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  1. Artikel ; Online: Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold

    Nur Adila Mohd Razali / Wei-Chih Lin

    Materials Today Bio, Vol 16, Iss , Pp 100347- (2022)

    2022  

    Abstract: Ideal artificial tissue scaffolds should provide an in vitro microenvironment comparable to native human skin tissue to direct cell functions, regulate tissue homeostasis, and promote tissue regeneration. A sandwich-like composite scaffold consisting of ... ...

    Abstract Ideal artificial tissue scaffolds should provide an in vitro microenvironment comparable to native human skin tissue to direct cell functions, regulate tissue homeostasis, and promote tissue regeneration. A sandwich-like composite scaffold consisting of a hydrogel layer and two aligned nanofibre layers was fabricated and applied as a wound-healing dressing. Gentamicin was preloaded into the hydrogel middle layer and naturally released for antibacterial activity during the healing period. Nanofibrous layers embedded on the top and bottom surfaces of the hydrogel improved the tensile strength fivefold (1560 kPa and 465% strain) while serving as a diffusion barrier to reduce the gentamicin initial burst release (30%–15%). Inspired by the extracellular matrix (ECM), the surface of nanofibre top layer was patterned with triangular microarrays using micro-moulding approach to reflect the multidimensional structure of ECM. Biocompatibility of the scaffold is proven from cytotoxicity and haemolysis studies. Fibroblast cells revealed a highly elongated and consistent alignment modulated by the micropatterned fibrous layer and directed their migration towards the wound area. Excisional wounds treated with the scaffold promoted 97.49% wound closure with low inflammation and rapid re-epithelialization and angiogenesis. This scaffold, with its tailored functionality capable of accelerating wound healing, has high potential in tissue engineering applications.
    Schlagwörter Micropattern nanofibre ; Topographical effect ; Nanofibre/hydrogel scaffold ; Tissue regeneration ; Wound healing ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Drivers of coastal benthic communities in a complex environmental setting.

    Lin, Yuting Vicky / Château, Pierre-Alexandre / Nozawa, Yoko / Wei, Chih-Lin / Wunderlich, Rainer Ferdinand / Denis, Vianney

    Marine pollution bulletin

    2024  Band 203, Seite(n) 116462

    Abstract: Analyzing the environmental factors affecting benthic communities in coastal areas is crucial for uncovering key factors that require conservation action. Here, we collected benthic and environmental (physical-chemical-historical and land-based) data for ...

    Abstract Analyzing the environmental factors affecting benthic communities in coastal areas is crucial for uncovering key factors that require conservation action. Here, we collected benthic and environmental (physical-chemical-historical and land-based) data for 433 transects in Taiwan. Using a k-means approach, five communities dominated by crustose coralline algae, turfs, stony corals, digitate, or bushy octocorals were first delineated. Conditional random forest models then identified physical, chemical, and land-based factors (e.g., light intensity, nitrite, and population density) relevant to community delineation and occurrence. Historical factors, including typhoons and temperature anomalies, had only little effect. The prevalent turf community correlated positively with chemical and land-based drivers, which suggests that anthropogenic impacts are causing a benthic homogenization. This mechanism may mask the effects of climate disturbances and regional differentiation of benthic assemblages. Consequently, management of nutrient enrichment and terrestrial runoff is urgently needed to improve community resilience in Taiwan amidst increasing challenges of climate change.
    Mesh-Begriff(e) Taiwan ; Animals ; Anthozoa ; Environmental Monitoring ; Climate Change ; Ecosystem ; Biodiversity
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2024.116462
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  3. Artikel ; Online: Ocean temperature drove changes in the mesopelagic fish community at the edge of the Pacific Warm Pool over the past 460,000 years.

    Lin, Chien-Hsiang / Wei, Chih-Lin / Ho, Sze Ling / Lo, Li

    Science advances

    2023  Band 9, Heft 27, Seite(n) eadf0656

    Abstract: Field observations and theoretical modeling suggest that ongoing anthropogenic ocean warming will lead to marine ecosystem degradation. Mesopelagic fish are a fundamental component of the pelagic ecosystem, and their role in linking the surface- and deep- ...

