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  1. Artikel ; Online: Study of stress-strain loops on cardiotoxicity related to immune checkpoint inhibitors.

    Chunlan, Shi / Bing, Yue / Xi, Wei

    Echocardiography (Mount Kisco, N.Y.)

    2024  Band 41, Heft 1, Seite(n) e15746

    Abstract: Objective: To evaluate the effect of immune checkpoint inhibitors (ICIs) on left ventricular myocardial work by pressure-strain loop (PSL).: Methods: Forty-three immunotherapy patients were enrolled in the case group, and another 43 healthy ... ...

    Abstract Objective: To evaluate the effect of immune checkpoint inhibitors (ICIs) on left ventricular myocardial work by pressure-strain loop (PSL).
    Methods: Forty-three immunotherapy patients were enrolled in the case group, and another 43 healthy volunteers were enrolled in the control group. They were examined by echocardiography before immunotherapy (T0 phase), after three cycles of treatment (T3 phase) and after six cycles of treatment (T6 phase). Conventional echocardiographic parameters, left ventricular global longitudinal strain (GLS), and myocardial work indices, including global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE), were collected for analysis to compare the results of the different immunotherapy cycles.
    Results: There were no statistically significant differences of baseline characteristics, conventional echocardiographic parameters, left ventricular strain, and myocardial work indices between T0 phase and control group (all p > .05). There were no statistically significant differences in LVEF between T0, T3, and T6 phase (all p > .05). GLS, GWI, GCW, and GWE were decreased and GWW was increased in T3 and T6 phase. There were no statistically significant difference between GLS in T3 and T0 phase (q = .9057, p > .05). The difference was statistically significant between GLS in T6 and T0 phase (q = 5.5651, p < .01). The difference was statistically significant between GLS in T3 and T6phase(q = 4.6594, p < .01). There were statistically significant difference in GWI, GCW, GWE, and GWW in the T3 and T6 phase compared with the T0 phase (p < .01).
    Conclusion: PSL can effectively evaluate the effect of ICIs on left ventricular myocardial work, to provide a new method for the early clinical detection of ICIs-related cardiotoxicity.
    Mesh-Begriff(e) Humans ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Immune Checkpoint Inhibitors ; Myocardium ; Echocardiography ; Healthy Volunteers ; Ventricular Function, Left ; Stroke Volume
    Chemische Substanzen Immune Checkpoint Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15746
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  2. Artikel ; Online: Progress of Mine Land Reclamation and Ecological Restoration Research Based on Bibliometric Analysis

    Ya Shao / Qinxue Xu / Xi Wei

    Sustainability, Vol 15, Iss 10458, p

    2023  Band 10458

    Abstract: The mining of mineral resources has caused serious damage to land and significant pressure on ecological environment. During the repairing of damaged land and degraded ecosystems, there have been many pieces of literature related to land reclamation and ... ...

    Abstract The mining of mineral resources has caused serious damage to land and significant pressure on ecological environment. During the repairing of damaged land and degraded ecosystems, there have been many pieces of literature related to land reclamation and ecological restoration (LRER) that have emerged. To understand the progress and prospect of LRER research, it is necessary to sort out such pieces of literature, analyze the current research status, and forecast the future research directions. Here, Bibliometrix R-package was used to analyze 2357 articles, which were derived from the core database of Web of Science, to explore the development of LRER from 1990 to 2022. The results are as follows. (1) The annual scientific output results show that both the number of articles published on LRER and the number of articles annually citied were increasing gradually from 1990 to 2022. (2) High-frequency keyword analysis indicates that heavy metal (Cd, Pb) pollution remediation is a research hotspot. The cluster analysis (CA) and multiple correspondence analysis (MCA) show that there are two clusters in the current research of LRER, in which one surrounds heavy metal pollution and the other focuses on ecological restoration of mining areas. The two clusters correspond to the remediation and ecological restoration (rehabilitation) stages of stepwise ecological restoration, respectively. Thematic evolution analysis shows that, for more than 30 years, mine drainage and heavy metal pollution treatment, soil reconstruction (soil profile reconstruction, soil improvement), and vegetation restoration have been the focus of research. (3) Future research should focus on the relationship between mine ecological restoration and carbon sequestration and the relationship between ecological restoration and biodiversity in mine areas. In addition, LRER technology exchange, international cooperation, and industrialization are also main directions of development. Generally, in this study, metrology software (Bibliometrix R-package 3.1.4) ...
    Schlagwörter mine ; land reclamation and ecological restoration (LRER) ; research status ; research directions ; Web of Science ; Bibliometrix ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 001
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Multivariate path analysis of factors influencing Larix principis-rupprechtii plantation regeneration in northern China

    Wenjun Liang / Xi Wei

    Ecological Indicators, Vol 129, Iss , Pp 107886- (2021)

    2021  

    Abstract: Forest regeneration is a critical indicator of the overall health of forest ecosystems, and is considered to be a vital process in which old and senescent trees are replaced by young ones. The seed-to-seedling transition entails seedlings’ emergence from ...

