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  1. Artikel ; Online: A fluorescence probe for imaging lipid droplet and visualization of diabetes-related polarity variations.

    Chen, Zehua / Yue, Lizhou / Guo, Yingxin / Huang, Huawei / Lin, Weiying

    Analytica chimica acta

    2024  Band 1312, Seite(n) 342748

    Abstract: Diabetes mellitus is a disorder that affects lipid metabolism. Abnormalities in the lipid droplets (LDs) can lead to disturbances in lipid metabolism, which is a significant feature of diabetic patients. Nevertheless, the correlation between diabetes and ...

    Abstract Diabetes mellitus is a disorder that affects lipid metabolism. Abnormalities in the lipid droplets (LDs) can lead to disturbances in lipid metabolism, which is a significant feature of diabetic patients. Nevertheless, the correlation between diabetes and the polarity of LDs has received little attention in the scientific literature. In order to detect LDs polarity changes in diabetes illness models, we created a new fluorescence probe LD-DCM. This probe has a stable structure, high selectivity, and minimal cytotoxicity. The probe formed a typical D-π-A molecular configuration with triphenylamine (TPA) and dicyanomethylene-4H-pyran (DCM) as electron donor and acceptor parts. The LD-DCM molecule has an immense solvatochromic effect (λ
    Mesh-Begriff(e) Fluorescent Dyes/chemistry ; Fluorescent Dyes/chemical synthesis ; Animals ; Lipid Droplets/chemistry ; Lipid Droplets/metabolism ; Mice ; Humans ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Optical Imaging ; Male ; Molecular Structure
    Chemische Substanzen Fluorescent Dyes
    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342748
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Revealing the Effects of Endoplasmic Reticulum Stress on Ferroptosis by Two-Channel Real-Time Imaging of pH and Viscosity

    Song, Wenhui / Zhang, Weiyao / Yue, Lizhou / Lin, Weiying

    Analytical chemistry. 2022 Apr. 18, v. 94, no. 17

    2022  

    Abstract: Endoplasmic reticulum (ER) is sensitive to changes in the intracellular environment such as pH and viscosity, and slight changes may trigger stress response. Besides, different from apoptosis and necrosis, ferroptosis is the result of lipid peroxidation ... ...

    Abstract Endoplasmic reticulum (ER) is sensitive to changes in the intracellular environment such as pH and viscosity, and slight changes may trigger stress response. Besides, different from apoptosis and necrosis, ferroptosis is the result of lipid peroxidation accumulation. There is evidence that ferroptosis is closely related to endoplasmic reticulum stress (ERS). However, the possible changes in the pH and viscosity of the ER during the ferroptosis process have not yet been studied. Therefore, we used a new type of ER-targeted dual-excitation fluorescent probe (DSPI-3) to investigate the possible changes of pH and viscosity of ER during the ferroptosis. The novel probe DSPI-3 exhibited a highly sensitive and selective response to pH and viscosity. During the bioimaging process, it was found that the ER acidified and viscosity increased during the ferroptosis process induced by erastin, while the cells treated with ferrostatin-1 did not alter significantly. In addition, when dithiothreitol (DTT) and erastin stimulated the cells at the same time, we discovered that ER was acidified considerably at short notice, but the pH was slightly increased in the later stage. Besides, the change of the viscosity enhanced slowly with the passage of time, and there was a noteworthy decline in the later stage, demonstrating that the DTT-induced ERS accelerated the process of ferroptosis. We hope that this unique fluorescent probe can provide an effective method for studying the relationship between ERS and ferroptosis.
    Schlagwörter analytical chemistry ; apoptosis ; bioimaging ; dithiothreitol ; endoplasmic reticulum ; endoplasmic reticulum stress ; ferroptosis ; fluorescent dyes ; lipid peroxidation ; necrosis ; pH ; stress response ; viscosity
    Sprache Englisch
    Erscheinungsverlauf 2022-0418
    Umfang p. 6557-6565.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c00387
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Strategy for Fluorescence/Photoacoustic Signal Maximization Using Dual-Wavelength-Independent Excitation.