    Abstract Field observations and theoretical modeling suggest that ongoing anthropogenic ocean warming will lead to marine ecosystem degradation. Mesopelagic fish are a fundamental component of the pelagic ecosystem, and their role in linking the surface- and deep-ocean ecosystems is essential for the biological carbon pump. However, their response to a warmer ocean is unconstrained because of data scarcity. Using extraordinarily well-preserved fish otoliths, we reconstruct a continuous mesopelagic fish community record in the Pacific Warm Pool region over 460,000 years. Fish production and diversity followed hump-shaped temperature gradients, with lower tipping point temperatures for the diversity than the production by ~1.5° to 2.0°C. During warmer-than-present interglacial periods, both production and diversity declined drastically. Our findings imply that the temperature-sensitive mesopelagic fish community at the southwestern margin of the Pacific Warm Pool, and possibly other hydrographically similar regions, may be especially affected if ocean warming continues unabated in the future.
    Mesh-Begriff(e) Animals ; Ecosystem ; Temperature ; Fishes ; Oceans and Seas ; Pacific Ocean
    Sprache Englisch
    Erscheinungsdatum 2023-07-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf0656
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Three new species of Paratanaoidea (Crustacea, Tanaidacea) from the South China Sea.

    Tzeng, You-Wei / Wei, Chih-Lin / Ma, Lin / Li, Xinzheng

    Zootaxa

    2023  Band 5375, Heft 1, Seite(n) 1–30

    Abstract: Three new crustacean species of the order Tanaidacea are described from the South China Sea. Alloleptochelia falciformes sp. nov. (Family Leptocheliidae) can be distinguished from the most similar species, A. evansi (Edgar, 2012), by the much stouter ... ...

    Abstract Three new crustacean species of the order Tanaidacea are described from the South China Sea. Alloleptochelia falciformes sp. nov. (Family Leptocheliidae) can be distinguished from the most similar species, A. evansi (Edgar, 2012), by the much stouter body, and fewer articles on the antennule flagellum and relatively longer pereopods 46 dactylus of the male. Kalloleptochelia multiarticulata sp. nov. (Family Leptocheliidae) can be easily differentiated from its congeners by the male having significantly more antennule flagellum articles, a two-articled uropod exopod, one additional dorsal seta on the pereopods 23 merus, and one additional spiniform seta on the pereopod-6 carpus. Paranesotanais incisus sp. nov. (Family Nototanaidae) differs from its only congener, P. longicephalus Larsen & Shimomura, 2008, by the female having one robust inner seta on the palm of the cheliped propodus, and the male having one long and conspicuous notch extending from the outer surface to the ventrodistal corner on the cheliped carpus. Morphological keys and comparison tables of all known species of the genera Alloleptochelia and Kalloleptochelia, as well as a key of the genus Paranesotanais, are provided.
    Mesh-Begriff(e) Female ; Male ; Animals ; Crustacea ; China ; Coleoptera
    Sprache Englisch
    Erscheinungsdatum 2023-11-21
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5375.1.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The Laetiporus sulphureus Fermented Product Enhances the Antioxidant Status, Intestinal Tight Junction, and Morphology of Broiler Chickens

    Wei Chih Lin / Tzu Tai Lee

    Animals, Vol 11, Iss 1, p

    2021  Band 149

    Abstract: The Laetiporus sp. is a fungal species that is traditionally used for medicinal purposes. This study investigated the effects of the Laetiporus sulphureus fermented product (FL) as a feed supplementation on the antioxidant activities, the intestinal ... ...

