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  1. Artikel ; Online: Impact of the Xinsorb Scaffold-Related Parameters on Platelet Reactivity in Patients with Single De Novo Coronary Artery Lesions Undergoing Clopidogrel Treatment.

    Yu, Shushu / Wang, Mingliang / Yan, Meiyu / Wang, Bo / Xu, Yawei

    Anatolian journal of cardiology

    2023  Band 27, Heft 7, Seite(n) 408–416

    Abstract: Background: This study aimed to assess the relationship between stent parameters and platelet function, as well as the platelet reactivity profiles over time in patients treated with the Xinsorb scaffold.: Methods: Adenosine diphosphate-induced ... ...

    Abstract Background: This study aimed to assess the relationship between stent parameters and platelet function, as well as the platelet reactivity profiles over time in patients treated with the Xinsorb scaffold.
    Methods: Adenosine diphosphate-induced maximal amplitude was measured as clopidogrel on-treatment platelet reactivity using thrombelastography. High residual platelet reactivity was defined as MAADP > 47 mm. Platelet function testing was induced at baseline, discharge, and 6- and 12-month visits.
    Results: A total of 40 individuals undergoing Xinsorb scaffold implantation and platelet function testing were included. No adverse events were recorded during follow-up. No correlation was observed among thrombelastography indices, stent diameters, and stent coverage surface area. Significant correlation was found between MAADP and lengths of stents (Spearman rank correlation = 0.324, P =.031). Multiple logistic regression analyses demonstrated that high levels of high-density lipoprotein cholesterol was an independent protective factor for high residual platelet reactivity (odds ratio = 0.049, 95% confidence interval = 0.011-0.296, P =.016). No significant risk factors were identified; MAADP presented to be 20.6 [13.1-36.2] mm, 26.8 [18.2-35.0] mm, and 30.0 [19.6-33.4] mm 48 hours, 6 months, and 12 months after procedure, respectively; 12-month MAADP was significantly higher than the 48-hour MAADP (P =.026). There was no obvious trend for platelet response status over time.
    Conclusion: Among patients on a clopidogrel-based dual antiplatelet treatment regimen following Xinsorb scaffold implantation, stent parameters had no significant effects on platelet reactivity. The high residual platelet reactivity phenotype is relatively stable over time. High residual platelet reactivity is more likely to occur in patients with lower high-density lipoprotein cholesterol levels.
    Mesh-Begriff(e) Humans ; Clopidogrel ; Platelet Aggregation Inhibitors/adverse effects ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/surgery ; Lipoproteins, HDL ; Cholesterol ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Chemische Substanzen Clopidogrel (A74586SNO7) ; Platelet Aggregation Inhibitors ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ZDB-ID 2278670-3
    ISSN 2149-2271 ; 2149-2271
    ISSN (online) 2149-2271
    ISSN 2149-2271
    DOI 10.14744/AnatolJCardiol.2023.3071
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Dynamic changes in inflammatory responses and 3-year clinical outcomes of XINSORB scaffolds in coronary stenting.

    Yu, Shushu / Wang, Mingliang / Yan, Meiyu / Wang, Bo / Xu, Yawei

    Cardiovascular revascularization medicine : including molecular interventions

    2023  Band 61, Seite(n) 70–81

    Abstract: Background: Inflammation is known to play a crucial role in the development of coronary atherosclerosis and vascular healing after stenting. This study aimed to investigate the dynamic changes in inflammatory responses between XINSORB and TIVOLI ... ...

