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  1. Artikel ; Online: Characterisation of strength and deformation characteristics of alkali-activated rice husk ash filler-assemblage perimeter rock

    Wenhua Zhao / Ruilin He / Qi Sun / Qi Gu

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 13

    Abstract: Abstract In this study, the strength characteristics, deformation characteristics and damage characteristics of three kinds of specimens, namely, surrounding rock, cemented paste backfill (CPB) and a surrounding rock-CPB combination, were studied by ... ...

    Abstract Abstract In this study, the strength characteristics, deformation characteristics and damage characteristics of three kinds of specimens, namely, surrounding rock, cemented paste backfill (CPB) and a surrounding rock-CPB combination, were studied by uniaxial compression testing using rice husk ash and slag as cementing materials, and the mechanical properties of the combination specimens with different height ratios were also analyzed. The results showed that the surrounding rock specimens were the strongest, followed by the composite body, and the CPB was the weakest. The relationship between different height ratios of the assemblage and the cut line modulus was found according to the fitted curves. The CPB specimens and the surrounding rock specimens showed ductile damage, while the assemblage specimens showed brittle damage.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Sodium-ion diffusion coefficients in tin phosphide determined with advanced electrochemical techniques

    Jun Wang / Emmanuel Pameté / Shengli Yan / Wenhua Zhao / Jianhui Zhang / Xiaotong He / Zhazira Supiyeva / Qamar Abbas / Xuexue Pan

    Electrochemistry Communications, Vol 150, Iss , Pp 107488- (2023)

    2023  

    Abstract: Sodium ion insertion plays a critical role in developing robust sodium-ion technologies (batteries and hybrid supercapacitors). Diffusion coefficient values of sodium (DNa+) in tin phosphide between 0.1 V and 2.0 V vs. Na/Na+ are systematically ... ...

    Abstract Sodium ion insertion plays a critical role in developing robust sodium-ion technologies (batteries and hybrid supercapacitors). Diffusion coefficient values of sodium (DNa+) in tin phosphide between 0.1 V and 2.0 V vs. Na/Na+ are systematically determined by galvanostatic intermittent titration technique (GITT), electrochemical impedance spectroscopy (EIS), and potentiostatic intermittent titration technique (PITT). These values range between 4.55 × 10−12 cm2 s−1 and 1.94 × 10−8 cm2 s−1 and depend on the insertion/de-insertion current and the thickness of the electrode materials. Additionally, DNa+ values differ between the first and second cation insertion because of the solid electrolyte interface (SEI) formation. DNa+ vs. insertion potential alters non-linearly in a “W” form due to the strong interactions of Na+ with tin phosphide particles. The results reveal that GITT is a more appropriate electrochemical technique than PITT and EIS for evaluating DNa+ in tin phosphide.
    Schlagwörter Tin phosphide ; Na+ diffusion coefficients ; Galvanostatic/potentiostatic intermittent titration technique ; Electrochemical impedance spectroscopy ; Industrial electrochemistry ; TP250-261 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: (1982-2015).

    Dongmei, Yu / Liyun, Zhao / Wenhua, Zhao

    Nutrition reviews

    2020  Band 78, Heft Suppl 1, Seite(n) 41–50

    Abstract: 1982-2015 20 、。 ，3 24 。，2015 20 281.1 /(145.6 /、120.7 /、14.8 /)；9.7 /，3.8 ，40%； 。1982 ， ，。 ， 。. ...

    Abstract 1982-2015 20 、。 ，3 24 。，2015 20 281.1 /(145.6 /、120.7 /、14.8 /)；9.7 /，3.8 ，40%； 。1982 ， ，。 ， 。.
    Sprache Englisch
    Erscheinungsdatum 2020-04-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 82067-2
    ISSN 1753-4887 ; 0029-6643
    ISSN (online) 1753-4887
    ISSN 0029-6643
    DOI 10.1093/nutrit/nuaa056
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Elementary screening of lymph node metastatic-related genes in gastric cancer based on the co-expression network of messenger RNA, microRNA and long non-coding RNA

    Zhonghua Song / Wenhua Zhao / Danfeng Cao / Jinqing Zhang / Shouhua Chen

    Brazilian Journal of Medical and Biological Research, Vol 51, Iss

    2018  Band 4

    Abstract: Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. The high mortality might be attributed to delay in detection and is closely related to lymph node metastasis. Therefore, it is of great ... ...

