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  1. Artikel ; Online: The Signaling Pathway of PGE

    An, Yang / Yao, Jiameng / Niu, Xiaoyin

    Mediators of inflammation

    2021  Band 2021, Seite(n) 9087816

    Abstract: Prostaglandin E2 ( ... ...

    Abstract Prostaglandin E2 (PGE
    Mesh-Begriff(e) Cell Differentiation ; Dinoprostone/physiology ; Humans ; Receptors, Prostaglandin E/physiology ; Signal Transduction/physiology ; T-Lymphocytes/cytology
    Chemische Substanzen Receptors, Prostaglandin E ; Dinoprostone (K7Q1JQR04M)
    Sprache Englisch
    Erscheinungsdatum 2021-11-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2021/9087816
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  2. Artikel ; Online: An Efficient Routing Protocol for Quantum Key Distribution Networks.

    Yao, Jiameng / Wang, Yaxing / Li, Qiong / Mao, Haokun / El-Latif, Ahmed A Abd / Chen, Nan

    Entropy (Basel, Switzerland)

    2022  Band 24, Heft 7

    Abstract: Quantum key distribution (QKD) can provide point-to-point information-theoretic secure key services for two connected users. In fact, the development of QKD networks needs more focus from the scientific community in order to broaden the service scale of ... ...

    Abstract Quantum key distribution (QKD) can provide point-to-point information-theoretic secure key services for two connected users. In fact, the development of QKD networks needs more focus from the scientific community in order to broaden the service scale of QKD technology to deliver end-to-end secure key services. Of course, some recent efforts have been made to develop secure communication protocols based on QKD. However, due to the limited key generation capability of QKD devices, high quantum secure key utilization is the major concern for QKD networks. Since traditional routing techniques do not account for the state of quantum secure keys on links, applying them in QKD networks directly will result in underutilization of quantum secure keys. Therefore, an efficient routing protocol for QKD networks, especially for large-scale QKD networks, is desperately needed. In this study, an efficient routing protocol based on optimized link-state routing, namely QOLSR, is proposed for QKD networks. QOLSR considerably improves quantum key utilization in QKD networks through link-state awareness and path optimization. Simulation results demonstrate the validity and efficiency of the proposed QOLSR routing protocol. Most importantly, with the growth of communication traffic, the benefit becomes even more apparent.
    Sprache Englisch
    Erscheinungsdatum 2022-06-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e24070911
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Mathematical model and topology evaluation of quantum key distribution network.

    Li, Qiong / Wang, Yaxing / Mao, Haokun / Yao, Jiameng / Han, Qi

    Optics express

    2020  Band 28, Heft 7, Seite(n) 9419–9434

    Abstract: Due to the intrinsic point-to-point characteristic of quantum key distribution (QKD) systems, it is necessary to study and develop QKD network technology to provide a secure communication service for a large-scale of nodes over a large area. Considering ... ...

    Abstract Due to the intrinsic point-to-point characteristic of quantum key distribution (QKD) systems, it is necessary to study and develop QKD network technology to provide a secure communication service for a large-scale of nodes over a large area. Considering the quality assurance required for such a network and the cost limitations, building an effective mathematical model of a QKD network becomes a critical task. In this paper, a flow-based mathematical model is proposed to describe a QKD network using mathematical concepts and language. In addition, an investigation on QKD network topology evaluation was conducted using a unique and novel QKD network performance indicator, the Information-Theoretic Secure communication bound, and the corresponding linear programming-based calculation algorithm. A large number of simulation results based on the SECOQC network and NSFNET network validate the effectiveness of the proposed model and indicator.
    Sprache Englisch
    Erscheinungsdatum 2020-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.387697
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: m

    Wang, Xuefei / Chen, Chen / Sun, Hongwei / Mao, Kaiqiong / Yao, Jiameng / Zhang, Weiqiao / Zhan, Meixiao / Li, Hua-Bing / Zhang, Zhiren / Zhu, Shu / Lu, Ligong

    Science China. Life sciences

    2023  Band 66, Heft 11, Seite(n) 2543–2552

    Abstract: ... ...

