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  1. Artikel: Palynology-based reconstruction of Holocene environmental history in the northern Yangtze Delta, China

    Ye, Liangtao / Gao, Lei / Li, Yongfei / Wang, Guoqiang

    Palaeogeography, palaeoclimatology, palaeoecology. 2022 Oct. 01, v. 603

    2022  

    Abstract: The Holocene vegetation in the Yangtze Delta is sensitive to global/regional climate change, sea-level oscillations, and human impacts, and it represents a valuable archive for deciphering environmental change. In this paper, the vegetation history of ... ...

    Abstract The Holocene vegetation in the Yangtze Delta is sensitive to global/regional climate change, sea-level oscillations, and human impacts, and it represents a valuable archive for deciphering environmental change. In this paper, the vegetation history of the northern Yangtze deltaic coast, and its response to climate/sea-level changes over the past 10.3 ka, have been investigated based on palynological assemblages from a well-dated sediment core (YZ07) in the northern Yangtze delta. Comparison of vegetation successions with regional climatic proxies, relative sea level change, and depositional environments suggests that this region was dominated by mixed subtropical and temperate forests in a warm /wet climate regime during the early Holocene (~10.3–8.7 ka), when it was characterized by tidally-influenced fluvial environments. From ~8.7 ka to 7.5 ka, subtropical and warm temperate pollen taxa decreased significantly while cool-tolerant conifers and grasses became more dominant, indicating a cooler and drier climate. During the mid-Holocene thermal optimum (~7.5–4.3 ka), mixed subtropical and temperate forests expanded markedly in coastal regions, caused by a return to a warm/wet climate during an episode of rising sea-level. At the start of late Holocene (~4.3 to 3.4 ka), subtropical and temperate trees were widely replaced by grasses around coastal environments, indicating a cooling climate. From ~3.4–1.7 ka, mixed subtropical and temperate forests flourished in the delta region, suggesting that climate returned to warm and wet conditions again. From ~1.7–1.3 ka, in delta environments, subtropical and temperate forests contracted under cool/dry climatic conditions. Since ~1.3 ka, subtropical and temperate pollen taxa increased around the marsh to intertidal flat environments, suggesting a warm/wet climate resurgence. The generally warm/wet Holoence climate of the Yangtze Delta region was interrupted by a series of short-term cold events at 8.2 ka, 7.3 ka, 4.2 ka, 3.5 ka and 1.4 ka. These fluctuations are broadly synchronous with regional climate variability and global sea-level oscillations. In addition, the influence of human cultivation on vegetation is recognized since the mid-Holocene (around 5.6 ka), with the appearance of Fagopyrum pollen in the northern Yangtze Delta.
    Schlagwörter Fagopyrum ; Holocene epoch ; climate change ; coasts ; cold ; humans ; littoral zone ; marshes ; palaeogeography ; paleoclimatology ; paleoecology ; palynology ; pollen ; river deltas ; sea level ; sediments ; China
    Sprache Englisch
    Erscheinungsverlauf 2022-1001
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 417718-6
    ISSN 0031-0182
    ISSN 0031-0182
    DOI 10.1016/j.palaeo.2022.111186
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Response to Chen et al.

    Ye, Liangtao / Reiter, Florian P / Guba, Markus / De Toni, Enrico N

    Clinical and translational gastroenterology

    2020  Band 11, Heft 8, Seite(n) e00205

    Mesh-Begriff(e) Carcinoma, Hepatocellular ; Extracellular Matrix Proteins ; Glycoproteins ; Humans ; Liver Neoplasms ; Prognosis
    Chemische Substanzen Extracellular Matrix Proteins ; Glycoproteins ; olfactomedin
    Sprache Englisch
    Erscheinungsdatum 2020-11-10
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000205
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A hormesis-like effect of FeS on heterotrophic denitrification and its mechanisms.

    Zha, Yunyi / Wan, Rui / Wu, Mengqi / Ye, Ping / Ye, Liangtao / Li, Xiaoxiao / Yang, Haifeng / Luo, Jingyang

    Chemosphere

    2022  Band 311, Heft Pt 1, Seite(n) 136855

    Abstract: To alleviate the insufficiency of carbon source in sewage, many sulfur-containing inorganic electron donors were added into traditional heterotrophic denitrification process. However, the effects of extraneous inorganic electron donors on heterotrophic ... ...

    Abstract To alleviate the insufficiency of carbon source in sewage, many sulfur-containing inorganic electron donors were added into traditional heterotrophic denitrification process. However, the effects of extraneous inorganic electron donors on heterotrophic denitrification were still largely unknown. In this study, a hormesis-like effect of ferrous sulfide (FeS, a representative inorganic electron donors) on Paracoccus denitrificans was observed. Total nitrogen (TN) removal efficiency of P. denitrificans rose by 15% with the increase of FeS dosage from 0 to 0.3 g L
    Mesh-Begriff(e) Denitrification ; Bioreactors/microbiology ; Hormesis ; Nitrates/metabolism ; Autotrophic Processes ; Nitrogen/metabolism ; Glucose/pharmacology
    Chemische Substanzen Nitrates ; Nitrogen (N762921K75) ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2022-10-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.136855
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4

