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  1. Article ; Online: Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

    Eric M. Trautmann / Daniel J. O’Shea / Xulu Sun / James H. Marshel / Ailey Crow / Brian Hsueh / Sam Vesuna / Lucas Cofer / Gergő Bohner / Will Allen / Isaac Kauvar / Sean Quirin / Matthew MacDougall / Yuzhi Chen / Matthew P. Whitmire / Charu Ramakrishnan / Maneesh Sahani / Eyal Seidemann / Stephen I. Ryu /
    Karl Deisseroth / Krishna V. Shenoy

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 20

    Abstract: Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic calcium ...

    Abstract Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic calcium signals to drive an optical brain-computer interface in macaques.
    Keywords Science ; Q
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Subcellular Imaging of Voltage and Calcium Signals Reveals Neural Processing In Vivo

    Yang, Helen H / François St-Pierre / Xulu Sun / Xiaozhe Ding / Michael Z. Lin / Thomas R. Clandinin

    Cell. 2016 June 30, v. 166

    2016  

    Abstract: A mechanistic understanding of neural computation requires determining how information is processed as it passes through neurons and across synapses. However, it has been challenging to measure membrane potential changes in axons and dendrites in vivo. ... ...

    Abstract A mechanistic understanding of neural computation requires determining how information is processed as it passes through neurons and across synapses. However, it has been challenging to measure membrane potential changes in axons and dendrites in vivo. We use in vivo, two-photon imaging of novel genetically encoded voltage indicators, as well as calcium imaging, to measure sensory stimulus-evoked signals in the Drosophila visual system with subcellular resolution. Across synapses, we find major transformations in the kinetics, amplitude, and sign of voltage responses to light. We also describe distinct relationships between voltage and calcium signals in different neuronal compartments, a substrate for local computation. Finally, we demonstrate that ON and OFF selectivity, a key feature of visual processing across species, emerges through the transformation of membrane potential into intracellular calcium concentration. By imaging voltage and calcium signals to map information flow with subcellular resolution, we illuminate where and how critical computations arise.
    Keywords Drosophila ; axons ; calcium ; calcium signaling ; dendrites ; image analysis ; membrane potential ; synapse
    Language English
    Dates of publication 2016-0630
    Size p. 245-257.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.05.031
    Database NAL-Catalogue (AGRICOLA)

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