Artikel ; Online: Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity.
International journal of molecular sciences
2023 Band 24, Heft 21
Abstract: Glial reactivity is considered a hallmark of damage-induced innate immune responses in the central nervous system. In the visual system, unilateral optic nerve damage elicits dramatic glial reactivity in the retina directly affected by the lesion and a ... ...
| Abstract | Glial reactivity is considered a hallmark of damage-induced innate immune responses in the central nervous system. In the visual system, unilateral optic nerve damage elicits dramatic glial reactivity in the retina directly affected by the lesion and a similar, albeit more modest, effect in the contralateral eye. Evaluation of astrocyte changes in a mouse model of optic nerve crush indicates that astrocyte reactivity, as a function of retinal coverage and cellular hypertrophy, occurs within both the experimental and contralateral retinas, although the hypertrophic response of the astrocytes in the contralateral eyes is delayed for at least 24 h. Evaluation of astrocytic reactivity as a function of |
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| Mesh-Begriff(e) | Mice ; Animals ; Astrocytes/metabolism ; Neuroglia/metabolism ; Retina/metabolism ; Optic Nerve Injuries/metabolism ; Optic Nerve/pathology ; Glial Fibrillary Acidic Protein/metabolism ; Nerve Tissue Proteins/metabolism ; Connexins/metabolism |
| Chemische Substanzen | Glial Fibrillary Acidic Protein ; Panx1 protein, mouse ; Nerve Tissue Proteins ; Connexins |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-10-27 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms242115641 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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