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  1. Buch ; Dissertation / Habilitation: Real-time detection of bone-invasive oral cancer with laser-induced breakdown spectroscopy: a proof-of-principle study

    Winnand, Philipp

    2023  

    Verfasserangabe vorgelegt von Dr.med. Philipp Winnand
    Umfang 8 Seiten, Illustrationen, Diagramme
    Erscheinungsort Aachen
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2023
    Anmerkung Die Dissertation besteht aus einem Aufsatz, der zuvor in der Zeitschrift "Oral Oncology" (2023; 138:106308 ) veröffentlicht wurde; DOI: 10.1016/j.oraloncology.2023.106308
    HBZ-ID HT030073546
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2023 D 289 bestellbar zur Ausleihe Magazin

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  2. Buch ; Dissertation / Habilitation: Molekulare Analyse der Leberregeneration im Rahmen des "In-situ Split"-Verfahrens

    Winnand, Philipp

    2020  

    Verfasserangabe vorgelegt von Philipp Winnand
    Sprache Deutsch
    Umfang 87 Seiten, Illustrationen, Diagramme
    Erscheinungsort Aachen
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2020
    HBZ-ID HT020572611
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2020 D 910 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: Assessment of the Electrolyte Heterogeneity of Tissues in Mandibular Bone-Infiltrating Head and Neck Cancer Using Laser-Induced Breakdown Spectroscopy.

    Winnand, Philipp / Boernsen, Klaus Olaf / Ooms, Mark / Heitzer, Marius / Vohl, Nils / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

    International journal of molecular sciences

    2024  Band 25, Heft 5

    Abstract: Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal ... ...

    Abstract Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal specimens and the use of nontumorous tissues. Accordingly, this study aimed to characterize the electrolyte composition of tissues in human mandibular bone-infiltrating head and neck cancer. Mandible cross-sections from 12 patients with bone-invasive head and neck cancers were natively investigated with LIBS. Representative LIBS spectra (n = 3049) of the inferior alveolar nerve, fibrosis, tumor stroma, and cell-rich tumor areas were acquired and histologically validated. Tissue-specific differences in the LIBS spectra were determined by receiver operating characteristics analysis and visualized by principal component analysis. The electrolyte emission values of calcium (Ca) and potassium (K) significantly (
    Mesh-Begriff(e) Animals ; Humans ; Spectrum Analysis/methods ; Lasers ; Head and Neck Neoplasms ; Electrolytes ; Mandible ; Fibrosis
    Chemische Substanzen Electrolytes
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052607
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Tensile strength of adhesives in peripheral nerve anastomoses: an in vitro biomechanical evaluation of four different neurorrhaphies.

    Heitzer, Marius / Kilic, Konrad / Merfort, Ricarda / Winnand, Philipp / Emonts, Caroline / Bock, Anna / Ooms, Mark / Steiner, Timm / Hölzle, Frank / Modabber, Ali

    European journal of medical research

    2024  Band 29, Heft 1, Seite(n) 264

    Abstract: Background: The fundamental prerequisite for prognostically favorable postoperative results of peripheral nerve repair is stable neurorrhaphy without interruption and gap formation.: Methods: This study evaluates 60 neurorrhaphies on femoral chicken ... ...

