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  1. Artikel ; Online: Pan-cancer analysis reveals a regulatory pattern of anoikis in human cancers.

    Wang, Xiaoyun / Yang, Chao / Wang, Xingjian / Duan, Pengfei

    Cellular and molecular biology (Noisy-le-Grand, France)

    2024  Band 70, Heft 2, Seite(n) 51–61

    Abstract: Anoikis emerges when a cell finds itself extricated from the appropriate extracellular matrix, leading to an interruption in integrin ligation and thus triggering programmed cellular demise. The cardinal role of Anoikis in the realms of tumor invasion ... ...

    Abstract Anoikis emerges when a cell finds itself extricated from the appropriate extracellular matrix, leading to an interruption in integrin ligation and thus triggering programmed cellular demise. The cardinal role of Anoikis in the realms of tumor invasion and metastasis is undeniable, although our grasp on its precise influence within the convoluted landscape of cancer biology remains somewhat circumscribed. Notably, both the immune milieu of the tumor and its inherent aggression are correlated with the fluctuating variables of Anoikis. We conducted a thorough evaluation of the genes associated with anoikis and studied the regulatory patterns of these genes as well as the prognostic impact of anoikis in 33 different types of tumors. We provided functional annotations for the regulatory patterns linked to Anoikis. Additionally, we described the associations between immunological factors and genes associated with Anoikis. By applying gene set variation analysis (GSVA), we utilized the inherent abilities of 34 basic genes to calculate the Anoikis index. The Anoikis index is closely related to prognosis, immune microenvironment, immunotherapy, and other aspects. Our functional research revealed a correlation between immune cell infiltration, EMT, and a regulatory gene that is synonymous with adverse survival outcomes. In addition, our observations revealed a direct relationship between the expression of CEACAM5 and CEACAM6,the amplification of epithelial mesenchymal transition (EMT) phenomenon, and a decrease in survival outcomes.The potential therapeutic utility of anoikis-related genes was highlighted by the possible links between TME, clinical samples, genetic mutations, drug resistance, and immunotherapy.
    Mesh-Begriff(e) Humans ; Anoikis/genetics ; Cell Line, Tumor ; Neoplasms/genetics
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2024.70.2.8
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  2. Artikel ; Online: Low illumination fog noise image denoising method based on ACE-GPM.

    Li, Wuyi / Zhou, Guanglu / Wang, Xingjian

    PloS one

    2024  Band 19, Heft 5, Seite(n) e0302492

    Abstract: The Perona-Malik (P-M) model exhibits deficiencies such as noise amplification, new noise introduction, and significant gradient effects when processing noisy images. To address these issues, this paper proposes an image-denoising algorithm, ACE-GPM, ... ...

    Abstract The Perona-Malik (P-M) model exhibits deficiencies such as noise amplification, new noise introduction, and significant gradient effects when processing noisy images. To address these issues, this paper proposes an image-denoising algorithm, ACE-GPM, which integrates an Automatic Color Equalization (ACE) algorithm with a gradient-adjusted P-M model. Initially, the ACE algorithm is employed to enhance the contrast of low-light images obscured by fog and noise. Subsequently, the Otsu method, a technique to find the optimal threshold based on between-class variance, is applied for precise segmentation, enabling more accurate identification of different regions within the image. After that, distinct gradients enhance the image's foreground and background via an enhancement function that accentuates edge and detailed information. The denoising process is finalized by applying the gradient P-M model, employing a gradient descent approach to further emphasize image edges and details. Experimental evidence indicates that the proposed ACE-GPM algorithm not only elevates image contrast and eliminates noise more effectively than other denoising methods but also preserves image details and texture information, evidenced by an average increase of 0.42 in the information entropy value. Moreover, the proposed solution achieves these outcomes with reduced computational resource expenditures while maintaining high image quality.
    Mesh-Begriff(e) Algorithms ; Signal-To-Noise Ratio ; Image Processing, Computer-Assisted/methods ; Lighting/methods ; Humans ; Color ; Image Enhancement/methods
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0302492
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  3. Artikel: Spatial distribution of Airbnb and its influencing factors: A case study of Suzhou, China

    Sun, Shijie / Wang, Xingjian / Hu, Mingxing

    Applied geography. 2022 Feb., v. 139

    2022  

    Abstract: The homestay model represented by Airbnb has developed rapidly in China over the last several years. By taking the city of Suzhou in China as a case study, this paper analyzes the distribution characteristics and impact factors of Airbnb in a typical ... ...

