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  1. Artikel: The Feasibility and Reliability of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Breast Cancer Patients With Negative Axillary Lymph Nodes-A Meta-analysis.

    Yu, Mengjie / Liu, Yu / Huang, Zenan / Zhu, Qingqing / Huang, Yong

    Breast cancer : basic and clinical research

    2024  Band 18, Seite(n) 11782234241255856

    Abstract: Background: The application of sentinel lymph node biopsy (SLNB) has expanded from early breast cancer to locally advanced breast cancer with neoadjuvant chemotherapy (NAC). For patients with negative axillary lymph nodes, performing SLNB before or ... ...

    Abstract Background: The application of sentinel lymph node biopsy (SLNB) has expanded from early breast cancer to locally advanced breast cancer with neoadjuvant chemotherapy (NAC). For patients with negative axillary lymph nodes, performing SLNB before or after NAC remains controversial.
    Objectives: To evaluate the diagnostic feasibility and reliability of SLNB after NAC in breast cancer patients with negative axillary nodes at initial diagnosis.
    Design: To calculate pooled identification rate (IR) and false negative rate (FNR) of SLNB after NAC on breast cancer patients with initially negative axillary nodes by enrolling relevant studies and perform subgroup analysis by the type of tracer and the number of biopsied sentinel lymph nodes in average.
    Data sources and methods: The PubMed, Embase, Cochrane, Web of Science, and Scopus databases from January 1, 2002, to March 1, 2022, were searched for studies. The QUADAS-2 tool and MINORS item were employed to evaluate the quality of the included studies.
    Results: A total of 21 studies covering 1716 patients were enrolled in this study (IR = 93%, 95% CI = 90-96; FNR = 8%, 95% CI = 6-11).
    Conclusion: The SLNB after NAC can serve as a feasible and reliable approach in breast cancer patients with negative axillary lymph node. In our study, no significant impact of tracer was found on the IR and FNR of SLNB, and the number of biopsy nodes >2 leads to the decreased FNR of SLNB.
    Sprache Englisch
    Erscheinungsdatum 2024-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2423804-1
    ISSN 1178-2234
    ISSN 1178-2234
    DOI 10.1177/11782234241255856
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Effect of gillnet mesh size on the capture probability and capture patterns in the Asian paddle crab (

    Yu, Mengjie / Herrmann, Bent / Cerbule, Kristine / Liu, Changdong / Zhang, Liyou / Tang, Yanli

    Heliyon

    2024  Band 10, Heft 4, Seite(n) e25771

    Abstract: In the Asian paddle crab ( ...

    Abstract In the Asian paddle crab (
    Sprache Englisch
    Erscheinungsdatum 2024-02-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25771
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Ghost fishing efficiency in swimming crab (Portunus trituberculatus) pot fishery.

    Yu, Mengjie / Herrmann, Bent / Cerbule, Kristine / Liu, Changdong / Dou, Yilin / Zhang, Liyou / Tang, Yanli

    Marine pollution bulletin

    2024  Band 201, Seite(n) 116192

    Abstract: Abandoned, lost, or otherwise discarded fishing gear (ALDFG) is a global challenge that negatively affects marine environment through plastic pollution and continued capture of marine animals, so-called "ghost fishing". In different pot fisheries, ghost ... ...

    Abstract Abandoned, lost, or otherwise discarded fishing gear (ALDFG) is a global challenge that negatively affects marine environment through plastic pollution and continued capture of marine animals, so-called "ghost fishing". In different pot fisheries, ghost fishing related to ALDFG is of concern, including pot fishery targeting swimming crab (Portunus trituberculatus). This study quantified the ghost fishing efficiency by comparing it to the catch efficiency of actively fished pots of the commercial fishery. The results showed that the ghost fishing affects both target and bycatch species. On average, the ghost fishing pots captured 12.53 % (confidence intervals: 10.45 %-15.00 %) undersized crab and 15.70 % (confidence intervals: 12.08 %-20.74 %) legal-sized crab compared to the actively fished pots. Few individuals of several bycatch species were also captured by ghost fishing pots. The results of this study emphasized the need to develop new management strategies for reducing marine pollution by ALDFG and associated negative effects in this pot fishery.
    Mesh-Begriff(e) Animals ; Fisheries ; Brachyura ; Hunting ; Swimming ; Water Pollution
    Sprache Englisch
    Erscheinungsdatum 2024-02-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2024.116192
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.