    Abstract Background: The fundamental prerequisite for prognostically favorable postoperative results of peripheral nerve repair is stable neurorrhaphy without interruption and gap formation.
    Methods: This study evaluates 60 neurorrhaphies on femoral chicken nerves in terms of the procedure and the biomechanical properties. Sutured neurorrhaphies (n = 15) served as control and three sutureless adhesive-based nerve repair techniques: Fibrin glue (n = 15), Histoacryl glue (n = 15), and the novel polyurethane adhesive VIVO (n = 15). Tensile and elongation tests of neurorrhaphies were performed on a tensile testing machine at a displacement rate of 20 mm/min until failure. The maximum tensile force and elongation were recorded.
    Results: All adhesive-based neurorrhaphies were significant faster in preparation compared to sutured anastomoses (p < 0.001). Neurorrhaphies by sutured (102.8 [cN]; p < 0.001), Histoacryl (91.5 [cN]; p < 0.001) and VIVO (45.47 [cN]; p < 0.05) withstood significant higher longitudinal tensile forces compared to fibrin glue (10.55 [cN]). VIVO, with △L/L
    Conclusion: Within the limitations of an in vitro study the adhesive-based neurorrhaphy technique with VIVO and Histoacryl have the biomechanical potential to offer alternatives to sutured neuroanastomosis because of their stability, and faster handling. Further in vivo studies are required to evaluate functional outcomes and confirm safety.
    Mesh-Begriff(e) Tensile Strength ; Animals ; Anastomosis, Surgical/methods ; Chickens ; Biomechanical Phenomena ; Tissue Adhesives/pharmacology ; Fibrin Tissue Adhesive/pharmacology ; Peripheral Nerves/surgery ; Peripheral Nerves/physiology ; Adhesives ; Neurosurgical Procedures/methods
    Chemische Substanzen Tissue Adhesives ; Fibrin Tissue Adhesive ; Adhesives
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-024-01858-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation-A Microstructural Volumetric Analysis in a Rodent Model.

    Heitzer, Marius / Winnand, Philipp / Ooms, Mark / Magnuska, Zuzanna / Kiessling, Fabian / Buhl, Eva Miriam / Hölzle, Frank / Modabber, Ali

    International journal of molecular sciences

    2024  Band 25, Heft 8

    Abstract: In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive ... ...

    Abstract In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential of VIVO in terms of bone regeneration has not yet been explored. The present rodent study compared the post-extraction bone healing of a collagen sponge (COSP) and VIVO in the context of ongoing anticoagulation therapy. According to a split-mouth design, a total of 178 extraction sockets were generated under rivaroxaban treatment, of which 89 extraction sockets were treated with VIVO and 89 with COSP. Post-extraction bone analysis was conducted via in vivo micro-computed tomography (µCT), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) after 5, 10, and 90 days. During the observation time of 90 days, µCT analysis revealed that VIVO and COSP led to significant increases in both bone volume and bone density (
    Mesh-Begriff(e) Animals ; Bone Regeneration/drug effects ; Tooth Extraction/adverse effects ; Rats ; X-Ray Microtomography ; Male ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Tissue Adhesives/pharmacology ; Alveolar Bone Loss/etiology ; Alveolar Bone Loss/diagnostic imaging ; Alveolar Bone Loss/drug therapy ; Collagen/metabolism
    Chemische Substanzen Anticoagulants ; Tissue Adhesives ; Collagen (9007-34-5)
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084210
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Real-time detection of bone-invasive oral cancer with laser-induced breakdown spectroscopy: A proof-of-principle study.

    Winnand, Philipp / Ooms, Mark / Heitzer, Marius / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

    Oral oncology

    2023  Band 138, Seite(n) 106308

    Abstract: Objectives: Intraoperative definition of resection margin status in bone-invasive oral cancer is a fundamental problem in oncologic surgery due to the lack of rapid bone analysis methods. Laser-induced breakdown spectroscopy (LIBS) provides direct ... ...

    Abstract Objectives: Intraoperative definition of resection margin status in bone-invasive oral cancer is a fundamental problem in oncologic surgery due to the lack of rapid bone analysis methods. Laser-induced breakdown spectroscopy (LIBS) provides direct measurement with real-time examination of a minimal tissue sample. This proof-of-principle study aimed to evaluate the possibility of distinguishing tumorous and healthy areas with LIBS.
    Materials and methods: LIBS experiments were executed on native segmental mandibulectomy specimens from 15 patients with bone-invasive oral cancer. Normalized and intensity-matched spectra were compared. Under biological derivation, peak area calculation and principal component analysis (PCA) were applied. The discriminatory power of the PCAs was correlated with the architectural and cytological characteristics of the lasered tumor tissue. Receiver operating characteristics analysis was used to evaluate the performance of LIBS in the real-time detection of bone-invasive cancer.
    Results: Calcium (Ca), which is high in healthy bone, is replaced by potassium (K) and sodium (Na) in bone-invasive cancer. The degree of stromal induction is significantly correlated with the discriminatory power between healthy and tumorous spectra. In this study, LIBS ensured an overall sensitivity of 95.51% and a specificity of 98.64% via the intracellular detection of K and Na.
    Conclusion: This study demonstrated robust real-time detection of bone-invasive oral cancer with LIBS, which may lay the foundation for establishing LIBS as a rapid bone analysis method. Further development of a LIBS-guided assessment of bone tumor resection margins might reduce the extent of bony resection without compromising oncologic safety.
    Mesh-Begriff(e) Humans ; Spectrum Analysis/methods ; Lasers ; Mouth Neoplasms ; Bone Neoplasms
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106308
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Zs.A 4869: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.A 456: Hefte anzeigen Standort:
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  7. Artikel ; Online: Evaluation of electrolyte element composition in human tissue by laser-induced breakdown spectroscopy (LIBS).