    Abstract Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. The high mortality might be attributed to delay in detection and is closely related to lymph node metastasis. Therefore, it is of great importance to explore the mechanism of lymph node metastasis and find strategies to block GC metastasis. Messenger RNA (mRNA), microRNA (miRNA) and long non-coding RNA (lncRNA) expression data and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. A total of 908 differentially expressed factors with variance >0.5 including 542 genes, 42 miRNA, and 324 lncRNA were screened using significant analysis microarray algorithm, and interaction networks were constructed using these differentially expressed factors. Furthermore, we conducted functional modules analysis in the network, and found that yellow and turquoise modules could separate samples efficiently. The groups classified in the yellow and turquoise modules had a significant difference in survival time, which was verified in another independent GC mRNA dataset (GSE62254). The results suggested that differentially expressed factors in the yellow and turquoise modules may participate in lymph node metastasis of GC and could be applied as potential biomarkers or therapeutic targets for GC.
    Schlagwörter Gastric cancer ; Lymph node metastasis ; Co-expression network ; Modular analysis ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag Associação Brasileira de Divulgação Científica
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Research on the Mechanism of Kaempferol for Treating Senile Osteoporosis by Network Pharmacology and Molecular Docking

    Fuyu Tang / Peng Zhang / Wenhua Zhao / Guangye Zhu / Gengyang Shen / Honglin Chen / Xiang Yu / Zhida Zhang / Qi Shang / De Liang / Xiaobing Jiang / Hui Ren

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Band 2022

    Abstract: Kaempferol (KP), as a natural anti-inflammatory compound, has been reported to have curative effects on alleviating senile osteoporosis (SOP), which is an inflammation-related musculoskeletal disease, but the molecular mechanisms remain unclear due to ... ...

    Abstract Kaempferol (KP), as a natural anti-inflammatory compound, has been reported to have curative effects on alleviating senile osteoporosis (SOP), which is an inflammation-related musculoskeletal disease, but the molecular mechanisms remain unclear due to scanty relevant studies. We predicted the targets of KP and SOP, and the common targets of them were subsequently used to carry out PPI analysis. Moreover, we adopted GO and KEGG enrichment analysis and molecular docking to explore potential mechanisms of KP against SOP. There were totally 152 KP-related targets and 978 SOP-related targets, and their overlapped targets comprised 68 intersection targets. GO enrichment analysis showed 1529 biological processes (p<0.05), which involved regulation of inflammatory response, oxidative stress, regulation of bone resorption and remodeling, osteoblast and osteoclast differentiation, etc. Moreover, KEGG analysis revealed 146 items including 44 signaling pathways (p<0.05), which were closely linked to TNF, IL-17, NF-kappa B, PI3K-Akt, MAPK, estrogen, p53, prolactin, VEGF, and HIF-1 signaling pathways. By means of molecular docking, we found that kaempferol is bound with the key targets’ active pockets through some connections such as hydrogen bond, pi-alkyl, pi-sigma, pi-pi Stacked, pi-pi T-shaped, and van der Waals, illustrating that kaempferol has close combination with the key targets. Collectively, various targets and pathways involve in the process of kaempferol treatment against SOP through regulating inflammatory response, oxidative stress, bone homeostasis, etc. Moreover, our study first reported that kaempferol may regulate core targets’ expression with involvement of inflammatory response, oxidative stress, and bone homeostasis, thus treating SOP.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
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  6. Artikel: Preparation of pure chitosan film using ternary solvents and its super absorbency

    Wang, Xuejun / Guojun Song / Tao Lou / Wenhua Zhao

    Carbohydrate polymers. 2016 Nov. 20, v. 153

    2016  

    Abstract: Chemical modification and graft copolymerization were commonly adopted to prepare super absorbent materials. However, physical microstructure of pure chitosan film was optimized to improve the water uptake capacity in this study. Chitosan films with ... ...