    Abstract The Laetiporus sp. is a fungal species that is traditionally used for medicinal purposes. This study investigated the effects of the Laetiporus sulphureus fermented product (FL) as a feed supplementation on the antioxidant activities, the intestinal Tight Junction (TJ) mRNA expression, and the intestinal morphology of broiler chickens. Four-hundred one-day-old male broilers (Ross 308) were randomly allocated to five experimental diets: (1) a corn-soybean meal basal diet (control), (2) a basal diet replaced with 5% Wheat Bran (5% WB), (3) a basal diet replaced with 10% WB (10% WB), (4) a basal diet replaced with 5% FL (5% FL), and (5) a basal diet replaced with 10% FL (10% FL). The FL-supplemented groups exhibited a better feed conversion ratio in the overall experimental period compared to the WB and control groups. The serum antioxidant profiles of 35-day-old broilers showed that, compared to the control and 10% WB groups, the 5% FL supplementation group had a significantly increased superoxide dismutase activity, while it down-regulated the concentration of malondialdehyde in the serum ( p < 0.05). The assessment of selected antioxidant gene expression showed that the 5% FL group significantly elevated heme oxygenase-1 and nuclear factor erythroid 2–related factor 2 expression, compared to the control and WB groups ( p < 0.05). Furthermore, both of the FL supplemented groups had a significantly higher expression of glutathione peroxidase and catalase, compared to that of the WB and control groups in the jejunum ( p < 0.05). The TJ mRNA expression in the jejunum showed that 5% FL significantly elevated the zonula occludens-1, claudin-1, and mucin-2 expression ( p < 0.05), while 5% and 10% FL supplementation significantly improved OCLN expression in both the jejunum and ileum, compared to control group ( p < 0.05). The intestinal morphology of 35-day-old broilers showed that a 5% FL supplementation significantly increased the villus height in the ileum and jejunum, compared to the WB and control ...
    Schlagwörter Laetiporus sulphureus ; broiler chickens ; antioxidant ; tight junction ; intestinal morphology ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Effects of Laetiporus sulphureus -Fermented Wheat Bran on Growth Performance, Intestinal Microbiota and Digesta Characteristics in Broiler Chickens

    Wei Chih Lin / Tzu Tai Lee

    Animals, Vol 10, Iss 1457, p

    2020  Band 1457

    Abstract: This study investigated the effects of a Laetiporus sulphureus -fermented wheat bran (LS) supplementation on the microbiota and digesta characteristics of broiler chickens. Two hundred and forty male broilers (Ross 308) were randomly allocated into three ...

    Abstract This study investigated the effects of a Laetiporus sulphureus -fermented wheat bran (LS) supplementation on the microbiota and digesta characteristics of broiler chickens. Two hundred and forty male broilers (Ross 308) were randomly allocated into three groups fed with a corn–soybean-based diet (control), and the control diet being replaced with 5% wheat bran (WB) and 5% LS, respectively. Each group had four replicates and 20 birds per pen. Metagenomics analysis results of the ileum microbiota showed that, at the family level, the 5% LS groups had over 40% higher Lactobacillaceae compared to the control group in a mean difference comparison. Heat maps showed that, at the phylum level, the population of Firmicutes was higher and Proteobacteria was lower in the ileum of 5% LS compared to the control group. Results of the stack column plots of the top ten OTUs at the family level showed that a 5% LS and 5% WB supplementation altered the broiler microbiota distribution by increasing the relative abundance of Lactobacillaceae. Cecal microbiota analysis showed that the 5% LS-supplemented group had approximately 5% and 3% higher Veillonellaceae and Lactobacillaceae, respectively. Stack column plots of the top ten OTUs indicated that the distribution of cecal bacteria in each group was not markedly different. Both the ileum and cecum digesta in the 5% LS supplementation group had a slight and not significant elevation on the total VFA, while the pH values and ammonia nitrogen were significantly lowered compared to the control and 5% WB groups ( p < 0.05). In addition, the 5% LS supplementation group had a significantly higher lactic acid concentration in both the ileum and cecum compared to the control and 5% WB groups ( p < 0.05). In conclusion, a 5% LS supplementation could potentially enhance the feed conversion ratio and European Broiler Index (EBI) of broilers by elevating the family Lactobacillaceae and suppressing the phylum Proteobacteria’s population, thus creating changed intestinal environments that ...
    Schlagwörter Laetiporus sulphureus ; intestinal microbiota ; metagenomics ; broilers ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Evaluation of a Passive Upper-Limb Exoskeleton Applied to Assist Farming Activities in Fruit Orchards

    Hsien-Min Wang / Dang Khanh Linh Le / Wei-Chih Lin

    Applied Sciences, Vol 11, Iss 2, p

    2021  Band 757

    Abstract: Work-related musculoskeletal disorder (WMSD) is a common occupational injury. Among the occupational injuries of agricultural workers, 93% are related to WMSD, with the shoulder being the second most affected area. This paper presents a passive upper- ... ...

