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  1. Article ; Online: Corrigendum to "Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho" [Biomed. Pharmacother. 118 (2019) 109335].

    Guo, Hao / Wan, Xinhuan / Niu, Fengju / Sun, Jujie / Shi, Chenxiao / Ye, Jessica Meng / Zhou, Changzheng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2020  Volume 123, Page(s) 109809

    Language English
    Publishing date 2020-01-06
    Publishing country France
    Document type Journal Article ; Published Erratum
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.109809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho.

    Guo, Hao / Wan, Xinhuan / Niu, Fengju / Sun, Jujie / Shi, Chenxiao / Ye, Jessica Meng / Zhou, Changzheng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2019  Volume 118, Page(s) 109335

    Abstract: In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its ... ...

    Abstract In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its antiviral effect on different kinds of viruses was evaluated in vitro by MTT staining. The long-term toxicity of RPTF on rats was evaluated through the detection of general behavior, body weight, food intake and related organ tissue sections of experimental animals. We found that RPTF produced significantly inhibitory effects on HSV-1 and EV-71 viruses with the therapeutic index TI values 113.8 and 46.2, respectively. Moreover, toxicity evaluation in vivo showed no significantly adverse effects in rats, indicating that RPTF was safe in use. In conclusion, we demonstrated that RPTF, natural compounds in the Chinese traditional medicine, could act as promising and effective antiviral therapeutics with relative safety in use.
    MeSH term(s) Animals ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; Body Weight/drug effects ; Feeding Behavior/drug effects ; Female ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Flavonoids/toxicity ; Liver/drug effects ; Liver/pathology ; Male ; Rats, Wistar ; Robinia/chemistry ; Toxicity Tests
    Chemical Substances Antiviral Agents ; Flavonoids
    Language English
    Publishing date 2019-08-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.109335
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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