    Ren, Yan / Yu, Mengjie / Zheng, Danna / He, Wenfang / Jin, Juan

    Archives of medical science : AMS

    2023  Band 20, Heft 1, Seite(n) 233–247

    Abstract: Introduction: Diabetic nephropathy (DN) is a leading cause of kidney failure. Lysozyme (LYZ) is an essential component of innate immunity and exhibits antibacterial properties. However, LYZ has been reported to induce nephropathy, implying a possible ... ...

    Abstract Introduction: Diabetic nephropathy (DN) is a leading cause of kidney failure. Lysozyme (LYZ) is an essential component of innate immunity and exhibits antibacterial properties. However, LYZ has been reported to induce nephropathy, implying a possible association between impaired renal function and lysozyme expression.
    Material and methods: Bioinformatics analysis was used to predict the hub gene associated with DN, and the differential expression of the hub gene was confirmed using a mouse model. A mouse model of streptozotocin (STZ)-induced diabetic nephropathy was established to investigate the correlation between DN and LYZ expression, and the functionality of LYZ was verified through knockdown and overexpression experiments conducted
    Results: Mechanistically, 25 mM glucose promotes the expression of LYZ in fibroblastic cells, and LYZ may in turn promote the proliferation of renal interstitial fibroblasts. Western blot shows that glucose can activate STAT3 in an LYZ-dependent manner, and the JAK inhibitor AG490 can partially suppress LYZ-induced STAT3 activation. Furthermore,
    Conclusions: Lysozyme promotes kidney fibrosis via the JAK/STAT3 signaling pathway in diabetic nephropathy, and glucose may promote fibroblast proliferation by promoting LYZ auto-secretion.
    Sprache Englisch
    Erscheinungsdatum 2023-07-31
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms/170160
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Effects of trichlorobisphenol A on the expression of proteins and genes associated with puberty initiation in GT1-7 cells and the relevant molecular mechanism.

    Yang, Yingxin / Xu, Lanbing / Lei, Bingli / Huang, Yaoyao / Yu, Mengjie

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2023  Band 183, Seite(n) 114258

    Abstract: This study evaluated the effects of ... ...

    Abstract This study evaluated the effects of Cl
    Mesh-Begriff(e) Kisspeptins/genetics ; Kisspeptins/metabolism ; Kisspeptins/pharmacology ; Cell Line ; Sexual Maturation ; Gonadotropin-Releasing Hormone/genetics ; Gonadotropin-Releasing Hormone/metabolism ; Signal Transduction
    Chemische Substanzen Kisspeptins ; Gonadotropin-Releasing Hormone (33515-09-2)
    Sprache Englisch
    Erscheinungsdatum 2023-11-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.114258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 529: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Artikel ; Online: Identification of Hub Genes in the Remodeling of Non-Infarcted Myocardium Following Acute Myocardial Infarction.

    Wang, Lingxiao / Zhang, Yan / Yu, Mengjie / Yuan, Wuzhou

    Journal of cardiovascular development and disease

    2022  Band 9, Heft 12

    Abstract: 1) Background: There are few diagnostic and therapeutic targets for myocardial remodeling in the salvageable non-infarcted myocardium. (2) Methods: Hub genes were identified through comprehensive bioinformatics analysis (GSE775, GSE19322, and GSE110209 ... ...

