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  1. Book ; Thesis: The function of Krüppel-like factor in B-cell development

    Winkelmann, Rebecca

    = Die Funktion von Krüppel-like Faktor 2 in der B-Zellentwicklung

    2010  

    Title variant Die Funktion von Krüppel-like Faktor 2 in der B-Zellentwicklung
    Author's details vorgelegt von Rebecca Winkelmann, geb. Heidbüchel
    Language English
    Size V, 93 S. : Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2010
    HBZ-ID HT016777024
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 D 548 order for loan Magazin

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  2. Conference proceedings ; Online: Hysteresis of idealized marine outlet glaciers under variation of pinning-point buttressing

    Feldmann, J. / Winkelmann, R. / Levermann, A.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: Ice-shelf pinning points such as ice rises or ice rumples can have an important role in regulating the ice discharge of marine outlet glaciers. For instance, the observed gradual ungrounding of the ice shelf of West Antarctica's Thwaites Glacier from its ...

    Abstract Ice-shelf pinning points such as ice rises or ice rumples can have an important role in regulating the ice discharge of marine outlet glaciers. For instance, the observed gradual ungrounding of the ice shelf of West Antarctica's Thwaites Glacier from its last pinning points diminishes the buttressing effect of the ice shelf and thus contributes to the destabilization of the outlet. Here we use an idealized experimental setting to simulate the response of an Antarctic-type marine outlet glacier to a successive ungrounding of its ice shelf from a pinning point. This is realized by perturbing steady states by a step-wise lowering of the pinning point, which induces a buttressing reduction. After the complete detachment of the ice shelf from the pinning point the perturbation is reversed, i.e., the pinnning point is incrementally elevated toward its initial elevation. First results show that the glacier retreat down the landward down-sloping (retrograde) bed, induced by the loss in buttressing, can be reversible in case of a relatively flat retrograde bed slope. For steeper slopes, glacier retreat and re-advance show a hysteretic behavior. Thus, if the bed depression is sufficiently deep, the glacier does not recover from its fully retreated state even for pinning-point elevations that are higher than the initial elevation.
    Subject code 290 ; 515
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Conference proceedings ; Online: Simulation of the Antarctic Ice Sheet over last glacial cycle with the coupled solid Earth – ice sheet model PISM-VILMA

    Albrecht, T. / Bagge, M. / Winkelmann, R. / Klemann, V.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: The Antarctic Ice Sheet is the largest but also the most uncertain potential contributor to future sea level rise. Understanding involved feedback mechanisms require physically-based models. Confidence in future projections can be improved by models that ...

    Abstract The Antarctic Ice Sheet is the largest but also the most uncertain potential contributor to future sea level rise. Understanding involved feedback mechanisms require physically-based models. Confidence in future projections can be improved by models that reproduce past ice sheet changes and present change rates. The complex interaction between ice, bedrock and sea level plays an important role for the stability of marine ice sheets with characteristic response time scales varying regionally between years and thousands of years due to the heterogeneous Earth structure underneath Antarctica and the interacting ice sheet dynamics.We have coupled the VIscoelastic Lithosphere and MAntle model (VILMA) to the Parallel Ice Sheet Model (PISM v2.0, www.pism.io) and have run simulations over the last two glacial cycles. In this framework, VILMA considers both, viscoelastic deformations of the solid Earth by considering a three-dimensional mantle-viscosity distribution and a gravitationally self-consistent mass redistribution in the ocean by solving for the sea-level equation. PISM solves for the stress balance for a changing bed topography, which can be updated with coupling intervals up to 1 year in view of fast changes in ice sheet flow and grounding line dynamics.Here, we show results of coupled PISM-VILMA simulations scored against a database of geological constraints around Antarctica (AntICE2), including sea level index points and GPS uplift rates. We discuss the implications of a three-dimensional Earth structure over one-dimensional profiles for Antarctic ice sheet changes. This project is part of the German Climate Modeling Initiative PalMod.
    Subject code 290
    Language English
    Publishing date 2023-07-11
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A flexible copula regression model with Bernoulli and Tweedie margins for estimating the effect of spending on mental health.