    Abstract N
    Mesh-Begriff(e) Animals ; Mice ; Th17 Cells ; Autoimmunity/genetics ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Cell Differentiation/genetics ; Methyltransferases/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Mice, Inbred C57BL
    Chemische Substanzen Methyltransferases (EC 2.1.1.-) ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2023-06-29
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2546732-3
    ISSN 1869-1889 ; 1674-7305
    ISSN (online) 1869-1889
    ISSN 1674-7305
    DOI 10.1007/s11427-022-2323-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  5. Buch ; Online: Mathematical Model and Topology Evaluation of Quantum Secure Communication Network

    Li, Qiong / Wang, Yaxing / Mao, Haokun / Yao, Jiameng / Han, Qi

    2019  

    Abstract: Due to the intrinsic point-to-point characteristic of quantum key distribution (QKD) systems, it is necessary to study and develop QKD network technology to provide a secure communication service for a large-scale of nodes over a large area. Considering ... ...

    Abstract Due to the intrinsic point-to-point characteristic of quantum key distribution (QKD) systems, it is necessary to study and develop QKD network technology to provide a secure communication service for a large-scale of nodes over a large area. Considering the quality assurance required for such a network and the cost limitations, building an effective mathematical model of a QKD network becomes a critical task. In this paper, a flow-based mathematical model is proposed to describe a QKD network using mathematical concepts and language. In addition, an investigation on QKD network topology evaluation was conducted using a unique and novel QKD network performance indicator, the Information-Theoretic Secure communication bound, and the corresponding linear programming-based calculation algorithm. A large number of simulation results based on the topologies of SECOQC network and NSFNET network validate the effectiveness of the proposed model and indicator.

    Comment: 16 pages, 4 figures
    Schlagwörter Quantum Physics ; Computer Science - Cryptography and Security
    Thema/Rubrik (Code) 000
    Erscheinungsdatum 2019-09-05
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer.

    Chen, Huifang / Yao, Jiameng / Bao, Rujuan / Dong, Yu / Zhang, Ting / Du, Yanhua / Wang, Gaoyang / Ni, Duan / Xun, Zhenzhen / Niu, Xiaoyin / Ye, Youqiong / Li, Hua-Bing

    Molecular cancer

    2021  Band 20, Heft 1, Seite(n) 29

    Abstract: Background: The four major RNA adenosine modifications, i.e., m: Methods: We systematically characterized mRNA expression and genetic alterations of 26 RNA modification "writers" in colorectal cancer (CRC), and evaluated their expression pattern in ... ...

    Abstract Background: The four major RNA adenosine modifications, i.e., m
    Methods: We systematically characterized mRNA expression and genetic alterations of 26 RNA modification "writers" in colorectal cancer (CRC), and evaluated their expression pattern in 1697 CRC samples from 8 datasets. We used an unsupervised clustering method to assign the samples into two patterns of expression of RNA modification "writers". Subsequently, we constructed the RNA modification "writer" Score (WM_Score) model based on differentially expressed genes (DEGs) responsible for the RNA modification patterns to quantify the RNA modification-related subtypes of individual tumors. Furthermore, we performed association analysis for WM_Score and characteristics of TME, consensus molecular subtypes (CMSs), clinical features, transcriptional and post-transcriptional regulation, drug response, and the efficacy of immunotherapy.
    Results: We demonstrated that multi-layer alterations of RNA modification "writer" are associated with patient survival and TME cell-infiltrating characteristics. We identified two distinct RNA modification patterns, characterized by a high and a low WM_Score. The WM_Score-high group was associated with worse patient overall survival and with the infiltration of inhibitory immune cells, such as M2 macrophages, EMT activation, and metastasis, while the WM_Score-low group was associated with a survival advantage, apoptosis, and cell cycle signaling pathways. WM_Score correlated highly with the regulation of transcription and post-transcriptional events contributing to the development of CRC. In response to anti-cancer drugs, WM_Score highly negatively correlated (drug sensitive) with drugs which targeted oncogenic related pathways, such as MAPK, EGFR, and mTOR signaling pathways, positively correlated (drug resistance) with drugs which targeted in apoptosis and cell cycle. Importantly, the WM_Score was associated with the therapeutic efficacy of PD-L1 blockade, suggesting that the development of potential drugs targeting these "writers" to aid the clinical benefits of immunotherapy.
    Conclusions: Our study is the first to provide a comprehensive analysis of four RNA modifications in CRC. We revealed the potential function of these writers in TME, transcriptional and post-transcriptional events, and identified their therapeutic liability in targeted therapy and immunotherapy. This work highlights the cross-talk and potential clinical utility of RNA modification "writers" in cancer therapy.
    Mesh-Begriff(e) Biomarkers, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Combined Modality Therapy ; Computational Biology/methods ; Disease Management ; Disease Susceptibility ; Epithelial-Mesenchymal Transition ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Pharmacogenetics/methods ; Prognosis ; Proportional Hazards Models ; RNA Processing, Post-Transcriptional/drug effects ; Transcription, Genetic ; Transcriptome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2021-02-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1476-4598
    ISSN (online) 1476-4598
    DOI 10.1186/s12943-021-01322-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Pooled CRISPR screening identifies m

