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  1. Artikel ; Online: A 3-miRNA Risk Scoring Signature in Early Diabetic Retinopathy

    Jiali Wu / Ke Shi / Fang Zhang / Xiaodong Sun

    Journal of Clinical Medicine, Vol 12, Iss 1777, p

    2023  Band 1777

    Abstract: Purpose: The aim of our study was to investigate a comprehensive profile of streptozotocin (STZ)-induced early diabetic retinopathy (DR) mice to identify a risk scoring signature based on micorRNAs (miRNAs) for early DR diagnosis. Methods: RNA sequencing ...

    Abstract Purpose: The aim of our study was to investigate a comprehensive profile of streptozotocin (STZ)-induced early diabetic retinopathy (DR) mice to identify a risk scoring signature based on micorRNAs (miRNAs) for early DR diagnosis. Methods: RNA sequencing was performed to obtain the gene expression profile of retinal pigment epithelium (RPE) in early STZ-induced mice. Differentially expressed genes (DEGs) were determined with log2|fold change (FC)| > 1 and p value < 0.05. Functional analysis was carried out based on gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and the protein–protein interaction (PPI) network. We predicted the potential miRNAs via online tools and ROC curves were then conducted. Three potential miRNAs with AUC > 0.7 were explored via public datasets and a formula was further established to evaluate DR severity. Results: In total, 298 DEGs (200 up-regulating and 98 down-regulating) were obtained through RNA sequencing. Hsa-miR-26a-5p, hsa-miR-129-2-3p and hsa-miR-217 were three predicted miRNAs with AUC > 0.7, suggesting their potential to distinguish healthy controls from early DR. The formula of DR severity score = 19.257 − 0.004 × hsa-miR-217 + 5.09 × 10 −5 × hsa-miR-26a-5p − 0.003 × hsa-miR-129-2-3p was established based on regression analysis. Conclusions: In the present study, we investigated the candidate genes and molecular mechanisms based on RPE sequencing in early DR mice models. Hsa-miR-26a-5p, hsa-miR-129-2-3p and hsa-miR-217 could work as biomarkers for early DR diagnosis and DR severity prediction, which was beneficial for DR early intervention and treatment.
    Schlagwörter diabetic retinopathy ; differentially expressed gene ; miRNA ; risk score signature ; Medicine ; R
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: How Ski Tourism Involvement Promotes Tourists’ Low-Carbon Behavior?

    Yang Yang / Xiaodong Sun / Lingli Hu / Yuzhu Ma / He Bu

    Sustainability, Vol 15, Iss 10277, p

    2023  Band 10277

    Abstract: China’s ski tourism industry has grown tremendously in the past few years, leading to an increasing amount of tourism-related carbon emissions with negative environmental impacts. Although the government and other market participants are trying to solve ... ...

    Abstract China’s ski tourism industry has grown tremendously in the past few years, leading to an increasing amount of tourism-related carbon emissions with negative environmental impacts. Although the government and other market participants are trying to solve the problem from both legislative and technological perspectives, encouraging tourists to engage in low-carbon behavior may play a more important role. This study aims to explore how tourism involvement influences ski tourists’ low-carbon behavior. A sampling survey was conducted to collect 422 valid responses from two ski resorts (indoor and outdoor). Findings from structural equation modeling revealed a significant positive impact of tourism involvement on both low-carbon tourism behavior and low-carbon daily behavior, and this impact can be serially mediated by place attachment and environmental responsibility. In addition, we confirmed that the impact of ski tourism involvement on place attachment is more significant for outdoor ski resorts compared with indoor ones. This study expands the categories of destinations for research on ski tourism and low-carbon behavior. It provides implications for encouraging visitor pro-environmental behavior while corroborating the social value of ski tourism in addressing environmental issues. It also offers insights for government low-carbon campaigns, business management practices, and individuals with actionable attitudes. However, it is worth noting that this study was conducted in a single latitude region and did not conduct a comparative analysis with different locations across latitudes. Future research could investigate skiers in cities of different latitudes to gain a more comprehensive understanding.
    Schlagwörter ski tourism ; tourism involvement ; low-carbon tourism behavior ; daily low-carbon behavior ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Research on Output Voltage Stability of Non-Contact Excitation Motor

    Ke Li / Xuan Meng / Xiaodong Sun

    Applied Sciences, Vol 12, Iss 3666, p

    2022  Band 3666

    Abstract: In recent years, electric vehicles have developed rapidly. However, many electric cars are equipped with permanent magnet synchronous motors. Permanent magnet synchronous motors have several disadvantages: For example, permanent magnets tend to ... ...

