Artikel ; Online: Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.
JCI insight
2024 Band 9, Heft 3
Abstract: Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component ... ...
Abstract | Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component of this immune milieu, the biology and the contribution of these cells in HS pathogenesis are unclear. We aimed to investigate the dynamics and microenvironmental interactions of B cells within cutaneous HS lesions. Combining histological analysis, single-cell RNA sequencing, and spatial transcriptomics profiling of HS lesions, we defined the tissue microenvironment relative to B cell activity within this disease. Our findings identified tertiary lymphoid structures (TLSs) within HS lesions and described organized interactions among T cells, B cells, antigen-presenting cells, and skin stroma. We found evidence that B cells within HS TLSs actively underwent maturation, including participation in germinal center reactions and class switch recombination. Moreover, skin stroma and accumulating T cells were primed to support the formation of TLSs and facilitate B cell recruitment during HS. Our data definitively demonstrated the presence of TLSs in lesional HS skin and point to ongoing cutaneous B cell maturation through class switch recombination and affinity maturation during disease progression in this inflamed nonlymphoid tissue. |
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Mesh-Begriff(e) | Humans ; Hidradenitis Suppurativa/pathology ; Tertiary Lymphoid Structures/pathology ; Skin/pathology ; B-Lymphocytes/pathology ; T-Lymphocytes/pathology |
Sprache | Englisch |
Erscheinungsdatum | 2024-02-08 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ISSN | 2379-3708 |
ISSN (online) | 2379-3708 |
DOI | 10.1172/jci.insight.169870 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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