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  1. Artikel ; Online: RNA polymerase tracking along damaged DNA: Impact on DNA repair and mutagenesis.

    Chiou, Yi-Ying / Kemp, Michael G

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Band 121, Heft 23, Seite(n) e2408073121

    Mesh-Begriff(e) DNA Repair ; Mutagenesis ; DNA Damage ; DNA-Directed RNA Polymerases/metabolism ; DNA-Directed RNA Polymerases/genetics ; DNA/genetics ; DNA/metabolism ; Humans
    Chemische Substanzen DNA-Directed RNA Polymerases (EC 2.7.7.6) ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2024-05-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2408073121
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  2. Artikel: Relationship between

    Liu, Yi-Ying / Wan, Qin

    World journal of diabetes

    2023  Band 14, Heft 12, Seite(n) 1803–1812

    Abstract: Background: Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment ... ...

    Abstract Background: Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment is difficult and the prognosis is poor. At present, the pathogenesis of diabetic kidney disease is still unclear, and it is believed that it is associated with genetic and environmental factors.
    Aim: To explore the relationship between the glucokinase regulatory protein (
    Methods: We selected 252 patients (126 males and 126 females) with T2D admitted to our hospital from January 2020 to October 2020, and 66 healthy people (44 females and 22 males). According to the urinary albumin/creatinine ratio, the subjects were divided into group I (control), group II (T2D with normoalbuminuria), group III (T2D with microalbuminuria), and group IV (T2D with macroalbuminuria). Additionly, the subjects were divided into group M (normal group) or group N (albuminuria group) according to whether they developed albuminuria. We detected the
    Results: Gene distribution and genotype distribution among groups I-IV accorded with the Hardy-Weinberg equilibrium. Genotype frequency was significantly different among the four groups (
    Conclusion: CT + TT genotype is a risk factor for T2D with albuminuria. In the future, we can assess the risk of individuals carrying susceptible genes to delay the onset of T2D.
    Sprache Englisch
    Erscheinungsdatum 2023-12-04
    Erscheinungsland United States
    Dokumenttyp Clinical Trial
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v14.i12.1803
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  3. Artikel: Smartphone addiction, gender and interpersonal attachment: A cross-sectional analytical survey in Taiwan.

    Wu, Yi-Ying / Chou, Wen-Huei

    Digital health

    2023  Band 9, Seite(n) 20552076231177134

    Abstract: Overview: Smartphone use has dramatically increased worldwide, contributing to a profound change in interpersonal interactions. They have become the primary medium of human interaction, and smartphone addiction, consequently, has become a modern-day ... ...

    Abstract Overview: Smartphone use has dramatically increased worldwide, contributing to a profound change in interpersonal interactions. They have become the primary medium of human interaction, and smartphone addiction, consequently, has become a modern-day reality. Recent research on smartphone addiction has provided diverse explanations regarding the correlation between gender and addiction. Therefore, this study aims to analyse the correlation and variance among smartphone addiction, gender and interpersonal attachment.
    Methods: The participants included Taiwanese citizens and the questionnaires were randomly distributed; 1190 valid questionnaires (534 males, 656 females) were collected. Descriptive statistics were computed to observe the average value and standard deviation between interpersonal attachment and gender. Next, Spearman's ρ was conducted to interpret the correlation among smartphone addiction, gender and interpersonal attachment. Finally, the participants were divided into three groups based on their pre-determined level of smartphone addiction: high, moderate and low addictions. The Analysis of variance (ANOVA) was performed based on interpersonal attachment as the independent variable to determine any statistically significant difference among the three levels.
    Results: There are four patterns of interpersonal attachment: secure, avoidant, dismissing and anxious attachments. The correlation analysis revealed a significant positive correlation between interpersonal attachment and smartphone addiction (
    Conclusion: This study revealed that there was no correlation between gender and smartphone addiction, but rather, a positive correlation between smartphone addiction and interpersonal attachment. This positive correlation suggests both high and moderate addiction groups display insecurity in their interpersonal attachment. Therefore, to lower the prevalence of unhealthy smartphone addiction, maintaining healthy interpersonal relationships is suggested.
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2819396-9
    ISSN 2055-2076
    ISSN 2055-2076
    DOI 10.1177/20552076231177134
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  4. Artikel ; Online: A Bibliometric Analysis to Identify Research Trends in Intervention Programs for Smartphone Addiction.

