LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 6 von insgesamt 6

Suchoptionen

  1. Artikel ; Online: Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation.

    Sun, Kerry T / Patel, Tark / Kang, Sang-Gyun / Yarahmady, Allan / Srinivasan, Mahalashmi / Julien, Olivier / Heras, Jónathan / Mok, Sue-Ann

    ACS chemical neuroscience

    2023  Band 14, Heft 24, Seite(n) 4282–4297

    Abstract: The accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. Cryo-EM studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, such as Alzheimer' ...

    Abstract The accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. Cryo-EM studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy. A subset of tauopathies are linked to missense mutations in the tau protein, but it is not clear whether these mutations impact the structure of tau fibrils. To answer this question, we developed a high-throughput protein purification platform and purified a panel of 37 tau variants using the full-length 0N4R splice isoform. Each of these variants was used to create fibrils
    Mesh-Begriff(e) Humans ; tau Proteins/metabolism ; Tauopathies/metabolism ; Alzheimer Disease/metabolism ; Mutation/genetics
    Chemische Substanzen tau Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-12-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00422
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.

    Paul, Pallabi Sil / Patel, Tark / Cho, Jae-Young / Yarahmady, Allan / Khalili, Aria / Semenchenko, Valentyna / Wille, Holger / Kulka, Marianna / Mok, Sue-Ann / Kar, Satyabrata

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 144

    Abstract: Evidence suggests that beta-amyloid (Aβ)-induced phosphorylation/aggregation of tau protein plays a critical role in the degeneration of neurons and development of Alzheimer's disease (AD), the most common cause of dementia affecting the elderly ... ...

    Abstract Evidence suggests that beta-amyloid (Aβ)-induced phosphorylation/aggregation of tau protein plays a critical role in the degeneration of neurons and development of Alzheimer's disease (AD), the most common cause of dementia affecting the elderly population. Many studies have pursued a variety of small molecules, including nanoparticles conjugated with drugs to interfere with Aβ and/or tau aggregation/toxicity as an effective strategy for AD treatment. We reported earlier that FDA approved PLGA nanoparticles without any drug can attenuate Aβ aggregation/toxicity in cellular/animal models of AD. In this study, we evaluated the effects of native PLGA on Aβ seed-induced aggregation of tau protein using a variety of biophysical, structural and spectroscopic approaches. Our results show that Aβ
    Mesh-Begriff(e) Aged ; Animals ; Humans ; Alzheimer Disease/metabolism ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Phosphorylation ; Nanoparticles
    Chemische Substanzen tau Proteins ; Amyloid beta-Peptides
    Sprache Englisch
    Erscheinungsdatum 2024-01-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50465-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

    Carling, Gillian K / Fan, Li / Foxe, Nessa R / Norman, Kendra / Ye, Pearly / Wong, Man Ying / Zhu, Daphne / Yu, Fangmin / Xu, Jielin / Yarahmady, Allan / Chen, Hao / Huang, Yige / Amin, Sadaf / Zacharioudakis, Emmanouil / Chen, Xiaoying / Holtzman, David M / Mok, Sue-Ann / Gavathiotis, Evripidis / Sinha, Subhash C /
    Cheng, Feixiong / Luo, Wenjie / Gong, Shiaoching / Gan, Li

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The strongest risk factors for Alzheimer's disease (AD) include the χ4 allele of apolipoprotein E (APOE), ... ...

    Abstract The strongest risk factors for Alzheimer's disease (AD) include the χ4 allele of apolipoprotein E (APOE), the
    Sprache Englisch
    Erscheinungsdatum 2024-01-25
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.01.24.577107
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.

    Parra Bravo, Celeste / Giani, Alice Maria / Madero-Perez, Jesus / Zhao, Zeping / Wan, Yuansong / Samelson, Avi J / Wong, Man Ying / Evangelisti, Alessandro / Cordes, Ethan / Fan, Li / Ye, Pearly / Zhu, Daphne / Pozner, Tatyana / Mercedes, Maria / Patel, Tark / Yarahmady, Allan / Carling, Gillian K / Sterky, Fredrik H / Lee, Virginia M Y /
    Lee, Edward B / DeTure, Michael / Dickson, Dennis W / Sharma, Manu / Mok, Sue-Ann / Luo, Wenjie / Zhao, Mingrui / Kampmann, Martin / Gong, Shiaoching / Gan, Li

    Cell

    2024  Band 187, Heft 10, Seite(n) 2446–2464.e22

    Abstract: Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal lines to ... ...