    Abstract In recent years, electric vehicles have developed rapidly. However, many electric cars are equipped with permanent magnet synchronous motors. Permanent magnet synchronous motors have several disadvantages: For example, permanent magnets tend to demagnetize at high temperatures. Electrically excited synchronous motors have several excellent properties. First, they are cheaper because the stator and rotor of the motor only need to be wound, which is more affordable than permanent magnets for speed regulation. When the armature current reaches the maximum value, the excitation current can also be adjusted for speed regulation, which makes the speed regulation more flexible. In the case of a short circuit, the corresponding direct-axis current is smaller than the quadrature-axis current, so the fault tolerance is better. Since the traditional electric excitation motor has brushes and slips rings, sparks will be generated during commutation. Therefore, a new excitation method is adopted to make non-contact motor excitation, and the motor operation is safer and more environmentally friendly. At the same time, to ensure that the output power of the non-contact electric excitation motor remains stable, a step-down circuit and power-type fast discrete terminal sliding mode control are added after the full-bridge rectifier circuit to make the excitation current and voltage output of the motor more stable. That is, the output power reaches a steady production. In this paper, an improved sliding mode control algorithm is used to stabilize the output voltage of the non-contact excitation motor, which can still ensure the stable output of the voltage when the equivalent load changes. It is confirmed that the non-contact excitation motor can be applied to various complex situations, and the proposed algorithm is simulated and experimentally verified to verify the accuracy of the proposed algorithm.
    Schlagwörter contactless excitation ; a resonant circuit ; buck transform ; power type fast discrete terminal sliding mode control ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 629
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Study the Effect of eHMI Projection Distance and Contrast on People Acceptance in Blind-Spot Detection Scenario

    Ali Hassan Shah / Xiaodong Sun / Yandan Lin

    Applied Sciences, Vol 12, Iss 6730, p

    2022  Band 6730

    Abstract: External human-machine interaction (eHMI) road projections are a new feature for automotive lighting to improve vehicle communication with other road users. These modalities are used to draw users’ attention and awareness to specific situations. However, ...

    Abstract External human-machine interaction (eHMI) road projections are a new feature for automotive lighting to improve vehicle communication with other road users. These modalities are used to draw users’ attention and awareness to specific situations. However, such advanced capabilities are still being debated to be used on the road in the context of whether or not such road projections can provide a clear and understandable message to road users in a specific scenario or lead to anticipation and change in the driving behavior. Therefore, it is necessary to investigate human factors aspects, such as the feeling of safety, useability, understanding, acceptability, and driver behavior. This study investigates the change in distance and luminance contrast and its effect on human driving behavior and acceptability in blind spot detection scenarios on the highway. A lab experiment with 12 participants is performed to analyze: understanding, satisfaction, usability, visibility, safety, workload, and driving behavior towards eHMI projection while varying projecting distance and luminance contrast. Video recordings and a designed questionnaire were used during the whole process. Results show that ego vehicle drivers prefer a projection distance between 5 to 10 m. However, a distance of 5 m is preferred by overtaking vehicle drivers in terms of visibility and safety. Luminance contrasts have no significant effect on the symbol’s visibility in 5 m and 10 m projection distances. In contrast, participants in overtaking vehicles feel difficult to understand the situation for 15 m condition, which increases their overall workload significantly ( p < 0.019). No significant effect is recorded in terms of change in driving behavior.
    Schlagwörter eHMI projection system ; autonomous vehicles ; human factors ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 380
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: An Overview of Position Sensorless Techniques for Switched Reluctance Machine Systems

    Xingtao Tang / Xiaodong Sun / Ming Yao

    Applied Sciences, Vol 12, Iss 3616, p

    2022  Band 3616

    Abstract: Accurate real-time rotor position is indispensable for switched reluctance motors (SRM) speed and torque control. Traditional position sensors add complexity and potential failure risk to the system. Owing to the added advantages of high stability and ... ...

    Abstract Accurate real-time rotor position is indispensable for switched reluctance motors (SRM) speed and torque control. Traditional position sensors add complexity and potential failure risk to the system. Owing to the added advantages of high stability and low cost, the position sensorless method of SRMs has been extensively studied to advance its use in vehicles and construction machinery. This paper presents an overview of position sensorless control techniques from the perspective of whether the method requires the establishment of complex mathematical models. Various types of methods are compared for performance, such as speed regulation range, algorithm complexity, and requirement of the pre-stored parameter. A discussion is presented concerning current trends in technological development, which will facilitate the research addressing potentially effective methods for position estimation in SRM drive systems.
    Schlagwörter additional components ; hybrid detection method ; position sensorless control ; magnetic-model-based ; switched reluctance machine (SRM) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 629
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Optimization Design and Control of Six-Phase Switched Reluctance Motor with Decoupling Winding Connections

    Wei Qiao / Shouyi Han / Kaikai Diao / Xiaodong Sun

    Applied Sciences, Vol 12, Iss 8801, p

    2022  Band 8801

    Abstract: In this paper, a design optimization method is proposed to reduce the current asymmetric and consequent torque ripple for a six-phase Switched Reluctance Motor (SRM). First, the inconsistent current phenomenon of the investigated SRM is introduced, and ... ...

