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  1. Artikel ; Online: Unfolded protein response pathway in leishmaniasis: A review.

    Edirisinghe, Nimesha Madhushani / Manamperi, Nuwani Harshamali / Wanasinghe, Vishmi Samudika / Karunaweera, Nadira

    Parasite immunology

    2023  Band 45, Heft 11, Seite(n) e13009

    Abstract: Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, ... ...

    Abstract Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species.
    Mesh-Begriff(e) Animals ; Unfolded Protein Response ; Endoplasmic Reticulum Stress/physiology ; Leishmaniasis/pathology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/pathology ; Leishmania
    Sprache Englisch
    Erscheinungsdatum 2023-08-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.13009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic

    Manamperi, Nuwani H / Edirisinghe, Nimesha Madhushani / Wijesinghe, Harshima / Pathiraja, Lakmali / Pathirana, Nishantha / Wanasinghe, Vishmi Samudika / de Silva, Chamalka Gimhani / Abeyewickreme, W / Karunaweera, Nadira D

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights in leishmaniasis research, in comparison to that of the parasite. The primary objective of this study was to comprehensively ... ...

    Abstract Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights in leishmaniasis research, in comparison to that of the parasite. The primary objective of this study was to comprehensively analyze the proteomic profile of the skin lesions tissues in patients with CL, by mass spectrometry, and subsequent validation of these findings through immunohistochemical methods. Sixty-seven proteins exhibited significant differential expression between tissues of CL lesions and healthy controls (p<0.01), representing numerous enriched biological processes within the lesion tissue, as evident by both the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome databases. Among these, the integrated endoplasmic reticulum stress response (IERSR) emerges as a pathway characterized by the up-regulated proteins in CL tissues compared to healthy skin. Expression of endoplasmic reticulum (ER) stress sensors, inositol-requiring enzyme-1 (IRE1), protein kinase RNA-like ER kinase (PERK), and activating transcription factor 6 (ATF6) in lesion tissue was validated by immunohistochemistry. In conclusion, proteomic profiling of skin lesions carried out as a discovery phase study revealed a multitude of probable immunological and pathological mechanisms operating in patients with CL in Sri Lanka, which needs to be further elaborated using more in-depth and targeted investigations.
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.01.07.574579
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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