    Abstract The homestay model represented by Airbnb has developed rapidly in China over the last several years. By taking the city of Suzhou in China as a case study, this paper analyzes the distribution characteristics and impact factors of Airbnb in a typical historical and cultural tourism city and discusses the uniqueness of Suzhou. This paper identifies the explanatory variables of the spatial distribution of Airbnb through literature review and the analysis of local characteristics of Suzhou. The spatial Durbin model in the spatial econometric model was chosen to analyze the influencing factors of the spatial distribution of Airbnb in Suzhou. The results showed that the factors influencing the distribution of Airbnb in Suzhou include traditional folk dwellings, restaurants, shopping malls, and tourist attractions and also reveal the differences between the old city and the new city in influencing the spatial distribution of Airbnb. The study found that historical and cultural resources and local characteristics are the most important factors influencing the distribution of Airbnb in historic cities. Airbnb's rapid rise in urban historical districts may challenge the government by causing negative impacts on historic preservation, and the results of the study can help improve the management of B&B in cities.
    Schlagwörter case studies ; econometric models ; geography ; historic preservation ; hospitality industry ; tourism ; tourists ; China
    Sprache Englisch
    Erscheinungsverlauf 2022-02
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ISSN 0143-6228
    DOI 10.1016/j.apgeog.2022.102641
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Pandemic effect on corporate financial asset holdings: Precautionary or return-chasing?

    Gao, Haoyu / Wen, Huiyu / Wang, Xingjian

    Research in international business and finance

    2022  Band 62, Seite(n) 101750

    Abstract: This study empirically investigates whether and how the COVID-19 pandemic affects corporate financial asset holdings. We find that firms with higher pandemic exposure are less likely to hold financial assets. Mechanism analyses suggest that the return- ... ...

    Abstract This study empirically investigates whether and how the COVID-19 pandemic affects corporate financial asset holdings. We find that firms with higher pandemic exposure are less likely to hold financial assets. Mechanism analyses suggest that the return-chasing rationale dominates the precautionary motive concerning the pandemic effect on corporate financial asset holdings. Furthermore, firms prefer to liquidate highly liquid financial assets to fill the pandemic-induced liquidity shortage. This study contributes to the economic consequences of the COVID-19 pandemic regarding corporate portfolio choice, and sheds light on corporate resilience to crises.
    Sprache Englisch
    Erscheinungsdatum 2022-08-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1878-3384
    ISSN (online) 1878-3384
    DOI 10.1016/j.ribaf.2022.101750
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  5. Artikel ; Online: Increased carotid intima-media thickness is independently associated with the occurrence of depressive disorders in patients with obstructive sleep apnea without cardiocerebrovascular disease.

    Li, Xiaomeng / Wang, Xingjian / Li, Wenyang / Wang, Wei

    Journal of psychiatric research

    2022  Band 150, Seite(n) 122–129

    Abstract: Study objectives: This study aimed to explore the relationship between carotid intima-media thickness (cIMT) and depression in patients with obstructive sleep apnea (OSA) without cardiocerebrovascular diseases.: Methods: This study evaluated self- ... ...

    Abstract Study objectives: This study aimed to explore the relationship between carotid intima-media thickness (cIMT) and depression in patients with obstructive sleep apnea (OSA) without cardiocerebrovascular diseases.
    Methods: This study evaluated self-rating depression scale (SDS) scores, night sleep, and cIMT in 114 patients with OSA without cardiocerebrovascular diseases.
    Results: Among the 114 patients, 79.8% were male (mean age: 46.7 ± 11.58 years; range: 22-72 years). Moreover, 46.5%, 44.7%, and 7.89% of the patients presented with depressive disorders (8, 24, and 21 with severe, moderate, and mild degrees of depression, respectively), cIMT increase, and carotid plaques, respectively. Logistic regression with adjustment for age, sex, and other confounding factors revealed that, compared with patients with OSA without depressive disorders, those with depressive disorders had higher cIMT (odds ratio [OR] = 1.839; 95% confidence interval [CI]: 1.210-2.795), D-value (the difference between nocturnal mean blood oxygen saturation and the lowest blood oxygen saturation; OR = 1.434; 95% CI: 1.259-1.633]), and time spent at O
    Conclusions: cIMT and D-value are independently associated with depression in patients with OSA, which provides clinical evidence regarding the involvement of vascular damage in OSA-induced depression.
    Mesh-Begriff(e) Adult ; Carotid Intima-Media Thickness ; Depressive Disorder/complications ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Sleep Apnea, Obstructive/complications
    Sprache Englisch
    Erscheinungsdatum 2022-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2022.03.043
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Accuracy of portable spirometers in the diagnosis of chronic obstructive pulmonary disease A meta-analysis.

    Zhou, Jiawei / Li, Xiaomeng / Wang, Xingjian / Yu, Na / Wang, Wei

    NPJ primary care respiratory medicine

    2022  Band 32, Heft 1, Seite(n) 15

    Abstract: Portable spirometers has been approved for diagnosing chronic obstructive pulmonary disease (COPD). However, their diagnostic accuracy has not been reviewed. Therefore, the purpose of this study was to systematically evaluate the diagnostic value of ... ...

