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  1. Article ; Online: Template synthesis of copper azide primary explosive through Cu2O@HKUST-1 core-shell composite prepared by “bottle around ship” method

    Xu-wen Liu / Yan Hu / Jia-heng Hu / Jia-xin Su / Cai-min Yang / Ying-hua Ye / Rui-qi Shen

    Defence Technology, Vol 25, Iss , Pp 99-

    2023  Volume 111

    Abstract: Copper azide (CA), as a primary explosive with high energy density, has not been practically used so far because of its high electrostatic sensitivity. The Cu2O@HKUST-1 core-shell structure hybrid material was synthesized by the “bottle around ship” ... ...

    Abstract Copper azide (CA), as a primary explosive with high energy density, has not been practically used so far because of its high electrostatic sensitivity. The Cu2O@HKUST-1 core-shell structure hybrid material was synthesized by the “bottle around ship” methodology in this research by regulating the dissolution rate of Cu2O and the generation rate of metal-organic framework (MOF) materials. Cu2O@HKUST-1 was carbonized to form a CuO@porous carbon (CuO@PC) composite material. CuO@PC was synthesized into a copper azide (CA) @PC composite energetic material through a gas-solid phase in-situ azidation reaction. CA is encapsulated in PC framework, which acts as a nanoscale Faraday cage, and its excellent electrical conductivity prevents electrostatic charges from accumulating on the energetic material's surface. The CA@PC composite energetic material has a CA content of 89.6%, and its electrostatic safety is nearly 30 times that of pure CA (1.47 mJ compared to 0.05 mJ). CA@PC delivers an outstanding balance of safety and energy density compared to similar materials.
    Keywords Composite energetic materials ; Copper azide ; Carbonization ; Template method ; Core-shell composite ; Electrostatic safety ; Military Science ; U
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.

    Young Suk Jung / Xu-Wen Liu / Rosemarie Chirco / Richard B Warner / Rafael Fridman / Hyeong-Reh Choi Kim

    PLoS ONE, Vol 7, Iss 6, p e

    2012  Volume 38773

    Abstract: Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) regulate epithelial-mesenchymal transition (EMT) critical for the development of epithelial organs as well as cancer cell invasion. TIMP-1 is frequently overexpressed in several ... ...

    Abstract Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) regulate epithelial-mesenchymal transition (EMT) critical for the development of epithelial organs as well as cancer cell invasion. TIMP-1 is frequently overexpressed in several types of human cancers and serves as a prognostic marker. The present study investigates the roles of TIMP-1 on the EMT process and formation of the lumen-like structure in a 3D Matrigel culture of MDCK cells. We show that TIMP-1 overexpression effectively prevents cell polarization and acinar-like structure formation. TIMP-1 induces expression of the developmental EMT transcription factors such as SLUG, TWIST, ZEB1 and ZEB2, leading to downregulation of epithelial marker and upregulation of mesenchymal markers. Importantly, TIMP-1's ability to induce the EMT-like process is independent of its MMP-inhibitory domain. To our surprise, TIMP-1 induces migratory and invasive properties in MDCK cells. Here, we present a novel finding that TIMP-1 signaling upregulates MT1-MMP and MMP-2 expression, and potentiates MT1-MMP activation of pro-MMP-2, contributing to tumor cell invasion. In spite of the fact that TIMP-1, as opposed to TIMP-2, does not interact with and inhibit MT1-MMP, TIMP-1 may act as a key regulator of MT1-MMP/MMP-2 axis. Collectively, our findings suggest a model in which TIMP-1 functions as a signaling molecule and also as an endogenous inhibitor of MMPs. This concept represents a paradigm shift in the current view of TIMP-1/MT1-MMP interactions and functions during cancer development/progression.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Comparative analysis of the compatibility effects of Danggui-Sini Decoction on a blood stasis syndrome rat model using untargeted metabolomics

    Wu, Jin-Xia / Hua Zheng / Xia Yao / Xu-Wen Liu / Hong-Jia Zhu / Chun-Li Yin / Xi Liu / Yi-Yi Mo / Hui-Min Huang / Bang Cheng / Fang Wu / Zhao-Ni Chen / Fang-Ming Song / Jun-Xiang Ruan / Hong-Ye Zhang / Ping Liu / Yong-Hong Liang / Hui Song / Hong-Wei Guo /
    Zhi-Heng Su

    Journal of chromatography. 2019 Jan. 15, v. 1105

    2019  

    Abstract: Danggui-Sini Decoction (DSD) is one of the most widely used traditional Chinese medicine formulae (TCMF) for treating various diseases caused by cold coagulation and blood stasis due to its effect of nourishing blood to warm meridians in clinical use. ... ...

