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  1. Artikel: Sodium-glucose co-transporter-2 inhibitors and the risk of perioperative euglycaemic diabetic ketoacidosis.

    Williams, Samuel P / Stevens, Jia L / Rajendran, Yohinee K

    British journal of hospital medicine (London, England : 2005)

    2022  Band 83, Heft 11, Seite(n) 1–2

    Abstract: Sodium-glucose co-transporter-2 inhibitors are increasingly prescribed for patients with type 2 diabetes. Their use has been associated with life-threatening diabetic ketoacidosis. The risk is increased during times of fasting and intercurrent medical ... ...

    Abstract Sodium-glucose co-transporter-2 inhibitors are increasingly prescribed for patients with type 2 diabetes. Their use has been associated with life-threatening diabetic ketoacidosis. The risk is increased during times of fasting and intercurrent medical illness, which are common in the perioperative period. Diagnosis can be difficult, so perioperative clinicians must be familiar with preventing and recognising such complications.
    Mesh-Begriff(e) Humans ; Diabetic Ketoacidosis/chemically induced ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Symporters ; Glucose ; Sodium
    Chemische Substanzen Sodium-Glucose Transporter 2 Inhibitors ; Symporters ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Sprache Englisch
    Erscheinungsdatum 2022-11-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2022.0398
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Increased use of cross-sectional imaging for follow-up does not improve post-recurrence survival of surgically treated initially localized R.C.C.: results from a European multicenter database (R.E.C.U.R.).

    Dabestani, Saeed / Beisland, Christian / Stewart, Grant D / Bensalah, Karim / Gudmundsson, Eirikur / Lam, Thomas B / Gietzmann, William / Zakikhani, Paimaun / Marconi, Lorenzo / Fernandéz-Pello, Sergio / Monagas, Serenella / Williams, Samuel P / Powles, Thomas / Van Werkhoven, Erik / Meijer, Richard / Volpe, Alessandro / Staehler, Michael / Ljungberg, Börje / Bex, Axel

    Scandinavian journal of urology

    2019  Band 53, Heft 1, Seite(n) 14–20

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Aged ; Carcinoma, Renal Cell/diagnostic imaging ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/surgery ; Databases, Factual ; Diagnostic Imaging/methods ; Europe ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/mortality ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2019-03-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2019.1588919
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Long-term Outcomes of Follow-up for Initially Localised Clear Cell Renal Cell Carcinoma: RECUR Database Analysis.

    Dabestani, Saeed / Beisland, Christian / Stewart, Grant D / Bensalah, Karim / Gudmundsson, Eirikur / Lam, Thomas B / Gietzmann, William / Zakikhani, Paimaun / Marconi, Lorenzo / Fernandéz-Pello, Sergio / Monagas, Serenella / Williams, Samuel P / Torbrand, Christian / Powles, Thomas / Van Werkhoven, Erik / Meijer, Richard / Volpe, Alessandro / Staehler, Michael / Ljungberg, Börje /
    Bex, Axel

    European urology focus

    2018  Band 5, Heft 5, Seite(n) 857–866

    Abstract: Background: Optimal follow-up (FU) strategy to detect potentially curable (PC) recurrences after treatment of localised clear cell renal cell carcinoma (ccRCC) is unclear. This study retrospectively analysed a large international database to determine ... ...

    Abstract Background: Optimal follow-up (FU) strategy to detect potentially curable (PC) recurrences after treatment of localised clear cell renal cell carcinoma (ccRCC) is unclear. This study retrospectively analysed a large international database to determine recurrence patterns and overall survival (OS), as part of a wider project to issue recommendations on FU protocols.
    Objective: To analyse associations between RCC recurrences in patients with ccRCC, their risk group stratifications, treatments, and subsequent outcomes.
    Design, setting, and participants: Nonmetastatic ccRCC patients treated with curative intent between 1 January 2006 and 31 December 2011, with at least 4 yr of FU, were included. Patient, tumour and recurrence characteristics, Leibovich score, and management and survival data were recorded. Isolated local, solitary, and oligometastatic (three or fewer lesions at a single site) recurrences were considered PC, while all others were probably incurable (PI).
    Intervention: Primarily curative surgical treatment of ccRCC while at recurrence detection metastasectomy, systemic therapy, best supportive care, or observation.
    Outcome measurements and statistical analysis: Incidence, time to recurrence (TTR), and OS were measured. Competing risk analysis, Kaplan-Meier, and Cox regression models were used.
    Results and limitation: Of 1265 patients with ccRCC, 286 had a recurrence, with 131 being PC and 155 PI. Five-year cumulative risks of recurrence for low- (n=53), intermediate- (n=105), and high-risk (n=128) patients were, respectively, 7.2%, 23.2%, and 61.6%, of whom 52.8%, 37.1%, and 30.5% were PC, respectively. Median TTR was 25.0 for PC patients versus 17.3 mo for PI patients (p=0.004). Median OS was longer in PC compared with that in PI patients (p<0.001). Competing risk analysis showed highest risk of ccRCC-related death in younger and high-risk patients. Limitations were no data on comorbidities, retrospective cohort, and insufficient data excluding 12% of cohort.
    Conclusions: Low-risk group recurrences are rare and develop later. Treatment of recurrences with curative intent is disappointing, especially in high-risk patients. An age- and risk score-dependent FU approach is suggested.
    Patient summary: We analysed data from eight European countries, and found that the incidence of the kidney cancer recurrence and patient survival correlated with clinical factors known to predict cancer recurrence reliably and age. We conclude that these factors should be used to design follow-up strategies.
    Mesh-Begriff(e) Aged ; Carcinoma, Renal Cell/epidemiology ; Carcinoma, Renal Cell/therapy ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Retrospective Studies ; Survival Rate ; Time Factors ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2018-03-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2018.02.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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