    Abstract Background: Inflammation is known to play a crucial role in the development of coronary atherosclerosis and vascular healing after stenting. This study aimed to investigate the dynamic changes in inflammatory responses between XINSORB and TIVOLI scaffolds and their correlation with 3-year clinical outcomes.
    Method: A total of 140 patients in the XINSORB group and 42 patients in the TIVOLI group were included in this prospective, single-center study, conducted in Shanghai tenth People's Hospital. Blood samples were collected at baseline, 24 h, 6 months, and 12 months after stent implantation to measure high sensitivity C-reactive protein (hsCRP), fibrinogen (FBG), white blood cell count (WBC), tumor necrosis factor (TNF), and interleukin-6 (IL-6). Receiver-operating characteristic curves and proportional hazards models were generated to evaluate the relationship between 24-h postoperative inflammatory indicators and 3-year patient-oriented composite endpoints (POCE).
    Result: The levels of hsCRP, FBG, WBC, TNF, and IL-6 reached their peak levels 24 h after stenting and then gradually decreased to levels comparable to baseline at 6 and 12 months. During the 3-year follow-up, 11.4 % of the XINSORB cohort and 9.5 % of the TIVOLI cohort experienced POCE (P = 0.948). High levels of hsCRP and IL-6 24 h after the procedure were associated with clinical endpoints, and the combination of these two biomarkers improved the predictive ability of prognosis.
    Conclusions: There were no significant differences between the changes in the concentration of inflammatory biomarkers after XINSORB stents or drug-eluting stent implantation. Reduction in postoperative inflammatory levels may decrease the occurrence of clinical outcomes. This study provides insights into the dynamic changes of inflammatory responses and their correlation with clinical outcomes, which could have implications for the management of patients undergoing coronary stenting.
    Trial registration: The study has been registered on the official website of the China Clinical Trial Registry (ChiCTR1800014966).
    Mesh-Begriff(e) Humans ; Drug-Eluting Stents ; Sirolimus ; Coronary Angiography ; C-Reactive Protein ; Interleukin-6 ; Prospective Studies ; Treatment Outcome ; China ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Stents ; Biomarkers ; Percutaneous Coronary Intervention/adverse effects
    Chemische Substanzen Sirolimus (W36ZG6FT64) ; C-Reactive Protein (9007-41-4) ; Interleukin-6 ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2023.10.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Development and validation of a prediction model for in-hospital death in patients with heart failure and atrial fibrillation.

    Yan, Meiyu / Liu, Huizhu / Xu, Qunfeng / Yu, Shushu / Tang, Ke / Xie, Yun

    BMC cardiovascular disorders

    2023  Band 23, Heft 1, Seite(n) 505

    Abstract: Background: To develop a prediction model for in-hospital mortality of patients with heart failure (HF) and atrial fibrillation (AF).: Methods: This cohort study extracted the data of 10,236 patients with HF and AF upon intensive care unit (ICU) from ...

    Abstract Background: To develop a prediction model for in-hospital mortality of patients with heart failure (HF) and atrial fibrillation (AF).
    Methods: This cohort study extracted the data of 10,236 patients with HF and AF upon intensive care unit (ICU) from the Medical Information Mart for Intensive Care (MIMIC). The subjects from MIMIC-IV were divided into the training set to construct the prediction model, and the testing set to verify the performance of the model. The samples from MIMIC-III database and eICU-CRD were included as the internal and external validation set to further validate the predictive value of the model, respectively. Univariate and multivariable Logistic regression analyses were used to explore predictors for in-hospital death in patients with HF and AF. The receiver operator characteristic (ROC), calibration curves and the decision curve analysis (DCA) curves were plotted to evaluate the predictive values of the model.
    Results: The mean survival time of participants from MIMIC-III was 11.29 ± 10.05 days and the mean survival time of participants from MIMIC-IV was 10.56 ± 9.19 days. Simplified acute physiology score (SAPSII), red blood cell distribution width (RDW), beta-blocker, race, respiratory rate, urine output, coronary artery bypass grafting (CABG), Charlson comorbidity index, renal replacement therapies (RRT), antiarrhythmic, age, and anticoagulation were predictors finally included in the prediction model. The AUC of our prediction model was 0.810 (95%CI: 0.791-0.828) in the training set, 0.757 (95%CI: 0.729-0.786) in the testing set, 0.792 (95%CI: 0.774-0.810) in the internal validation set, and 0.724 (95%CI: 0.687-0.762) in the external validation set. The calibration curves of revealed that the predictive probabilities of our model for the in-hospital death in patients with HF and AF deviated slightly from the ideal model. The DCA curves revealed that the use of our prediction model increased the net benefit than use no model.
    Conclusion: The prediction model had good discriminative ability, and might provide a tool to timely identify patients with HF complicated with AF who were at high risk of in-hospital mortality.
    Mesh-Begriff(e) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Hospital Mortality ; Cohort Studies ; Heart Failure/diagnosis ; Heart Failure/therapy ; Anti-Arrhythmia Agents ; Intensive Care Units
    Chemische Substanzen Anti-Arrhythmia Agents
    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03521-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Influence of Different Obstetric Factors on Early Postpartum Pelvic Floor Function in Primiparas After Vaginal Delivery.

