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  1. Article: Recombinant BCG-LTAK63 Vaccine Candidate for Tuberculosis Induces an Inflammatory Profile in Human Macrophages.

    Dos Santos, Carina C / Walburg, Kimberley V / van Veen, Suzanne / Wilson, Louis G / Trufen, Carlos E M / Nascimento, Ivan P / Ottenhoff, Tom H M / Leite, Luciana C C / Haks, Mariëlle C

    Vaccines

    2022  Volume 10, Issue 6

    Abstract: Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain expressing the genetically detoxified A subunit of the thermolabile toxin ... ...

    Abstract Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain expressing the genetically detoxified A subunit of the thermolabile toxin from
    Language English
    Publishing date 2022-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10060831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effect of hyperglycaemia on in vitro cytokine production and macrophage infection with Mycobacterium tuberculosis.

    Lachmandas, Ekta / Vrieling, Frank / Wilson, Louis G / Joosten, Simone A / Netea, Mihai G / Ottenhoff, Tom H / van Crevel, Reinout

    PloS one

    2015  Volume 10, Issue 2, Page(s) e0117941

    Abstract: Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of hyperglycaemia, a hallmark of diabetes, on the cytokine response to and macrophage infection with ... ...

    Abstract Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of hyperglycaemia, a hallmark of diabetes, on the cytokine response to and macrophage infection with Mycobacterium tuberculosis. Increasing in vitro glucose concentrations from 5 to 25 mmol/L had marginal effects on cytokine production following stimulation of peripheral blood mononuclear cells (PBMCs) with M. tuberculosis lysate, LPS or Candida albicans, while 40 mmol/L glucose increased production of TNF-α, IL-1β, IL-6 and IL-10, but not of IFN-γ, IL-17A and IL-22. Macrophage differentiation under hyperglycaemic conditions of 25 mmol/L glucose was also associated with increased cytokine production upon stimulation with M. tuberculosis lysate and LPS but in infection experiments no differences in M. tuberculosis killing or outgrowth was observed. The phagocytic capacity of these hyperglycaemic macrophages also remained unaltered. The fact that only very high glucose concentrations were able to significantly influence cytokine production by macrophages suggests that hyperglycaemia alone cannot fully explain the increased susceptibility of diabetes mellitus patients to tuberculosis.
    MeSH term(s) Candida albicans/immunology ; Cell Differentiation/immunology ; Diabetes Mellitus, Type 2/immunology ; Diabetes Mellitus, Type 2/microbiology ; Humans ; Hyperglycemia/immunology ; Hyperglycemia/microbiology ; Interferon-gamma/immunology ; Interleukins/immunology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/microbiology ; Lipopolysaccharides/immunology ; Macrophages/immunology ; Macrophages/microbiology ; Middle Aged ; Mycobacterium tuberculosis/immunology ; Tuberculosis/immunology ; Tuberculosis/microbiology ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances Interleukins ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0117941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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