    Abstract Forest regeneration is a critical indicator of the overall health of forest ecosystems, and is considered to be a vital process in which old and senescent trees are replaced by young ones. The seed-to-seedling transition entails seedlings’ emergence from seeds and their establishment, this phase being the most vulnerable to mortality effects from biotic and abiotic factors. Larix principis-rupprechtii is a typical tree species in northern China, where the natural regeneration of artificial forests dominated by this species is very limited. This study explored the limiting factors affecting the natural regeneration of Larix principis-rupprechtii forests via field surveys of large-scale sampling plots. Redundancy analysis and structural equation models were developed and applied to determine the relative importance of direct and indirect factors affecting the regeneration of Larix principis-rupprechtii plantations. We found a negative relationship between the regeneration index and stand structure, for which the path coefficient was –0.54, the strongest correlation. Conversely, the regeneration index was positively correlated with the herb index, soil index, and elevation, having path coefficients of 0.06, 0.07, and 0.32, respectively. The soil index was negative correlated with both elevation and herb index, with path coefficients of –0.31 and –0.53, respectively, while stand structure was negatively correlated with the herb index and positively correlated with elevation (respective path coefficients: –0.62 and 0.29). Stand density and tree height to crown base were the main factors representing stand structure and, accordingly, the most important factors influencing forest regeneration of the species. At a stand density of ca. 200 trees·hm−2, the number and quality of seedling regeneration were robust. In later stages of stand management and thinning, the proper adjustment of stand density and timely pruning interventions can promote this tree’s natural regeneration to achieve the sustainable development of forest resources.
    Schlagwörter Forest regeneration ; Limiting factor ; Artificial disturbance ; Forest sustainability ; Ecology ; QH540-549.5
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Assessment of causal associations between obesity and peripheral artery disease: a bidirectional Mendelian randomization study.

    Huang, Xi-Wei / Pang, Shu-Wen / Zhang, Tao / Huang, Chuang-Wei

    Frontiers in cardiovascular medicine

    2024  Band 11, Seite(n) 1332530

    Abstract: Background: Several observational studies have documented a potential link between obesity and peripheral artery disease (PAD), although conflicting findings exist. The causal relationship between obesity and PAD continues to be a subject of ongoing ... ...

    Abstract Background: Several observational studies have documented a potential link between obesity and peripheral artery disease (PAD), although conflicting findings exist. The causal relationship between obesity and PAD continues to be a subject of ongoing debate in the medical community.
    Objectives: In this study, we employed a bidirectional Mendelian randomization (MR) analysis to explore the potential causal relationship between obesity and the risk of PAD.
    Methods: To investigate these causal relationships, we conducted bidirectional MR analysis using publicly available genome-wide association study (GWAS) data. Effect estimates were calculated using the random-effects inverse variance-weighted (IVW) method.
    Results: We identified eight independent single nucleotide polymorphisms (SNPs) associated with obesity in 218,735 samples involving 16,380,465 SNPs, all of which met the genome-wide significance threshold (
    Conclusions: In summary, our study offers genetic evidence suggesting a possible causal link between obesity and PAD. While we did not find evidence supporting the "obesity paradox", prudent weight management remains crucial, as lower weight does not necessarily guarantee better outcomes. As with any study, caution is required in interpreting the findings. Further research is essential to assess the clinical relevance of weight in preventing PAD, which could inform the development of more precise intervention strategies.
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1332530
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Biomaterial scaffolds in maxillofacial bone tissue engineering

    Xiangya Huang / Yaxin Lou / Yihong Duan / He Liu / Jun Tian / Ya Shen / Xi Wei

    Bioactive Materials, Vol 33, Iss , Pp 129-

    A review of recent advances

    2024  Band 156

    Abstract: Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone ... ...