    Tong, Jiyu / Wang, Xuefei / Liu, Yongbo / Ren, Xingxing / Wang, Anmin / Chen, Zonggui / Yao, Jiameng / Mao, Kaiqiong / Liu, Tingting / Meng, Fei-Long / Pan, Wen / Zou, Qiang / Liu, Jun / Zhou, Yu / Xia, Qiang / Flavell, Richard A / Zhu, Shu / Li, Hua-Bing

    Science advances

    2021  Band 7, Heft 18

    Abstract: ... ...

    Abstract m
    Mesh-Begriff(e) Adenosine/metabolism ; Animals ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Lipopolysaccharides ; Macrophage Activation/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice
    Chemische Substanzen Lipopolysaccharides ; Methyltransferases (EC 2.1.1.-) ; Adenosine (K72T3FS567)
    Sprache Englisch
    Erscheinungsdatum 2021-04-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abd4742
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: [IDUA gene mutation analysis and prenatal diagnosis of two families affected with mucopolysaccharidosis type I].

    Yang, Xinyu / Mei, Shiyue / Kong, Xiangdong / Zhao, Zhenhua / Cai, Aojie / Yao, Jiameng / Li, Yiying / Qin, Zhi

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2017  Band 34, Heft 3, Seite(n) 347–351

    Abstract: Objective: To analyze mutations of IDUA gene in two pedigrees affected with mucopolysaccharidosis type I and provide prenatal diagnosis for them.: Methods: The 14 exons of the IDUA gene were subjected to PCR amplification and Sanger sequencing.: ... ...

    Abstract Objective: To analyze mutations of IDUA gene in two pedigrees affected with mucopolysaccharidosis type I and provide prenatal diagnosis for them.
    Methods: The 14 exons of the IDUA gene were subjected to PCR amplification and Sanger sequencing.
    Results: For pedigree 1, the proband was found to harbor compound heterozygous mutations c.46-57delTCGCTCCTGGCC (p.Ser16_Ala19del) of exon 1 and c.1147delC (p.Arg383Alafs*57) of exon 8 of the IDUA gene, which were inherited from his father and mother, respectively. The latter was unreported previously. Prenatal diagnosis suggested that the fetus has carried a heterozygous c.46-57delTCGCTCCTGGCC mutation. For family 2, the proband was also found to carry compound mutations of the IDUA gene, namely c.721T to C (p.Cys241Arg) of exon 6 and c.1491delG (p.Thr497fs27) of exon 8, which were inherited from her mother and father, respectively. Neither mutation was reported previously. Prenatal diagnosis suggested that the fetus has carried a heterozygous c.721T to C mutation.
    Conclusion: Mutations of the IDUA gene probably underlie the MPS-I in both pedigrees. Above results have enriched the spectrum of IDUA gene mutations and facilitated prenatal diagnosis for both families.
    Mesh-Begriff(e) Adult ; Asian Continental Ancestry Group/genetics ; Base Sequence ; Child ; Child, Preschool ; China ; DNA Mutational Analysis ; Female ; Fetal Diseases/diagnosis ; Fetal Diseases/genetics ; Heterozygote ; Humans ; Iduronidase/genetics ; Male ; Molecular Sequence Data ; Mucopolysaccharidosis I/diagnosis ; Mucopolysaccharidosis I/embryology ; Mucopolysaccharidosis I/genetics ; Pedigree ; Pregnancy ; Prenatal Diagnosis ; Sequence Deletion
    Chemische Substanzen IDUA protein, human (EC 3.2.1.76) ; Iduronidase (EC 3.2.1.76)
    Sprache Chinesisch
    Erscheinungsdatum 2017-06-10
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 1003-9406
    ISSN 1003-9406
    DOI 10.3760/cma.j.issn.1003-9406.2017.03.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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