    Wu, Yi-Ying / Chou, Wen-Huei

    International journal of environmental research and public health

    2023  Band 20, Heft 5

    Abstract: Smartphone addiction is a serious social problem that necessitates research. To identify trends in intervention programs for smartphone addiction, distribution of research topics, and inter-relationships in academic research. We analyzed 104 studies ... ...

    Abstract Smartphone addiction is a serious social problem that necessitates research. To identify trends in intervention programs for smartphone addiction, distribution of research topics, and inter-relationships in academic research. We analyzed 104 studies published between 30 June 2022, and 31 August 2022, on the Web of Science (WoS). We applied the bibliometric method and identified the relationship and development trends of academic research in the field using descriptive analysis, the Latent Dirichlet Allocation (LDA), co-citation analysis, bibliographic coupling, and co-occurrence. There were four findings: First, intervention programs are classified into 10 types: psychological, social support, lifestyle, technological, family, medical care, educational, exercise, mindfulness, and meditation. Second, the volume of research on intervention programs increased every year. Third, China and South Korea had the highest research involvement. Finally, academic studies were split into either the human behavior or social science categories. Most of them defined the symptoms in terms of individual behavior and social relations, implying that smartphone addiction is not yet recognized as a disorder. Smartphone addiction has not yet been internationally recognized as a disorder, despite its impact on human physiology, psychology, and social behavior. Most related studies have been conducted in Asia, specifically in China and South Korea; Spain has the most outside Asia. Additionally, most of the research subjects were students, probably because of the convenience of sampling. As smartphones gain popularity among older adults, future studies could focus on smartphone addiction among individuals of varied ages.
    Mesh-Begriff(e) Humans ; Aged ; Internet Addiction Disorder ; Behavior Therapy ; Social Behavior ; Exercise ; Smartphone ; Bibliometrics ; Behavior, Addictive
    Sprache Englisch
    Erscheinungsdatum 2023-02-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20053840
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma.

    Wang, Yi-Ying / Shen, Mei-Mei / Gao, Jian

    World journal of gastroenterology

    2024  Band 30, Heft 8, Seite(n) 901–918

    Abstract: Background: Metadherin (: Aim: To explore the role of : Methods: MTDH: Results: HCC tissues expressed higher levels of : Conclusion: High levels of MTDH expression in patients with HCC are associated with poor prognosis, promoting tumor ... ...

    Abstract Background: Metadherin (
    Aim: To explore the role of
    Methods: MTDH
    Results: HCC tissues expressed higher levels of
    Conclusion: High levels of MTDH expression in patients with HCC are associated with poor prognosis, promoting tumor stemness, immune infiltration, and HCC progression.
    Mesh-Begriff(e) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; CD8-Positive T-Lymphocytes ; Transcription Factors/genetics ; Stem Cells/pathology ; Phenotype ; Cell Line, Tumor ; Membrane Proteins/genetics ; RNA-Binding Proteins/genetics
    Chemische Substanzen Transcription Factors ; MTDH protein, human ; Membrane Proteins ; RNA-Binding Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i8.901
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6039: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Artikel ; Online: Predicting the cryotolerance of boar sperm through antioxidant stress.

    Wang, Shih-Chung / Wu, Yi-Ying / Chen, Ming-Cheng

    Reproduction in domestic animals = Zuchthygiene

    2024  Band 59, Heft 4, Seite(n) e14554

    Abstract: High sperm cryotolerance is crucial to the successful cryopreservation of boar sperm. Evaluating the cryotolerance of boar sperm by using a rapid and convenient technique can enhance the commercial viability of these sperm. This study investigated the ... ...

    Abstract High sperm cryotolerance is crucial to the successful cryopreservation of boar sperm. Evaluating the cryotolerance of boar sperm by using a rapid and convenient technique can enhance the commercial viability of these sperm. This study investigated the correlation between sperm parameters for three sample subsets-fresh sperm, sperm with H
    Mesh-Begriff(e) Swine ; Male ; Animals ; Antioxidants/pharmacology ; Semen ; Hydrogen Peroxide/pharmacology ; Semen Preservation/veterinary ; Semen Preservation/methods ; Spermatozoa ; Cryopreservation/veterinary ; Cryopreservation/methods ; Sperm Motility
    Chemische Substanzen Antioxidants ; Hydrogen Peroxide (BBX060AN9V)
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1015187-4
    ISSN 1439-0531 ; 0936-6768
    ISSN (online) 1439-0531
    ISSN 0936-6768
    DOI 10.1111/rda.14554
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A Bibliometric Analysis to Identify Research Trends in Intervention Programs for Smartphone Addiction