    Abstract Chemical modification and graft copolymerization were commonly adopted to prepare super absorbent materials. However, physical microstructure of pure chitosan film was optimized to improve the water uptake capacity in this study. Chitosan films with micro-nanostructure were prepared by a ternary solvent system. The optimal process parameters are 1% acetic acid water solution: dioxane: dimethyl sulfoxide=90: 2.5: 7.5 (v/v/v) with chitosan concentration at 1.25% (w/v). The water uptake capacity of the chitosan film prepared under the optimal process parameters was 896g/g. The prepared chitosan films also exhibited high water uptake capacity in response to external stimuli such as temperature, pH and salt. This finding may provide another way for improving the water absorbency. The pure chitosan film may find potential applications especially in the fields of hygienic products and biomedicine due to its super water absorbency and nontoxicity.
    Schlagwörter acetic acid ; chitosan ; dioxane ; medicine ; microstructure ; pH ; solvents ; temperature
    Sprache Englisch
    Erscheinungsverlauf 2016-1120
    Umfang p. 253-257.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2016.07.081
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Short-term Forecast Technology in Load of Electrified Railway based on Wavelet-extreme Learning Machine

    Wentao Zhang / Wenhua Zhao / Xinhui Du

    Journal of Networks, Vol 9, Iss 6, Pp 1502-

    2014  Band 1508

    Abstract: With the development of economy and the progress of science, the proportion of electrified railway load in the power gird has been keeping on increasing, which impacts the short-term forecasting in load a lot, therefore, it is very important to analyze ... ...

    Abstract With the development of economy and the progress of science, the proportion of electrified railway load in the power gird has been keeping on increasing, which impacts the short-term forecasting in load a lot, therefore, it is very important to analyze short-term load of electrified railway forecasting. This paper analyzes the power gird load-forecasting considering the influence of the electrified railway load, and introduces wavelet mechanism for data processing based on the research of electrified railway load. The wavelet-extreme learning machine algorithm is proposed and used in the short-term forecast in load of electric railway on the platform of MATLAB. The application in the local electric power company indicates that the wavelet-extreme learning mechanism model has the features of accurate prediction, quick response, and strong practicability
    Schlagwörter Load Forecasting ; Electrified Railway ; Extreme Learning Machine ; Wavelet Decomposition ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
    Thema/Rubrik (Code) 330
    Sprache Englisch
    Erscheinungsdatum 2014-06-01T00:00:00Z
    Verlag Academy Publisher
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Preparation of lignosulfonate–acrylamide–chitosan ternary graft copolymer and its flocculation performance

    He, Kunpeng / Tao Lou / Wenhua Zhao / Xuejun Wang

    International journal of biological macromolecules. 2015 Nov., v. 81

    2015  

    Abstract: As flocculant plays an important role in wastewater treatment, searching for high efficient and cost-effective flocculants has always become the challenge in chemical industry. In the current work, lignosulfonate–acrylamide–chitosan ternary copolymer ...

    Abstract As flocculant plays an important role in wastewater treatment, searching for high efficient and cost-effective flocculants has always become the challenge in chemical industry. In the current work, lignosulfonate–acrylamide–chitosan ternary copolymer was designed and prepared as a new kind of flocculant. The elemental analysis and structure characterization of FTIR and XRD showed that acrylamide successfully grafted onto the two natural polymers and amorphous macromolecules were formed. The natural polymers-based flocculant was water soluble and pH independent. As it had multiple functional groups from the raw materials, the amphoteric flocculant showed high color removal efficiency to anionic (acid blue 113, >95%), neutral (reactive black 5, >95%) and cationic dyes (methyl orange, >50%) in a wide range of flocculant dosage and pH windows. The ternary flocculant, based on lignosulfonate, chitosan, and acrylamide, might be a promising material in practical applications from the perspective of cost, source and performance.
    Schlagwörter acrylamides ; chemical industry ; chitosan ; composite polymers ; cost effectiveness ; decolorization ; dyes ; flocculants ; flocculation ; Fourier transform infrared spectroscopy ; lignosulfonates ; methyl orange ; pH ; raw materials ; wastewater treatment ; X-ray diffraction
    Sprache Englisch
    Erscheinungsverlauf 2015-11
    Umfang p. 1053-1058.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2015.09.054
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Network Pharmacology Integrated with Molecular Docking Explores the Mechanisms of Naringin against Osteoporotic Fracture by Regulating Oxidative Stress

    Xiang Yu / Peng Zhang / Kai Tang / Gengyang Shen / Honglin Chen / Zhida Zhang / Wenhua Zhao / Qi Shang / Guangye Zhu / Riwei Tan / Yanchi Gan / You Zhang / De Liang / Hui Ren / Xiaobing Jiang / Bengen Zhou

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Band 2021

    Abstract: Naringin (NG), as the most abundant component of Drynariae Rhizoma (Chinese name: Gusuibu), has been proved to be an antioxidant flavonoid on promoting osteoporotic fracture (OF) healing, but relevant research is scanty on the underlying mechanisms. We ... ...