    Abstract Portable spirometers has been approved for diagnosing chronic obstructive pulmonary disease (COPD). However, their diagnostic accuracy has not been reviewed. Therefore, the purpose of this study was to systematically evaluate the diagnostic value of portable spirometers in detecting COPD. A comprehensive literature search for relevant studies was conducted in PubMed, Embase, CNKI, Wan Fang, and Web of Science databases. Pooled sensitivity, specificity, summary receiver operating characteristic (SROC), area under the curve (AUC), and other related indices were calculated using the bivariate mixed-effect model. Subgroup analysis was performed to explore the source of heterogeneity. Thirty one studies were included in the meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic ratio (DOR), SROC, and AUC of the SROC of portable spirometers were 0.85 (0.81-0.88), 0.85 (0.81-0.88), 5.6 (4.4-7.3), 0.18 (0.15-0.22), 31 (21-46) and 0.91 (0.89-0.94), respectively. Among the three commonly used types of portable spirometers, the accuracy of PIKO-6 was higher (0.95) than that of COPD-6 (0.91) and PEF (0.82). Subgroup analysis indicated that the accuracy of a multi-indices portable spirometer was higher than that of a single-index one (P < 0.05). In addition, portable spirometry performed by professional technicians in tertiary hospitals was more accurate than for those conducted by trained technicians in primary care facilities and communities (P < 0.05). Moreover, the accuracy of studies conducted in developing country was superior to developed country (P < 0.05). Portable spirometers have high accuracy in the diagnosis of COPD. Multi-index COPD-6 and PIKO-6 displayed higher accuracy than others. Standardized training of instrument operators should be considered to achieve reliable results.
    Mesh-Begriff(e) Area Under Curve ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; ROC Curve ; Sensitivity and Specificity ; Spirometry
    Sprache Englisch
    Erscheinungsdatum 2022-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2780812-9
    ISSN 2055-1010 ; 2055-1010
    ISSN (online) 2055-1010
    ISSN 2055-1010
    DOI 10.1038/s41533-022-00275-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Phase Transformation Behavior of the Aluminosilicate Phase During High-Pressure Hydrothermal Reduction of High-Iron Red Mud.

    Wang, Xingjian / Wang, Yiyong / Jin, Hui / Li, Jidong / Wang, Xiaomin

    Bulletin of environmental contamination and toxicology

    2022  Band 109, Heft 1, Seite(n) 186–193

    Abstract: One-step separation and recovery of sodium, aluminum and iron in high-iron red mud in a high-calcium alkaline hydrothermal system is realized by a high-pressure hydrothermal reduction process. The transformation behavior of the aluminasilica phase in ... ...

    Abstract One-step separation and recovery of sodium, aluminum and iron in high-iron red mud in a high-calcium alkaline hydrothermal system is realized by a high-pressure hydrothermal reduction process. The transformation behavior of the aluminasilica phase in high-iron red mud is mainly investigated. The results show that under the optimized conditions, a temperature of 290℃, a Na
    Sprache Englisch
    Erscheinungsdatum 2022-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 6895-0
    ISSN 1432-0800 ; 0007-4861
    ISSN (online) 1432-0800
    ISSN 0007-4861
    DOI 10.1007/s00128-022-03492-9
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  8. Artikel ; Online: Ca

    Wang, Xingjian / Zheng, Wei

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2019  Band 33, Heft 6, Seite(n) 6697–6712

    Abstract: Emerging evidence indicates that ... ...

    Abstract Emerging evidence indicates that Ca
    Mesh-Begriff(e) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Calcium/metabolism ; Calcium Signaling ; Cell Membrane/metabolism ; Homeostasis ; Humans ; Organelles/metabolism
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2019-03-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201801751R
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The Impact of COVID-19 on Cancer.

    Li, Yue / Wang, Xingjian / Wang, Wei

    Infection and drug resistance

    2021  Band 14, Seite(n) 3809–3816

    Abstract: Since late December 2019, the 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid international spread have posed a global health threat. The World Health Organization has declared the ... ...

    Abstract Since late December 2019, the 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid international spread have posed a global health threat. The World Health Organization has declared the outbreak of COVID-19 as "public health emergency of international concern". COVID-19 not only brings tremendous pressure to the medical system but also brings new challenges to the global economy. The occurrence and development of cancer has always been an area of active research, and COVID-19 also has a long-lasting impact on the diagnosis, treatment, and research of cancer. In the context, we review the adverse effects of COVID-19 on the screening, diagnosis, treatment and prognosis of cancer patients and the countermeasures in this situation, and provide solutions for improving the quality of life of cancer patients in the normalized prevention and control of COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2021-09-17
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S324569
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Malnutrition and Venous Thromboembolism are Specific Issues in Elderly Patients with Coronavirus Disease 2019.

    Qin, Zheng / Wang, Xingjian / Wang, Wei

    Journal of translational internal medicine

    2021  Band 9, Heft 3, Seite(n) 223–224

    Sprache Englisch
    Erscheinungsdatum 2021-09-28
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2861892-0
    ISSN 2224-4018 ; 2450-131X
    ISSN (online) 2224-4018
    ISSN 2450-131X
    DOI 10.2478/jtim-2021-0027
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