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  1. Artikel ; Online: trans

    Alzahrani, Seraj O / McRobbie, Graeme / Khan, Abid / D'huys, Thomas / Van Loy, Tom / Walker, Ashlie N / Renard, Isaline / Hubin, Timothy J / Schols, Dominique / Burke, Benjamin P / Archibald, Stephen J

    Dalton transactions (Cambridge, England : 2003)

    2024  Band 53, Heft 12, Seite(n) 5616–5623

    Abstract: The chemokine receptor CXCR4 is implicated in multiple diseases including inflammatory disorders, cancer growth and metastasis, and HIV/AIDS. CXCR4 targeting has been evaluated in treating cancer metastasis and therapy resistance. Cyclam derivatives, ... ...

    Abstract The chemokine receptor CXCR4 is implicated in multiple diseases including inflammatory disorders, cancer growth and metastasis, and HIV/AIDS. CXCR4 targeting has been evaluated in treating cancer metastasis and therapy resistance. Cyclam derivatives, most notably AMD3100 (Plerixafor™), are a common motif in small molecule CXCR4 antagonists. However, AMD3100 has not been shown to be effective in cancer treatment as an individual agent. Configurational restriction and transition metal complex formation increases receptor binding affinity and residence time. In the present study, we have synthesized novel
    Mesh-Begriff(e) Benzylamines ; Coordination Complexes/pharmacology ; Cyclams ; Heterocyclic Compounds/pharmacology ; Heterocyclic Compounds/chemistry ; Receptors, CXCR4/antagonists & inhibitors
    Chemische Substanzen Benzylamines ; Coordination Complexes ; cyclam (295-37-4) ; Cyclams ; Heterocyclic Compounds ; plerixafor (S915P5499N) ; Receptors, CXCR4
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt01729j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A Bridge too Far? Comparison of Transition Metal Complexes of Dibenzyltetraazamacrocycles with and without Ethylene Cross-Bridges: X-ray Crystal Structures, Kinetic Stability, and Electronic Properties.

    Walker, Ashlie N / Ayala, Megan A / Mondal, Somrita / Bergagnini, Mackenzie C / Bui, Phuong John D / Chidester, Stephanie N / Doeden, Chad I / Esjornson, Louise / Sweany, Brian R / Garcia, Leslie / Krause, Jeanette A / Oliver, Allen G / Prior, Timothy J / Hubin, Timothy J

    Molecules (Basel, Switzerland)

    2023  Band 28, Heft 2

    Abstract: Tetraazamacrocycles, cyclic molecules with four nitrogen atoms, have long been known to produce highly stable transition metal complexes. Cross-bridging such molecules with two-carbon chains has been shown to enhance the stability of these complexes even ...

    Abstract Tetraazamacrocycles, cyclic molecules with four nitrogen atoms, have long been known to produce highly stable transition metal complexes. Cross-bridging such molecules with two-carbon chains has been shown to enhance the stability of these complexes even further. This provides enough stability to use the resulting compounds in applications as diverse and demanding as aqueous, green oxidation catalysis all the way to drug molecules injected into humans. Although the stability of these compounds is believed to result from the increased rigidity and topological complexity imparted by the cross-bridge, there is insufficient experimental data to exclude other causes. In this study, standard organic and inorganic synthetic methods were used to produce unbridged dibenzyl tetraazamacrocycle complexes of Co, Ni, Cu, and Zn that are analogues of known cross-bridged tetraazamacrocycles and their transition metal complexes to allow direct comparison of molecules that are identical except for the cross-bridge. The syntheses of the known tetraazamacrocycles and the new transition metal complexes were successful with high yields and purity. Initial chemical characterization of the complexes was conducted by UV-Visible spectroscopy, while cyclic voltammetry showed more marked differences in electronic properties from bridged versions. Direct comparison studies of the unbridged and bridged compounds' kinetic stabilities, as demonstrated by decomposition using high acid concentration and elevated temperature, showed that the cyclen-based complex stability did not benefit from cross-bridging. This is likely due to poor complementarity with the Cu
    Sprache Englisch
    Erscheinungsdatum 2023-01-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28020895
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  3. Artikel ; Online: Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes.

    Massie, Allyssa A / Denler, Melissa C / Cardoso, Luísa Thiara / Walker, Ashlie N / Hossain, M Kamal / Day, Victor W / Nordlander, Ebbe / Jackson, Timothy A

    Angewandte Chemie (International ed. in English)

    2017  Band 56, Heft 15, Seite(n) 4178–4182

    Abstract: Manganese(IV)-oxo complexes are often invoked as intermediates in Mn-catalyzed C-H bond activation reactions. While many synthetic ... ...