    Ye, Liangtao / Ziesch, Andreas / Schneider, Julia S / Ofner, Andrea / Nieß, Hanno / Denk, Gerald / Hohenester, Simon / Mayr, Doris / Mahajan, Ujjwal M / Munker, Stefan / Khaled, Najib Ben / Wimmer, Ralf / Gerbes, Alexander L / Mayerle, Julia / He, Yulong / Geier, Andreas / Toni, Enrico N De / Zhang, Changhua / Reiter, Florian P

    Aging and disease

    2024  Band 15, Heft 1, Seite(n) 338–356

    Abstract: Primary sclerosing cholangitis (PSC) represents a chronic liver disease characterized by poor prognosis and lacking causal treatment options. Yes-associated protein (YAP) functions as a critical mediator of fibrogenesis; however, its therapeutic ... ...

    Abstract Primary sclerosing cholangitis (PSC) represents a chronic liver disease characterized by poor prognosis and lacking causal treatment options. Yes-associated protein (YAP) functions as a critical mediator of fibrogenesis; however, its therapeutic potential in chronic biliary diseases such as PSC remains unestablished. The objective of this study is to elucidate the possible significance of YAP inhibition in biliary fibrosis by examining the pathophysiology of hepatic stellate cells (HSC) and biliary epithelial cells (BEC). Human liver tissue samples from PSC patients were analyzed to assess the expression of YAP/connective tissue growth factor (CTGF) relative to non-fibrotic control samples. The pathophysiological relevance of YAP/CTGF in HSC and BEC was investigated in primary human HSC (phHSC), LX-2, H69, and TFK-1 cell lines through siRNA or pharmacological inhibition utilizing verteporfin (VP) and metformin (MF). The Abcb4
    Mesh-Begriff(e) Mice ; Animals ; Humans ; Hepatic Stellate Cells ; Liver Cirrhosis/drug therapy ; Fibrosis ; Cholestasis/metabolism ; Bile Ducts ; Epithelium/metabolism
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0602
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Durable Complete Response of Brain Metastasis From Hepatocellular Carcinoma On Treatment With Nivolumab and Radiation Treatment.

    Ye, Liangtao / Zhang, Changhua / Seidensticker, Max / Mayerle, Julia / Reiter, Florian P / De Toni, Enrico N

    The American journal of gastroenterology

    2020  Band 115, Heft 12, Seite(n) 2114–2116

    Mesh-Begriff(e) Antineoplastic Agents, Immunological/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/therapy ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Nivolumab/therapeutic use ; Remission Induction
    Chemische Substanzen Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN)
    Sprache Englisch
    Erscheinungsdatum 2020-08-27
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000800
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Nano-fumed silica as a novel pollutant that inhibits the algicidal effect of p-hydroxybenzoic acid on Microcystis aeruginosa.

    Jiang, Xiaofeng / Zuo, Shengpeng / Ye, Liangtao / Hong, Wenxiu

    Environmental technology

    2017  Band 40, Heft 6, Seite(n) 693–700

    Abstract: Nanomaterials and/or contaminants are becoming more common in the developing world, but their effects on interspecific interactions are rarely reported, particularly in aquatic ecosystems. Thus, the present study determined the effects of the novel ... ...

    Abstract Nanomaterials and/or contaminants are becoming more common in the developing world, but their effects on interspecific interactions are rarely reported, particularly in aquatic ecosystems. Thus, the present study determined the effects of the novel pollutant nano-fumed silica (NFS) on algal control by a macrophyte via the allelochemical p-hydroxybenzoic acid in a microcosm test. The allelochemical p-hydroxybenzoic acid caused significant decreases in chlorophyll a, but increased the amount of superoxide anion radicals (
    Mesh-Begriff(e) Chlorophyll A ; Ecosystem ; Environmental Pollutants ; Microcystis ; Silicon Dioxide
    Chemische Substanzen Environmental Pollutants ; Silicon Dioxide (7631-86-9) ; Chlorophyll A (YF5Q9EJC8Y)
    Sprache Englisch
    Erscheinungsdatum 2017-11-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1479-487X
    ISSN (online) 1479-487X
    DOI 10.1080/09593330.2017.1404135
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Combined Hepatocellular-Cholangiocarcinoma: Biology, Diagnosis, and Management.

    Ye, Liangtao / Schneider, Julia S / Ben Khaled, Najib / Schirmacher, Peter / Seifert, Carolin / Frey, Lea / He, Yulong / Geier, Andreas / De Toni, Enrico N / Zhang, Changhua / Reiter, Florian P

    Liver cancer

    2023  Band 13, Heft 1, Seite(n) 6–28

    Abstract: Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic differentiation.: Summary: Because of its aggressive nature, patients with ... ...