    Abstract (1) Background: There are few diagnostic and therapeutic targets for myocardial remodeling in the salvageable non-infarcted myocardium. (2) Methods: Hub genes were identified through comprehensive bioinformatics analysis (GSE775, GSE19322, and GSE110209 from the gene expression omnibus (GEO) database) and the biological functions of hub genes were examined by gene ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Furthermore, the differential expression of hub genes in various cell populations between the acute myocardial infarction (AMI) and sham-operation groups was analyzed by processing scRNA data (E-MTAB-7376 from the ArrayExpress database) and RNA-seq data (GSE183168). (3) Results: Ten strongly interlinked hub genes (
    Sprache Englisch
    Erscheinungsdatum 2022-11-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd9120409
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A new concept for bycatch reduction in small-scale accordion-shaped trap fisheries of the Yellow Sea, China

    Yu, Mengjie / Liu, Changdong / Sun, Liyuan / Zhang, Liyou / Tang, Yanli

    Fisheries Research. 2023 July, v. 263 p.106685-

    2023  

    Abstract: The bycatch issue is a major concern in small-scale accordion-shaped trap fisheries in the Yellow Sea of China because of the poor species and size selectivity of fishing gear and the co-occurrence of multispecies. Two threatened flatfish species ... ...

    Abstract The bycatch issue is a major concern in small-scale accordion-shaped trap fisheries in the Yellow Sea of China because of the poor species and size selectivity of fishing gear and the co-occurrence of multispecies. Two threatened flatfish species assessed by the IUCN, marbled flounder (Pseudopleuronectes yokohamae) and stone flounder (Platichthys bicoloratus), are the two main bycatches in accordion-shaped trap fisheries. This fishery also captures a large proportion of juvenile target species, resulting in both recruitment and growth overfishing of these species. In this study, we introduced a new concept of a combined sorting grid and escape vent (CSEV), a selection device aimed at reducing the bycatch of flatfish and undersized target species in mixed-species trap fisheries. We used a catch comparison method to assess the performance of the CSEV in field experiments, with conventional traps as the baseline. Our results demonstrated that the CSEV significantly improved the species and size selectivity of the traps. Test traps mounted with the CSEV significantly reduced the catch rates of marbled flounder and stone flounder by 70% and 74% throughout the length class, respectively, compared with conventional traps. The catch of undersized target species, namely, fat greenling (Hexagrammos otakii), black rockfish (Sebastes schlegelii), and Asian paddle crab (Charybdis japonica), was reduced by 79%, 75%, and 80%, respectively, while the catch rates of target-sized individuals were maintained or even improved. Given these promising results, the CSEV may have great potential for application in accordion-shaped trap fisheries and similar fisheries.
    Schlagwörter Charybdis ; Hexagrammos otakii ; Kareius bicoloratus ; Pseudopleuronectes yokohamae ; Sebastes melanops ; Sebastes schlegelii ; bycatch ; crabs ; juveniles ; research ; China ; Yellow Sea ; Threatened species ; Mixed-species trap fisheries ; CSEV ; Marbled flounder ; Stone flounder
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    ZDB-ID 406532-3
    ISSN 0165-7836
    ISSN 0165-7836
    DOI 10.1016/j.fishres.2023.106685
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 3666: Hefte anzeigen

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  8. Artikel ; Online: Tetrachlorobisphenol A and bisphenol AF induced cell migration by activating PI3K/Akt signaling pathway via G protein‐coupled estrogen receptor 1 in SK‐BR‐3 cells

    Yu, Mengjie / Xu, Lanbing / Lei, Bingli / Sun, Su / Yang, Yingxin

    Environmental Toxicology. 2023 Jan., v. 38, no. 1 p.126-135

    2023  

    Abstract: Different subtypes of breast cancer express positively G protein‐coupled estrogen receptor 1 (GPER1). Our previous studies found that tetrachlorobisphenol A (TCBPA) and bisphenol AF (BPAF) significantly promoted SK‐BR‐3 cell proliferation by activating ... ...