    Winnand, Philipp / Boernsen, K Olaf / Bodurov, Georgi / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 16391

    Abstract: Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because these studies rarely consider basic physical principles. The aim of this ... ...

    Abstract Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because these studies rarely consider basic physical principles. The aim of this study was to test the suitability of LIBS spectra as an analytical method for biomarker assays and to evaluate the composition of electrolyte elements in human biomaterial. LIBS as an analytical method was evaluated by establishing KCl calibration curves to demonstrate linearity, by the correct identification of emission lines with corresponding reference spectra, and by the feasibility to use LIBS in human biomaterial, analyzing striated muscle tissues from the oral regions of two patients. Lorentzian peak fit and peak area calculations resulted in better linearity and reduced shot-to-shot variance. Correct quantitative measurement allowed for differentiation of human biomaterial between patients, and determination of the concentration ratios of main electrolytes within human tissue. The clinical significance of LIBS spectra should be evaluated using peak area rather than peak intensity. LIBS might be a promising tool for analyzing a small group of living cells. Due to linearity, specificity and robustness of the proposed analytical method, LIBS could be a component of future biomarker studies.
    Mesh-Begriff(e) Biocompatible Materials ; Calibration ; Electrolytes ; Humans ; Lasers ; Spectrum Analysis/methods
    Chemische Substanzen Biocompatible Materials ; Electrolytes
    Sprache Englisch
    Erscheinungsdatum 2022-09-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-20825-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Attached compared with unattached surface probes for monitoring flap perfusion in microvascular head and neck reconstruction: a feasibility study.

    Ooms, Mark / Winnand, Philipp / Heitzer, Marius / Peters, Florian / Bock, Anna / Katz, Marie Sophie / Hölzle, Frank / Modabber, Ali

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 15939

    Abstract: Unattached surface probes are commonly used with the O2C analysis system (LEA Medizintechnik, Germany) to monitor microvascular free flap perfusion. This study compared attached and unattached surface probes for extraoral free flaps. The study included ... ...

    Abstract Unattached surface probes are commonly used with the O2C analysis system (LEA Medizintechnik, Germany) to monitor microvascular free flap perfusion. This study compared attached and unattached surface probes for extraoral free flaps. The study included 34 patients who underwent extraoral microvascular head and neck reconstruction between 2020 and 2022. Flap perfusion was monitored postoperatively using the O2C analysis system at 0, 12, 24, 36, and 48 h, with an attached surface probe at 3 mm tissue depth and an unattached surface probe at 2 mm and 8 mm tissue depths. Clinical complications, technical errors, and perfusion measurement values were compared. No clinical complications (attachment suture infections) or technical errors (probe detachment) occurred. Flap blood flow values of the probes were partially different (3 mm vs. 2 and 8 mm: p < 0.001; p = 0.308) and moderately correlated (3 mm with 2 and 8 mm: r = 0.670, p < 0.001; r = 0.638, p < 0.001). Hemoglobin concentration and oxygen saturation values were generally different (3 mm vs. 2 and 8 mm: all p < 0.001) and variably correlated (3 mm with 2 and 8 mm: r = 0.756, r = 0.645; r = 0.633, r = 0.307; all p < 0.001). Both probes are comparable in terms of technical feasibility and patient safety, with flap perfusion values dependent on tissue measurement depth.
    Mesh-Begriff(e) Humans ; Feasibility Studies ; Perfusion ; Head ; Neck ; Free Tissue Flaps
    Sprache Englisch
    Erscheinungsdatum 2023-09-24
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43151-5
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  9. Artikel: Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model.

