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  1. Artikel ; Online: The role of serum asprosin levels in predicting the severity of coronary artery disease in patients with diabetes mellitus.

    Yigitdol, Ismail / Gulumsek, Erdinc / Demirtas, Derya / Ardic, Mustafa Lutfullah / Baylan, Filiz Alkan / Ozturk, Huseyin Ali / Arici, Fatih Necip / Seker, Taner / Sumbul, Hilmi Erdem

    Irish journal of medical science

    2024  Band 193, Heft 3, Seite(n) 1239–1247

    Abstract: Background: Asprosin is an emerging biomarker that plays a role in metabolic diseases. This study investigates asprosin as a predictive marker for coronary artery disease (CAD) severity in diabetic patients.: Methods: Diabetic patients (n = 181) and ... ...

    Abstract Background: Asprosin is an emerging biomarker that plays a role in metabolic diseases. This study investigates asprosin as a predictive marker for coronary artery disease (CAD) severity in diabetic patients.
    Methods: Diabetic patients (n = 181) and healthy controls (n = 60) were analyzed. CAD severity was assessed using SYNTAX score. Diabetic patients were divided into 3 groups. Group 1 = patients without CAD, group 2 = patients with low SYNTAX score, and group 3 = patients with moderate-high SYNTAX score. Asprosin levels were measured for all participants using an enzyme-linked immunosorbent assay (ELISA).
    Results: Asprosin levels were significantly higher in patient group compared to control group (p < 0.001). Asprosin levels were significantly higher in group 3 compared to group 1 and group 2 (p = 0.002). In logistic regression analysis, asprosin levels independently predicted patients with moderate-high SYNTAX scores. According to this analysis, 1 ng/mL increase in asprosin level was found to increase the risk of having moderate-high SYNTAX score by 14.1%. When the threshold value of asprosin level was set as 22.17 ng/mL, it predicted patients with moderate-high SYNTAX score with 63.6% sensitivity and 62.6% specificity. In multivariate regression analysis, SYNTAX score independently correlated with asprosin level.
    Conclusion: This is the first study in the literature to demonstrate a positive correlation between asprosin levels and SYNTAX scores in diabetic patients with CAD. More comprehensive studies with larger groups are needed.
    Mesh-Begriff(e) Humans ; Coronary Artery Disease/blood ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Male ; Female ; Middle Aged ; Fibrillin-1/blood ; Biomarkers/blood ; Severity of Illness Index ; Aged ; Diabetes Mellitus/blood ; Case-Control Studies ; Extracellular Matrix Proteins/blood ; Adipokines
    Chemische Substanzen Fibrillin-1 ; Biomarkers ; FBN1 protein, human ; Extracellular Matrix Proteins ; Adipokines
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-024-03616-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel ; Online: Serum Periostin Levels are Significantly Higher in Patients with Primary Hyperparathyroidism and Closely Related to Osteoporosis.

    Yigitdol, Ismail / Gulumsek, Erdinc / Ozturk, Huseyin Ali / Arici, Fatih Necip / Akbal, Kubilay / Pirinci, Okan / Karacay, Mert / Cihan, Tutku Naz / Totik, Zeynep Gizem / Akyildiz, Mustafa Aykut / Avci, Begum Seyda / Avci, Akkan / Sumbul, Hilmi Erdem

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

    2023  Band 131, Heft 9, Seite(n) 449–455

    Abstract: Background: Periostin is an emerging biomarker that plays a role in bone metabolism and may be associated with bone mineral density (BMD). This study is aimed to investigate serum periostin levels in patients with primary hyperparathyroidism (PHPT) and ... ...

    Abstract Background: Periostin is an emerging biomarker that plays a role in bone metabolism and may be associated with bone mineral density (BMD). This study is aimed to investigate serum periostin levels in patients with primary hyperparathyroidism (PHPT) and its correlation with BMD in these patients.
    Methods: Forty patients with newly diagnosed PHPT without co-morbidities and 30 healthy controls were included. Laboratory tests for the diagnosis of PHPT and serum levels of periostin were measured for all patients. BMD was measured on lumbar spines L1 and L4 by dual-energy X-ray absorptiometry (DEXA). Serum periostin levels were detected using an enzyme-linked immunosorbent assay (ELISA).
    Results: Serum periostin levels were significantly higher in patients with PHPT than in healthy controls (p<0.001). Serum periostin levels were also significantly higher (mean 59.7±11.0 ng/mL) in PHPT patients with osteoporosis than those without osteoporosis (p=0.004). In logistic regression analysis, only serum periostin levels independently predicted the patients with osteoporosis. According to this analysis, every 1 ng/mL increase in serum periostin increased the risk of having osteoporosis by 20.6%. When the cut-off for serum periostin level was 49.75 ng/mL, the patients with osteoporosis were predicted with 71.4% sensitivity and 69.2% specificity. Multivariate regression analysis revealed a negative correlation between serum periostin levels and L1-L4 T scores on DEXA.
    Conclusion: This is the first study to determine that serum periostin levels are higher in PHPT patients than those without PHPT and to demonstrate a significant association between serum periostin levels and T scores on DEXA in patients with PHPT. These findings will aid in detecting osteoporosis in patients with PHPT and making the decision for surgery in PHPT patients with no need for DEXA imaging that involves radiation.
    Mesh-Begriff(e) Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/surgery ; Absorptiometry, Photon/methods ; Osteoporosis/diagnosis ; Osteoporosis/etiology ; Bone Density ; Biomarkers
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-06-05
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-2053-8090
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Should lactate be added to Tokyo criteria for the evaluation of patients with acute cholangitis?

