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  1. Artikel ; Online: Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.

    Lee, Jeong-Yun / You, Taeyi / Woo, Choong-Wan / Kim, Seong-Gi

    International journal of molecular sciences

    2022  Band 23, Heft 20

    Abstract: Sensory processing is a complex neurological process that receives, integrates, and responds to information from one's own body and environment, which is closely related to survival as well as neurological disorders. Brain-wide networks of sensory ... ...

    Abstract Sensory processing is a complex neurological process that receives, integrates, and responds to information from one's own body and environment, which is closely related to survival as well as neurological disorders. Brain-wide networks of sensory processing are difficult to investigate due to their dynamic regulation by multiple brain circuits. Optogenetics, a neuromodulation technique that uses light-sensitive proteins, can be combined with functional magnetic resonance imaging (ofMRI) to measure whole-brain activity. Since ofMRI has increasingly been used for investigating brain circuits underlying sensory processing for over a decade, we systematically reviewed recent ofMRI studies of sensory circuits and discussed the challenges of optogenetic fMRI in rodents.
    Mesh-Begriff(e) Optogenetics/methods ; Magnetic Resonance Imaging/methods ; Brain Mapping/methods ; Brain/diagnostic imaging ; Brain/physiology ; Perception
    Sprache Englisch
    Erscheinungsdatum 2022-10-14
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232012268
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Characterization of brain-wide somatosensory BOLD fMRI in mice under dexmedetomidine/isoflurane and ketamine/xylazine.

    You, Taeyi / Im, Geun Ho / Kim, Seong-Gi

    Scientific reports

    2021  Band 11, Heft 1, Seite(n) 13110

    Abstract: Mouse fMRI under anesthesia has become increasingly popular due to improvement in obtaining brain-wide BOLD response. Medetomidine with isoflurane has become well-accepted for resting-state fMRI, but whether this combination allows for stable, expected, ... ...

    Abstract Mouse fMRI under anesthesia has become increasingly popular due to improvement in obtaining brain-wide BOLD response. Medetomidine with isoflurane has become well-accepted for resting-state fMRI, but whether this combination allows for stable, expected, and robust brain-wide evoked response in mice has yet to be validated. We thus utilized intravenous infusion of dexmedetomidine with inhaled isoflurane and intravenous infusion of ketamine/xylazine to elucidate whether stable mouse physiology and BOLD response are obtainable in response to simultaneous forepaw and whisker-pad stimulation throughout 8 h. We found both anesthetics result in hypercapnia with depressed heart rate and respiration due to self-breathing, but these values were stable throughout 8 h. Regardless of the mouse condition, brain-wide, robust, and stable BOLD response throughout the somatosensory axis was observed with differences in sensitivity and dynamics. Dexmedetomidine/isoflurane resulted in fast, boxcar-like, BOLD response with consistent hemodynamic shapes throughout the brain. Ketamine/xylazine response showed higher sensitivity, prolonged BOLD response, and evidence for cortical disinhibition as significant bilateral cortical response was observed. In addition, differing hemodynamic shapes were observed between cortical and subcortical areas. Overall, we found both anesthetics are applicable for evoked mouse fMRI studies.
    Mesh-Begriff(e) Anesthetics, Combined/pharmacology ; Animals ; Brain/diagnostic imaging ; Brain/drug effects ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/pharmacology ; Functional Neuroimaging ; Infusions, Intravenous ; Isoflurane/administration & dosage ; Isoflurane/pharmacology ; Ketamine/administration & dosage ; Ketamine/pharmacology ; Magnetic Resonance Imaging ; Mice ; Mice, Inbred C57BL ; Somatosensory Cortex/diagnostic imaging ; Somatosensory Cortex/drug effects ; Xylazine/administration & dosage ; Xylazine/pharmacology
    Chemische Substanzen Anesthetics, Combined ; Xylazine (2KFG9TP5V8) ; Dexmedetomidine (67VB76HONO) ; Ketamine (690G0D6V8H) ; Isoflurane (CYS9AKD70P)
    Sprache Englisch
    Erscheinungsdatum 2021-06-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-92582-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance.

    Lee, Jeong-Yun / You, Taeyi / Lee, Choong-Hee / Im, Geun Ho / Seo, Heewon / Woo, Choong-Wan / Kim, Seong-Gi

    Current biology : CB

    2022  Band 32, Heft 13, Seite(n) 2834–2847.e5

    Abstract: Although pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using ... ...

    Abstract Although pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using behavioral experiments and functional magnetic resonance imaging with optogenetics at 15.2 T, we demonstrate that the ACC is a part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement rather than carrying sensory information. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) especially enhances both reflexive and active avoidance behavior toward pain. Collectively, our results indicate that increased signals from the ACC to the dl/lPAG might be critical for excessive fear avoidance in chronic pain disability.
    Mesh-Begriff(e) Chronic Pain ; Gyrus Cinguli ; Humans ; Magnetic Resonance Imaging/methods ; Optogenetics ; Periaqueductal Gray
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.04.090
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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