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  1. Artikel ; Online: Dynamic changes of circulating soluble PD-1/PD-L1 and its association with patient survival in immune checkpoint blockade-treated melanoma.

    Lu, Lingeng / Risch, Evan / Halaban, Ruth / Zhen, Pinyi / Bacchiocchi, Antonella / Risch, Harvey A

    International immunopharmacology

    2023  Band 118, Seite(n) 110092

    Abstract: Immune checkpoint PD-1 and its ligand PD-L1 lead to T cell exhaustion, and a high level of circulating soluble PD-L1 at baseline indicates a poor prognosis in melanoma and other solid tumor types. Here we show that the dynamic changes of circulating ... ...

    Abstract Immune checkpoint PD-1 and its ligand PD-L1 lead to T cell exhaustion, and a high level of circulating soluble PD-L1 at baseline indicates a poor prognosis in melanoma and other solid tumor types. Here we show that the dynamic changes of circulating soluble PD-1 and PD-L1 across the course of immune checkpoint blockades (ICBs) and their changes associate with patient survival in melanoma in a retrospective study. A high change of soluble PD-L1 level at a time-point but not PD-1 significantly increased the mortality, whereas a high change of soluble PD-1/PD-L1 ratio significantly reduced the mortality. After the initial immunotherapy, both soluble PD-1 and PD-L1 increased. However, the change pattern of soluble PD-L1 level was particularly dependent on patients' survival status. These findings indicate that the magnitudes of circulating soluble PD-L1 and PD-1/PD-L1 ratio changes over the time may reflect the patients' response to ICBs or the progression of the disease and predict the survival in melanoma patients treated with ICBs.
    Mesh-Begriff(e) Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; B7-H1 Antigen/metabolism ; Retrospective Studies ; Melanoma ; Immunotherapy
    Chemische Substanzen Immune Checkpoint Inhibitors ; B7-H1 Antigen
    Sprache Englisch
    Erscheinungsdatum 2023-03-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110092
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in

    Lu, Lingeng / Zhang, Qian / Shen, Xinyi / Zhen, Pinyi / Marin, Audrey / Garcia-Milian, Rolando / Roper, Jatin / Khan, Sajid A / Johnson, Caroline H

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The nutrient status of the tumor microenvironment has major impacts on cell growth. Under nutrient depletion, asparagine synthetase (ASNS)-mediated asparagine production increases to sustain cell survival. G protein-coupled estrogen receptor-1 (GPER1) ... ...

    Abstract The nutrient status of the tumor microenvironment has major impacts on cell growth. Under nutrient depletion, asparagine synthetase (ASNS)-mediated asparagine production increases to sustain cell survival. G protein-coupled estrogen receptor-1 (GPER1) signaling converges via cAMP/PI3K/AKT with KRAS signaling to regulate
    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.05.05.539577
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone.

    Li, Xian / Zeng, Hanxian / Wang, Pengfei / Lin, Lu / Liu, Lin / Zhen, Pinyi / Fu, Yuanzhe / Lu, Panpan / Zhu, Huanzhang

    Current HIV research

    2016  Band 14, Heft 6, Seite(n) 484–490

    Abstract: Background: Current antiretroviral therapy (ART) cannot cure HIV-1 infection due to the presence of latent viral reservoirs. The "shock and kill" strategy is a promising approach to eliminate the viral reservoir. However, there are various limits ... ...

    Abstract Background: Current antiretroviral therapy (ART) cannot cure HIV-1 infection due to the presence of latent viral reservoirs. The "shock and kill" strategy is a promising approach to eliminate the viral reservoir. However, there are various limits existing in current latency-reversing agents, searching for new activators are urgently needed.
    Objective: The present study aimed at investigating the ability of hymecromone and scoparone for activating HIV-1 from latent reservoirs.
    Methods: Jurkat T cell model of HIV-1 latently were used to evaluate the effect of hymecromone and scoparone. The percentage of green florescence protein expression as a marker for reactivation of HIV-1 promoter was measured via FACScan. The expression of CD25 and CD69 in human peripheral blood mononuclear cells was measured by flow cytometry at 72 h post-treatment with hymecromone or scoparone or prostratin using antibodies against CD25 and CD69.
    Results: Hymecromone and scoparone can induce HIV-1 LTR reactivation in a dose and timedependent. We further show that hymecromone and scoparone can reactivate latent virus without inducing the activation of global T cells. We also found that scoparone acts by NF-κB signal pathway.
    Conclusion: Hymecromone and scoparone can effectively reactivate latent HIV-1 with low cellular toxicity, indicating hymecromone and scoparone might be potential drugs for HIV-1 reservoir eradication strategies in the future.
    Mesh-Begriff(e) Adult ; Antigens, CD/analysis ; Antigens, Differentiation, T-Lymphocyte/analysis ; Artificial Gene Fusion ; Cells, Cultured ; Coumarins/metabolism ; Flow Cytometry ; Genes, Reporter ; Green Fluorescent Proteins/analysis ; Green Fluorescent Proteins/biosynthesis ; Green Fluorescent Proteins/genetics ; HIV-1/drug effects ; Humans ; Hymecromone/metabolism ; Interleukin-2 Receptor alpha Subunit/analysis ; Lectins, C-Type/analysis ; Leukocytes, Mononuclear/chemistry ; Leukocytes, Mononuclear/drug effects ; Proviruses/drug effects ; Virus Activation/drug effects
    Chemische Substanzen Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD69 antigen ; Coumarins ; IL2RA protein, human ; Interleukin-2 Receptor alpha Subunit ; Lectins, C-Type ; Green Fluorescent Proteins (147336-22-9) ; Hymecromone (3T5NG4Q468) ; scoparone (H5841PDT4Y)
    Sprache Englisch
    Erscheinungsdatum 2016-09-05
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2192348-6
    ISSN 1873-4251 ; 1570-162X
    ISSN (online) 1873-4251
    ISSN 1570-162X
    DOI 10.2174/1570162x14666161003152458
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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