Artikel: Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Cell. 2021 Nov. 11, v. 184, no. 23
2021
Abstract: Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United ... ...
Körperschaft | on behalf of the PITCH Consortium | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Abstract | Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6–14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4⁺ T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol. |
||||||||||
Schlagwörter | Severe acute respiratory syndrome coronavirus 2 ; health services ; immunogenicity ; interleukin-2 ; vaccines ; United Kingdom | ||||||||||
Sprache | Englisch | ||||||||||
Erscheinungsverlauf | 2021-1111 | ||||||||||
Umfang | p. 5699-5714.e11. | ||||||||||
Erscheinungsort | Elsevier Inc. | ||||||||||
Dokumenttyp | Artikel | ||||||||||
ZDB-ID | 187009-9 | ||||||||||
ISSN | 1097-4172 ; 0092-8674 | ||||||||||
ISSN (online) | 1097-4172 | ||||||||||
ISSN | 0092-8674 | ||||||||||
DOI | 10.1016/j.cell.2021.10.011 | ||||||||||
Signatur |
|
||||||||||
Datenquelle | NAL Katalog (AGRICOLA) |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Bonn
Z 75/702: Hefte anzeigen | ||||
Z 93: Hefte anzeigen |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.
Fernleihe an ZB MED
Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.