    Marra, Giampiero / Fasiolo, Matteo / Radice, Rosalba / Winkelmann, Rainer

    Health economics

    2023  Volume 32, Issue 6, Page(s) 1305–1322

    Abstract: We develop a flexible two-equation copula model to address endogeneity of medical expenditures in a distribution regression for health. The expenditure margin uses the compound gamma distribution, a special case of the Tweedie family of distributions, to ...

    Abstract We develop a flexible two-equation copula model to address endogeneity of medical expenditures in a distribution regression for health. The expenditure margin uses the compound gamma distribution, a special case of the Tweedie family of distributions, to account for a spike at zero and a highly skewed continuous part. An efficient estimation algorithm offers flexible choices of copulae and link functions, including logit, probit and cloglog for the health margin. Our empirical application revisits data from the Rand Health Insurance Experiment. In the joint model, using random insurance plan assignment as instrument for spending, a $1000 increase is estimated to reduce the probability of a low post-program mental health index by 1.9 percentage points. The effect is not statistically significant. Ignoring endogeneity leads to a spurious positive effect estimate.
    MeSH term(s) Humans ; Mental Health ; Insurance, Health ; Health Expenditures ; Probability ; Algorithms
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1135838-5
    ISSN 1099-1050 ; 1057-9230
    ISSN (online) 1099-1050
    ISSN 1057-9230
    DOI 10.1002/hec.4668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Neoadjuvante Radiochemotherapie für Mundhöhlenkarzinome-INVERT. Prospektive, unizentrische, einarmige, Proof-of-Principle-Studie (ARO 2022-4)

    von der Grün, J. / Winkelmann, R. / Burck, I.

    Forum / Deutsche Krebsgesellschaft

    2022  Volume 37, Issue 4, Page(s) 311

    Language German
    Document type Article
    ZDB-ID 1218650-8
    ISSN 0947-0255
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2355: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Testing the binomial fixed effects logit model, with an application to female labour supply.

    Winkelmann, Rainer / Xu, Lin

    Empirical economics

    2021  Volume 62, Issue 2, Page(s) 679–708

    Abstract: Regression models for proportions are frequently encountered in applied work. The conditional expectation function is bounded between 0 and 1 and therefore must be nonlinear, requiring nonstandard panel data extensions. One possible approach is the ... ...

    Abstract Regression models for proportions are frequently encountered in applied work. The conditional expectation function is bounded between 0 and 1 and therefore must be nonlinear, requiring nonstandard panel data extensions. One possible approach is the binomial panel logit model with fixed effects (Machado in J Econom 119:73-98, 2004). We propose a new and simple implementation of this conditional maximum likelihood estimator for standard software. We investigate the properties of the estimator under misspecification and derive a new test for overdispersion. Estimator and test are applied in a study of contracted working volumes, measured as proportion of full-time work, for women in Switzerland.
    Language English
    Publishing date 2021-03-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 1462176-9
    ISSN 1435-8921 ; 0377-7332
    ISSN (online) 1435-8921
    ISSN 0377-7332
    DOI 10.1007/s00181-021-02034-2
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  7. Book ; Online: Revisiting temperature sensitivity

    Nicola, Lena / Notz, Dirk / Winkelmann, Ricarda

    eISSN: 1994-0424

    How does Antarctic precipitation change with temperature?

    2023  

    Abstract: With progressing global warming, snowfall in Antarctica is expected to increase, which could counteract or even temporarily overcompensate ice-sheet mass losses through increased ice discharge, calving and melting. For sea-level projections it is ... ...