    Abstract Different subtypes of breast cancer express positively G protein‐coupled estrogen receptor 1 (GPER1). Our previous studies found that tetrachlorobisphenol A (TCBPA) and bisphenol AF (BPAF) significantly promoted SK‐BR‐3 cell proliferation by activating GPER1‐regulated signals. The present study further investigated the effects of TCBPA and BPAF on the migration of SK‐BR‐3 cells and examined the role of phosphatidylinositol 3‐kinase‐protein kinase B (PI3K/Akt) and its downstream signal targets in this process. We found that low‐concentration BPAF and TCBPA markedly accelerated the migration of SK‐BR‐3 cells and elevated the mRNA levels of target genes associated with PI3K/Akt and mitogen‐activated protein kinase (MAPK) signals. TCBPA‐ and BPAF‐induced upregulation of target genes was significantly reduced by GPER1 inhibitor G15, the PI3K/Akt inhibitor wortmannin (WM), and the epidermal growth factor receptor (EGFR) inhibitor ZD1839 (ZD). G15 and WM also decreased cell migration induced by TCBPA and BPAF. The findings revealed that TCBPA and BPAF promoted SK‐BR‐3 cell migration ability by activating PI3K/Akt signaling pathway via GPER1‐EGFR.
    Schlagwörter bisphenol AF ; breast neoplasms ; cell movement ; cell proliferation ; ecotoxicology ; epidermal growth factor receptors ; estrogen receptors ; mitogen-activated protein kinase
    Sprache Englisch
    Erscheinungsverlauf 2023-01
    Umfang p. 126-135.
    Erscheinungsort John Wiley & Sons, Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23669
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 4957: Hefte anzeigen

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  9. Artikel ; Online: Stabilizing High-Voltage Cathodes via Ball-Mill Coating with Flame-Made Nanopowder Electrolytes.

    Yu, Mengjie / Brandt, Taylor G / Temeche, Eleni / Laine, Richard M

    ACS applied materials & interfaces

    2022  

    Abstract: ... ...

    Abstract LiMn
    Sprache Englisch
    Erscheinungsdatum 2022-10-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c09284
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Plasma metabolomics reveals risk factors for lung adenocarcinoma.

    Yu, Mengjie / Wen, Wei / Wang, Yue / Shan, Xia / Yi, Xin / Zhu, Wei / Aa, Jiye / Wang, Guangji

    Frontiers in oncology

    2024  Band 14, Seite(n) 1277206

    Abstract: Background: Metabolic reprogramming plays a significant role in the advancement of lung adenocarcinoma (LUAD), yet the precise metabolic changes remain incompletely understood. This study aims to uncover metabolic indicators associated with the ... ...

    Abstract Background: Metabolic reprogramming plays a significant role in the advancement of lung adenocarcinoma (LUAD), yet the precise metabolic changes remain incompletely understood. This study aims to uncover metabolic indicators associated with the progression of LUAD.
    Methods: A total of 1083 subjects were recruited, including 670 LUAD, 135 benign lung nodules (BLN) and 278 healthy controls (HC). Gas chromatography-mass spectrometry (GC/MS) was used to identify and quantify plasma metabolites. Odds ratios (ORs) were calculated to determine LUAD risk factors, and machine learning algorithms were utilized to differentiate LUAD from BLN.
    Results: High levels of oxalate, glycolate, glycine, glyceric acid, aminomalonic acid, and creatinine were identified as risk factors for LUAD (adjusted ORs>1.2, P<0.03). Remarkably, oxalate emerged as a distinctive metabolic risk factor exhibiting a strong correlation with the progression of LUAD (adjusted OR=5.107, P<0.001; advanced-stage vs. early-stage). The Random Forest (RF) model demonstrated a high degree of efficacy in distinguishing between LUAD and BLN (accuracy = 1.00 and 0.73, F1-score= 1.00 and 0.79, and AUC = 1.00 and 0.76 in the training and validation sets, respectively). TCGA and GTEx gene expression data have shown that lactate dehydrogenase A (LDHA), a crucial enzyme involved in oxalate metabolism, is increasingly expressed in the progression of LUAD. High LDHA expression levels in LUAD patients are also linked to poor prognoses (HR=1.66, 95% CI=1.34-2.07, P<0.001).
    Conclusions: This study reveals risk factors associated with LUAD.
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1277206
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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