    Abstract Danggui-Sini Decoction (DSD) is one of the most widely used traditional Chinese medicine formulae (TCMF) for treating various diseases caused by cold coagulation and blood stasis due to its effect of nourishing blood to warm meridians in clinical use. However, studies of the mechanism of how it dispels blood stasis and its compatible regularity are challenging because of the complex pathophysiology of blood stasis syndrome (BSS) and the complexity of DSD, with multiple active ingredients acting on different targets. Observing variations of endogenous metabolites in rats with BSS after administering DSD may further our understanding of the mechanism of BSS and the compatible regularity of DSD. In this study, to understand the pathogenesis of BSS and assess the compatibility effects of DSD, an ultra-performance liquid chromatography quadrupole-time of flight mass spectrometry-based untargeted metabolomics approach was used. Serum metabolic profiles in rats with BSS that was induced by an ice water bath associated with subcutaneous injection of epinephrine hydrochloride were compared with the intervention groups which were administered with DSD or its compatibility. Using pattern recognition analysis, a clear separation between the BSS model and control group was observed; DSD and its compatibility intervention groups were clustered closer toward the control than the model group, which corroborates results of hemorheology studies. In addition, 20 metabolites were considered as potential biomarkers associated with the development of BSS. Nine metabolites were regulated by DSD in intervening blood stasis, they were considered to be correlated with the effect of nourishing blood to warm meridians. Additionally, the results suggested that the intervention effect of DSD on BSS may involve regulating four pathways, namely, arachidonic acid metabolism, glycerophospholipid metabolism, bile acid biosynthesis, and pyruvate metabolism. Moreover, each functional unit (monarch, minister, and assistant) in DSD regulates different metabolites and metabolic pathways to achieve different effects on dispelling blood stasis; however, their intervention efficacies are inferior to the holistic formula, which may be due to the synergism of the bioactive ingredients in seven herbs of DSD. This study demonstrated that metabolomics is a powerful tool for evaluating the efficacy and compatibility effects of traditional Chinese medicine (TCM).
    Keywords Oriental traditional medicine ; active ingredients ; animal models ; arachidonic acid ; bile acids ; biochemical pathways ; biomarkers ; biosynthesis ; blood serum ; blood stasis ; coagulation ; cold ; epinephrine ; herbs ; ice ; mass spectrometry ; metabolites ; metabolomics ; pathogenesis ; pathophysiology ; pyruvic acid ; rats ; subcutaneous injection ; synergism ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2019-0115
    Size p. 164-175.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2018.12.017
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: [Identification of herbal tea ingredient Plumeria rubra and its adulterants using DNA barcoding].

    Shi, Yu-Hua / Sun, Wei / Fang, Guang-Hong / Zheng, Rong-Bo / Xu, Wen-Liu / Huang, Xiao-Dan / Weng, Shao-Quan / Li, Chu-Yuan / Chen, Shi-Lin

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2014  Volume 39, Issue 12, Page(s) 2199–2203

    Abstract: ITS2 sequence was used as a barcode to identify herbal tea ingredient Plumeria rubra and its adulterants. Genomic DNAs from forty eight samples were extracted, the ITS2 sequences were amplified and sequenced bi-direstionlly, and then assembled and ... ...

    Abstract ITS2 sequence was used as a barcode to identify herbal tea ingredient Plumeria rubra and its adulterants. Genomic DNAs from forty eight samples were extracted, the ITS2 sequences were amplified and sequenced bi-direstionlly, and then assembled and obtained using CodonCode Aligner. The sequences were aligned using ClustalW, the genetic distances were computed by kimura 2-parameter (K2P) model and the Neighbor-joining (NJ) phylogenetic trees were constructed using MEGA5.0. Results showed that the length of ITS2 sequence of P. rubra were 244 bp. The intra-specific genetic distances (0-0. 016 6) were much smaller than inter-specific ones between P. rubra and its adulterants(0.320 8-0.650 4). The NJ tree indicated that P. rubra and its adulterants could be distinguished clearly. Therefore, Using ITS2 barcode can accurately andeffectively distinguish herbal tea ingredient P. rubra from its adulterants, which providesa new molecular method to identify P. rubra and ensure its safety in use.
    MeSH term(s) Apocynaceae/classification ; Apocynaceae/genetics ; DNA Barcoding, Taxonomic/methods ; DNA, Plant/genetics ; DNA, Ribosomal Spacer/genetics ; Drug Contamination/prevention & control ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/classification ; Flowers/chemistry ; Flowers/classification ; Molecular Sequence Data ; Phylogeny ; Quality Control
    Chemical Substances DNA, Plant ; DNA, Ribosomal Spacer ; Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2014-06
    Publishing country China
    Document type English Abstract ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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