Article ; Online: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour: facts and controversies.
2023 Volume 84, Issue 1, Page(s) 86–101
Abstract: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour are unique entities in the 5th edition of the World Health Organisation (WHO) Classification of Thoracic Tumours, whose definitions include molecular genetic abnormalities. These ... ...
Abstract | NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour are unique entities in the 5th edition of the World Health Organisation (WHO) Classification of Thoracic Tumours, whose definitions include molecular genetic abnormalities. These aggressive tumours require rapid work-ups on biopsies, but a broad list of differential diagnoses poses challenges for practising pathologists. This review provides an update on their key clinicopathological and molecular characteristics, as well as controversies regarding tumour classification and diagnostic strategy. Phenotypical assessment plays a substantial role in diagnosis because recurrent and predictable clinicopathological findings exist, including robust immunohistochemical phenotypes. Accurate diagnosis is crucial for appropriate management and a clearer understanding of the disease. |
---|---|
MeSH term(s) | Humans ; Transcription Factors/genetics ; Nuclear Proteins/genetics ; DNA Helicases/genetics ; Biomarkers, Tumor ; Carcinoma/diagnosis ; Carcinoma/pathology ; Thoracic Neoplasms/diagnosis ; Thoracic Neoplasms/genetics ; Thoracic Neoplasms/pathology |
Chemical Substances | Transcription Factors ; Nuclear Proteins ; DNA Helicases (EC 3.6.4.-) ; Biomarkers, Tumor ; SMARCA4 protein, human (EC 3.6.1.-) |
Language | English |
Publishing date | 2023-10-24 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 131914-0 |
ISSN | 1365-2559 ; 0309-0167 |
ISSN (online) | 1365-2559 |
ISSN | 0309-0167 |
DOI | 10.1111/his.15063 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 1328: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.