    Abstract In this paper, a design optimization method is proposed to reduce the current asymmetric and consequent torque ripple for a six-phase Switched Reluctance Motor (SRM). First, the inconsistent current phenomenon of the investigated SRM is introduced, and the relationship between the magnetic distribution and the phase currents is investigated by magnetic circuit analysis. Then, for the reduction in computational cost, a surrogate model is utilized to establish the response surface model between the optimization objectives and variables. Furthermore, multiobjective optimization is performed based on structural design optimization and asymmetric control, and the best design solution is selected for the drive system. Compared with the traditional symmetric control, it can be found that the proposed asymmetric control can mitigate the inconsistent phase currents and reduce the torque ripple. Finally, a prototype motor is manufactured and tested. Both the simulation and experimental results verify the effectiveness and the reasonability of the analysis and the optimization.
    Schlagwörter finite-element model (FEM) ; multiobjective optimization ; switched reluctance motor ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 510
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Optical Coherence Tomography Angiography Characteristics Serve as Retinal Vein Occlusion Therapeutic Biomarkers for Dexamethasone Intravitreal Implant

    Ke Shi / Xiaodong Sun / Jingfa Zhang

    Disease Markers, Vol

    2021  Band 2021

    Abstract: Background. Retinal vein occlusion (RVO) is the second most common vision-threatening retinal vascular disease. Intravitreal dexamethasone implant has been applied to treat macular edema secondary to RVO (RVO-ME). However, the alteration of morphologic ... ...

    Abstract Background. Retinal vein occlusion (RVO) is the second most common vision-threatening retinal vascular disease. Intravitreal dexamethasone implant has been applied to treat macular edema secondary to RVO (RVO-ME). However, the alteration of morphologic features detected with optical coherence tomography angiography (OCTA) has not been fully studied in RVO-ME patients before and after the treatment. Objective. This study is aimed at identifying potential therapeutic targets in RVO with integrative bioinformatic analysis and compares the OCTA characteristics alterations in patients with RVO-ME receiving injection of dexamethasone intravitreal implant. Methods. Bioinformatic analysis was analyzed in GSE101398 dataset from the Gene Expression Omnibus database. Multiple functional enrichment analyses were performed, and protein-protein interaction network was constructed to visualize the key node genes. Eleven eyes with RVO-ME were examined with OCTA before and after intravitreal dexamethasone implant. The OCTA parameters, including macular thickness, vessel density, foveal avascular zone parameters, the number of hyperreflective foci (HRF), area of cystoid edema, and subretinal fluid (SRF), were compared. The correlation was analyzed between best-corrected visual acuity (BCVA) and OCTA parameters. Results. A total of 79 differentially expressed genes were identified. Functional enrichment analyses revealed the enriched inflammatory events in RVO. In RVO-ME, Pearson correlation revealed that baseline BCVA was positively correlated with the area of SRF and central macular thickness, while no correlation was detected between baseline BCVA and HRF number or the area of cystoid edema. The visual acuity improved, and the central macular thickness was decreased after intravitreal dexamethasone implant injection. Besides, the number of HRF, the area of cystoid edema, and SRF were significantly alleviated after dexamethasone intravitreal injection. Conclusion. Retinal inflammation plays a crucial role in RVO pathogenesis. ...
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Cysteine Substitution and Calcium-Binding Mutations in FBN1 cbEGF-Like Domains Are Associated With Severe Ocular Involvement in Patients With Congenital Ectopia Lentis

    Min Zhang / Zexu Chen / Tianhui Chen / Xiaodong Sun / Yongxiang Jiang

    Frontiers in Cell and Developmental Biology, Vol

    2022  Band 9

    Abstract: Purpose: To investigate the clinical manifestations of congenital ectopia lentis (CEL) in patients with fibrillin (FBN1) calcium-binding epidermal growth factor (cbEGF)-like mutations.Design: Retrospective cohort study.Methods: Consecutive 68 CEL ... ...