    Abstract Work-related musculoskeletal disorder (WMSD) is a common occupational injury. Among the occupational injuries of agricultural workers, 93% are related to WMSD, with the shoulder being the second most affected area. This paper presents a passive upper-limb exoskeleton (PULE) with a gas spring and four-bar mechanism developed to aid the daily activities associated with orchard farming. The PULE is used to assist the arm-lifting process, reducing the physical exertion of farmers and the risk of developing WMSD. Electromyography (EMG) measurements of 26 participants were obtained to evaluate the difference in physical exertion with and without the PULE. Two arm activities: fruit thinning, with the arms raised and maintained at 100°, and pesticide spraying, with the hands swinging from 0° to 100° and back, were simulated. Using the PULE decreased muscle tension of the anterior deltoid (AD) by 17.64–19.86%. The PULE also decreased the AD activity by 37.67–39.57% during the actual orchard farming operations. The Qualisys motion capture system indicated that the difference in the lifting angle of the upper limb with and without the PULE was less than 1° and not significant (α > 0.05). Thus, the PULE did not affect the flexibility of the wearer in orchard farming activities.
    Schlagwörter work-related musculoskeletal disorders ; upper-limb exoskeleton ; four-bar mechanism ; electromyography ; muscle tension ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Vulnerability of exploited deep-sea demersal species to ocean warming, deoxygenation, and acidification

    Cheung, William W. L. / Wei, Chih-Lin / Levin, Lisa A.

    Environ Biol Fish. 2022 Oct., v. 105, no. 10 p.1301-1315

    2022  

    Abstract: Vulnerability of marine species to climate change (including ocean acidification, deoxygenation, and associated changes in food supply) depends on species’ ecological and biological characteristics. Most existing assessments focus on coastal species but ... ...

    Abstract Vulnerability of marine species to climate change (including ocean acidification, deoxygenation, and associated changes in food supply) depends on species’ ecological and biological characteristics. Most existing assessments focus on coastal species but systematic analysis of climate vulnerability for the deep sea is lacking. Here, we combine a fuzzy logic expert system with species biogeographical data to assess the risks of climate impacts to the population viability of 32 species of exploited demersal deep-sea species across the global ocean. Climatic hazards are projected to emerge from historical variabilities in all the recorded habitats of the studied species by the mid-twenty-first century. Species that are both at very high risk of climate impacts and highly vulnerable to fishing include Antarctic toothfish (Dissostichus mawsoni), rose fish (Sebastes norvegicus), roughhead grenadier (Macrourus berglax), Baird’s slickhead (Alepocephalus bairdii), cusk (Brosme brosme), and Portuguese dogfish (Centroscymnus coelepis). Most exploited deep-sea fishes are likely to be at higher risk of local, or even global, extinction than previously assessed because of their high vulnerability to both climate change and fishing. Spatially, a high concentration of deep-sea species that are climate vulnerable is predicted in the northern Atlantic Ocean and the Indo-Pacific region. Aligning carbon mitigation with improved fisheries management offers opportunities for overall risk reduction in the coming decades. Regional fisheries management organizations (RFMOs) have an obligation to incorporate climate change in their deliberations. In addition, deep-sea areas that are not currently managed by RFMOs should be included in existing or new international governance institutions or arrangements.
    Schlagwörter Alepocephalus ; Brosme brosme ; Centroscymnus ; Dissostichus mawsoni ; Sebastes ; acidification ; carbon ; climate ; climate change ; extinction ; fish ; food availability ; fuzzy logic ; geographical distribution ; governance ; ocean acidification ; oceans ; population viability ; risk ; risk reduction ; Atlantic Ocean
    Sprache Englisch
    Erscheinungsverlauf 2022-10
    Umfang p. 1301-1315.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel ; Online
    ZDB-ID 196790-3
    ISSN 1573-5133 ; 0378-1909
    ISSN (online) 1573-5133
    ISSN 0378-1909
    DOI 10.1007/s10641-022-01321-w
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Micropatterned Fibrous Scaffold Produced by Using Template-Assisted Electrospinning Technique for Wound Healing Application

    Norul Ashikin Norzain / Zhi-Wei Yu / Wei-Chih Lin / Hsing-Hao Su

    Polymers, Vol 13, Iss 2821, p

    2021  Band 2821

    Abstract: This paper describes the fabrication of a structural scaffold consisting of both randomly oriented nanofibers and triangular prism patterns on the scaffold surface using a combination technique of electrospinning and collector templates. The ... ...