    Chi, Xiaolei / Yu, Shushu / Zhu, Kun / Chen, Yiyao / Chu, Yi / Chen, Xinliang

    International journal of women's health

    2023  Band 15, Seite(n) 81–90

    Abstract: Purpose: This study sought to explore the obstetric factors affecting early postpartum pelvic floor function of primiparas after vaginal delivery.: Patients and methods: We included 3362 primiparas who underwent postpartum re-examination in ... ...

    Abstract Purpose: This study sought to explore the obstetric factors affecting early postpartum pelvic floor function of primiparas after vaginal delivery.
    Patients and methods: We included 3362 primiparas who underwent postpartum re-examination in International Peace Maternity and Child Health Hospital at 42-60 days after delivery. The Glazer Protocol was used to evaluate their pelvic floor function, and univariate and multivariate logistic regression analyses were performed to identify obstetric factors that might affect it.
    Results: Forceps-assisted delivery significantly increased the risk of the decline in fast- and slow-twitch muscle strength in the early postpartum period when compared with natural vaginal delivery (P < 0.05). Women with a pre-pregnancy body mass index (BMI) of ≥18.5 kg/m
    Conclusion: Both pre-pregnancy underweight and obesity may cause impairment of early postpartum pelvic floor function. Forceps delivery, anemia during pregnancy, and the length of second stage of labor are independent factors leading to pelvic floor function impairment.
    Sprache Englisch
    Erscheinungsdatum 2023-01-22
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2508161-5
    ISSN 1179-1411
    ISSN 1179-1411
    DOI 10.2147/IJWH.S390626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis.

    Wang, KunWei / Lin, Yingnan / Shen, Honghui / Yu, Shushu / Xu, Jiahong

    Journal of cardiovascular pharmacology

    2023  Band 81, Heft 3, Seite(n) 192–202

    Abstract: Abstract: Nowadays, there is limited prevention and treatment for myocardial fibrosis in diabetic cardiomyopathy (DCM). Our study aimed to depict the mechanism of the lncRNA TUG1/miR-145a-5p/Cfl2 axis in DCM and to provide a molecular basis for the ... ...

    Abstract Abstract: Nowadays, there is limited prevention and treatment for myocardial fibrosis in diabetic cardiomyopathy (DCM). Our study aimed to depict the mechanism of the lncRNA TUG1/miR-145a-5p/Cfl2 axis in DCM and to provide a molecular basis for the study of this disease. Male C57BL/6J mice were intraperitoneally injected with streptozotocin to establish DCM mouse models. The expression levels of lncRNA TUG1, miR-145a-5p, and Cfl2 in myocardial tissues of mice were tested by RT-qPCR or Western blot. Cardiac function was assessed by echocardiography. The contents of Ang-II, TNF-α, and IL-1β were measured using ELISA. The histopathological observation was performed by HE staining and Masson staining. The expression levels of myocardial fibrosis-related genes COL1A1, MMP2, and FN1 were determined by RT-qPCR. In addition, bioinformatics website, RIP assay, pull-down assay, and luciferase activity assay were conducted to verify the relationships of lncRNA TUG1, miR-145a-5p, and Cfl2. In the DCM mouse model, lncRNA TUG1 and Cfl2 expression levels were upregulated and miR-145a-5p expression was downregulated. Downregulation of lncRNA TUG1 improved cardiac function and myocardial fibrosis; decreased COL1A1, MMP2, and FN1 expression levels; as well as TNF-α, IL-1β, and Ang-II contents in myocardial tissues of DCM mice. Upregulation of miR-145a-5p showed the same trend as downregulation of lncRNA TUG1. In addition, upregulating miR-145a-5p reversed the promotion roles of lncRNA TUG1 on myocardial fibrosis in DCM mice, and upregulating Cfl2 compromised the improvement effect of downregulated lncRNA TUG1 on myocardial fibrosis in DCM mice. Mechanistically, there was a binding site between lncRNA TUG1 and miR-145a-5p, and miR-145a-5p had a targeting relationship with Cfl2. This study highlights that lncRNA TUG1 sponges miR-145a-5p to aggravate myocardial fibrosis in DCM mice by promoting Cfl2.
    Mesh-Begriff(e) Animals ; Male ; Mice ; Cofilin 2 ; Diabetes Mellitus ; Diabetic Cardiomyopathies/genetics ; Disease Models, Animal ; Matrix Metalloproteinase 2 ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Tumor Necrosis Factor-alpha
    Chemische Substanzen Cfl2 protein, mouse ; Cofilin 2 ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; MicroRNAs ; RNA, Long Noncoding ; TUG1 noncoding RNA, mouse ; Tumor Necrosis Factor-alpha ; MIRN145a microRNA, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-03-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001391
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1471: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Artikel ; Online: In-depth Understanding of