    Abstract Manganese(IV)-oxo complexes are often invoked as intermediates in Mn-catalyzed C-H bond activation reactions. While many synthetic Mn
    Mesh-Begriff(e) Catalysis ; Coordination Complexes/chemistry ; Density Functional Theory ; Ligands ; Manganese/chemistry ; Molecular Conformation ; Oxidation-Reduction ; Oxygen/chemistry
    Chemische Substanzen Coordination Complexes ; Ligands ; Manganese (42Z2K6ZL8P) ; Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2017-03-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201612309
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads.

    Hubin, Timothy J / Walker, Ashlie N / Davilla, Dustin J / Freeman, TaRynn N Carder / Epley, Brittany M / Hasley, Travis R / Amoyaw, Prince N A / Jain, Surendra / Archibald, Stephen J / Prior, Timothy J / Krause, Jeanette A / Oliver, Allen G / Tekwani, Babu L / Khan, M Omar F

    Polyhedron

    2019  Band 163, Seite(n) 42–53

    Abstract: A total of 44 bis-aryl-monocyclic polyamines, monoaryl-monocyclic polyamines and their transition metal complexes were prepared, chemically characterized, and screened in vitro against ... ...

    Abstract A total of 44 bis-aryl-monocyclic polyamines, monoaryl-monocyclic polyamines and their transition metal complexes were prepared, chemically characterized, and screened in vitro against the
    Sprache Englisch
    Erscheinungsdatum 2019-02-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2000326-2
    ISSN 0277-5387
    ISSN 0277-5387
    DOI 10.1016/j.poly.2019.02.027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads

    Hubin, Timothy J. / Walker, Ashlie N. / Davilla, Dustin J. / Carder Freeman, TaRynn N. / Epley, Brittany M. / Hasley, Travis R. / Amoyaw, Prince N.A. / Jain, Surendra / Archibald, Stephen J. / Prior, Timothy J. / Krause, Jeanette A. / Oliver, Allen G. / Tekwani, Babu L. / Khan, M. Omar F.

    Polyhedron. 2019 May 01, v. 163

    2019  

    Abstract: A total of 44 bis-aryl-monocyclic polyamines, monoaryl-monocyclic polyamines and their transition metal complexes were prepared, chemically characterized, and screened in vitro against the Leishmania donovani promastigotes, axenic amastigotes and ... ...

    Abstract A total of 44 bis-aryl-monocyclic polyamines, monoaryl-monocyclic polyamines and their transition metal complexes were prepared, chemically characterized, and screened in vitro against the Leishmania donovani promastigotes, axenic amastigotes and intracellular amastigotes in THP1 cells. The IC(50) and/or IC(90) values showed that 10 compounds were similarly active at about 2-fold less potent than known drug pentamidine against promastigotes. The most potent compound had an IC(50) of 2.82 µM (compared to 2.93 µM for pentamidine). Nine compounds were 1.1–13.6-fold more potent than pentamidine against axenic amastigotes, the most potent one being about 2-fold less potent than amphotericin B. Fourteen compounds were about 2–10 fold more potent than pentamidine, the most potent one is about 2-fold less potent than amphotericin B against intracellular amastigotes in THP1 cells. The 2 most promising compounds (FeL7Cl(2) and MnL7Cl(2)), with strong activity against both promastigotes and amastigotes and no observable toxicity against the THP1 cells are the Fe(2+)- and Mn(2+)-complexes of a dibenzyl cyclen derivative. Only 2 of the 44 compounds showed observable cytotoxicity against THP1 cells. Tetraazamacrocyclic monocyclic polyamines represent a new class of antileishmanial lead structures that warrant follow up studies.
    Schlagwörter Leishmania donovani ; amastigotes ; amphotericin B ; cytotoxicity ; polyamines ; promastigotes
    Sprache Englisch
    Erscheinungsverlauf 2019-0501
    Umfang p. 42-53.
    Erscheinungsort Elsevier BV
    Dokumenttyp Artikel
    ZDB-ID 2000326-2
    ISSN 0277-5387
    ISSN 0277-5387
    DOI 10.1016/j.poly.2019.02.027
    Datenquelle NAL Katalog (AGRICOLA)

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