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  1. Artikel: TopDIA: A Software Tool for Top-Down Data-Independent Acquisition Proteomics.

    Basharat, Abdul Rehman / Xiong, Xingzhao / Xu, Tian / Zang, Yong / Sun, Liangliang / Liu, Xiaowen

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Top-down mass spectrometry is widely used for proteoform identification, characterization, and quantification owing to its ability to analyze intact proteoforms. In the last decade, top-down proteomics has been dominated by top-down data-dependent ... ...

    Abstract Top-down mass spectrometry is widely used for proteoform identification, characterization, and quantification owing to its ability to analyze intact proteoforms. In the last decade, top-down proteomics has been dominated by top-down data-dependent acquisition mass spectrometry (TD-DDA-MS), and top-down data-independent acquisition mass spectrometry (TD-DIA-MS) has not been well studied. While TD-DIA-MS produces complex multiplexed tandem mass spectrometry (MS/MS) spectra, which are challenging to confidently identify, it selects more precursor ions for MS/MS analysis and has the potential to increase proteoform identifications compared with TD-DDA-MS. Here we present TopDIA, the first software tool for proteoform identification by TD-DIA-MS. It generates demultiplexed pseudo MS/MS spectra from TD-DIA-MS data and then searches the pseudo MS/MS spectra against a protein sequence database for proteoform identification. We compared the performance of TD-DDA-MS and TD-DIA-MS using
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.04.05.588302
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Tetrahydrocurcumin Ameliorates Acute Hypobaric Hypoxia-Induced Cognitive Impairment in Mice.

    Ma, Xuexinyu / Pan, Yang / Xue, Yuye / Li, Yao / Zhang, Yan / Zhao, Yani / Xiong, Xingzhao / Wang, Jianbo / Yang, Zhifu

    High altitude medicine & biology

    2022  Band 23, Heft 3, Seite(n) 264–272

    Abstract: Ma, Xuexinyu, Yang Pan, Yuye Xue, Yao Li, Yan Zhang, Yani Zhao, Xingzhao Xiong, Jianbo Wang, and Zhifu Yang. Tetrahydrocurcumin ameliorates acute hypobaric hypoxia-induced cognitive impairment in mice. ...

    Abstract Ma, Xuexinyu, Yang Pan, Yuye Xue, Yao Li, Yan Zhang, Yani Zhao, Xingzhao Xiong, Jianbo Wang, and Zhifu Yang. Tetrahydrocurcumin ameliorates acute hypobaric hypoxia-induced cognitive impairment in mice.
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Curcumin/analogs & derivatives ; Dronabinol ; Glucose Transporter Type 1/metabolism ; Hypoxia/complications ; Hypoxia/drug therapy ; Hypoxia/metabolism ; Mice ; Mice, Inbred C57BL ; Occludin/metabolism ; Oxidative Stress ; Superoxide Dismutase/metabolism
    Chemische Substanzen Antioxidants ; Glucose Transporter Type 1 ; Occludin ; tetrahydrocurcumin (00U0645U03) ; Dronabinol (7J8897W37S) ; Superoxide Dismutase (EC 1.15.1.1) ; Curcumin (IT942ZTH98)
    Sprache Englisch
    Erscheinungsdatum 2022-06-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2076262-8
    ISSN 1557-8682 ; 1527-0297
    ISSN (online) 1557-8682
    ISSN 1527-0297
    DOI 10.1089/ham.2021.0061
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Huangqi-Honghua Combination Prevents Cerebral Infarction with Qi Deficiency and Blood Stasis Syndrome in Rats by the Autophagy Pathway.

    Chen, Yue / Lei, Lu / Wang, Kai / Liang, Ruimin / Qiao, Yi / Feng, Zhijun / Zhang, Juanli / Bai, Min / Chen, Haixia / Zhao, Jiaxin / Xiong, Xingzhao / Cao, Jinyi / Shen, Xia / Yang, Zhifu

    Evidence-based complementary and alternative medicine : eCAM

    2022  Band 2022, Seite(n) 9496926

    Abstract: Background: Cerebral ischemia/reperfusion injury (CI/RI) contributes to the process of autophagy. Huangqi-Honghua combination (HQ-HH) is a traditional Chinese medicine (TCM) combination that has been widely used in the treatment of cerebrovascular ... ...

    Abstract Background: Cerebral ischemia/reperfusion injury (CI/RI) contributes to the process of autophagy. Huangqi-Honghua combination (HQ-HH) is a traditional Chinese medicine (TCM) combination that has been widely used in the treatment of cerebrovascular diseases in China. The role of autophagy in HQ-HH-mediated treatment of CI/RI is unclear.
    Methods: Sprague-Dawley (SD) rats were used to establish the middle cerebral artery occlusion (MCAO) with QDBS syndrome model and evaluate the function of HQ-HH in protecting against CI/RI.
    Results: HQ-HH significantly improved the neuronal pathology and reduced infarct volume, neurological deficits, and whole blood viscosity in rats with CI/RI. Western blot results showed that the expression of autophagy marker proteins LC3II/LC3I and Beclin1 in the HQ-HH group was significantly lower than that in the model group, while the expression of p62 was significantly higher in the HQ-HH group as compared with the model group. There were no significant differences in PI3K, Akt, and mTOR levels between the HQ-HH group and the model group; however, p-PI3K, p-Akt, and p-mTOR were significantly upregulated. In addition, HQ-HH also changed the composition and function of intestinal flora in MCAO + QDBS model rats.
    Conclusion: HQ-HH protects from CI/RI, and its underlying mechanism may involve the activation of the PI3K-Akt-mTOR signaling pathway, relating to the changes in the composition of intestinal flora.
    Sprache Englisch
    Erscheinungsdatum 2022-01-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9496926
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5995: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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