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  1. Artikel ; Online: Lipid composition dictates the rate of lipid peroxidation in artificial lipid droplets.

    Lange, Mike / Wagner, Pia Viktoria / Fedorova, Maria

    Free radical research

    2021  Band 55, Heft 4, Seite(n) 469–480

    Abstract: Cellular and organismal redox imbalance leading to the accumulation of reactive oxygen species significantly enhances lipid peroxidation (LPO). LPO is relatively well studied for phospholipid membranes and to some extent for circulating lipoproteins. ... ...

    Abstract Cellular and organismal redox imbalance leading to the accumulation of reactive oxygen species significantly enhances lipid peroxidation (LPO). LPO is relatively well studied for phospholipid membranes and to some extent for circulating lipoproteins. However, it is rarely addressed for intracellular lipid droplets (LDs). Here we optimized an
    Mesh-Begriff(e) Lipid Droplets/chemistry ; Lipid Droplets/metabolism ; Lipid Peroxidation ; Lipids/chemistry ; Liposomes/chemistry ; Liposomes/metabolism ; Oxidation-Reduction ; Particle Size
    Chemische Substanzen Lipids ; Liposomes
    Sprache Englisch
    Erscheinungsdatum 2021-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1194130-3
    ISSN 1029-2470 ; 1071-5762
    ISSN (online) 1029-2470
    ISSN 1071-5762
    DOI 10.1080/10715762.2021.1898603
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Local Fixation of Colistin With Fibrin Spray: An

    Janko, Maren / Dust, Fabian / Wagner, Pia Viktoria / Gurke, Robert / Frank, Johannes / Henrich, Dirk / Marzi, Ingo / Verboket, René Danilo

    Frontiers in surgery

    2022  Band 9, Seite(n) 749600

    Abstract: Objective: Skin and soft tissue infections (SSTI) are a commonly known entity of diseases associated with difficult treatment procedures. The current gold standard when there is a rapidly progressing infection of soft tissues with a risk of sepsis is ... ...

    Abstract Objective: Skin and soft tissue infections (SSTI) are a commonly known entity of diseases associated with difficult treatment procedures. The current gold standard when there is a rapidly progressing infection of soft tissues with a risk of sepsis is radical surgical debridement accompanied by systemic antibiotic therapy. In clinical settings, local antibiotics alone or formulated within carrier material are commonly used alongside this therapy regimen. One possibility of local antibiotic application is the fixation of colistin with fibrin glue spray. It is not yet sufficiently researched how the local antibiotic concentrations remain as high as possible over time.
    Methods: We conducted an animal study including 29 male Wistar rats inducing sterile back sores reaching the muscle fascia. We sprayed only colistin, simultaneously or consecutively, with fibrin glue in different groups in order to measure the tissue concentration of the antibiotic applied locally.
    Results: After liquid chromatography and quadrupole mass spectrometry analysis, it could be demonstrated that in comparison to the colistin group, tissue concentrations of colistin stayed significantly higher in the wound tissue when it was fixed with fibrin glue. This was observed in both groups, the simultaneous as well as in the consecutively fibrin glue sprayed groups after colistin application.
    Conclusion: The fixation of colistin with the fibrin-glue-spray technique as a carrier for local antibiotic therapy is an easy and inexpensive method and shows promising potential for the treatment of SSTI.
    Sprache Englisch
    Erscheinungsdatum 2022-03-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.749600
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Immuno-inflammatory

    Roser, Luise A / Luckhardt, Sonja / Ziegler, Nicole / Thomas, Dominique / Wagner, Pia Viktoria / Damm, Georg / Scheffschick, Andrea / Hewitt, Philip / Parnham, Michael J / Schiffmann, Susanne

    Frontiers in immunology

    2023  Band 14, Seite(n) 1275368

    Abstract: Introduction: Hepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect ... ...

    Abstract Introduction: Hepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect in clinical trials. As hepatotoxicity is a frequent reason for post-authorisation drug withdrawal, there is an urgent need for immuno-inflammatory
    Methods: Co-culture models of primary human CD8
    Results: We identified CD8
    Discussion: The
    Mesh-Begriff(e) Humans ; Interleukin-2/pharmacology ; Biological Products ; CD8-Positive T-Lymphocytes ; Drug-Related Side Effects and Adverse Reactions ; Chemical and Drug Induced Liver Injury/etiology
    Chemische Substanzen aldesleukin (M89N0Q7EQR) ; Interleukin-2 ; Biological Products
    Sprache Englisch
    Erscheinungsdatum 2023-11-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1275368
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol.

    Schiffmann, Susanne / Gunne, Sandra / Ulshöfer, Thomas / Henke, Marina / Roser, Luise A / Schneider, Ann-Kathrin / Cinatl, Jindrich / Thomas, Dominique / Schreiber, Yannick / Wagner, Pia Viktoria / Grünweller, Arnold / Parnham, Michael J

    Pharmaceuticals (Basel, Switzerland)

    2022  Band 15, Heft 9

    Abstract: We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an ... ...

    Abstract We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an EC
    Sprache Englisch
    Erscheinungsdatum 2022-08-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15091086
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype.

    Hansen, Lena / Lohfink, Niklas / Vutukuri, Rajkumar / Kestner, Roxane-Isabelle / Trautmann, Sandra / Hecht, Max / Wagner, Pia Viktoria / Spitzer, Daniel / Khel, Maryam Ibrahim / Macas, Jadranka / Ferreirós, Nerea / Gurke, Robert / Günther, Stefan / Pfeilschifter, Waltraud / Devraj, Kavi

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2021  Band 42, Heft 10, Seite(n) 1908–1929

    Abstract: The precise regulation of blood-brain barrier (BBB) permeability for immune cells and blood-borne substances is essential to maintain brain homeostasis. Sphingosine-1-phosphate (S1P), a lipid signaling molecule enriched in plasma, is known to affect BBB ... ...

    Abstract The precise regulation of blood-brain barrier (BBB) permeability for immune cells and blood-borne substances is essential to maintain brain homeostasis. Sphingosine-1-phosphate (S1P), a lipid signaling molecule enriched in plasma, is known to affect BBB permeability. Previous studies focused on endothelial S1P receptors 1 and 2, reporting a barrier-protective effect of S1P1 and a barrier-disruptive effect of S1P2. Here, we present novel data characterizing the expression, localization, and function of the S1P receptor 4 (S1P4) on primary brain microvascular endothelial cells (BMECs). Hitherto, the receptor was deemed to be exclusively immune cell associated. We detected a robust expression of S1P4 in homeostatic murine BMECs (MBMECs), bovine BMECs (BBMECs), and porcine BMECs (PBMECs) and pinpointed its localization to abluminal endothelial membranes via immunoblotting of fractionated brain endothelial membrane fragments. Apical S1P treatment of BMECs tightened the endothelial barrier
    Mesh-Begriff(e) Animals ; Blood-Brain Barrier/metabolism ; Cattle ; Endothelial Cells/metabolism ; Homeostasis ; Lysophospholipids/metabolism ; Lysophospholipids/pharmacology ; Mice ; Mice, Knockout ; Permeability ; Phenotype ; Receptors, Lysosphingolipid/genetics ; Sphingosine/metabolism ; Sphingosine/pharmacology ; Sphingosine-1-Phosphate Receptors/metabolism ; Stroke/metabolism ; Swine
    Chemische Substanzen Lysophospholipids ; Receptors, Lysosphingolipid ; Sphingosine-1-Phosphate Receptors ; Sphingosine (NGZ37HRE42)
    Sprache Englisch
    Erscheinungsdatum 2021-12-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0188-21.2021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1668: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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