    Heitzer, Marius / Winnand, Philipp / Bock, Anna / Ooms, Mark / Katz, Marie Sophie / Kniha, Kristian / Grottke, Oliver / Hölzle, Frank / Modabber, Ali

    Journal of functional biomaterials

    2023  Band 14, Heft 7

    Abstract: An increase in rivaroxaban therapies is associated with increased numbers of postoperative bleeding despite the use of hemostatic sponges, which are currently the gold standard treatment. VIVO has shown promising hemostatic results, favorable tissue ... ...

    Abstract An increase in rivaroxaban therapies is associated with increased numbers of postoperative bleeding despite the use of hemostatic sponges, which are currently the gold standard treatment. VIVO has shown promising hemostatic results, favorable tissue properties, and ease of application, although it has not yet been used in the oral cavity. The aim of this study was to evaluate the hemostatic properties of VIVO in the extraction sockets of 31 rodents and compare this to gelatin sponge (GSP) therapy. At rivaroxaban concentrations of 264.10 ± 250.10 ng/mL, 62 extraction sockets were generated, of which 31 were treated with VIVO and 31 with GSP. The duration time, early and late bleeding events, and wound healing score were determined. Histologic examinations of the tissues were performed after 5 days. VIVO presented a longer procedure, 1.26 ± 0.06 min, but a significantly shorter bleeding time, 0.14 ± 0.03 min. There was no difference between the two groups in terms of the severity and timing of bleeding. More minor early bleeding events were observed for GSP. VIVO showed a significantly better healing score, with favorable histological results. In an animal study, VIVO showed promising hemostatic properties after tooth extraction under ongoing anticoagulative therapy.
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14070333
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Effect of systemic antiresorptive medication on the histopathological parameters of implant osseointegration in an in vivo rodent study.

    Kniha, Kristian / Hermanns-Sachweh, Benita / Möhlhenrich, Stephan Christian / Peters, Florian / Heitzer, Marius / Winnand, Philipp / Hölzle, Frank / Modabber, Ali

    BMC oral health

    2023  Band 23, Heft 1, Seite(n) 117

    Abstract: Background: The purpose of this study was to evaluate the osseointegration of zirconia and titanium implants in the rat maxilla in specimens under systemic antiresorptive therapy.: Materials and methods: After 4 weeks of systematic medication ... ...

    Abstract Background: The purpose of this study was to evaluate the osseointegration of zirconia and titanium implants in the rat maxilla in specimens under systemic antiresorptive therapy.
    Materials and methods: After 4 weeks of systematic medication administration (either zoledronic acid or alendronic acid), 54 rats received one zirconia and one titanium implants that were immediately inserted in the rat maxilla after tooth extraction. Twelve weeks after implant placement, histopathological samples were evaluated for implant osteointegration parameters.
    Results: The bone-implant-contact (BIC) ratio revealed no significant inter-group or inter-material differences. The distance between the implant shoulder to the bone level was significantly greater around the titanium implants of the zoledronic acid group compared to the zirconia implants of the control group (p = 0.0005). On average, signs of new bone formation could be detected in all groups, although often without statistical differences. Signs of bone necrosis were only detected around the zirconia implants of the control group (p < 0.05).
    Conclusions: At the 3-month follow-up, no implant material was demonstrably better than the others in terms of osseointegration metrics under systemic antiresorptive therapy. Further studies are necessary to determine whether there are differences in the osseointegration behavior of the different materials.
    Mesh-Begriff(e) Rats ; Animals ; Osseointegration ; Dental Implants ; Zoledronic Acid ; Rodentia ; Titanium ; Dental Prosthesis Design ; Bone Density Conservation Agents ; Maxilla ; Surface Properties
    Chemische Substanzen Dental Implants ; zirconium oxide (S38N85C5G0) ; Zoledronic Acid (6XC1PAD3KF) ; Titanium (D1JT611TNE) ; Bone Density Conservation Agents
    Sprache Englisch
    Erscheinungsdatum 2023-02-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-02763-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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