    Abstract Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic differentiation.
    Summary: Because of its aggressive nature, patients with cHCC-iCCA exhibit a poorer prognosis than those with HCC. Surgical resection and liver transplantation may be considered curative treatment approaches; however, only a minority of patients are eligible at the time of diagnosis, and postoperative recurrence rates are high. For cases that are not eligible for surgery, locoregional and systemic therapy are often administered based on treatment protocols applied for HCC or iCCA. Owing to the rarity of this cancer, there are still no established standard treatment protocols; therefore, the choice of therapy is often personalized and guided by the suspected predominant component. Further, the genomic and molecular heterogeneity of cHCC-iCCA can severely compromise the efficacy of the available therapies.
    Key messages: In the present review, we summarize the latest advances in cHCC-iCCA and attempt to clarify its terminology and molecular biology. We provide an overview of the etiology of cHCC-iCCA and present new insights into the molecular pathology of this disease that could contribute to further studies aiming to improve the patient outcomes through new systemic therapies.
    Sprache Englisch
    Erscheinungsdatum 2023-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2666925-0
    ISSN 1664-5553 ; 2235-1795
    ISSN (online) 1664-5553
    ISSN 2235-1795
    DOI 10.1159/000530700
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch ; Online ; Dissertation / Habilitation: Novel targets and therapeutic strategies for the treatment of hepatocellular carcinoma (HCC)

    Ye, Liangtao [Verfasser] / Toni, Enrico de [Akademischer Betreuer]

    2019  

    Verfasserangabe Liangtao Ye ; Betreuer: Enrico de Toni
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Englisch
    Verlag Universitätsbibliothek der Ludwig-Maximilians-Universität
    Erscheinungsort München
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  9. Artikel ; Konferenzbeitrag: Prognostic significance of platelet count in HCC patients adjusted for surrogate parameters of portal hypertension

    Rodriguez, Isaac / Philipp, Alexander / Katrin, Lisa Katrin / Ye, Liangtao / Ben-Khaled, Najib / Reiter, Florian / Mayerle, Julia / de Toni, Enrico N / Munker, Stefan

    Zeitschrift für Gastroenterologie

    2024  Band 62, Heft 01

    Veranstaltung/Kongress 40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
    Sprache Deutsch
    Erscheinungsdatum 2024-01-01
    Verlag Georg Thieme Verlag
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1777625
    Datenquelle Thieme Verlag

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  10. Artikel ; Online: Atezolizumab/bevacizumab or lenvatinib in hepatocellular carcinoma: Multicenter real-world study with focus on bleeding and thromboembolic events.

    Ben Khaled, Najib / Möller, Marie / Jochheim, Leonie S / Leyh, Catherine / Ehmer, Ursula / Böttcher, Katrin / Pinter, Matthias / Balcar, Lorenz / Scheiner, Bernhard / Weich, Alexander / Leicht, Hans Benno / Zarka, Valentina / Ye, Liangtao / Schneider, Julia / Piseddu, Ignazio / Öcal, Osman / Rau, Monika / Sinner, Friedrich / Venerito, Marino /
    Gairing, Simon Johannes / Förster, Friedrich / Mayerle, Julia / De Toni, Enrico N / Geier, Andreas / Reiter, Florian P

    JHEP reports : innovation in hepatology

    2024  Band 6, Heft 6, Seite(n) 101065

    Abstract: Background & aims: Atezolizumab/bevacizumab (atezo/bev) and lenvatinib have demonstrated efficacy as first-line therapies for hepatocellular carcinoma (HCC). However, vascular endothelial growth factor (VEGF) inhibition with these therapies may be ... ...

    Abstract Background & aims: Atezolizumab/bevacizumab (atezo/bev) and lenvatinib have demonstrated efficacy as first-line therapies for hepatocellular carcinoma (HCC). However, vascular endothelial growth factor (VEGF) inhibition with these therapies may be associated with the risk of bleeding and thromboembolic events. In this study, we evaluated the efficacy and safety with focus on the bleeding and thromboembolic events of atezo/bev
    Methods: This study is based on HCC cohorts from seven centers in Germany and Austria. Incidences of bleeding or thromboembolic events and efficacy outcomes were assessed and compared.
    Results: In total, 464 patients treated with atezo/bev (n = 325) or lenvatinib (n = 139) were analyzed. Both groups were balanced with respect to demographics, presence of liver cirrhosis, and variceal status. Duration of therapy did not differ between groups. Within 3 months of therapy, bleeding episodes were described in 57 (18%) patients receiving atezo/bev compared with 15 (11%) patients receiving lenvatinib (
    Conclusions: Safety considerations related to bleeding and thromboembolic events may not be helpful in guiding clinical decision-making when choosing between atezo/bev and lenvatinib.
    Impact and implications: The inhibition of VEGF by current first-line therapies for HCC, such as atezolizumab/bevacizumab or lenvatinib, may be associated with the risk of bleeding and thromboembolic events. Studies comparing the incidence of these side effects between atezolizumab/bevacizumab and lenvatinib, which are preferred treatments over sorafenib for HCC, are needed. Differences in this side effect profile may influence the choice of first-line therapy by treating physicians. Because no significant differences were observed regarding bleeding or thromboembolic events between both therapies in the present study, we conclude that safety considerations related to these events may not be helpful in guiding clinical decision-making when choosing between atezolizumab/bevacizumab and lenvatinib.
    Sprache Englisch
    Erscheinungsdatum 2024-04-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2024.101065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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