    Abstract This paper describes the fabrication of a structural scaffold consisting of both randomly oriented nanofibers and triangular prism patterns on the scaffold surface using a combination technique of electrospinning and collector templates. The polycaprolactone (PCL) nanofibers were electrospun over a triangular prism pattern mold, which acted as a template. The deposited scaffold was removed from the template to produce a standalone structural scaffold of three-dimensional micropatterned nanofibers. The fabricated structural scaffold was compared with flat randomly oriented nanofibers based on in vitro and in vivo studies. The in vitro study indicated that the structural scaffold demonstrated higher fibroblast cell proliferation, cell elongation with a 13.48 ± 2.73 aspect ratio and 70% fibroblast cell orientation compared with flat random nanofibers. Among the treatment groups, the structural scaffold escalated the wound closure to 92.17% on day 14. Histological staining of the healed wound area demonstrated that the structural scaffold exhibited advanced epithelization of the epidermal layer accompanied by mild inflammation. The proliferated fibroblast cells and collagen fibers in the structural scaffold appeared denser and arranged more horizontally. These results determined the potential of micropatterned scaffolds for stimulating cell behavior and their application for wound healing.
    Schlagwörter electrospinning ; template-assisted ; patterned nanofibers ; tissue engineering ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Development and Characterisation of the Imiquimod Poly(2-(2-methoxyethoxy)ethyl Methacrylate) Hydrogel Dressing for Keloid Therapy

    Wei-Chih Lin / Sin-Han Liou / Yohei Kotsuchibashi

    Polymers, Vol 9, Iss 11, p

    2017  Band 579

    Abstract: The imiquimod-poly(2-(2-methoxyethoxy)ethyl methacrylate) hydrogel (poly(MEO2MA) hydrogel) dressing was developed for the keloid therapy application. Four groups of the hydrogels, including the imiquimod-poly(MEO2MA) hydrogel, crosslinked with 0.2 mol %, ...

    Abstract The imiquimod-poly(2-(2-methoxyethoxy)ethyl methacrylate) hydrogel (poly(MEO2MA) hydrogel) dressing was developed for the keloid therapy application. Four groups of the hydrogels, including the imiquimod-poly(MEO2MA) hydrogel, crosslinked with 0.2 mol %, 0.4 mol %, 0.6 mol %, and 0.8 mol % of di(ethylene glycol) dimethacrylate cross-linker (DEGDMA), were synthesised and characterised for fabricating the imiquimod-poly(MEO2MA) hydrogel pad. The lower critical solution temperature (LCST) of the poly(MEO2MA) hydrogel was measured at approximately 28 °C and was used as a trigger to control the imiquimod loading and release. The loaded amounts of the imiquimod in the poly(MEO2MA) hydrogel, crosslinked with 0.2 mol % and 0.8 mol % of DEGDMA, were about 27.4 μg and 14.1 μg per 1 mm3 of the hydrogel, respectively. The imiquimod-release profiles of two samples were characterised in a phosphate buffered saline (PBS) solution at 37 °C and the released imiquimod amount were about 45% and 46% of the total loaded imiquimod. The Cell Counting Kit-8 (CCK-8) assay was utilised to analyse the cell viability of keloid fibroblasts cultured on the samples of imiquimod-poly(MEO2MA) hydrogel, crosslinked with 0.2 mol % and 0.8 mol % of DEGDMA. There was around a 34% decrease of the cell viabilities after 2 days, compared with the pure-poly(MEO2MA) hydrogel samples. Therefore, the developed imiquimod-poly(MEO2MA) hydrogel dressing can affect the proliferation of keloid fibroblasts. It should be possible to utilise the hydrogel dressing for the keloid therapy application.
    Schlagwörter MEO2MA ; imiquimod ; keloid fibroblast ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2017-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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