    Gulumsek, Erdinc / Yesildal, Fatih / Yigitdol, Ismail / Erdem, İbrahim / Arbag, Huseyin Can / Avci, Akkan / Saler, Tayyibe / Kara, Banu / Tas, Adnan / Sumbul, Hilmi Erdem

    Irish journal of medical science

    2022  Band 191, Heft 3, Seite(n) 1177–1183

    Abstract: Background: Tokyo guidelines (TG13/18) are used for the severity assessment of acute cholangitis (AC). Lactate is a clinical marker of tissue hypoxia and disease severity, independent from blood pressure.: Aim: The aim of this study is to investigate ...

    Abstract Background: Tokyo guidelines (TG13/18) are used for the severity assessment of acute cholangitis (AC). Lactate is a clinical marker of tissue hypoxia and disease severity, independent from blood pressure.
    Aim: The aim of this study is to investigate the relationship between blood lactate level and TG13/18 criteria in patients diagnosed with AC.
    Methods: One hundred fifteen patients with AC were included in this retrospective study. Demographic characteristics of the patients and laboratory data were scanned from their hospital medical records. According to TG13/18 guidelines, the patients were divided into 3 groups as mild (grade 1), moderate (grade 2), and severe (grade 3) AC.
    Results: Sixty three (54.7%) of the patients were grade 1, 37 (32.1%) were grade 2, and 15 (13.0%) were grade 3. It was found that blood lactate level increased significantly from grade 1 to grade 3 (p < 0.001). In logistic regression analysis, white blood cell (WBC) count, total bilirubin and blood lactate levels independently determined the patients to be grade 2 or 3 AC. When the blood lactate cut-off value was taken as 16.5 mg/dL, we diagnosed grade 2 or 3 AC with a sensitivity of 78.8% and a specificity of 75.7%. From among lactate, WBC, and C reactive protein, lactate showed the highest value regarding the area under the curve, which is an index for predicting grade III upon ROC analysis.
    Conclusion: The blood lactate level is associated with the severity of AC. In addition to TG13/18 guidelines, blood lactate level can be a useful biomarker in the severity grading of AC.
    Mesh-Begriff(e) Acute Disease ; Biomarkers ; Cholangitis/diagnosis ; Humans ; Lactic Acid ; Retrospective Studies ; Severity of Illness Index ; Tokyo
    Chemische Substanzen Biomarkers ; Lactic Acid (33X04XA5AT)
    Sprache Englisch
    Erscheinungsdatum 2022-02-08
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-022-02941-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Titelangabe fehlt]

    Yigitdol, Ismail / Gulumsek, Erdinc / Ozturk, Huseyin Ali / Arici, Fatih Necip / Akbal, Kubilay / Pirinci, Okan / Karacay, Mert / Cihan, Tutku Naz / Totik, Zeynep Gizem / Akyildiz, Mustafa Aykut / Avci, Begum Seyda / Avci, Akkan / Sumbul, Hilmi Erdem

    Experimental and Clinical Endocrinology & Diabetes

    2023  Band 131, Heft 09, Seite(n) 449–455

    Abstract: Background: Periostin is an emerging biomarker that plays a role in bone metabolism and may be associated with bone mineral density (BMD). This study is aimed to investigate serum periostin levels in patients with ...

    Abstract Background: Periostin is an emerging biomarker that plays a role in bone metabolism and may be associated with bone mineral density (BMD). This study is aimed to investigate serum periostin levels in patients with primary hyperparathyroidism (PHPT) and its correlation with BMD in these patients.
    Methods: Forty patients with newly diagnosed PHPT without co-morbidities and 30 healthy controls were included. Laboratory tests for the diagnosis of PHPT and serum levels of periostin were measured for all patients. BMD was measured on lumbar spines L1 and L4 by dual-energy X-ray absorptiometry (DEXA). Serum periostin levels were detected using an enzyme-linked immunosorbent assay (ELISA).
    Results: Serum periostin levels were significantly higher in patients with PHPT than in healthy controls (p<0.001). Serum periostin levels were also significantly higher (mean 59.7±11.0 ng/mL) in PHPT patients with osteoporosis than those without osteoporosis (p=0.004). In logistic regression analysis, only serum periostin levels independently predicted the patients with osteoporosis. According to this analysis, every 1 ng/mL increase in serum periostin increased the risk of having osteoporosis by 20.6%. When the cut-off for serum periostin level was 49.75 ng/mL, the patients with osteoporosis were predicted with 71.4% sensitivity and 69.2% specificity. Multivariate regression analysis revealed a negative correlation between serum periostin levels and L1-L4 T scores on DEXA.
    Conclusion: This is the first study to determine that serum periostin levels are higher in PHPT patients than those without PHPT and to demonstrate a significant association between serum periostin levels and T scores on DEXA in patients with PHPT. These findings will aid in detecting osteoporosis in patients with PHPT and making the decision for surgery in PHPT patients with no need for DEXA imaging that involves radiation.
    Schlagwörter primary hyperparathyroidism ; periostin ; osteoporosis ; bone mineral density
    Sprache Englisch
    Erscheinungsdatum 2023-06-05
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-2053-8090
    Datenquelle Thieme Verlag

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