    Abstract With progressing global warming, snowfall in Antarctica is expected to increase, which could counteract or even temporarily overcompensate ice-sheet mass losses through increased ice discharge, calving and melting. For sea-level projections it is therefore vital to understand the processes determining snowfall changes in Antarctica. Here we revisit the relationship between Antarctic temperature changes and precipitation changes, identifying and explaining regional differences and deviations from the theoretical approach based on the Clausius-Clapeyron relationship. Analysing the latest estimates from global (CMIP6) and regional (RACMO2.3) model projections, we find an average increase of 5.5 % in annual precipitation over Antarctica per degree of warming, with a minimum sensitivity of 2 % K -1 near Siple Coast, and a maximum sensitivity > 10 % K -1 at the East Antarctic Plateau region. This large range can be explained by the prevailing climatic conditions, with local temperatures determining the Clausius-Clapeyron sensitivity that is counteracted in some regions by the prevalence of the coastal wind regime. We compare different approaches of deriving the sensitivity factor, which in some cases can lead to sensitivity changes of up to 7 % for the same model. Importantly, local sensitivity-factors are found to be strongly dependent on the warming level, suggesting that some ice-sheet models which base their precipitation estimates on parameterizations derived from these sensitivity factors might overestimate warming-induced snowfall changes, particularly in high-emission scenarios. This would have consequences for Antarctic sea-level projections for this century and beyond.
    Subject code 910
    Language English
    Publishing date 2023-01-02
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Revisiting temperature sensitivity

    Nicola, Lena / Notz, Dirk / Winkelmann, Ricarda

    eISSN: 1994-0424

    how does Antarctic precipitation change with temperature?

    2023  

    Abstract: With progressing global warming, snowfall in Antarctica is expected to increase, which could counteract or even temporarily overcompensate increased ice-sheet mass losses caused by increased ice discharge and melting. For sea-level projections it is ... ...

    Abstract With progressing global warming, snowfall in Antarctica is expected to increase, which could counteract or even temporarily overcompensate increased ice-sheet mass losses caused by increased ice discharge and melting. For sea-level projections it is therefore vital to understand the processes determining snowfall changes in Antarctica. Here we revisit the relationship between Antarctic temperature changes and precipitation changes, identifying and explaining regional differences and deviations from the theoretical approach based on the Clausius–Clapeyron relationship. Analysing the latest estimates from global (CMIP6, Coupled Model Intercomparison Project Phase 6) and regional (RACMO2.3) model projections, we find an average increase of 5.5 % in annual precipitation over Antarctica per degree of warming, with a minimum sensitivity of 2 % K −1 near Siple Coast and a maximum sensitivity of > 10 % K −1 at the East Antarctic plateau region. This large range can be explained by the prevailing climatic conditions, with local temperatures determining the Clausius–Clapeyron sensitivity that is counteracted in some regions by the prevalence of the coastal wind regime. We compare different approaches of deriving the sensitivity factor, which in some cases can lead to sensitivity changes of up to 7 percentage points for the same model. Importantly, local sensitivity factors are found to be strongly dependent on the warming level, suggesting that some ice-sheet models which base their precipitation estimates on parameterisations derived from these sensitivity factors might overestimate warming-induced snowfall changes, particularly in high-emission scenarios. This would have consequences for Antarctic sea-level projections for this century and beyond.
    Subject code 910
    Language English
    Publishing date 2023-07-03
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book: Glossary of basic dermatology lesions

    Winkelmann, R. K.

    (Acta dermato-venereologica : Supplementum ; 130)

    1987  

    Institution International League of Dermatological Societies / Committee on Nomenclature
    Author's details Internat. League of Dermatological Societies, Committee on Nomenclature. R. K. Winkelmann, chairman
    Series title Acta dermato-venereologica : Supplementum ; 130
    Acta dermato-venereologica
    Acta dermato-venereologica ; Supplementum
    Collection Acta dermato-venereologica
    Acta dermato-venereologica ; Supplementum
    Keywords Skin Diseases / dictionaries
    Language English
    Size 16 S.
    Publisher Almqvist & Wiksell
    Publishing place Stockholm
    Publishing country Sweden
    Document type Book
    HBZ-ID HT003062876
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui VI Zs 101 -Suppl.130- verfügbar in Königswinter Königswinter

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  10. Book ; Thesis: Die geburtstraumatische Zwerchfellähmung und ihre Spätergebnisse

    Winkelmann, Ragnar

    1986  

    Size 200 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1986
    HBZ-ID HT003139407
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    88 D 1809 order for loan Magazin

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