Artikel ; Online: Individualized positive end-expiratory pressure guided by end-expiratory lung volume in early acute respiratory distress syndrome: study protocol for the multicenter, randomized IPERPEEP trial.
2022 Band 23, Heft 1, Seite(n) 63
Abstract: Background: In acute respiratory distress syndrome (ARDS), response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability. The search for a tool to individualize PEEP based on patients' individual ... ...
Abstract | Background: In acute respiratory distress syndrome (ARDS), response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability. The search for a tool to individualize PEEP based on patients' individual response is warranted. End-expiratory lung volume (EELV) assessment by nitrogen washing-washout aids bedside estimation of PEEP-induced alveolar recruitment and may therefore help titrate PEEP on patient's individual recruitability. We designed a randomized trial to test whether an individualized PEEP setting protocol driven by EELV measurement may improve a composite clinical outcome in patients with moderate-to-severe ARDS (IPERPEEP trial). Methods: IPERPEEP is an open-label, multicenter, randomized trial that will be conducted in 10 intensive care units in Italy and will enroll 132 ARDS patients showing PaO Discussion: The IPERPEEP study is a randomized trial powered to elucidate whether an individualized PEEP setting protocol based on bedside assessment of lung recruitability can improve a composite clinical outcome during moderate-to-severe ARDS. Trial registration: ClinicalTrials.gov NCT04012073 . Registered 9 July 2019. |
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Mesh-Begriff(e) | Humans ; Lung ; Lung Volume Measurements ; Multicenter Studies as Topic ; Positive-Pressure Respiration ; Randomized Controlled Trials as Topic ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; Tidal Volume |
Sprache | Englisch |
Erscheinungsdatum | 2022-01-20 |
Erscheinungsland | England |
Dokumenttyp | Clinical Trial Protocol ; Journal Article |
ZDB-ID | 2040523-6 |
ISSN | 1745-6215 ; 1468-6694 ; 1745-6215 |
ISSN (online) | 1745-6215 |
ISSN | 1468-6694 ; 1745-6215 |
DOI | 10.1186/s13063-021-05993-0 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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