    Abstract Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape, complex structure, and unique biological functions. Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity, costs, operational convenience. etc. In this review, we first highlight the special considerations of bone regeneration in maxillofacial region and provide an overview of the biomaterial scaffolds for maxillofacial bone regeneration under clinical examination and their efficacy, which provide basis and directions for future scaffold design. Latest advances of these scaffolds are then discussed, as well as future perspectives and challenges. Deepening our understanding of these scaffolds will help foster better innovations to improve the outcome of maxillofacial bone tissue engineering.
    Schlagwörter Biomaterial scaffolds ; Maxillofacial region ; Bone regeneration ; Tissue engineering ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2024-03-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Forest Gaps Modulate the Composition and Co-Occurrence Network of Soil Bacterial Community in Larix principis-rupprechtii Mayr Plantation

    Yajie Niu / Wenjun Liang / Xi Wei / Youzhi Han

    Agronomy, Vol 13, Iss 38, p

    2022  Band 38

    Abstract: Forest gaps create a favorable microenvironment for the growth of the soil microbial community. This study aimed to explore the effects of gap-related microenvironmental heterogeneity on soil bacterial communities in Larix principis-rupprechtii Mayr ... ...

    Abstract Forest gaps create a favorable microenvironment for the growth of the soil microbial community. This study aimed to explore the effects of gap-related microenvironmental heterogeneity on soil bacterial communities in Larix principis-rupprechtii Mayr forest gaps. Therefore, the redundancy analysis (RDA) and structure equations modeling (SEM) of affecting elements were further used to test the significance of forest gaps’ effect on soil bacterial community composition and co-occurrence structure complexity. The formation of forest gaps increased canopy opening (CO) and significantly increased soil moisture content (SW), soil temperature (ST) and the accumulation of acid phosphatase (PHO) and sucrase (INV) in the soil, and the G250 (forest gap size: >250 m 2 ) was most conductive to the accumulation of light and soil total nutrient. G50, G70, and G100 (forest gap size: 50–70 m 2 , 70–100 m 2 , 100–125 m 2 ) were most favorable for the natural regeneration of the L. principis-rupprechtii Mayr plantation. The light properties under the forest gaps were the most significant factor that influenced the soil bacterial community composition, followed by the size of the forest gap, with standard path coefficients (Std. PCs) of 0.45 and −0.37, respectively. The canopy opening (CO), relative light intensity (RLA) and leaf area index (LAI) were considered to be the most important environmental factors affecting bacterial community composition (Std. PCs: 0.97, 0.99, and −0.93, respectively). The natural regeneration density under the forest gap was the most significant factor influencing the complexity of the soil bacterial community co-occurrence network, followed by soil nutrients (Std. PCs: 0.87 and −0.76, respectively).
    Schlagwörter forest gap ; microenvironmental factors ; soil bacteria ; Larix principis-rupprechtii Mayr ; Agriculture ; S
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Relationships between ecosystems above and below ground including forest structure, herb diversity and soil properties in the mountainous area of Northern China

    Wenjun Liang / Xi Wei

    Global Ecology and Conservation, Vol 24, Iss , Pp e01228- (2020)

    2020  

    Abstract: One hundred field plots of 20 m × 20 m were established in a typical secondary forest of Populus davidiana and Betula platyphylla Suk. in the mountainous area of northern China. The aim was to explore quantitative tree–herb–soil relationships at three ... ...

    Abstract One hundred field plots of 20 m × 20 m were established in a typical secondary forest of Populus davidiana and Betula platyphylla Suk. in the mountainous area of northern China. The aim was to explore quantitative tree–herb–soil relationships at three different soil depths, using a structural equation model (SEM) approach to reveal the connection between the above and below ground ecosystems. The corrected model (ratio of the chi-square degree of freedom <3, p-value >0.05, the root meant square error of approximation <0.05, and all the fix indexes were from 0.9 to 1.0) confirmed that the total effects between tree canopy stand structure and understory herb diversity were negative and significant, with standard path coefficients (Std. PCs) of −0.87, −0.84, and −0.98 from the topsoil down to the deepest layer. The positive relationship of soil properties with stand structure (Std. PCs: 0.90, 0.30, and 0.01, respectively) and herb diversity (Std. PCs: 0.54, 0.44, and 0.32, respectively) decreased with soil depth, and the effect was greatest in the 0–20 cm layer. Average DBH, stand density, and Simpson index were the major drivers of structure and diversity, with path coefficients more than 0.8 at all the soil depths. Total phosphorus (Std. PC: 0.83 at 0–20 cm), total nitrogen (Std. PC: 0.62 at 20–40 cm), and available potassium and organic matter (Std. PCs: 0.86 and 0.77, respectively at 40–60 cm) were significant to soil properties, and even to trees and herbs. Hence, management to improve both the overstory and understory of forest ecosystems in similar mountainous area of northern China should be more targeted towards optimization of soil properties, stand structure, and herb diversity simultaneously, by increasing litter thickness as well as soil microbial activity of the topsoil, optimizing stand density, and planting different grass seeds.
    Schlagwörter Structural equation modeling ; Stand structure ; Herb diversity ; Soil characteristics ; Above ground and below ground ecosystem ; Ecology ; QH540-549.5
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Factors promoting the natural regeneration of Larix principis-rupprechtii plantation in the Lvliang Mountains of central China

