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  1. Artikel ; Online: Racial/ ethnic disparities in availability of volunteer unrelated donors for allogeneic transplantation.

    Fingrut, Warren B / Davis, Eric / Archer, Anne / Brown, Samantha / Devlin, Sean M / Nhaissi, Melissa / Rapoport, Candice / Chinapen, Stephanie / Kelly, Amanda / Wells, Deborah S / Scaradavou, Andromachi / Gyurkocza, Boglarka / Papadopoulos, Esperanza B / Politikos, Ioannis / Shaffer, Brian C / Barker, Juliet

    Blood advances

    2024  

    Abstract: Despite the global unrelated donor (URD) registry size, the degree to which URD availability is a transplant barrier is not established. We evaluated the availability of 3,843 URDs requested for 455 diverse adult patients (predominantly with acute ... ...

    Abstract Despite the global unrelated donor (URD) registry size, the degree to which URD availability is a transplant barrier is not established. We evaluated the availability of 3,843 URDs requested for 455 diverse adult patients (predominantly with acute leukemia). URDs for non-Europeans were more likely to be domestic and had markedly lower Donor Readiness Scores. Of URDs requested for confirmatory HLA-typing (CT) alone (i.e. without simultaneous workup), 1,894/3,529 (54%) were available. Availability of domestic URDs was 45%. Donor Readiness Score was highly predictive of CT availability. Compared with Europeans (n=335), more non-European patients (n=120) had >10 URDs requested and <5 available. Of workup requests (after CT or CT-workup), <70% (604/889, 68%) were available. More non-Europeans had <2 URDs available. URD availability for CT was markedly worse for non-Europeans, with availabilities for African, non-Black Hispanic, and Asian patients of 150/458 (33%), 120/258 (47%) and 119/270 (44%), respectively, with further decrements in URD workup availability. Our data suggest the functional size of the URD pool is much smaller than appreciated, mandating major operational changes for transplant Centers and donor registries. Likelihood of donor availability should have a high priority in donor selection. Considering patient ancestry and URD Donor Readiness Scores, Centers should pursue, and registries permit, simultaneous pursuit of many URDs, and abandon futile searches. Patients should be informed about their likelihood of donor availability and alternative options. Finally, while registries should address high URD attrition and speed procurement, use of all HLA-disparate graft types is needed to facilitate timely transplantation for all.
    Sprache Englisch
    Erscheinungsdatum 2024-03-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023012385
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Prospective Evaluation of Unrelated Donor Cord Blood and Haploidentical Donor Access Reveals Graft Availability Varies by Patient Ancestry: Practical Implications for Donor Selection.

    Kosuri, Satyajit / Wolff, Tara / Devlin, Sean M / Byam, Courtney / Mazis, Christopher M / Naputo, Kristine / Davis, Eric / Paulson, Jennifer / Nhaissi, Melissa / Wells, Deborah S / Dahi, Parastoo / Giralt, Sergio A / Jakubowski, Ann / Perales, Miguel-Angel / Shaffer, Brian C / Scaradavou, Andromachi / Ponce, Doris M / Barker, Juliet N

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2017  Band 23, Heft 6, Seite(n) 965–970

    Abstract: The availability of cord blood (CB) and haploidentical (haplo) donors in all patient populations is not established. We have investigated the addition of haplo- ... ...

    Abstract The availability of cord blood (CB) and haploidentical (haplo) donors in all patient populations is not established. We have investigated the addition of haplo-CD34
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Cord Blood Stem Cell Transplantation/ethnology ; Cord Blood Stem Cell Transplantation/methods ; Donor Selection/methods ; Hematologic Neoplasms/therapy ; Histocompatibility ; Humans ; Middle Aged ; Prospective Studies ; Racial Groups ; Transplantation, Haploidentical/methods ; Unrelated Donors/supply & distribution ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2017-03-02
    Erscheinungsland United States
    Dokumenttyp Clinical Trial ; Journal Article
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2017.03.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities.

    Barker, Juliet N / Byam, Courtney E / Kernan, Nancy A / Lee, Sinda S / Hawke, Rebecca M / Doshi, Kathleen A / Wells, Deborah S / Heller, Glenn / Papadopoulos, Esperanza B / Scaradavou, Andromachi / Young, James W / van den Brink, Marcel R M

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2010  Band 16, Heft 11, Seite(n) 1541–1548

    Abstract: Allogeneic transplant access can be severely limited for patients of racial and ethnic minorities without suitable sibling donors. Whether cord blood (CB) transplantation can extend transplant access because of the reduced stringency of required HLA- ... ...

    Abstract Allogeneic transplant access can be severely limited for patients of racial and ethnic minorities without suitable sibling donors. Whether cord blood (CB) transplantation can extend transplant access because of the reduced stringency of required HLA-match is not proven. We prospectively evaluated availability of unrelated donors (URD) and CB according to patient ancestry in 553 patients without suitable sibling donors. URDs had priority if adequate donors were available. Otherwise ≥4/6 HLA-matched CB grafts were chosen utilizing double units to augment graft dose. Patients had highly diverse ancestries including 35% non-Europeans. In 525 patients undergoing combined searches, 10/10 HLA-matched URDs were identified in 53% of those with European ancestry, but only 21% of patients with non-European origins (P < .001). However, the majority of both groups had 5-6/6 CB units. The 269 URD transplant recipients were predominantly European, with non-European patients accounting for only 23%. By contrast, 56% of CB transplant recipients had non-European ancestries (P < .001). Of 26 patients without any suitable stem cell source, 73% had non-European ancestries (P < .001). Their median weight was significantly higher than CB transplant recipients (P <.001), partially accounting for their lack of a CB graft. Availability of CB significantly extends allo-transplant access, especially in non-European patients, and has the greatest potential to provide a suitable stem cell source regardless of race or ethnicity. Minority patients in need of allografts, but without suitable matched sibling donors, should be referred for combined URD and CB searches to optimize transplant access.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Bone Marrow Cells/cytology ; Cell Count ; Child ; Child, Preschool ; Continental Population Groups/statistics & numerical data ; Cord Blood Stem Cell Transplantation/statistics & numerical data ; Demography ; Ethnic Groups/statistics & numerical data ; Fetal Blood/cytology ; Health Services Accessibility/statistics & numerical data ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation/statistics & numerical data ; Hematopoietic Stem Cells/cytology ; Histocompatibility ; Histocompatibility Testing ; Humans ; Infant ; Living Donors/statistics & numerical data ; Middle Aged ; Minority Groups/statistics & numerical data ; New York City ; Transplantation, Homologous/statistics & numerical data ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2010-08-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2010.08.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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    Zs.MO 462: Hefte anzeigen

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