    Yi-Ying Wu / Wen-Huei Chou

    International Journal of Environmental Research and Public Health, Vol 20, Iss 3840, p

    2023  Band 3840

    Abstract: Smartphone addiction is a serious social problem that necessitates research. To identify trends in intervention programs for smartphone addiction, distribution of research topics, and inter-relationships in academic research. We analyzed 104 studies ... ...

    Abstract Smartphone addiction is a serious social problem that necessitates research. To identify trends in intervention programs for smartphone addiction, distribution of research topics, and inter-relationships in academic research. We analyzed 104 studies published between 30 June 2022, and 31 August 2022, on the Web of Science (WoS). We applied the bibliometric method and identified the relationship and development trends of academic research in the field using descriptive analysis, the Latent Dirichlet Allocation (LDA), co-citation analysis, bibliographic coupling, and co-occurrence. There were four findings: First, intervention programs are classified into 10 types: psychological, social support, lifestyle, technological, family, medical care, educational, exercise, mindfulness, and meditation. Second, the volume of research on intervention programs increased every year. Third, China and South Korea had the highest research involvement. Finally, academic studies were split into either the human behavior or social science categories. Most of them defined the symptoms in terms of individual behavior and social relations, implying that smartphone addiction is not yet recognized as a disorder. Smartphone addiction has not yet been internationally recognized as a disorder, despite its impact on human physiology, psychology, and social behavior. Most related studies have been conducted in Asia, specifically in China and South Korea; Spain has the most outside Asia. Additionally, most of the research subjects were students, probably because of the convenience of sampling. As smartphones gain popularity among older adults, future studies could focus on smartphone addiction among individuals of varied ages.
    Schlagwörter smartphone addiction ; research trend ; intervention program ; bibliometric analysis ; LDA ; Medicine ; R
    Thema/Rubrik (Code) 001
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: The heterogeneity of the COVID-19 pandemic and national responses

    Yi-Ying Chen / Yibeltal Assefa

    BMC Public Health, Vol 21, Iss 1, Pp 1-

    an explanatory mixed-methods study

    2021  Band 15

    Abstract: Abstract Background The coronavirus disease of 2019 (COVID-19) has quickly spread to all corners of the world since its emergence in Wuhan, China in December of 2019. The disease burden has been heterogeneous across regions of the world, with Americas ... ...

    Abstract Abstract Background The coronavirus disease of 2019 (COVID-19) has quickly spread to all corners of the world since its emergence in Wuhan, China in December of 2019. The disease burden has been heterogeneous across regions of the world, with Americas leading in cumulative cases and deaths, followed by Europe, Southeast Asia, Eastern Mediterranean, Africa and Western Pacific. Initial responses to COVID-19 also varied between governments, ranging from proactive containment to delayed intervention. Understanding these variabilities allow high burden countries to learn from low burden countries on ways to create more sustainable response plans in the future. Methods This study used a mixed-methods approach to perform cross-country comparisons of pandemic responses in the United States (US), Brazil, Germany, Australia, South Korea, Thailand, New Zealand, Italy and China. These countries were selected based on their income level, relative COVID-19 burden and geographic location. To rationalize the epidemiological variability, a list of 14 indicators was established to assess the countries’ preparedness, actual response, and socioeconomic and demographic profile in the context of COVID-19. Results As of 1 April 2021, the US had the highest cases per million out of the nine countries, followed by Brazil, Italy, Germany, South Korea, Australia, New Zealand, Thailand and China. Meanwhile, Italy ranked first out of the nine countries’ total deaths per million, followed by the US, Brazil, Germany, Australia, South Korea, New Zealand, China and Thailand. The epidemiological differences between these countries could be explained by nine indicators, and they were 1) leadership, governance and coordination of response, 2) communication, 3) community engagement, 4) multisectoral actions, 5) public health capacity, 6) universal health coverage, 7) medical services and hospital capacity, 8) demography and 9) burden of non-communicable diseases. Conclusion The COVID-19 pandemic manifests varied outcomes due to differences in ...
    Schlagwörter COVID-19 pandemic response ; Australia ; Brazil ; China ; Germany ; Italy ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 950
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Correlation of serum uromodulin levels with renal fibrosis and renal function progression in patients with CKD.

