6 years (range: 1 year 2 months–12 years). Undernutrition was associated with a significant increase in toxicity ( p = 0.02). Fifty-two percent of children had evidence of toxicity, elevated transaminases being the most common. There were recurring symptoms resulting in 53 episodes of toxicities overall. Incidence of toxicity was more in the early cycles (<3).
    Conclusion: The pre- and post-MTX hydration is an effective way to reduce toxicities with the Capizzi-style MTX and this course can be administered with ease on outpatient basis with minimal need for monitoring or admission.
    Schlagwörter administration ; the Capizzi interim maintenance ; toxicity profile
    Sprache Englisch
    Erscheinungsdatum 2021-10-01
    Verlag Thieme Medical and Scientific Publishers Pvt. Ltd.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 2181724-8
    ISSN 0975-2129 ; 0971-5851 ; 0975-2129
    ISSN (online) 0975-2129
    ISSN 0971-5851 ; 0975-2129
    DOI 10.1055/s-0041-1740442
    Datenquelle Thieme Verlag

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