    Abstract Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons. 4R-P301S neurons display progressive Tau inclusions upon seeding with Tau fibrils and recapitulate features of tauopathy phenotypes including shared transcriptomic signatures, autophagic body accumulation, and reduced neuronal activity. A CRISPRi screen of genes associated with Tau pathobiology identified over 500 genetic modifiers of seeding-induced Tau propagation, including retromer VPS29 and genes in the UFMylation cascade. In progressive supranuclear palsy (PSP) and Alzheimer's Disease (AD) brains, the UFMylation cascade is altered in neurofibrillary-tangle-bearing neurons. Inhibiting the UFMylation cascade in vitro and in vivo suppressed seeding-induced Tau propagation. This model provides a robust platform to identify novel therapeutic strategies for 4R tauopathy.
    Mesh-Begriff(e) Humans ; Induced Pluripotent Stem Cells/metabolism ; tau Proteins/metabolism ; Tauopathies/metabolism ; Tauopathies/pathology ; Neurons/metabolism ; Neurons/pathology ; Animals ; Mice ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/genetics ; Brain/metabolism ; Brain/pathology ; Supranuclear Palsy, Progressive/metabolism ; Supranuclear Palsy, Progressive/pathology ; Supranuclear Palsy, Progressive/genetics ; Cell Differentiation ; Mutation ; Autophagy
    Chemische Substanzen tau Proteins ; MAPT protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.03.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1167: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.

    Bravo, Celeste Parra / Giani, Alice Maria / Perez, Jesus Madero / Zhao, Zeping / Samelson, Avi / Wong, Man Ying / Evangelisti, Alessandro / Fan, Li / Pozner, Tatyana / Mercedes, Maria / Ye, Pearly / Patel, Tark / Yarahmady, Allan / Carling, Gillian / Lee, Virginia M Y / Sharma, Manu / Mok, Sue-Ann / Luo, Wenjie / Zhao, Mingrui /
    Kampmann, Martin / Gong, Shiaoching / Gan, Li

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to lack of appropriate human models. Current human induced pluripotent stem cell (hiPSC)-derived neurons express very low levels of 4- ... ...

    Abstract Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to lack of appropriate human models. Current human induced pluripotent stem cell (hiPSC)-derived neurons express very low levels of 4-repeat (4R)-tau isoforms that are normally expressed in adult brain. Here, we engineered new iPSC lines to express 4R-tau and 4R-tau carrying the P301S
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.06.19.544278
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.

    Udeochu, Joe C / Amin, Sadaf / Huang, Yige / Fan, Li / Torres, Eileen Ruth S / Carling, Gillian K / Liu, Bangyan / McGurran, Hugo / Coronas-Samano, Guillermo / Kauwe, Grant / Mousa, Gergey Alzaem / Wong, Man Ying / Ye, Pearly / Nagiri, Ravi Kumar / Lo, Iris / Holtzman, Julia / Corona, Carlo / Yarahmady, Allan / Gill, Michael T /
    Raju, Ravikiran M / Mok, Sue-Ann / Gong, Shiaoching / Luo, Wenjie / Zhao, Mingrui / Tracy, Tara E / Ratan, Rajiv R / Tsai, Li-Huei / Sinha, Subhash C / Gan, Li

    Nature neuroscience

    2023  Band 26, Heft 5, Seite(n) 737–750

    Abstract: Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP-AMP synthase (cGAS) diminishes cognitive ... ...

    Abstract Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP-AMP synthase (cGAS) diminishes cognitive resilience by decreasing the neuronal transcriptional network of myocyte enhancer factor 2c (MEF2C) through type I interferon (IFN-I) signaling. Pathogenic tau activates cGAS and IFN-I responses in microglia, in part mediated by cytosolic leakage of mitochondrial DNA. Genetic ablation of Cgas in mice with tauopathy diminished the microglial IFN-I response, preserved synapse integrity and plasticity and protected against cognitive impairment without affecting the pathogenic tau load. cGAS ablation increased, while activation of IFN-I decreased, the neuronal MEF2C expression network linked to cognitive resilience in AD. Pharmacological inhibition of cGAS in mice with tauopathy enhanced the neuronal MEF2C transcriptional network and restored synaptic integrity, plasticity and memory, supporting the therapeutic potential of targeting the cGAS-IFN-MEF2C axis to improve resilience against AD-related pathological insults.
    Mesh-Begriff(e) Animals ; Mice ; Cognition ; Immunity, Innate ; Interferons ; MEF2 Transcription Factors/genetics ; Microglia/metabolism ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; tau Proteins
    Chemische Substanzen Interferons (9008-11-1) ; MEF2 Transcription Factors ; Mef2c protein, mouse ; Nucleotidyltransferases (EC 2.7.7.-) ; tau Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-04-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01315-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4891: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 67: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang