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  1. Artikel: Successful weaning of a patient with severe COVID-19 pneumonia under prolonged midazolam sedation using morphine.

    Kunimasa, Kei / Ohashi, Yoshifumi / Okawa, Megumi / Iida, Hiroshi / Sonoda, Shunji / Hiuge, Yuki / Hachimine, Masaaki / Yamamura, Ai / Kawamura, Takahisa / Inoue, Takako / Tamiya, Motohiro / Kuhara, Hanako / Nishino, Kazumi / Nakamoto, Naoki / Kumagai, Toru / Tanigami, Hironobu

    Oxford medical case reports

    2022  Band 2022, Heft 6, Seite(n) omac051

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic continues to spread around the world. In April 2021, Japan experienced a fourth wave of COVID-19 infections, which led to the breakdown of the medical system. Osaka, Japan, was particularly affected, with ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to spread around the world. In April 2021, Japan experienced a fourth wave of COVID-19 infections, which led to the breakdown of the medical system. Osaka, Japan, was particularly affected, with many severe cases and the highest number of COVID-19-associated deaths in Japan. Herein, we present a patient with severe COVID-19 infection who received prolonged midazolam (MDZ) treatment since propofol was not available due to shortage of medical resources. Moreover, the duration of mechanical ventilation was extended due to the development of a pneumothorax. When MDZ tapering was initiated, tachypnea was observed, which resulted failure in ventilator weaning. However, the use of continuous morphine infusion led a successful weaning off the ventilator. We suggest that the administration of morphine may allow for a smoother weaning process for some patients with severe COVID-19 infection.
    Sprache Englisch
    Erscheinungsdatum 2022-06-23
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omac051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Metal-ion-assisted hydrolysis of dipeptides involving a serine residue in a neutral aqueous solution.

    Yashiro, Morio / Sonobe, Yoko / Yamamura, Ai / Takarada, Tohru / Komiyama, Makoto / Fujii, Yuki

    Organic & biomolecular chemistry

    2003  Band 1, Heft 4, Seite(n) 629–632

    Abstract: Dipeptides having a serine residue at the C-terminus, X-Ser, where X is an appropriate amino acid residue, were efficiently hydrolyzed in the presence of ZnCl2 at pH 7.0. The rapid hydrolysis of X-Ser is due to an autocatalysis of the hydroxy group in ... ...

    Abstract Dipeptides having a serine residue at the C-terminus, X-Ser, where X is an appropriate amino acid residue, were efficiently hydrolyzed in the presence of ZnCl2 at pH 7.0. The rapid hydrolysis of X-Ser is due to an autocatalysis of the hydroxy group in the serine residue, and is found to be accelerated by a metal ion, in particular by ZnCl2. Roles of the metal ion in the hydrolysis of peptides involving a serine residue, in relation to the recently reported protein cleavages, are discussed.
    Mesh-Begriff(e) Chlorides/chemistry ; Dipeptides/chemistry ; Hydrolysis ; Kinetics ; Metals/chemistry ; Serine/chemistry ; Solutions ; Zinc Compounds/chemistry
    Chemische Substanzen Chlorides ; Dipeptides ; Metals ; Solutions ; Zinc Compounds ; Serine (452VLY9402) ; zinc chloride (86Q357L16B)
    Sprache Englisch
    Erscheinungsdatum 2003-08-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/b209565c
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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