Artikel: PCNA cycling dynamics during DNA replication and repair in mammals.
2024 Band 40, Heft 6, Seite(n) 526–539
Abstract: Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association ... ...
Abstract | Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association and dissociation of PCNA from DNA are mediated by clamp-loader complexes. PCNA must be actively released from DNA after completion of its function. If it is not released, abnormal accumulation of PCNA on chromatin will interfere with DNA metabolism. ATAD5 containing replication factor C-like complex (RLC) is a PCNA-unloading clamp-loader complex. ATAD5 deficiency causes various DNA replication and repair problems, leading to genome instability. Here, we review recent progress regarding the understanding of the action mechanisms of PCNA unloading complex in DNA replication/repair pathways. |
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Mesh-Begriff(e) | DNA Replication/genetics ; Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; DNA Repair/genetics ; Animals ; Humans ; Mammals/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Genomic Instability/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA/genetics ; DNA/metabolism ; ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism |
Chemische Substanzen | Proliferating Cell Nuclear Antigen ; Chromatin ; DNA-Binding Proteins ; DNA (9007-49-2) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; ATAD5 protein, human |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-13 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 619240-3 |
ISSN | 1362-4555 ; 0168-9525 ; 0168-9479 |
ISSN (online) | 1362-4555 |
ISSN | 0168-9525 ; 0168-9479 |
DOI | 10.1016/j.tig.2024.02.006 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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