    Zhou, Junqin / Lu, Mengqi / Yu, Shushu / Liu, Yiyao / Yang, Jin / Tan, Xiaofeng

    International journal of molecular sciences

    2020  Band 21, Heft 5

    Abstract: Oil-tea tree ( ...

    Abstract Oil-tea tree (
    Mesh-Begriff(e) Apoptosis ; Camellia/cytology ; Camellia/genetics ; Camellia/metabolism ; China ; Flowers/genetics ; Flowers/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Metabolic Networks and Pathways/genetics ; Metabolic Networks and Pathways/physiology ; Metabolome ; Mitogen-Activated Protein Kinases ; Plant Growth Regulators ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Pollen Tube ; Pollination/physiology ; Proteome/metabolism ; Proteomics ; Transcriptome ; Ubiquitination
    Chemische Substanzen Plant Growth Regulators ; Plant Proteins ; Proteome ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Sprache Englisch
    Erscheinungsdatum 2020-02-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21051600
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Activation of GPR39 with the agonist TC-G 1008 ameliorates ox-LDL-induced attachment of monocytes to endothelial cells.

    Xu, Yiguan / Wang, Mingliang / Xie, Yun / Jiang, Yumei / Liu, Min / Yu, Shushu / Wang, Bo / Liu, Qiliang

    European journal of pharmacology

    2019  Band 858, Seite(n) 172451

    Abstract: Attachment of monocytes to endothelial cells is a major event in the pathogenesis of atherosclerosis and cardiovascular disease. As atherosclerosis is considered to be an inflammatory disease, increased expression of proinflammatory cytokines greatly ... ...

    Abstract Attachment of monocytes to endothelial cells is a major event in the pathogenesis of atherosclerosis and cardiovascular disease. As atherosclerosis is considered to be an inflammatory disease, increased expression of proinflammatory cytokines greatly contributes to endothelial dysfunction and atherogenesis. Additionally, attachment of monocytes to endothelial cells triggered by cellular adhesion molecules such as vascular cellular adhesion molecule 1 (VCAM-1) and E-selectin plays a vital role in the development of atherosclerotic plaques. Zinc therapy has been suggested as a potential strategy for countering atherosclerosis. In the present study, for the first time to our knowledge, we investigated the potential role of the GPR39 zinc-sensing receptor in mediating the adhesion of monocytes to endothelial cells, oxidative stress and inflammation in human aortic endothelial cells induced by oxidized low-density lipoprotein (ox-LDL). Our findings show that agonism of GPR39 by the selective agonist TC-G 1008 potently reversed the effects of ox-LDL including increased expression of proinflammatory cytokines and chemokines, markers of oxidative stress, and enhanced expression of cellular adhesion molecules. Importantly, we also show that this protective effect is mediated through the nuclear factor-κB (NF-κB) pathway. Taken together, our findings suggest a potential role of GPR39 as a novel therapeutic target for the treatment and prevention of atherosclerosis induced by ox-LDL.
    Mesh-Begriff(e) Cell Adhesion/drug effects ; Cell Line, Tumor ; Cytokines/metabolism ; E-Selectin/metabolism ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Gene Expression Regulation/drug effects ; Humans ; Lipoproteins, LDL/pharmacology ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Phosphorylation/drug effects ; Pyrimidines/pharmacology ; Receptors, G-Protein-Coupled/agonists ; Sulfonamides/pharmacology ; Vascular Cell Adhesion Molecule-1/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemische Substanzen Cytokines ; E-Selectin ; GPR39 protein, human ; GPR39-C3 ; Lipoproteins, LDL ; NF-kappa B ; Pyrimidines ; Receptors, G-Protein-Coupled ; Sulfonamides ; Vascular Cell Adhesion Molecule-1 ; oxidized low density lipoprotein ; NF-KappaB Inhibitor alpha (139874-52-5) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Sprache Englisch
    Erscheinungsdatum 2019-06-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2019.172451
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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