    Abstract Naringin (NG), as the most abundant component of Drynariae Rhizoma (Chinese name: Gusuibu), has been proved to be an antioxidant flavonoid on promoting osteoporotic fracture (OF) healing, but relevant research is scanty on the underlying mechanisms. We adopted target prediction, protein-protein interaction (PPI) analysis, Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and molecular docking to establish a system pharmacology database of NG against OF. Totally 105 targets of naringin were obtained, including 26 common targets with OF. A total of 415 entries were obtained through GO Biological Process enrichment analysis (P<0.05), and 37 entries were obtained through KEGG pathway enrichment analysis with seven signaling pathways included (P<0.05), which were primarily concerned with p53, IL-17, TNF, estrogen, and PPAR signaling pathways. According to the results of molecular docking, naringin is all bound in the active pockets of the core targets with 3–9 hydrogen bonds through some connections such as hydrophobic interactions, Pi-Pi stacked interactions, and salt bridge, demonstrating that naringin binds tightly to the core targets. In general, naringin may treat OF through multiple targets and multiple pathways via regulating oxidative stress, etc. Notably, it is first reported that NG may regulate osteoclast differentiation and oxidative stress through the expression of the core targets so as to treat OF.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Zuo-Gui-Wan Aqueous Extract Ameliorates Glucocorticoid-Induced Spinal Osteoporosis of Rats by Regulating let-7f and Autophagy

    Gengyang Shen / Qi Shang / Zhida Zhang / Wenhua Zhao / Honglin Chen / Ibrayinjan Mijiti / Guifeng Chen / Xiang Yu / Fuyong Yu / Peng Zhang / Jiahui He / Xuelai Zhang / Jingjing Tang / Jianchao Cui / De Liang / Lingfeng Zeng / Hui Ren / Xiaobing Jiang

    Frontiers in Endocrinology, Vol

    2022  Band 13

    Abstract: ObjectiveThis study proposes to explore the protective effect of Zuo-Gui-Wan (ZGW) aqueous extract on spinal glucocorticoid-induced osteoporosis (GIOP) in vivo and in vitro, and the underlying mechanisms of ZGW in GIOP and osteogenic differentiation of ... ...

    Abstract ObjectiveThis study proposes to explore the protective effect of Zuo-Gui-Wan (ZGW) aqueous extract on spinal glucocorticoid-induced osteoporosis (GIOP) in vivo and in vitro, and the underlying mechanisms of ZGW in GIOP and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) were conducted.MethodsIn vivo, SD rats were randomly divided into three groups: control group (CON), dexamethasone (DEXM) group, and ZGW group, which were given vehicle, DEXM injection, and ZGW intragastric administration at the same time. Vertebral bone microarchitecture, biomechanics, histomorphology, serum AKP activity, and the autophagosome of osteoblasts were examined. The mRNA expressions of let-7f, autophagy-associated genes (mTORC1, Beclin-1, ATG12, ATG5, and LC3), Runx2, and CTSK were examined. In vitro, the let-7f overexpression/silencing vector was constructed and transfected to evaluate the osteogenic differentiation of BMSCs. Western blot was employed to detect the expression of autophagy-associated proteins (ULK2, ATG5, ATG12, Beclin-1, LC3).ResultsIn vivo, ZGW promoted the bone quantity, quality, and strength; alleviated histological damage; increased the serum AKP activity; and reduced the autophagosome number in osteoblasts. Moreover, ZGW increased the let-7f, mTORC1, and Runx2 mRNA expressions and reduced the Beclin-1, ATG12, ATG5, LC3, and CTSK mRNA expressions. In vitro, bioinformatics prediction and dual luciferase reporter gene assay verified that let-7f targeted the binding to ULK2 and negatively regulated the ULK2 expression. Furthermore, by let-7f overexpression/silencing, ZGW may promote osteoblast differentiation of BMSCs by regulating let-7f and autophagy as evidenced by Western blot (ULK2, ATG5, ATG12, Beclin-1, LC3).ConclusionsZGW may ameliorate GC-induced spinal osteoporosis by promoting osteoblast differentiation of BMSCs by activation of let-7f and suppression of autophagy.
    Schlagwörter ZGW aqueous extract ; GIOP ; let-7f ; autophagy ; Chinese medicine ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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