    Yue, Lizhou / Huang, Huawei / Li, Guofang / Chen, Zehua / Lin, Weiying

    Analytical chemistry

    2023  Band 95, Heft 49, Seite(n) 18029–18038

    Abstract: Dual-mode imaging of fluorescence-photoacoustics has emerged as a promising technique for biomedical applications. However, conventional dual-mode imaging is based on single-wavelength excitation, which often results in opposing fluorescence and ... ...

    Abstract Dual-mode imaging of fluorescence-photoacoustics has emerged as a promising technique for biomedical applications. However, conventional dual-mode imaging is based on single-wavelength excitation, which often results in opposing fluorescence and photoacoustic signals due to competing photophysical processes in one agent, rendering the maximization of both signals infeasible. To meet this challenge, we herein propose a new strategy by using the dual-excitation approach, where one excitation wavelength generates a fluorescence signal and the other produces a photoacoustic signal, thus achieving simultaneous maximization of both signals in one fluorescence-photoacoustic molecule. Based on this strategy, three dye molecules were employed for comparison, and it was surprising to find that
    Mesh-Begriff(e) Mice ; Animals ; Photoacoustic Techniques/methods ; Spectrum Analysis
    Sprache Englisch
    Erscheinungsdatum 2023-11-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02372
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4033: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Artikel ; Online: Revealing the Effects of Endoplasmic Reticulum Stress on Ferroptosis by Two-Channel Real-Time Imaging of pH and Viscosity.

    Song, Wenhui / Zhang, Weiyao / Yue, Lizhou / Lin, Weiying

    Analytical chemistry

    2022  Band 94, Heft 17, Seite(n) 6557–6565

    Abstract: Endoplasmic reticulum (ER) is sensitive to changes in the intracellular environment such as pH and viscosity, and slight changes may trigger stress response. Besides, different from apoptosis and necrosis, ferroptosis is the result of lipid peroxidation ... ...

    Abstract Endoplasmic reticulum (ER) is sensitive to changes in the intracellular environment such as pH and viscosity, and slight changes may trigger stress response. Besides, different from apoptosis and necrosis, ferroptosis is the result of lipid peroxidation accumulation. There is evidence that ferroptosis is closely related to endoplasmic reticulum stress (ERS). However, the possible changes in the pH and viscosity of the ER during the ferroptosis process have not yet been studied. Therefore, we used a new type of ER-targeted dual-excitation fluorescent probe (
    Mesh-Begriff(e) Dithiothreitol/pharmacology ; Endoplasmic Reticulum Stress ; Ferroptosis ; Fluorescent Dyes/pharmacology ; Hydrogen-Ion Concentration ; Viscosity
    Chemische Substanzen Fluorescent Dyes ; Dithiothreitol (T8ID5YZU6Y)
    Sprache Englisch
    Erscheinungsdatum 2022-04-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c00387
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4033: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel: Determination of melamine in milk based on β-cyclodextrin modified carbon nanoparticles via host–guest recognition

    Liao, Xiufen / Chen, Congjin / Shi, Panpan / Yue, Lizhou

    Food chemistry. 2021 Feb. 15, v. 338

    2021  

    Abstract: Illegal addition of melamine (MEL) to milk has caused serious food safety accident. It is urgent to develop a highly sensitive method for detecting MEL in milk. β-Cyclodextrin with inner hydrophobic and outer hydrophilic cavities have been widely used in ...

    Abstract Illegal addition of melamine (MEL) to milk has caused serious food safety accident. It is urgent to develop a highly sensitive method for detecting MEL in milk. β-Cyclodextrin with inner hydrophobic and outer hydrophilic cavities have been widely used in smart sensors design. In this study, an “ON-OFF-ON” sensor for MEL detection was constructed based on β-cyclodextrin modified carbon nanoparticles (β-CD-CNPs). The sensor is switched “OFF” when Fe³⁺ interacts with β-CD-CNPs and switched “ON” when MEL replaces Fe³⁺. Fluorescence recovery of β-CD-CNPs exhibits good linear correlations with MEL concentration ranging from 10.00 ng/mL ~ 180.00 ng/mL and 180.00 ~ 1000.00 ng/mL, the detection limit is 6.82 ng/mL. The sensor was applied to analysis melamine in milk samples with recovery between 94.80% ~ 102.05%, and RSD bellow 12.61%. The results show that this method can meet the requirements of real sample analysis.
    Schlagwörter accidents ; carbon nanoparticles ; design ; detection limit ; fluorescence ; food chemistry ; food safety ; hydrophilicity ; hydrophobicity ; melamine ; milk
    Sprache Englisch
    Erscheinungsverlauf 2021-0215
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2020.127769
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: Elevated hypochlorous acid levels in asthmatic mice were disclosed by a near-infrared fluorescence probe.