    Wenjun Liang / Xi Wei

    PeerJ, Vol 8, p e

    2020  Band 9339

    Abstract: Given their complexity, targeted care and management of different areas and tree species are necessary for enhancing the natural regeneration of forests. Thus, an understanding of changes in the overstory and understory is essential for ensuring ... ...

    Abstract Given their complexity, targeted care and management of different areas and tree species are necessary for enhancing the natural regeneration of forests. Thus, an understanding of changes in the overstory and understory is essential for ensuring successful regeneration. Promoting the natural regeneration of Larix principis-rupprechtii plantations is considered challenging; indeed, regional sustainable development through natural regeneration of many stands has often been considered unattainable. Here, we studied several plots with varying extents of regeneration to identify the most important factors that affect regeneration. The plots were divided into three forest types based on the number of regenerating plants. For each type of plot, we measured various factors that might potentially affect regeneration. Representational difference analysis was used to identify the most important factors >9% contribution). Based on these factors, multiple corrections were made to construct a structural equation model of topography, stand structure, soil properties and litter to identify the most important factors driving variation in regeneration. Positive correlations were detected between regeneration with diameter at breast height (0.21) and litter thickness (0.57). Regeneration was negatively correlated with soil (−0.54) and slope (−0.48). Additionally, the number of regenerating plants and the height of regenerating plants were strongly positively correlated. However, there was no significant relationship between regeneration and litter accumulation, stand density, altitude, average tree height, total P and total N. Overall, our study showed that key factors for promoting natural regeneration include appropriate litter thickness, strong parent trees, a gentle slope and sufficient quantities of soil nutrients. Moreover, our findings provide a reference for the design of effective management and restoration plans.
    Schlagwörter Forest plantations ; Natural regeneration ; Environmental factors ; Forest structure ; Soil nutrients ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 580 ; 571
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Estimating the Capital Service of Beijing

    XI Wei

    International Business and Management, Vol 8, Iss 2, Pp 28-

    1978-2012

    2014  Band 33

    Abstract: In macroeconomics, the measure of capital input and its contribution to production has been a spot in research. This paper takes Beijing city as the research object, referring to the 2008 SNA concepts and categories on capital service, making the full ... ...

    Abstract In macroeconomics, the measure of capital input and its contribution to production has been a spot in research. This paper takes Beijing city as the research object, referring to the 2008 SNA concepts and categories on capital service, making the full use of existing data, applying the PIM method to estimate the capital service and its index of 1978-2012. Because the capital service estimate is a new research field in China, the conclusions of this research can provide data support for the accurate accounting of total factor productivity and the decision support for the economic growth policies making in Beijing. Key words: Capital service; Beijing; Productive capital stock; Age-efficiency profile
    Schlagwörter Capital service ; Beijing ; Productive capital stock ; Age-efficiency profile ; Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H
    Sprache Englisch
    Erscheinungsdatum 2014-05-01T00:00:00Z
    Verlag Canadian Research & Development Center of Sciences and Cultures
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Pd-Catalyzed Cascade Cyclization/Thiocarbonylation with Thioformates: Synthesis of Thioester-Functionalized Oxindoles.

    Zhu, Xi-Wei / Ye, Hao / Pan, Yi-Yun / Wu, Yanan / Wu, Xin-Xing

    The Journal of organic chemistry

    2024  Band 89, Heft 5, Seite(n) 3471–3480

    Abstract: A Pd-catalyzed thiocarbonylative cyclization of N-( ...

    Abstract A Pd-catalyzed thiocarbonylative cyclization of N-(
    Sprache Englisch
    Erscheinungsdatum 2024-02-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02898
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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