Artikel ; Online: Fluconazole prophylaxis in extremely low birth weight infants and neurodevelopmental outcomes and quality of life at 8 to 10 years of age.
2011 Band 158, Heft 5, Seite(n) 759–765.e1
Abstract: Objective: To examine the long-term effects of fluconazole prophylaxis in extremely low birth weight infants.: Study design: Neurodevelopmental status and quality of life of survivors from a randomized, placebo-controlled trial of fluconazole ... ...
Abstract | Objective: To examine the long-term effects of fluconazole prophylaxis in extremely low birth weight infants. Study design: Neurodevelopmental status and quality of life of survivors from a randomized, placebo-controlled trial of fluconazole prophylaxis were evaluated at 8 to 10 years of life using the Vineland Adaptive Behavior Scales-II (VABS-II) and the Child Health Questionnaire Parent-Completed Form 28 (CHQ-PF28), respectively. Results: VABS-II Domain Scores for the fluconazole-treated (n = 21; 9.1 ± 0.7 years) compared with the placebo group (n = 17; 9.3 ± 0.8 years) were similar for communication [94.6 (±14.8) versus 92.6 (±12.6), P = .65], daily living skills [87.9 (±10.6) versus 87.4 (±9.3), P = .89], socialization [97.2 (±9.2) versus 94.4 (±7.9), P = .31], and motor skills [92.1 (±17.8) versus 95.1 (±14.6), P = .57]. Internalizing and externalizing behaviors and maladaptive behavior index were also similar. The CHQ-PF28 revealed no differences between the two groups regarding quality of life. Survivors were also happy or satisfied with school (90% versus 100%, P = .49), friendships (90% versus 88%, P = 1.00), and life (95% versus 100%, P = 1.00). Self esteem scores were 87.3 ± 15.7 versus 89.7 ± 10.4 (P = .59). There were also no differences between groups regarding emotional difficulties or behavior problems. Conclusions: Fluconazole prophylaxis for the prevention of invasive Candida infections is safe in extremely low birth weight infants and does not appear to be associated with any long-term adverse effects on neurodevelopment and quality of life at 8 to 10 years of life. |
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Mesh-Begriff(e) | Antifungal Agents/therapeutic use ; Candidiasis/prevention & control ; Child ; Developmental Disabilities/prevention & control ; Double-Blind Method ; Female ; Fluconazole/therapeutic use ; Follow-Up Studies ; Humans ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Male ; Prospective Studies ; Quality of Life ; Time Factors ; Treatment Outcome |
Chemische Substanzen | Antifungal Agents ; Fluconazole (8VZV102JFY) |
Sprache | Englisch |
Erscheinungsdatum | 2011-05 |
Erscheinungsland | United States |
Dokumenttyp | Comparative Study ; Journal Article ; Randomized Controlled Trial |
ZDB-ID | 3102-1 |
ISSN | 1097-6833 ; 0022-3476 |
ISSN (online) | 1097-6833 |
ISSN | 0022-3476 |
DOI | 10.1016/j.jpeds.2010.11.002 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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