    Huang, Huawei / Yue, Lizhou / Chen, Zehua / Li, Hao / Lin, Weiying

    Analytica chimica acta

    2022  Band 1232, Seite(n) 340480

    Abstract: Asthma is a respiratory inflammatory disease that seriously threatens human health. A growing body of evidence suggests that hypochlorous acid (HClO) plays an instrumental role in inflammation-related diseases, and therefore we hypothesize that it may be ...

    Abstract Asthma is a respiratory inflammatory disease that seriously threatens human health. A growing body of evidence suggests that hypochlorous acid (HClO) plays an instrumental role in inflammation-related diseases, and therefore we hypothesize that it may be associated with asthma. Unfortunately, tracking HClO levels in asthma remains challenging due to the lack of effective measures for in vivo imaging. Herein, we exquisitely designed a near-infrared fluorescence probe dicyanomethylene-4H-pyran-dimethylthiocarbamyl (DCM-DMTC) for exploring the relationship between HClO and asthma, which has high sensitivity (about 76 times), a low limit of detection (44 nM), and great selectivity for HClO. In addition, the probe DCM-DMTC was successfully employed in tracing exogenous and endogenous HClO in living cells. Notably, the higher levels of HClO in the lungs of asthmatic mice than in normal mice were visualized by fluorescence imaging for the first time, indicating a remarkably intimate association between asthma and the overproduction of HClO.
    Mesh-Begriff(e) Mice ; Humans ; Animals ; Hypochlorous Acid ; Fluorescent Dyes ; Optical Imaging/methods ; Asthma/diagnostic imaging
    Chemische Substanzen Hypochlorous Acid (712K4CDC10) ; Fluorescent Dyes
    Sprache Englisch
    Erscheinungsdatum 2022-10-04
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2022.340480
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Determination of melamine in milk based on β-cyclodextrin modified carbon nanoparticles via host-guest recognition.

    Liao, Xiufen / Chen, Congjin / Shi, Panpan / Yue, Lizhou

    Food chemistry

    2020  Band 338, Seite(n) 127769

    Abstract: Illegal addition of melamine (MEL) to milk has caused serious food safety accident. It is urgent to develop a highly sensitive method for detecting MEL in milk. β-Cyclodextrin with inner hydrophobic and outer hydrophilic cavities have been widely used in ...

    Abstract Illegal addition of melamine (MEL) to milk has caused serious food safety accident. It is urgent to develop a highly sensitive method for detecting MEL in milk. β-Cyclodextrin with inner hydrophobic and outer hydrophilic cavities have been widely used in smart sensors design. In this study, an "ON-OFF-ON" sensor for MEL detection was constructed based on β-cyclodextrin modified carbon nanoparticles (β-CD-CNPs). The sensor is switched "OFF" when Fe
    Mesh-Begriff(e) Animals ; Carbon/chemistry ; Food Analysis/methods ; Food Contamination/analysis ; Limit of Detection ; Milk/chemistry ; Nanoparticles/chemistry ; Spectrometry, Fluorescence ; Triazines/analysis ; Triazines/chemistry ; beta-Cyclodextrins/chemistry
    Chemische Substanzen Triazines ; beta-Cyclodextrins ; Carbon (7440-44-0) ; betadex (JV039JZZ3A) ; melamine (N3GP2YSD88)
    Sprache Englisch
    Erscheinungsdatum 2020-08-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2020.127769
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Bonn

    Z 3634: Hefte anzeigen

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