    Abstract Purpose: To investigate the clinical manifestations of congenital ectopia lentis (CEL) in patients with fibrillin (FBN1) calcium-binding epidermal growth factor (cbEGF)-like mutations.Design: Retrospective cohort study.Methods: Consecutive 68 CEL probands with FBN1 cbEGF-like mutations were recruited, mostly comprising Marfan syndrome (MFS) patients. Patients were classified into the cysteine group (n = 43), calcium (Ca2+)-binding group (n = 13) or the others (n = 12) according to their genotypes. Ocular biometrics, morbidities and visual performance were compared among different mutation groups. Linear regression was used to evaluate the risk factors for axial length (AL) elongation.Results: With age-adjustment, cysteine substitution and Ca2+-binding mutations positively contributed to AL elongation (standardized coefficient: 0.410 and 0.367, p = 0.008 and 0.017, respectively). In addition, cataract formation was more frequently detected in patients with Ca2+-binding mutations (observed n = 3, expected n = 1.0; p = 0.036). Patients with cysteine substitutions had the poorest preoperative visual acuity among the three groups (p = 0.012) and did not recover as well as other patients. More MFS diagnoses were made in patients with cysteine substitutions (observed n = 16, expected n = 12.6), while ectopia lentis syndrome was detected more often in patients with cbEGF-like mutations out of the functional regions (observed n = 6, expected n = 2.5; p = 0.023).Conclusion: Compared with patients with cbEGF-like mutations out of functional regions, patients with cysteine substitutions or Ca2+-binding mutations had longer ALs with age adjustment, poorer ocular involvement, visual performance, and systematic manifestations.
    Schlagwörter cbEGF-like ; FBN1 ; cysteine ; congenital ectopia lentis ; marfan syndrome ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Stability Analysis of Rotor-Bearing Systems under the Influence of Misalignment and Parameter Uncertainty

    Xiaodong Sun / Kian K. Sepahvand / Steffen Marburg

    Applied Sciences, Vol 11, Iss 7918, p

    2021  Band 7918

    Abstract: Stability is a well-known challenge for rotating systems supported by hydrodynamic bearings (HDBs), particularly for the condition where the misalignment effect and the parametric uncertainty are considered. This study investigates the impact of ... ...

    Abstract Stability is a well-known challenge for rotating systems supported by hydrodynamic bearings (HDBs), particularly for the condition where the misalignment effect and the parametric uncertainty are considered. This study investigates the impact of misalignment and inherent uncertainties in bearings on the stability of a rotor-bearing system. The misalignment effect is approximately described by introducing two misaligned angles. The characteristics of an HDB, such as pressure distribution and dynamic coefficients, are calculated by the finite difference method (FDM). The stability threshold is evaluated as the intersection of run-up curve and borderline. Viscosity and clearance are considered as uncertain parameters. The generalized polynomial chaos (gPC) expansion is adopted to quantify the uncertainty in parameters by evaluating unknown coefficients. The unknown gPC coefficients are obtained by using the collocation method. The results obtained by the gPC expansion are compared with those of the Monte Carlo (MC) simulation. The results show that the characteristics of the HDB and the stability threshold are affected by misalignment and parameter uncertainties. As the uncertainty analysis using the gPC expansion is performed on a relatively small number of predefined collocation points compared with the large number of MC samples, the method is very efficient in terms of computation time.
    Schlagwörter stability analysis ; hydrodynamic bearing ; misalignment effect ; generalized polynomial chaos expansion ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Epidemiological Characteristics of Human Rabies in Urban and Suburban Districts in Shanghai, 2006–2021

    Zhi Li / Jiayu Hu / Zhuoying Huang / Xiang Guo / Jia Ren / Jing Qiu / Xiaoying Ma / Han Yan / Fang Huang / Xiaodong Sun

    Zoonoses, Vol 4, Iss 1, p

    2024  Band 993

    Abstract: Rabies is a vaccine-preventable, viral zoonotic disease caused by a lyssavirus. This study was aimed at analyzing the epidemiological characteristics of human rabies in Shanghai to provide valuable information to support accurate prevention and control. ... ...

    Abstract Rabies is a vaccine-preventable, viral zoonotic disease caused by a lyssavirus. This study was aimed at analyzing the epidemiological characteristics of human rabies in Shanghai to provide valuable information to support accurate prevention and control. Individual-level data on human rabies and dog bites/attacks in Shanghai were collected from 2006 to 2021. Demographic characteristics, spatial and seasonal patterns, and correlations were analyzed to explore the epidemiological profiles. Infection risk was predicted with a Bayesian aggression model. A total of 43 human rabies cases were registered in Shanghai in 2006–2021; the annual average incidence rate was 0.01/100000. Males and residents at ages of 10 to 19 years and over 50 years had an elevated risk of rabies. All cases were reported in suburban districts and peaked in July. The body parts most frequently injured by dogs were the hands (48.84%). The fatality rate was 100%. Most cases (86.05%) were not treated after exposure. A total of 310 dog bites/attacks were reported and significantly correlated with the number of cases (P=0.010). The predicted risk of human rabies was higher in suburban than urban areas. The incidence of human rabies in Shanghai was relatively low; nevertheless, risk still existed, particularly in suburban areas.
    Schlagwörter Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Compuscript Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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