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  1. Artikel ; Online: Discovery from Hypericum elatoides and synthesis of hyperelanitriles as α-aminopropionitrile-containing polycyclic polyprenylated acylphloroglucinols

    Jin-Yan Xie / Pengfei Li / Xi-Tao Yan / Jin-Ming Gao

    Communications Chemistry, Vol 7, Iss 1, Pp 1-

    2024  Band 9

    Abstract: Abstract The search for lead compounds with anti-neuroinflammatory activity from structurally ‘optimized’ natural products is a crucial and promising strategy in the quest to discover safe and efficacious agents for treating neurodegenerative diseases. A ...

    Abstract Abstract The search for lead compounds with anti-neuroinflammatory activity from structurally ‘optimized’ natural products is a crucial and promising strategy in the quest to discover safe and efficacious agents for treating neurodegenerative diseases. A phytochemical investigation on the aerial portions of Hypericum elatoides led to the isolation of five nitrogenous polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperelanitriles A–D (1–4) and hyperelamine A (5). Their structures were determined by spectroscopic analysis, ECD and NMR calculations, and X-ray crystallography. To the best of our knowledge, compounds 1–4 represent the first examples of acylphloroglucinols featuring an α-aminonitrile moiety, while 5 is a rare enamine-containing PPAP. Further, the synthesis of these naturally occurring PPAP-based nitriles or amines was accomplished. Compound 5 exhibited inhibitory activity against LPS-activated NO production in BV-2 cells, potentially through the suppression of TLR-4/NF-κB signaling. Here we show the isolation, structural elucidation, synthesis, and bioactive evaluation of compounds 1–5.
    Schlagwörter Chemistry ; QD1-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway

    Cheng-Chen Zhang / Chen-Yu Cao / Miwa Kubo / Kenichi Harada / Xi-Tao Yan / Yoshiyasu Fukuyama / Jin-Ming Gao

    International Journal of Molecular Sciences, Vol 18, Iss 8, p

    2017  Band 1659

    Abstract: Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to improve memory. In this work, we investigated the neuroprotective and neuritogenic effects of the secondary metabolites isolated from the MeOH extract of cultured ... ...

    Abstract Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to improve memory. In this work, we investigated the neuroprotective and neuritogenic effects of the secondary metabolites isolated from the MeOH extract of cultured mycelium of H. erinaceus and the primary mechanisms involved. One new dihydropyridine compound (6) and one new natural product (2) together with five known compounds (1,3–5,7) were obtained and their structures were elucidated by spectroscopic analysis, including 2D NMR and HRMS. The cell-based screening for bioactivity showed that 4-chloro-3,5-dimethoxybenzoic methyl ester (1) and a cyathane diterpenoid, erincine A (3), not only potentiated NGF-induced neurite outgrowth but also protected neuronally-differentiated cells against deprivation of NGF in PC12 pheochromocytoma cells. Additionally, compound 3 induced neuritogenesis in primary rat cortex neurons. Furthermore, our results revealed that TrkA-mediated and Erk1/2-dependant pathways could be involved in 1 and 3-promoted NGF-induced neurite outgrowth in PC12 cells.
    Schlagwörter Hericium erinaceus ; erinacine A ; cyathane diterpenoid ; 4-chloro-3,5-dimethoxybenzoic methyl ester ; PC12 cell ; neuritogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: A new phenolic derivative with soluble epoxide hydrolase and nuclear factor-kappaB inhibitory activity from the aqueous extract of Acacia catechu

    Sun, Ya Nan / Wei Li / Seok Bean Song / Xi Tao Yan / Yan Zhao / A. Reum Jo / Jong Seong Kang / Kim Young Ho

    Natural product research. 2016 Sept. 16, v. 30, no. 18

    2016  

    Abstract: One novel phenolic compound, (4 S ,5 R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3 H)-one (1), as well as 12 known compounds (2 – 13) was obtained from the aqueous extract of Acacia catechu and their chemical structures were determined by ... ...

    Abstract One novel phenolic compound, (4 S ,5 R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3 H)-one (1), as well as 12 known compounds (2 – 13) was obtained from the aqueous extract of Acacia catechu and their chemical structures were determined by spectroscopic analysis. Compounds 8 and 9 exhibited significant soluble epoxide hydrolase (sEH) inhibitory activities with IC ₅₀ values of 26.6 ± 0.5 and 24.4 ± 5.6 μM, respectively. Compounds 7 – 10 showed significant inhibitory effects on TNFα-induced nuclear factor kappa B (NF-κB) transcriptional activity in a dose-dependent manner, with IC ₅₀ values ranging from 11.15 to 19.45 μM.
    Schlagwörter Acacia catechu ; chemical structure ; dose response ; epoxide hydrolase ; inhibitory concentration 50 ; spectroscopy ; transcription (genetics) ; transcription factor NF-kappa B
    Sprache Englisch
    Erscheinungsverlauf 2016-0916
    Umfang p. 2085-2092.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2015.1114937
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Isolation of Nematicidal Triterpenoid Saponins from Pulsatilla koreana Root and Their Activities against Meloidogyne incognita

    Byung Soo Han / Chang Sup Moon / Hyo Jeung Byun / Suk Jun Lee / Seo Young Yang / Xi Tao Yan / Ya Nan Sun / Wei Li / Young Ho Kim

    Molecules, Vol 18, Iss 5, Pp 5306-

    2013  Band 5316

    Abstract: Pulsatilla koreana, a species endemic to Korea, is an important herb used in traditional medicine to treat amoebic dysentery and malaria. In the present study, 23 oleanane-type triterpenoid saponins 1–23 and eight lupane-type triterpenoid saponins 24–31 ... ...

    Abstract Pulsatilla koreana, a species endemic to Korea, is an important herb used in traditional medicine to treat amoebic dysentery and malaria. In the present study, 23 oleanane-type triterpenoid saponins 1–23 and eight lupane-type triterpenoid saponins 24–31 were isolated from the roots of P. koreana. Their structures were elucidated on the basis of spectroscopic data. The methanol extract and isolated compounds were next assessed for nematicidal activity against the root-knot nematode (Meloidogyne incognita). The methanol extract showed strong nematicidal activity after 48 h, with a LC50 value of 92.8 μg/mL. Compounds 2, 5, 9, 20, and 21 showed significant effects, with LC50 values ranging from 70.1 to 94.7 μg/mL after 48 h. These results suggest that triterpenoid saponins from P. koreana should be explored as potential natural nematicides for developing new agents to control root-knot nematode disease
    Schlagwörter Pulsatilla koreana ; triterpene saponin ; Meloidogyne incognita ; nematicidal activity ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2013-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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