Artikel: Human muscle in gene edited pigs for treatment of volumetric muscle loss.
2022 Band 13, Seite(n) 948496
Abstract: Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment ... ...
Abstract | Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field. |
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Sprache | Englisch |
Erscheinungsdatum | 2022-07-25 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 2606823-0 |
ISSN | 1664-8021 |
ISSN | 1664-8021 |
DOI | 10.3389/fgene.2022.948496 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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