    Jie, Chen / Yi-Ying, Ying / Miao, Chen

    Pakistan journal of pharmaceutical sciences

    2021  Band 34, Heft 6(Special), Seite(n) 2417–2422

    Abstract: To explore the relationship of serum uromodulin levels with renal function progression and renal fibrosis in chronic kidney disease (CKD) patients. Totally 168 CKD patients treated in Department of Nephrology of the present hospital between June 2017 and ...

    Abstract To explore the relationship of serum uromodulin levels with renal function progression and renal fibrosis in chronic kidney disease (CKD) patients. Totally 168 CKD patients treated in Department of Nephrology of the present hospital between June 2017 and June 2019 were recruited. These patients were allocated to the deterioration and control groups according to the estimated glomerular filtration rate (eGFR). Multi-factor Logistic regression analysis was utilized for the correlation factors influencing renal function progression and the correlation between serum uromodulin and renal fibrosis was also compared. Number of patients receiving ARB or ACEI drugs intervention was lower in the deterioration group than that in the control group (P<0.05). 24-hour urine protein quantification and HA were higher, while eGFR and uromodulin were lower in the deterioration group compared with the control group (both P<0.05). eGFR (OR=0.373) and uromodulin (OR=0.717) were the protective factors for renal function progression. The risk of renal fibrosis was higher in the deterioration group compared with the control group (P<0.05). Uromodulin was significantly higher in the fibrosis group compared with the normal group (P<0.05). Serum uromodulin is an independent risk factor for renal function progression, and is remarkably correlated with renal fibrosis, which deserves clinical promotion.
    Mesh-Begriff(e) Adult ; Aged ; Biomarkers/blood ; Case-Control Studies ; Disease Progression ; Female ; Fibrosis ; Glomerular Filtration Rate ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Male ; Middle Aged ; Predictive Value of Tests ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology ; Risk Assessment ; Risk Factors ; Uromodulin/blood
    Chemische Substanzen Biomarkers ; UMOD protein, human ; Uromodulin
    Sprache Englisch
    Erscheinungsdatum 2021-11-17
    Erscheinungsland Pakistan
    Dokumenttyp Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6588: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Artikel: Central Channelopathies in Obesity.

    Li, Athena Hsu / Kuo, Yi-Ying / Yang, Shi-Bing / Chen, Pei-Chun

    Journal of physiological investigation

    2024  Band 67, Heft 1, Seite(n) 15–26

    Abstract: As obesity has raised heightening awareness, researchers have attempted to identify potential targets that can be treated for therapeutic intervention. Focusing on the central nervous system (CNS), the key organ in maintaining energy balance, a plethora ... ...

    Abstract As obesity has raised heightening awareness, researchers have attempted to identify potential targets that can be treated for therapeutic intervention. Focusing on the central nervous system (CNS), the key organ in maintaining energy balance, a plethora of ion channels that are expressed in the CNS have been inspected and determined through manipulation in different hypothalamic neural subpopulations for their roles in fine-tuning neuronal activity on energy state alterations, possibly acting as metabolic sensors. However, a remaining gap persists between human clinical investigations and mouse studies. Despite having delineated the pathways and mechanisms of how the mouse study-identified ion channels modulate energy homeostasis, only a few targets overlap with the obesity-related risk genes extracted from human genome-wide association studies. Here, we present the most recently discovered CNS-specific metabolism-correlated ion channels using reverse and forward genetics approaches in mice and humans, respectively, in the hope of illuminating the prospects for future therapeutic development.
    Mesh-Begriff(e) Humans ; Animals ; Obesity/genetics ; Obesity/metabolism ; Channelopathies/genetics ; Channelopathies/metabolism ; Ion Channels/genetics ; Ion Channels/metabolism ; Energy Metabolism/genetics ; Mice ; Central Nervous System/metabolism ; Central Nervous System/physiopathology
    Chemische Substanzen Ion Channels
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland India
    Dokumenttyp Journal Article ; Review
    ISSN 2950-6344
    ISSN 2950-6344
    DOI 10.4103/ejpi.EJPI-D-23-00029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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